메뉴 건너뛰기




Volumn 101, Issue 1, 1998, Pages 74-78

Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats

Author keywords

Adipose tissue; Insulin resistance; Neonatal exposure; Skeletal muscle; Testosterone

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; ESTRADIOL; INSULIN; PROGESTERONE; SOMATOMEDIN C; TESTOSTERONE; TESTOSTERONE PROPIONATE;

EID: 0031985351     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1353     Document Type: Article
Times cited : (100)

References (46)
  • 1
    • 0002551982 scopus 로고
    • Le virilisme pilaire et son association a l'insufficance glycolytique (diabete des femmes a barbe)
    • Achard, C., and J. Thiers. 1921. Le virilisme pilaire et son association a l'insufficance glycolytique (diabete des femmes a barbe). Bull. Acad. Nat. Med. 86:51-66.
    • (1921) Bull. Acad. Nat. Med. , vol.86 , pp. 51-66
    • Achard, C.1    Thiers, J.2
  • 2
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif, A., K.R. Segal, W. Futterweit, and A. Dobrjansky. 1989. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes. 38:1165-1174.
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3    Dobrjansky, A.4
  • 4
    • 0026053850 scopus 로고
    • Low sex-hormone binding globulin is an independent risk factor for the development of non-insulin diabetes mellitus. A 12-year follow-up of the population study of women in Gothenburg, Sweden
    • Lindstedt, G., P.-A. Lundberg, L. Lapidus, H. Lundgren, C. Bengtsson, and P. Björntorp. 1991. Low sex-hormone binding globulin is an independent risk factor for the development of non-insulin diabetes mellitus. A 12-year follow-up of the population study of women in Gothenburg, Sweden. Diabetes. 40: 123-128.
    • (1991) Diabetes , vol.40 , pp. 123-128
    • Lindstedt, G.1    Lundberg, P.-A.2    Lapidus, L.3    Lundgren, H.4    Bengtsson, C.5    Björntorp, P.6
  • 5
    • 0029969585 scopus 로고    scopus 로고
    • Sex hormone-binding protein, hyperinsulinemia, insulin resistance and noninsulin-dependent diabetes
    • Haffner, S.M. 1996. Sex hormone-binding protein, hyperinsulinemia, insulin resistance and noninsulin-dependent diabetes. Horm. Res. 45:233-237.
    • (1996) Horm. Res. , vol.45 , pp. 233-237
    • Haffner, S.M.1
  • 6
    • 0028244707 scopus 로고
    • Hyperandrogenicity as a prediabetic condition in women
    • Jermendy, G. 1994. Hyperandrogenicity as a prediabetic condition in women [letter]. J. Intern. Med. 236:101.
    • (1994) J. Intern. Med. , vol.236 , pp. 101
    • Jermendy, G.1
  • 7
    • 0020563854 scopus 로고
    • Relationship of androgenic activity to body fat topography, fat cell morphology and metabolic aberrations in menopausal women
    • Evans, P., R. Hoffman, R. Kalkhoff, and A. Kissebah. 1983. Relationship of androgenic activity to body fat topography, fat cell morphology and metabolic aberrations in menopausal women. J. Clin. Endocrinol. Metab. 57:304-310.
    • (1983) J. Clin. Endocrinol. Metab. , vol.57 , pp. 304-310
    • Evans, P.1    Hoffman, R.2    Kalkhoff, R.3    Kissebah, A.4
  • 8
    • 0027487857 scopus 로고
    • Regional obesity and NIDDM
    • Björntorp, P. 1993. Regional obesity and NIDDM. Adv. Exp. Med. Biol. 334:279-285.
    • (1993) Adv. Exp. Med. Biol. , vol.334 , pp. 279-285
    • Björntorp, P.1
  • 9
    • 0022530317 scopus 로고
    • Muscle tissue in obesity with different distribution of adipose tissue, effects of physical training
    • Krotkiewski, M., and P. Björntorp. 1986. Muscle tissue in obesity with different distribution of adipose tissue, effects of physical training. Int. J. Obesity. 10:331-341.
    • (1986) Int. J. Obesity , vol.10 , pp. 331-341
    • Krotkiewski, M.1    Björntorp, P.2
  • 10
    • 0025095874 scopus 로고
    • Effects of testosterone on muscle insulin sensitivity and morphology in female rats
    • Holmäng, A., J. Svedberg, E. Jennische, and P. Björntorp. 1990. Effects of testosterone on muscle insulin sensitivity and morphology in female rats. Am. J. Physiol. 259:E555-E560.
    • (1990) Am. J. Physiol. , vol.259
    • Holmäng, A.1    Svedberg, J.2    Jennische, E.3    Björntorp, P.4
  • 11
    • 0026637840 scopus 로고
    • Effects of short-term testosterone exposure on insulin sensitivity of muscles in female rats
    • Holmäng, A., B.-M. Larsson, Z. Brzezinska, and P. Björntorp. 1992. Effects of short-term testosterone exposure on insulin sensitivity of muscles in female rats. Am. J. Physiol. 262:E851-E855.
    • (1992) Am. J. Physiol. , vol.262
    • Holmäng, A.1    Larsson, B.-M.2    Brzezinska, Z.3    Björntorp, P.4
  • 13
    • 0029926833 scopus 로고    scopus 로고
    • Mechanisms behind insulin resistance in rat skeletal muscle following oophorectomy and additional testosterone treatment
    • Rincon, J., A. Holmäng, E. Wahlström, P. Lönnroth, P. Björntorp, H. Wallberg-Henriksson, and J. Zierath. 1996. Mechanisms behind insulin resistance in rat skeletal muscle following oophorectomy and additional testosterone treatment. Diabetes. 45:615-621.
    • (1996) Diabetes , vol.45 , pp. 615-621
    • Rincon, J.1    Holmäng, A.2    Wahlström, E.3    Lönnroth, P.4    Björntorp, P.5    Wallberg-Henriksson, H.6    Zierath, J.7
  • 15
    • 0030010984 scopus 로고    scopus 로고
    • Exogen androgens influence body composition and regional body fat distribution in obese postmenopausal women: A clinical research center study
    • Lovejoy, J.C., G.A. Bray, and M.O. Bourgeois. 1996. Exogen androgens influence body composition and regional body fat distribution in obese postmenopausal women: a clinical research center study. J. Clin. Endocrinol. Metab. 81:2198-2203.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 2198-2203
    • Lovejoy, J.C.1    Bray, G.A.2    Bourgeois, M.O.3
  • 16
    • 0028897316 scopus 로고
    • Clinical relevance of testosterone and dihydrotestosterone metabolism in women
    • Rittmaster, R.S. 1995. Clinical relevance of testosterone and dihydrotestosterone metabolism in women. Am. J. Med. 98:17S-21S.
    • (1995) Am. J. Med. , vol.98
    • Rittmaster, R.S.1
  • 17
    • 13844300199 scopus 로고
    • Androgenic disorders of women: Diagnostic and therapeutic decision making
    • Redmond, G.P. 1995. Androgenic disorders of women: diagnostic and therapeutic decision making. Am. J. Med. 98:120S-129S.
    • (1995) Am. J. Med. , vol.98
    • Redmond, G.P.1
  • 18
    • 0026061628 scopus 로고
    • On the paradox of insulin-induced hyperandrogenism in insulin-resistant states
    • Poretsky, L. 1991. On the paradox of insulin-induced hyperandrogenism in insulin-resistant states. Endocr. Rev. 12:3-13.
    • (1991) Endocr. Rev. , vol.12 , pp. 3-13
    • Poretsky, L.1
  • 20
    • 0020775331 scopus 로고
    • Sexual development, maturation, and behavior
    • Bain, J. 1983. Sexual development, maturation, and behavior. Compr. Ther. 9:21-31.
    • (1983) Compr. Ther. , vol.9 , pp. 21-31
    • Bain, J.1
  • 21
    • 0022967493 scopus 로고
    • Testosterone implants into the amygdala during the neonatal period masculinize the social play of juvenile female rats
    • Meaney, M.J., and B.S. McEwen. 1986. Testosterone implants into the amygdala during the neonatal period masculinize the social play of juvenile female rats. Brain Res. 398:324-328.
    • (1986) Brain Res. , vol.398 , pp. 324-328
    • Meaney, M.J.1    McEwen, B.S.2
  • 22
    • 0019421822 scopus 로고
    • Postnatal gonadal steroid effects on human behavior
    • Rubin, R.T., J.M. Reinisch, and R.F. Haskett. 1981. Postnatal gonadal steroid effects on human behavior. Science. 211:1318-1324.
    • (1981) Science , vol.211 , pp. 1318-1324
    • Rubin, R.T.1    Reinisch, J.M.2    Haskett, R.F.3
  • 23
    • 0017324607 scopus 로고
    • Biochemical determinants in gender identity
    • Hamilton, W., and P.H. Chapman. 1977. Biochemical determinants in gender identity. Padiatr. Padol. Suppl. 5:69-81.
    • (1977) Padiatr. Padol. Suppl. , vol.5 , pp. 69-81
    • Hamilton, W.1    Chapman, P.H.2
  • 24
    • 0022066451 scopus 로고
    • Relation between testosterone concentration, sex role identity, and personality among females
    • Baucom, D.H., P.K. Besch, and S. Callahan. 1985. Relation between testosterone concentration, sex role identity, and personality among females. J. Pers. Soc. Psychol. 48:1218-1226.
    • (1985) J. Pers. Soc. Psychol. , vol.48 , pp. 1218-1226
    • Baucom, D.H.1    Besch, P.K.2    Callahan, S.3
  • 25
    • 0030424070 scopus 로고    scopus 로고
    • Sexual differentiation of cognitive abilities in women exposed to diethylstilbestrol (DES) prenatally
    • Hines, M., and E.C. Sandberg. 1996. Sexual differentiation of cognitive abilities in women exposed to diethylstilbestrol (DES) prenatally. Horm. Behav. 30:354.
    • (1996) Horm. Behav. , vol.30 , pp. 354
    • Hines, M.1    Sandberg, E.C.2
  • 26
    • 0029335039 scopus 로고
    • Human behavioural sex differences: A role for gonadal hormones during early development?
    • Collaer, M.L., and M. Hines. 1995. Human behavioural sex differences: a role for gonadal hormones during early development? Psychol. Bull. 118:55-107.
    • (1995) Psychol. Bull. , vol.118 , pp. 55-107
    • Collaer, M.L.1    Hines, M.2
  • 27
    • 0020791161 scopus 로고
    • In vivo insulin sensitivity in the rat determined by euglycemic clamp
    • Kraegen, E., D. James, S. Bennett, and D. Chisholm. 1983. In vivo insulin sensitivity in the rat determined by euglycemic clamp. Am. J. Physiol. 245: E1-E7.
    • (1983) Am. J. Physiol. , vol.245
    • Kraegen, E.1    James, D.2    Bennett, S.3    Chisholm, D.4
  • 28
    • 0020741497 scopus 로고
    • In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats
    • Terretaz, J., and B. Jeanrenaud. 1983. In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats. Endocrinology. 112:1346-1353.
    • (1983) Endocrinology , vol.112 , pp. 1346-1353
    • Terretaz, J.1    Jeanrenaud, B.2
  • 29
    • 2642673791 scopus 로고    scopus 로고
    • Reduced extracellular levels of serotonin in the amygdala of androgenized female rats
    • In press
    • Sundblad, C., and E. Eriksson. 1998. Reduced extracellular levels of serotonin in the amygdala of androgenized female rats. Eur. Neuropsychopharmacol. In press.
    • (1998) Eur. Neuropsychopharmacol.
    • Sundblad, C.1    Eriksson, E.2
  • 30
    • 0023511449 scopus 로고
    • Sexual differentiation of androgen-sensitive and estrogen-sensitive regulatory systems for aggressive behaviour
    • Simon, N.G., and R.E. Whalen. 1987. Sexual differentiation of androgen-sensitive and estrogen-sensitive regulatory systems for aggressive behaviour. Horm. Behav: 21:493-500.
    • (1987) Horm. Behav , vol.21 , pp. 493-500
    • Simon, N.G.1    Whalen, R.E.2
  • 31
    • 0041594271 scopus 로고
    • Production of anovulatory, sterile rats by single injections of testosterone propionate
    • Barraclough, C.A. 1961. Production of anovulatory, sterile rats by single injections of testosterone propionate. Endocrinology. 68:62-67.
    • (1961) Endocrinology , vol.68 , pp. 62-67
    • Barraclough, C.A.1
  • 32
    • 0027185498 scopus 로고
    • The effects of estrogen and progesterone on insulin sensitivity in female rats
    • Kumagai, S., A. Holmäng, and P. Björntorp. 1993. The effects of estrogen and progesterone on insulin sensitivity in female rats. Acta. Physiol. Scand. 149:91-97.
    • (1993) Acta. Physiol. Scand. , vol.149 , pp. 91-97
    • Kumagai, S.1    Holmäng, A.2    Björntorp, P.3
  • 34
    • 0022383486 scopus 로고
    • Growth hormone in obesity and diabetes: Inappropriate hypothalamic control of secretion
    • Martin, R.J., and B. Jeanrenaud. 1985. Growth hormone in obesity and diabetes: inappropriate hypothalamic control of secretion. Int. J. Obesity. 9(Suppl. 1):99-104.
    • (1985) Int. J. Obesity , vol.9 , Issue.1 SUPPL. , pp. 99-104
    • Martin, R.J.1    Jeanrenaud, B.2
  • 35
    • 0029093504 scopus 로고
    • Sterility in neonatally androgenized female rats and the decidual cell reaction
    • Ohta, Y. 1995. Sterility in neonatally androgenized female rats and the decidual cell reaction. Int. Rev. Cytol. 160:1-52.
    • (1995) Int. Rev. Cytol. , vol.160 , pp. 1-52
    • Ohta, Y.1
  • 36
    • 0024026298 scopus 로고
    • Lilly Lecture. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo, R.A. 1988. Lilly Lecture. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes. 37:667-687.
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 37
    • 0025633635 scopus 로고
    • Upregulation of androgen receptor binding in male fat pad adipose precursor cells exposed to testosterone: Study in a whole cell assay system
    • De Pergola, G., X. Xu, S. Yang, R. Giorgino, and P. Björntorp. 1991. Upregulation of androgen receptor binding in male fat pad adipose precursor cells exposed to testosterone: study in a whole cell assay system. J. Ster. Biochem. Mol. Biol. 37:553-558.
    • (1991) J. Ster. Biochem. Mol. Biol. , vol.37 , pp. 553-558
    • De Pergola, G.1    Xu, X.2    Yang, S.3    Giorgino, R.4    Björntorp, P.5
  • 38
    • 0023219563 scopus 로고
    • A nuclear binding assay to assess the biological activity of steroid receptor in isolated animal and human tissues
    • Spelsberg, M., L.L. Graham, N.J. Berg, T. Umehara, E. Riehl, C.B. Coulam, and J.N. Ingle. 1987. A nuclear binding assay to assess the biological activity of steroid receptor in isolated animal and human tissues. Endocrinology. 121:631-644.
    • (1987) Endocrinology , vol.121 , pp. 631-644
    • Spelsberg, M.1    Graham, L.L.2    Berg, N.J.3    Umehara, T.4    Riehl, E.5    Coulam, C.B.6    Ingle, J.N.7
  • 39
    • 0029019984 scopus 로고
    • Androgen hormone binding to adipose tissue in rats
    • Sjögren, J., L. Min, and P. Björntorp. 1995. Androgen hormone binding to adipose tissue in rats. Biochim. Biophys. Acta. 1244:117-120.
    • (1995) Biochim. Biophys. Acta. , vol.1244 , pp. 117-120
    • Sjögren, J.1    Min, L.2    Björntorp, P.3
  • 40
    • 0025979966 scopus 로고
    • Testosterone increases lipolysis and the number of β-adrenoceptors in male rat adipocytes
    • Xu, X., G. De Pergola, and P. Björntorp. 1991. Testosterone increases lipolysis and the number of β-adrenoceptors in male rat adipocytes. Endocrinology. 128:379-382.
    • (1991) Endocrinology , vol.128 , pp. 379-382
    • Xu, X.1    De Pergola, G.2    Björntorp, P.3
  • 41
    • 0027481555 scopus 로고
    • Postreceptor events involved in the up-regulation of beta-adrenergic receptor mediated lipolysis by testosterone in rat white adipocytes
    • Xu, X., G. De Pergola, P.S. Eriksson, L. Fu, B. Carlsson, S. Yang, S. Eden, and P. Björntorp. 1993. Postreceptor events involved in the up-regulation of beta-adrenergic receptor mediated lipolysis by testosterone in rat white adipocytes. Endocrinology. 132:1651-1657.
    • (1993) Endocrinology , vol.132 , pp. 1651-1657
    • Xu, X.1    De Pergola, G.2    Eriksson, P.S.3    Fu, L.4    Carlsson, B.5    Yang, S.6    Eden, S.7    Björntorp, P.8
  • 42
    • 0025063941 scopus 로고
    • Evidence that testosterone modulates in vivo the adenylate cyclase activity in fat cells
    • Pecquery, R., M.N. Dieudonne, M.C. Leneveu, and Y. Giudicelli. 1990. Evidence that testosterone modulates in vivo the adenylate cyclase activity in fat cells. Endocrinology. 126:241-245.
    • (1990) Endocrinology , vol.126 , pp. 241-245
    • Pecquery, R.1    Dieudonne, M.N.2    Leneveu, M.C.3    Giudicelli, Y.4
  • 43
    • 0027385143 scopus 로고
    • Protein kinase in rat adipocytes: Influence of androgenic status and regional fat distribution
    • Lacasa, D., B. Agli, B. Mur, M.N. Dieudonne, and Y. Giudicelli. 1993. Protein kinase in rat adipocytes: influence of androgenic status and regional fat distribution. J. Endocrinol. 138:493-501.
    • (1993) J. Endocrinol. , vol.138 , pp. 493-501
    • Lacasa, D.1    Agli, B.2    Mur, B.3    Dieudonne, M.N.4    Giudicelli, Y.5
  • 44
    • 0026399706 scopus 로고
    • Effect of testosterone on abdominal adipose tissue in men
    • Rebuffe-Scrive, M., P. Mårin, and P. Björntorp. 1991. Effect of testosterone on abdominal adipose tissue in men. Int. J. Obesity. 15:791-795.
    • (1991) Int. J. Obesity , vol.15 , pp. 791-795
    • Rebuffe-Scrive, M.1    Mårin, P.2    Björntorp, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.