p53 patches are not increased in patients with multiple nonmelanoma skin cancers [2]

Journal of Investigative Dermatology

Volumn 117, Issue 5, 2001, Pages 1324-1325

  Le Pelletier, Francois ^a   Soufir, Nadem ^a   De La Salmoniere, Pauline ^a   Janin, Anne ^a   Basset Seguin, Nicole ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DIAMINOBENZIDINE; FORMALDEHYDE; HEMATOXYLIN; MUTANT PROTEIN; PARAFFIN; PEROXIDASE; PROTEIN P53;

ADULT; AGED; ANTIGEN RETRIEVAL; BASAL CELL; BASAL CELL CARCINOMA; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL NUCLEUS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; DYSPLASIA; EPIDERMIS; FEMALE; FISHER EXACT TEST; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; LETTER; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; MULTIPLE CANCER; NERVE; PRECANCER; PREVALENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; SECOND CANCER; SKIN CARCINOMA; SKIN CULTURE; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; SUN EXPOSURE; TISSUE FIXATION; ULTRAVIOLET IRRADIATION;

EID: 0035723380     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.t01-1-15292.x     Document Type: Letter

References (5)

1. Early p53 alterations in mouse skin carcinogenesis by UVB radiation: Immunohistochemical detection of mutant p 53 protein in clusters of preneoplastic epidermal cells
2. Frequent clones of p53-mutated keratinocytes in normal human skin
3. Benign clonal keratinocyte patches with p53 mutations show no genetic link to synchronous squamous cell precancer or cancer in human skin
4. Human epidermal cancer and accompanying precursors have identical p53 mutations different from adjacent areas of clonally expanded non-neoplastic keratinocytes
5. Low frequency of genetic change in p53 immunopositive clones in human epidermis