Sex differences in the associations of testosterone and sex hormone-binding globulin with metabolic syndrome in middle-aged and elderly Koreans: The Namwon study -

Circulation Journal

Volumn 77, Issue 3, 2013, Pages 734-740

  Kweon, Sun Seog ^a,b   Shin, Min Ho ^a   Nam, Hae Sung ^c   Jeong, Seul Ki ^d   Park, Kyeong Soo ^e   Choi, Jin Su ^a   Lee, Young Hoon ^f,g  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University Hwasun Hospital and Medical School   (South Korea)

^c Chungnam National University College of Medicine   (South Korea)

^d Chonbuk National University Medical School   (South Korea)

^e Seonam University   (South Korea)

^f Wonkwang University School of Medicine   (South Korea)

^g Wonkwang University Hospital   (South Korea)

Author keywords

Metabolic syndrome; Sex hormone binding globulin; Testosterone

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ABDOMINAL OBESITY; ADULT; AGED; ARTICLE; BLOOD PRESSURE; BODY MASS; CHEMOLUMINESCENCE; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MICROPARTICLE ENZYME IMMUNOASSAY; PREVALENCE; QUESTIONNAIRE; RISK; SEX DIFFERENCE; WAIST CIRCUMFERENCE;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREVALENCE; REPUBLIC OF KOREA; SEX FACTORS; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 84874433634     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-12-0613     Document Type: Article

References (32)

1. Galassi A, Reynolds K, He J. Metabolic syndrome and risk of cardiovascular disease: A meta-analysis. Am J Med 2006; 119: 812-819.
2. Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: A summary of the evidence. Diabetes Care 2005; 28: 1769-1778.
3. Saito I. Epidemiological evidence of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease in Japan. Circ J 2012; 76: 1066-1073.
4. Li C, Ford ES, Li B, Giles WH, Liu S. Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men. Diabetes Care 2010; 33: 1618-1624.
5. Kupelian V, Hayes FJ, Link CL, Rosen R, McKinlay JB. Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups. J Clin Endocrinol Metab 2008; 93: 3403-3410.
6. Muller M, Grobbee DE, den Tonkelaar I, Lamberts SW, van der Schouw YT. Endogenous sex hormones and metabolic syndrome in aging men. J Clin Endocrinol Metab 2005; 90: 2618-2623.
7. Laaksonen DE, Niskanen L, Punnonen K, Nyyssönen K, Tuomainen TP, Valkonen VP, et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 2004; 27: 1036-1041.
8. Brand JS, van der Tweel I, Grobbee DE, Emmelot-Vonk MH, van der Schouw YT. Testosterone, sex hormone-binding globulin and the metabolic syndrome: A systematic review and meta-analysis of observational studies. Int J Epidemiol 2011; 40: 189-207.
9. Patel SM, Ratcliffe SJ, Reilly MP, Weinstein R, Bhasin S, Blackman MR, et al. Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 2009; 94: 4776-4784.
10. Weinberg ME, Manson JE, Buring JE, Cook NR, Seely EW, Ridker PM, et al. Low sex hormone-binding globulin is associated with the metabolic syndrome in postmenopausal women. Metabolism 2006; 55: 1473-1480.
11. Santoro N, Torrens J, Crawford S, Allsworth JE, Finkelstein JS, Gold EB, et al. Correlates of circulating androgens in mid-life women: The study of women's health across the nation. J Clin Endocrinol Metab 2005; 90: 4836-4845.
12. Bhasin S, Jasjua GK, Pencina M, D'Agostino R Sr, Coviello AD, Vasan RS, et al. Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: The Framingham heart study. Diabetes Care 2011; 34: 2464-2470.
13. Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB. Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in non-obese men. J Clin Endocrinol Metab 2006; 91: 843-850.
14. Nam HS, Shin MH, Zmuda JM, Leung PC, Barrett-Connor E, Orwoll ES, et al. Race/ethnic differences in bone mineral densities in older men. Osteoporos Int 2010; 21: 2115-2123.
15. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999; 84: 3666-3672.
16. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al; American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112: 2735-2752.
17. Lee SY, Park HS, Kim DJ, Han JH, Kim SM, Cho GJ, et al. Appropriate waist circumference cutoff points for central obesity in Korean adults. Diabetes Res Clin Pract 2007; 75: 72-80.
18. Devaraj S, Valleggi S, Siegel D, Jialal I. Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome. Curr Atheroscler Rep 2010; 12: 110-118.
19. Torréns JI, Sutton-Tyrrell K, Zhao X, Matthews K, Brockwell S, Sowers M, et al. Relative androgen excess during the menopausal transition predicts incident metabolic syndrome in midlife women: Study of Women's Health Across the Nation. Menopause 2009; 16: 257-264.
20. Chubb SA, Hyde Z, Almeida OP, Flicker L, Norman PE, Jamrozik K, et al. Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: The Health in Men Study. Eur J Endocrinol 2008; 158: 785-792.
21. Atlantis E, Martin SA, Haren MT, O'Loughlin PD, Taylor AW, Anand-Ivell R, et al. Demographic, physical and lifestyle factors associated with androgen status: The Florey Adelaide Male Ageing Study (FAMAS). Clin Endocrinol (Oxf) 2009; 71: 261-272.
22. Torkler S, Wallaschofski H, Baumeister SE, Völzke H, Dörr M, Felix S, et al. Inverse association between total testosterone concentrations, incident hypertension and blood pressure. Aging Male 2011; 14: 176-182.
23. Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: A systematic review and meta-analysis. JAMA 2006; 295: 1288-1299.
24. Atlantis E, Lange K, Martin S, Haren MT, Taylor A, O'Loughlin PD, et al. Testosterone and modifiable risk factors associated with diabetes in men. Maturitas 2011; 68: 279-285.
25. Holmang A, Bjorntorp P. The effects of testosterone on insulin sensitivity in male rats. Acta Physiol Scand 1992; 146: 505-510.
26. Xu XF, De Pergola G, Björntorp P. Testosterone increases lipolysis and the number of beta-adrenoceptors in male rat adipocytes. Endocrinology 1991; 128: 379-382.
27. Nilsson C, Niklasson M, Eriksson E, Björntorp P, Holmäng A. Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats. J Clin Invest 1998; 101: 74-78.
28. Alexanderson C, Eriksson E, Stener-Victorin E, Lystig T, Gabrielsson B, Lönn M, et al. Postnatal testosterone exposure results in insulin resistance, enlarged mesenteric adipocytes, and an atherogenic lipid profile in adult female rats: Comparisons with estradiol and dihydrotestosterone. Endocrinology 2007; 148: 5369-5376.
29. Laaksonen DE, Niskanen L, Punnonen K, Nyyssönen K, Tuomainen TP, Valkonen VP, et al. The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: A prospective cohort study. J Clin Endocrinol Metab 2005; 90: 712-719.
30. Maggio M, Lauretani F, Ceda GP, Bandinelli S, Basaria S, Paolisso G, et al. Association of hormonal dysregulation with metabolic syndrome in older women: Data from the InCHIANTI study. Am J Physiol Endocrinol Metab 2007; 292: E353-E358.
31. Yki-Järvinen H, Mäkimattila S, Utriainen T, Rutanen EM. Portal insulin concentrations rather than insulin sensitivity regulate serum sex hormone-binding globulin and insulin-like growth factor binding protein 1 in vivo. J Clin Endocrinol Metab 1995; 80: 3227-3232.
32. Vermeulen A, Verdonck G. Representativeness of a single point plasma testosterone level for the long term hormonal milieu in men. J Clin Endocrinol Metab 1992; 74: 939-942.