Inverse association between cancer risks and age in schizophrenic patients: A 12-year nationwide cohort study

Cancer Science

Volumn 104, Issue 3, 2013, Pages 383-390

  Lin, Chun Yuan ^a,b,c   Lane, Hsien Yuan ^a,d   Chen, Tsi Ting ^e   Wu, Yu Hsin ^c   Wu, Chun Ying ^a,e,f,g   Wu, Vivian Y ^h  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b Chang Hua Hospital   (Taiwan)

^c NATIONAL CHANGHUA UNIVERSITY OF EDUCATION   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e NATIONAL YANG MING UNIVERSITY   (Taiwan)

^f TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^g NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^h UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGING; ARTICLE; CANCER RISK; COHORT ANALYSIS; COMORBIDITY; DATA BASE; DISEASE ASSOCIATION; FEMALE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CANCER; PRIORITY JOURNAL; PROSTATE CANCER; SCHIZOPHRENIA; STOMACH CANCER; STRATIFICATION;

ADULT; AGE FACTORS; AGE OF ONSET; AGED; COHORT STUDIES; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; NEOPLASMS; RISK FACTORS; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84874470423     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12094     Document Type: Article

References (48)

1. Amereican Psychiatry Association. Diagnostic and Stastistical Manual of Mental Disorders, 4th edn. Washington, DC: American Psychiatric Press, 1994.
2. Carney C, Jones L, Woolson R. Medical comorbidity in women and men with schizophrenia: a population-based controlled study. J Gen Intern Med 2006; 21: 1133-7.
3. Leucht S, Burkard T, Henderson J, Maj M, Sartorius N. Physical illness and schizophrenia: a review of the literature. Acta Psychiatr Scand 2007; 116: 317-33.
4. Lichtermann D, Ekelund J, Pukkala E, Tanskanen A, Lonnqvist J. Incidence of cancer among persons with schizophrenia and their relatives. Arch Gen Psychiatry 2001; 58: 573-8.
5. Mortensen PB. The incidence of cancer in schizophrenic patients. J Epidemiol Community Health 1989; 43: 43-7.
6. Barak Y, Achiron A, Mandel M, Mirecki I, Aizenberg D. Reduced cancer incidence among patients with schizophrenia. Cancer 2005; 104: 2817-21.
7. Grinshpoon A, Barchana M, Ponizovsky A et al. Cancer in schizophrenia: is the risk higher or lower? Schizophr Res 2005; 73: 333-41.
8. Chou FH, Tsai K, Su C, Lee C. The incidence and relative risk factors for developing cancer among patients with schizophrenia: a nine-year follow-up study. Schizophr Res 2011; 129: 97-103.
9. Goldacre MJ, Kurina LM, Wotton CJ, Yeates D, Seagroat V. Schizophrenia and cancer: an epidemiological study. Br J Psychiatry 2005; 187: 334-8.
10. Hippisley-Cox J, Vinogradova Y, Coupland C, Parker C. Risk of malignancy in patients with schizophrenia or bipolar disorder: nested case-control study. Arch Gen Psychiatry 2007; 64: 1368-76.
11. Gulbinat W, Dupont A, Jablensky A. Cancer incidence of schizophrenic patients: results of record linkage studies in 3 countries. Br J Psychiatry 1992; 161(Suppl): 75-83.
12. Jeste DV, Gladsjo JA, Lindamer LA, Lacro JP. Medical comorbidity in schizophrenia. Schizophr Bull 1996; 22: 413-30.
13. Catts V, Catts S. Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene? Schizophr Res 2000; 41: 405-15.
14. Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. Met, metastasis, motility and more. Nat Rev Mol Cell Biol 2003; 4: 915-25.
15. Margolese HC, Malchy L, Negrete JC, Tempier R, Gill K. Drug and alcohol use among patients with schizophrenia and related psychoses: levels and consequences. Schizophr Res 2004; 67: 157-66.
16. de Leon J, Diaz FJ. A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors. Schizophr Res 2005; 76: 135-57.
17. Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry 2007; 64: 1123-31.
18. Brown S, Kim M, Mitchell C, Inskip H. Twenty-five year mortality of a community cohort with schizophrenia. Br J Psychiatry 2010; 196: 116-21.
19. Urban Ö, Correia N, Brandt L, Ekbom A, Sparén P. Mortality and causes of death in schizophrenia in Stockholm County, Sweden. Schizophr Res 2000; 45: 21-8.
20. Kirkpatrick B, Messias E, Harvey PD, Fernandez-Egea E, Bowie CR. Is schizophrenia a syndrome of accelerated aging? Schizophr Bull 2008; 34: 1024-32.
21. Harris MJ, Jeste DV. Late-onset schizophrenia: an overview. Schizophr Bull 1988; 14: 39-55.
22. Howard R, Rabins PV, Seeman MV, Jeste DV. Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis: an international consensus. Am J Psychiatry 2000; 157: 172-8.
23. Cheng T. Taiwan's new national health insurance program: genesis and experience so far. Health Aff 2003; 22: 61-76.
24. Wu CY, Wu MS, Kuo KN, Wang CB, Chen YJ, Lin JT. Effective reduction of gastric cancer risk with regular use of nonsteroidal anti-inflammatory drugs in Helicobacter pylori-infected patients. J Clin Oncol 2010; 28: 2952-7.
25. Wu CY, Kuo KN, Wu MS, Chen YJ, Wang CB, Lin JT. Early Helicobacter pylori eradication decreases risk of gastric cancer in patients with peptic ulcer disease. Gastroenterology 2009; 137: 1641-8.
26. ICD9Data.com. Schizophrenic disorders. 2012. [Cited 5 Dec 2012]. Available from URL: http://www.icd9data.com/2012/Volume1/290-319/295-299/295/default.htm.
27. Department of Health NYS. Guidance for Health Outcome Data Review and Analysis Relating to Nysdec Environmental Justice and Permitting: Appendix B: Calculating Confidence Intervals, 2011. [Cited 5 Nov 2012.] Available from URL: http://www.health.ny.gov/environmental/investigations/environmental_justice/appendix_b.htm.
28. Shiels MS, Pfeiffer RM, Engels EA. Age at cancer diagnosis among persons with AIDS in the United States. Ann Intern Med 2010; 153: 452-60.
29. Dalton SO, Laursen TM, Mellemkjaer L, Johansen C, Mortensen PB. Risk for cancer in parents of patients with schizophrenia. Am J Psychiatry 2004; 161: 903-8.
30. Lin GM, Chen YJ, Kuo DJ et al. Cancer incidence in patients with schizophrenia or bipolar disorder: a nationwide population-based study in Taiwan, 1997-2009. Schizophr Bull 2011; doi: 10.1093/schbul/sbr162.
31. Dalton SO, Mellemkjaer L, Thomassen L, Mortensen PB, Johansen C. Risk for cancer in a cohort of patients hospitalized for schizophrenia in Denmark, 1969-1993. Schizophr Res 2005; 75: 315-24.
32. Barakat RR, Markman M, Randall ME. Principles and Practice of Gynecologic Oncology. Philadelphia, PA: Lippincott Williams & Wilkins, 2009.
33. Lin CH, Huang KH, Chang YC et al. Clozapine protects bone mineral density in female patients with schizophrenia. Int J Neuropsychopharmacol 2011; 15: 897-906.
34. Yamazawa K, Matsui H, Seki K, Sekiya S. A case-control study of endometrial cancer after antipsychotics exposure in premenopausal women. Oncology 2003; 64: 116-23.
35. Wang PS, Walker AM, Tsuang MT et al. Dopamine antagonists and the development of breast cancer. Arch Gen Psychiatry 2002; 59: 1147-54.
36. Akdeniz F. Female-specific health problems in mental patients. Curr Opin Psychiatry 2010; 23: 378-82.
37. Sasagawa T, Dong YZ, Saijoh K, Satake SI, Tateno M, Inoue M. Human papillomavirus infection and risk determinants for squamous intraepithelial lesion and cervical cancer in Japan. Cancer Sci 1997; 88: 376-84.
38. Chen Y, You S, Chen C et al. Effectiveness of national cervical cancer screening programme in Taiwan: 12-year experiences. Br J Cancer 2009; 101: 174-7.
39. Lin HC, Yang LY, Chiu WT. Cervix cancer screening of women with schizophrenia in Taiwan. Psychiatr Serv 2010; 61: 327-8.
40. Lee SY, Jeong SH, Kim YN et al. Cost-effective mammography screening in Korea: high incidence of breast cancer in young women. Cancer Sci 2009; 1020: 1105-11.
41. Fernandez-Egea E, García-Rizo C, Miller B et al. Testosterone in newly diagnosed, antipsychotic-naive men with nonaffective psychosis: a test of the accelerated aging hypothesis. Psychosom Med 2011; 73: 643-7.
42. Vahia I, Palmer B, Depp C et al. Is late-onset schizophrenia a subtype of schizophrenia? Acta Psychiatr Scand 2010; 122: 414-26.
43. Tran E, Rouillon F, Loze J-Y et al. Cancer mortality in patients with schizophrenia. Cancer 2009; 115: 3555-62.
44. McCreadie R, Macdonald E, Blacklock C et al. Dietary intake of schizophrenic patients in Nithsdale, Scotland: case-control study. BMJ 1998; 317: 784-5.
45. Allison DB, Fontaine KR, Heo M et al. The distribution of body mass index among individuals with and without schizophrenia schizophrenia. J Clin Psychiatry 1999; 60: 215-20.
46. Daumit GL, Goldberg RW, Anthony C et al. Physical activity patterns in adults with severe mental illness. J Nerv Ment Dis 2005; 193: 641-6.
47. Jablensky A, Lawrence D. Schizophrenia and cancer: is there a need to invoke a protective gene? Arch Gen Psychiatry 2001; 58: 579-80.
48. Sadock B, Sadock V. Kaplan & Sadock's Synopsis of Psychiatry, 9th edn. New York: Williams & Wilkins, 2003.