Synthesis and structure-activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 85-94

  Cappelli, Andrea ^a   Manini, Monica ^a   Valenti, Salvatore ^a   Castriconi, Federica ^a   Giuliani, Germano ^a   Anzini, Maurizio ^a   Brogi, Simone ^a   Butini, Stefania ^a   Gemma, Sandra ^a   Campiani, Giuseppe ^a   Giorgi, Gianluca ^a   Mennuni, Laura ^b   Lanza, Marco ^b   Giordani, Antonio ^b   Caselli, Gianfranco ^b   Letari, Ornella ^b   Makovec, Francesco ^b  

^a UNIVERSITY OF SIENA   (Italy)

^b Rotta Research Laboratorium   (Italy)

Author keywords

5 HT1A receptors; Arylpiperazine; Binding; Serotonin

Indexed keywords

2 [5 (4 (2 METHOXYPHENYL)PIPERAZIN 1 YL)PENTYL] 2,3 DIHYDRO 1H BENZO[E]ISOINDOL 1 ONE; 2 PYRROLIDONE DERIVATIVE; 4 CHLORO 2 [5 (4 (2 METHOXYPHENYL)PIPERAZIN 1 YL)PENTYL] 2,3 DIHYDRO 1H PYRROLOL[3,4 C]QUINOLIN 1 ONE; MOLECULAR SCAFFOLD; SEROTONIN 1A AGONIST; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROENCEPHALOGRAM; IN VITRO STUDY; MALE; MOLECULAR MODEL; MOTONEURON; MUSCLE TONE; NONHUMAN; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; AREA UNDER CURVE; HUMANS; INTESTINAL ABSORPTION; LIGANDS; MALE; METABOLIC CLEARANCE RATE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRROLIDINONES; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN 5-HT1 RECEPTOR AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874415806     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.044     Document Type: Article

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