Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 9, 2013, Pages 3405-3410

  Ardehali, Reza ^a   Ali, Shah R ^b   Inlay, Matthew A ^b   Abilez, Oscar J ^b   Chen, Michael Q ^b   Blauwkamp, Timothy A ^b   Yazawa, Masayuki ^b   Gong, Yongquan ^b   Nusse, Roeland ^b   Drukker, Micha ^b   Weissman, Irving L ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clonal analysis; Engraftment; Mature cardiomyocytes; Stem cells; Surface markers

Indexed keywords

MICROSOMAL AMINOPEPTIDASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN; PROTEIN ROR2; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CLONE; CELL ISOLATION; CELL POPULATION; CELL STRUCTURE; CELL TRANSPLANTATION; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; EXTERNAL EAR; FETUS HEART; FIRST TRIMESTER PREGNANCY; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; SCID MOUSE; SECOND TRIMESTER PREGNANCY; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; BIOLOGICAL MARKERS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINEAGE; CELL SEPARATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; ENDOTHELIUM, VASCULAR; FETUS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; HUMANS; MESODERM; MICE; MULTIPOTENT STEM CELLS; MYOCARDIUM; MYOCYTES, CARDIAC; MYOCYTES, SMOOTH MUSCLE; PRIMITIVE STREAK; RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTORS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; STEM CELL TRANSPLANTATION; TISSUE SURVIVAL; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84874451266     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220832110     Document Type: Article

References (34)

1. Bergmann O, et al. (2009) Evidence for cardiomyocyte renewal in humans. Science 324 (5923): 98-102.
2. Porrello ER, et al. (2011) Transient regenerative potential of the neonatal mouse heart. Science 331(6020): 1078-1080.
3. Segers VF, Lee RT (2008) Stem-cell therapy for cardiac disease. Nature 451(7181): 937-942.
4. Laflamme MA, Murry CE (2011) Heart regeneration. Nature 473(7347): 326-335.
5. Soonpaa MH, Koh GY, Klug MG, Field LJ (1994) Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium. Science 264(5155): 98-101.
6. Wagers AJ, Weissman IL (2004) Plasticity of adult stem cells. Cell 116(5): 639-648.
7. Balsam LB, et al. (2004) Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 428(6983): 668-673.
8. Fukuda K, Yuasa S (2006) Stem cells as a source of regenerative cardiomyocytes. Circ Res 98(8): 1002-1013.
9. Arbel G, et al. (2010) Methods for human embryonic stem cells derived cardiomyocytes cultivation, genetic manipulation, and transplantation. Methods Mol Biol 660: 85-95.
10. Kattman SJ, et al. (2011) Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 8(2): 228-240.
11. Yang L, et al. (2008) Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 453(7194): 524-528.
12. Laflamme MA, et al. (2007) Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance functionof infarctedrathearts. NatBiotechnol 25(9): 1015-1024.
13. Xue T, et al. (2005) Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: Insights into the development of cell-based pacemakers. Circulation 111(1): 11-20.
14. Shiba Y, et al. (2012) Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature 489(7415): 322-325.
15. Ardehali R, et al. (2011) Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors. Proc Natl Acad Sci USA 108(8): 3282-3287.
16. Filipczyk AA, Passier R, Rochat A, Mummery CL (2007) Regulation of cardiomyocyte differentiation of embryonic stem cells by extracellular signalling. Cell Mol Life Sci 64(6): 704-718.
17. Drukker M, et al. (2012) Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells. Nat Biotechnol 30(6): 531-542.
18. Kataoka H, et al. (1997) Expressions of PDGF receptor alpha, c-Kit and Flk1 genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells. Dev Growth Differ 39(6): 729-740.
19. David R, et al. (2008) MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling. Nat Cell Biol 10(3): 338-345.
20. Srivastava D (2006) Making or breaking the heart: from lineage determination to morphogenesis. Cell 126(6): 1037-1048.
21. Jacot JG, et al. (2010) Cardiac myocyte force development during differentiation and maturation. Ann N Y Acad Sci 1188: 121-127.
22. Fey TA, et al. (1998) Improved methods for transplanting split-heart neonatal cardiac grafts into the ear pinna of mice and rats. J Pharmacol Toxicol Methods 39(1): 9-17.
23. Billingham M, Warnke R, Weissman IL (1977) The cellular infiltrate in cardiac allograft rejection in mice. Transplantation 23(2): 171-176.
24. Roell W, et al. (2007) Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia. Nature 450(7171): 819-824.
25. Alvarez-Dolado M, et al. (2003) Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425(6961): 968-973.
26. Nygren JM, et al. (2004) Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med 10(5): 494-501.
27. Nomi M, et al. (2001) Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: Redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Mol Cell Biol 21(24): 8329-8335.
28. Schwabe GC, et al. (2004) Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome. Dev Dyn 229(2): 400-410.
29. Matsuda T, et al. (2001) Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development. Mech Dev 105(1-2): 153-156.
30. Minami Y, Oishi I, Endo M, Nishita M (2010) Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases. Dev Dyn 239(1): 1-15.
31. Afzal AR, et al. (2000) Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nat Genet 25(4): 419-422.
32. Lee AS, et al. (2009) Effects of cell number on teratoma formation by human embryonic stem cells. Cell Cycle 8(16): 2608-2612.
33. Fernandes S, et al. (2010) Human embryonic stem cell-derived cardiomyocytes engraft but do not alter cardiac remodeling after chronic infarction in rats. J Mol Cell Cardiol 49(6): 941-949.
34. Kehat I, et al. (2004) Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 22(10): 1282-1289.