Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: A meta-analysis

Experimental and Clinical Psychopharmacology

Volumn 20, Issue 5, 2012, Pages 420-429

  Schreiner, Amy M ^a   Dunn, Michael E ^a  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

Cannabis; Marijuana; Meta analysis; Neurocognitive; Residual effects

Indexed keywords

CANNABIS; TETRAHYDROCANNABINOL;

ABSTINENCE; ARTICLE; ATTRIBUTABLE RISK; BRAIN FUNCTION; CLINICAL ASSESSMENT; COGNITION; DRUG EFFICACY; DRUG USE; EFFECT SIZE; EVIDENCE BASED MEDICINE; HUMAN; MEDLINE; META ANALYSIS; OUTCOME ASSESSMENT; SYSTEMATIC REVIEW; WITHDRAWAL SYNDROME; CANNABIS SMOKING; CHEMICALLY INDUCED DISORDER; COGNITIVE DEFECT; DRUG EFFECT; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; TIME; UNITED STATES;

COGNITION; COGNITION DISORDERS; HUMANS; MARIJUANA SMOKING; NEUROPSYCHOLOGICAL TESTS; SUBSTANCE WITHDRAWAL SYNDROME; TIME FACTORS; UNITED STATES;

EID: 84874414165     PISSN: 10641297     EISSN: 19362293     Source Type: Journal    
DOI: 10.1037/a0029117     Document Type: Article

References (65)

1. Bartholomew, J., Holroyd, S., & Heffernan, T. M. (2010). Does cannabis use affect prospective memory in young adults? Journal of Psychopharmacology, 24, 241-246. doi:10.1177/0269881109106909
2. Battisti, R. A., Roodenrys, S., Johnstone, S. J., Pesa, N., Hermens, D. F., & Solowij, N. (2010a). Chronic cannabis users show altered neurophysiological functioning on Stroop task conflict resolution. Psychopharmacology, 212, 613-624. doi:10.1007/s00213-010-1988-3
3. Battisti, R. A., Roodenrys, S., Johnstone, S. J., Respondek, C., Hermens, D. F., & Solowij, N. (2010b). Chronic use of cannabis and poor neural efficiency in verbal memory ability. Psychopharmacology, 209, 319-330. doi:10.1007/s00213-010-1800-4
4. Block, R. I., O'Leary, D. S., Hichwa, R. D., Augustinack, J. C., Ponto, L., Ghoneim, M. M.,... Andreasen, N. C. (2002). Effects of frequent marijuana use on memory-related regional cerebral blood flow. Pharmacology, Biochemistry and Behavior, 72, 237-250. doi:10.1016/S0091-3057(01)00771-7
5. Bolla, K., Eldreth, D., Matochik, J., & Cadet, J. (2005). Neural substrates of faulty decision-making in abstinent marijuana users. Neuroimage, 26, 480-492. doi:10.1016/j.neuroimage.2005.02.012
6. Borenstein, M., Hedges, L. V., Higgins, J. P., & Rothstein, H. R. (2005). Comprehensive Meta-Analysis (Version 2.0) [Computer Software]. Englewood, NJ: Biostat.
7. Borenstein, M., Hedges, L. V., Higgins, J. P., & Rothstein, H. R. (2009). Introduction to meta-analysis. West Sussex, UK: John Wiley and Sons, Ltd. doi:10.1002/9780470743386
8. Bowman, M., & Pihl, R. O. (1973). Cannabis: Psychological effects of chronic heavy use: A controlled study of intellectual functioning in chronic users of high potency cannabis. Psychopharmacologia, 29, 159-170. doi:10.1007/BF00422648
9. Budney, A. J., Moore, B. A., Vandrey, R. G., & Hughes, J. R. (2003). The time course and significance of cannabis withdrawal. Journal of Abnormal Psychology, 112, 393-402. doi:10.1037/0021-843X.112.3.393
10. Carlin, A. S., & Trupin, E. W. (1977). The effect of long-term chronic marijuana use on neuropsychological functioning. International Journal of the Addictions, 12, 617-624.
11. Chang, L., Yakupov, R. R., Cloak, C. C., & Ernst, T. T. (2006). Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation. Brain: A Journal of Neurology, 129, 1096-1112. doi:10.1093/brain/awl064
12. Crean, R. D., Crane, N. A., & Mason, B. J. (2011). An evidence-based review of acute and long-term effects of cannabis use on executive cognitive functions. Journal of Addiction Medicine, 5, 1-8. doi:10.1097/ADM.0b013e31820c23fa
13. Croft, R. J., Mackay, A. J., Mills, A. D., & Gruzelier, J. H. (2001). The relative contributions of ecstasy and cannabis to cognitive impairment. Psychopharmacology, 153, 373-379. doi:10.1007/s002130000591
14. Eldreth, D., Matochik, J., Cadet, J., & Bolla, K. (2004). Abnormal brain activity in prefrontal brain regions in abstinent marijuana users. Neuroimage, 23, 914-920. doi:10.1016/j.neuroimage.2004.07.032
15. Ellis, G. M., Jr., Mann, M. A., Judson, B. A., Schramm, N. T., & Taschian, A. (1985). Excretion patterns of cannabinoid metabolites after last use in a group of chronic users. Clinical Pharmacology & Therapeutics, 38, 572-578. doi:10.1038/clpt.1985.226
16. Entin, E. E., & Goldzung, P. J. (1973). Residual effects of marihuana usage on learning and memory. The Psychological Record, 23, 169-178.
17. Fletcher, J., Page, J., Francis, D., Copeland, K., Naus, M., Davis, C.,... Satz, P. (1996). Cognitive correlates of long-term cannabis use in Costa Rican men. Archives of General Psychiatry, 53, 1051-1057. doi:10.1001/archpsyc.1996.01830110089011
18. Fontes, M., Bolla, K., Cunha, P., Almeida, P., Jungerman, F., Laranjeira, R.,... Lacerda, A. (2011). Frontal Assessment Battery (FAB) is a simple tool for detecting executive deficits in chronic cannabis users. Journal of Clinical and Experimental Neuropsychology, 33, 523-531. doi:10.1080/13803395.2010.535505
19. Fried, P., Watkinson, B., & Gray, R. (2005). Neurocognitive consequences of marihuana-a comparison with pre-drug performance. Neurotoxicology and Teratology, 27, 231-239. doi:10.1016/j.ntt.2004.11.003
20. Fried, P., Watkinson, B., James, D., & Gray, R. (2002). Current and former marijuana use: Preliminary findings of a longitudinal study of effects on IQ in young adults. CMAJ: Canadian Medical Association Journal (Journal De L'association Medicale Canadienne), 166, 887-891.
21. Gansler, D., Jerram, M., Vannorsdall, T., & Schretlen, D. (2011). Does the Iowa gambling task measure executive function? Archives of Clinical Neuropsychology: The Official Journal of the National Academy of Neuropsychologists, 26, 706-717.
22. Gonzalez, R. (2007). Acute and non-acute effects of cannabis on brain functioning and neuropsychological performance. Neuropsychology Review, 17, 347-361. doi:10.1007/s11065-007-9036-8
23. Gouzoulis-Mayfrank, E., Daumann, J., Tuchtenhagen, F., Pelz, S., Becker, S., Kunert, H.,... Sass, H. (2000). Impaired cognitive performance in drug free users of recreational ecstasy (MDMA). Journal of Neurology, Neurosurgery & Psychiatry, 68, 719-725. doi:10.1136/jnnp.68.6.719
24. Grant, I., Gonzalez, R., Carey, C. L., Natarajan, L., & Wolfson, T. (2003). Non-acute (residual) neurocognitive effects of cannabis use: A metaanalytic study. Journal of the International Neuropsychological Society, 9, 679-689. doi:10.1017/S1355617703950016
25. Grant, I., Rochford, J., Fleming, T., & Stunkard, A. (1973). A neuropsychological assessment of the effects of moderate marihuana use. Journal of Nervous and Mental Disease, 156, 278-280. doi:10.1097/00005053-197304000-00008
26. Grotenhermen, F. (2003). Pharmacokinetics and pharmacodynamics of cannabinoids. Clinical Pharmacokinetics, 42, 327-360. doi:10.2165/00003088-200342040-00003
27. Hermann, D., Sartorius, A., Welzel, H., Walter, S., Skopp, G., Ende, G., & Mann, K. (2007). Dorsolateral prefrontal cortex N-acetylaspartate/ total creatine (NAA/tCr) loss in male recreational cannabis users. Biological Psychiatry, 61, 1281-1289. doi:10.1016/j.biopsych.2006.08.027
28. Hester, R., Nestor, L., & Garavan, H. (2009). Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users. Neuropsychopharmacology, 34, 2450-2458. doi:10.1038/npp.2009.67
29. Huestegge, L., Kunert, H. J., & Radach, R. (2010). Long-term effects of cannabis on eye movement control in reading. Psychopharmacology, 209, 77-84. doi:10.1007/s00213-009-1769-z
30. Huestegge, L., Radach, R. R., & Kunert, H. J. (2009). Long-term effects of cannabis on oculomotor function in humans. Journal of Psychopharmacology, 23, 714-722. doi:10.1177/0269881108091601
31. Huestegge, L., Radach, R., Kunert, H., & Heller, D. (2002). Visual search in long-term cannabis users with early age of onset. Progress in Brain Research, 140, 377-394.
32. Jacobsen, L. K., Mencl, W., Westerveld, M., & Pugh, K. R. (2004). Impact of cannabis use on brain function in adolescents. In R. E. Dahl & L. Spear (Eds.), Adolescent brain development: Vulnerabilities and opportunities (pp. 384-390). New York, NY: New York Academy of Sciences.
33. Jacobsen, L. K., Pugh, K., Constable, R., Westerveld, M., & Mencl, W. (2007). Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users. Biological Psychiatry, 61, 31-40. doi:10.1016/j.biopsych.2006.02.014
34. Kanayama, G., Rogowska, J., Pope, H. G., Gruber, S. A., & Yurgelun-Todd, D. A. (2004). Spatial working memory in heavy cannabis users: A functional magnetic resonance imaging study. Psychopharmacology, 176, 239-247. doi:10.1007/s00213-004-1885-8
35. Kelleher, L. M., Stough, C., Sergejew, A. A., & Rolfe, T. (2004). The effects of cannabis on information-processing speed. Addictive Behaviors, 29, 1213-1219. doi:10.1016/j.addbeh.2004.03.039
36. Lyons, M. J., Bar, J. L., Panizzon, M. S., Toomey, R. R., Eisen, S. S., Xian, H. H., & Tsuang, M. T. (2004). Neuropsychological consequences of regular marijuana use: A twin study. Psychological Medicine: A Journal of Research in Psychiatry and the Allied Sciences, 34, 1239-1250. doi:10.1017/S0033291704002260
37. Mahmood, O. M., Jacobus, J., Bava, S., Scarlett, A., & Tapert, S. F. 2010). Learning and memory performance in adolescent users of alcohol and marijuana: Interactive effects. Journal of Studies on Alcohol and Drugs, 71, 885-894.
38. Medina, K., Hanson, K. L., Schweinsburg, A. D., Cohen-Zion, M., Nagel, B. J., & Tapert, S. F. (2007). Neuropsychological functioning in adolescent marijuana users: Subtle deficits detectable after a month of abstinence. Journal of the International Neuropsychological Society, 13, 807-820. doi:10.1017/S1355617707071032
39. Messinis, L., Kyprianidou, A., Malefaki, S., & Papathanasopoulos, P. (2006). Neuropsychological deficits in long-term frequent cannabis users. Neurology, 66, 737-739. doi:10.1212/01.wnl.0000201279.83203.c6
40. Morgan, C., Rothwell, E., Atkinson, H., Mason, O., & Curran, H. (2010). Hyper-priming in cannabis users: A naturalistic study of the effects of cannabis on semantic memory function. Psychiatry Research, 176, 213- 218. doi:10.1016/j.psychres.2008.09.002
41. Padula, C. B., Schweinsburg, A. D., & Tapert, S. F. (2007). Spatial working memory performance and fMRI activation interaction in abstinent adolescent marijuana users. Psychology of Addictive Behaviors, 21, 478-487. doi:10.1037/0893-164X.21.4.478
42. Pillay, S. S., Rogowska, J., Kanayama, G., Gruber, S., Simpson, N., Pope, H., & Yurgelun-Todd, D. (2008). Cannabis and motor function: FMRI changes following 28 days of discontinuation. Experimental and Clinical Psychopharmacology, 16, 22-32. doi:10.1037/1064-1297.16.1.22
43. Pillay, S. S., Rogowska, J., Kanayama, G., Jon, D., Gruber, S., Simpson, N.,... Yurgelun-Todd, D. A. (2004). Neurophysiology of motor function following cannabis discontinuation in chronic cannabis smokers: An fMRI study. Drug and Alcohol Dependence, 76, 261-271. doi:10.1016/j.drugalcdep.2004.05.009
44. Pope, H. G., Gruber, A. J., Hudson, J. I., Cohane, G., Heustis, M. A., & Yurgelun-Todd, D. (2003). Early-onset cannabis use and cognitive deficits: What is the nature of the association? Drug and Alcohol Dependence, 69, 303-310. doi:10.1016/S0376-8716(02)00334-4
45. Pope, H. G., Gruber, A. J., Hudson, J. I., Huestis, M. A., & Yurgelun-Todd, D. (2001). Neuropsychological performance in long-term cannabis users. Archives of General Psychiatry, 58, 909-915. doi:10.1001/archpsyc.58.10.909
46. Pope, H. G., Gruber, A. J., Hudson, J. I., Huestis, M. A., & Yurgelun-Todd, D. (2002). Cognitive measures in long-term cannabis users. Journal of Clinical Pharmacology, 42, 41S-47S.
47. Pope, H. G., Gruber, A. J., & Yurgelun-Todd, D. (1995). The residual neuropsychological effects of cannabis: The current status of research. Drug and Alcohol Dependence, 38, 25-34. doi:10.1016/0376-8716(95)01097-I
48. Quednow, B., Jessen, F., Kuhn, K., Maier, W., Daum, I., & Wagner, M. (2006). Memory deficits in abstinent MDMA (ecstasy) users: Neuropsychological evidence of frontal dysfunction. Journal of Psychopharmacology (Oxford, England), 20, 373-384. doi:10.1177/0269881106061200
49. Ranganathan, M., & D'Souza, D. (2006). The acute effects of cannabinoids on memory in humans: A review. Psychopharmacology, 188, 425-444. doi:10.1007/s00213-006-0508-y
50. Rodgers, J. (2000). Cognitive performance amongst recreational users of 'ecstasy.' Psychopharmacology, 151, 19-24. doi:10.1007/s002130000467
51. Rosenthal, R., & DiMatteo, M. R. (2001). Meta-analysis: Recent developments in quantitative methods for literature reviews. Annual Review of Psychology, 52, 59-82. doi:10.1146/annurev.psych.52.1.59
52. Schweinsburg, A., Nagel, B., Schweinsburg, B., Park, A., Theilmann, R., & Tapert, S. (2008). Abstinent adolescent marijuana users show altered fMRI response during spatial working memory. Psychiatry Research, 163, 40-51. doi:10.1016/j.pscychresns.2007.04.018
53. Schweinsburg, A., Schweinsburg, B., Nagel, B., Eyler, L., & Tapert, S. (2011). Neural correlates of verbal learning in adolescent alcohol and marijuana users. Addiction, 106, 564-573. doi:10.1111/j.1360-0443.2010.03197.x
54. Skosnik, P. D., Edwards, C., O'Donnell, B., Steffen, A., Steinmetz, J., & Hetrick, W. (2008). Cannabis use disrupts eyeblink conditioning: Evidence for cannabinoid modulation of cerebellar-dependent learning. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 33, 1432-1440. doi:10.1038/sj.npp.1301506
55. Skosnik, P. D., Krishnan, G. P., Vohs, J. L., & O'Donnell, B. F. (2006). The effect of cannabis use and gender on the visual steady state evoked potential. Clinical Neurophysiology, 117, 144-156. doi:10.1016/j.clinph.2005.09.024
56. Skosnik, P. D., Spatz-Glenn, L., & Park, S. (2001). Cannabis use is associated with schizotypy and attentional disinhibition. Schizophrenia Research, 48, 83-92. doi:10.1016/S0920-9964(00)00132-8
57. Solowij, N., & Battisti, R. (2008). The chronic effects of cannabis on memory in humans: A review. Current Drug Abuse Reviews, 1, 81-98. doi:10.2174/1874473710801010081
58. Solowij, N., Stephens, R. S., Roffman, R. A., Babor, T., Kadden, R., Miller, M., Vendetti, J. (2002). Cognitive functioning of long-term heavy cannabis users seeking treatment. Journal of the American Medical Association, 287, 1123-1131. doi:10.1001/jama.287.9.1123
59. Soueif, M. (1976). Differential association between chronic cannabis use and brain function deficits. Annals Of The New York Academy Of Sciences, 282, 323-343.
60. Substance Abuse and Mental Health Services Administration (2011). Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings. Rockville, MD: NSDUH Series H-41, HHS Publication No. (SMA) 11-4658.
61. Tapert, S. F., Schweinsburg, A. D., Drummond, S. A., Paulus, M. P., Brown, S. A., Yang, T. T., & Frank, L. R. (2007). Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology, 194, 173-183. doi:10.1007/s00213-007-0823-y
62. Varma, V. K., Malhotra, A. K., Dang, R., & Das, K. (1988). Cannabis and cognitive functions: A prospective study. Drug and Alcohol Dependence, 21, 147-152. doi:10.1016/0376-8716(88)90061-0
63. Verdejo-Garcia, A., Benbrook, A., Funderburk, F., David, P., Cadet, J., & Bolla, K. I. (2007). The differential relationship between cocaine use and marijuana use on decision-making performance over repeat testing with the Iowa Gambling Task. Drug and Alcohol Dependence, 90, 2-11. doi:10.1016/j.drugalcdep.2007.02.004
64. Whitlow, C., Liguori, A., Livengood, L., Hart, S., Mussat-Whitlow, B., Lamborn, C., Porrino, L. (2004). Long-term heavy marijuana users make costly decisions on a gambling task. Drug and Alcohol Dependence, 76, 107-111. doi:10.1016/j.drugalcdep.2004.04.009
65. Yücel, M., Solowij, N., Respondek, C., Whittle, S., Fornito, A., Pantelis, C., & Lubman, D. I. (2008). Regional brain abnormalities associated with long-term heavy cannabis use. Archives of General Psychiatry, 65, 694-701. doi:10.1001/archpsyc.65.6.694