메뉴 건너뛰기




Volumn 33, Issue 3, 2013, Pages 621-628

Fenofibrate inhibits endothelin-1 expression by peroxisome proliferator-activated receptor α-dependent and independent mechanisms in human endothelial cells

Author keywords

endothelin 1; endothelium; glycogen synthase kinase 3; peroxisome proliferator activated receptor a; type 2 diabetes mellitus

Indexed keywords

ENDOTHELIN 1; FENOFIBRATE; GLYCOGEN SYNTHASE KINASE 3; INSULIN; INSULIN RECEPTOR; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 11; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 84874365433     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.112.300665     Document Type: Article
Times cited : (28)

References (42)
  • 1
    • 12444272739 scopus 로고    scopus 로고
    • Mechanisms, significance and treatment of vascular dysfunction in type 2 diabetes mellitus: Focus on lipidregulating therapy
    • Woodman RJ, Chew GT, Watts GF. Mechanisms, significance and treatment of vascular dysfunction in type 2 diabetes mellitus: focus on lipidregulating therapy. Drugs. 2005;65:31-74.
    • (2005) Drugs , vol.65 , pp. 31-74
    • Woodman, R.J.1    Chew, G.T.2    Watts, G.F.3
  • 2
    • 56849101712 scopus 로고    scopus 로고
    • The importance of endothelin-1 for microvascular dysfunction in diabetes
    • Kalani M. The importance of endothelin-1 for microvascular dysfunction in diabetes. Vasc Health Risk Manag. 2008;4:1061-1068.
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 1061-1068
    • Kalani, M.1
  • 3
    • 64749088854 scopus 로고    scopus 로고
    • Fibrates and microvascular complications in diabetes-insight from the FIELD study
    • Ansquer JC, Foucher C, Aubonnet P, Le Malicot K. Fibrates and microvascular complications in diabetes-insight from the FIELD study. Curr Pharm Des. 2009;15:537-552.
    • (2009) Curr Pharm des , vol.15 , pp. 537-552
    • Ansquer, J.C.1    Foucher, C.2    Aubonnet, P.3    Le Malicot, K.4
  • 4
    • 80052048877 scopus 로고    scopus 로고
    • Prevention of microvascular diabetic complications by fenofibrate: Lessons from FIELD and ACCORD
    • Hermans MP. Prevention of microvascular diabetic complications by fenofibrate: lessons from FIELD and ACCORD. Diab Vasc Dis Res. 2011;8:180-189.
    • (2011) Diab Vasc Dis Res , vol.8 , pp. 180-189
    • Hermans, M.P.1
  • 6
    • 33644652183 scopus 로고    scopus 로고
    • Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis
    • Lefebvre P, Chinetti G, Fruchart JC, Staels B. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J Clin Invest. 2006;116:571-580.
    • (2006) J Clin Invest , vol.116 , pp. 571-580
    • Lefebvre, P.1    Chinetti, G.2    Fruchart, J.C.3    Staels, B.4
  • 7
    • 50649089597 scopus 로고    scopus 로고
    • Fibrates and future PPARalpha agonists in the treatment of cardiovascular disease
    • Staels B, Maes M, Zambon A. Fibrates and future PPARalpha agonists in the treatment of cardiovascular disease. Nat Clin Pract Cardiovasc Med. 2008;5:542-553.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 542-553
    • Staels, B.1    Maes, M.2    Zambon, A.3
  • 9
    • 1842475911 scopus 로고    scopus 로고
    • Regulation of endothelial nitric oxide synthase by PPAR agonists: Molecular and clinical perspectives
    • Watts GF, Staels B. Regulation of endothelial nitric oxide synthase by PPAR agonists: molecular and clinical perspectives. Arterioscler Thromb Vasc Biol. 2004;24:619-621.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 619-621
    • Watts, G.F.1    Staels, B.2
  • 11
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1
    • Delerive P, De Bosscher K, Besnard S, Vanden Berghe W, Peters JM, Gonzalez FJ, Fruchart JC, Tedgui A, Haegeman G, Staels B. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. J Biol Chem. 1999;274:32048-32054.
    • (1999) J Biol Chem , vol.274 , pp. 32048-32054
    • Delerive, P.1    De Bosscher, K.2    Besnard, S.3    Vanden Berghe, W.4    Peters, J.M.5    Gonzalez, F.J.6    Fruchart, J.C.7    Tedgui, A.8    Haegeman, G.9    Staels, B.10
  • 13
    • 34547483404 scopus 로고    scopus 로고
    • TGF-beta1 and TSC-22 gene polymorphisms and susceptibility to microvascular complications in type 2 diabetes
    • Buraczynska M, Baranowicz-Gaszczyk I, Borowicz E, Ksiazek A. TGF-beta1 and TSC-22 gene polymorphisms and susceptibility to microvascular complications in type 2 diabetes. Nephron Physiol. 2007;106:p69-p75.
    • (2007) Nephron Physiol , vol.106
    • Buraczynska, M.1    Baranowicz-Gaszczyk, I.2    Borowicz, E.3    Ksiazek, A.4
  • 14
    • 0038801663 scopus 로고    scopus 로고
    • Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression
    • Rodríguez-Pascual F, Redondo-Horcajo M, Lamas S. Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression. Circ Res. 2003;92:1288-1295.
    • (2003) Circ Res , vol.92 , pp. 1288-1295
    • Rodríguez-Pascual, F.1    Redondo-Horcajo, M.2    Lamas, S.3
  • 15
    • 0035694910 scopus 로고    scopus 로고
    • Smad regulation in TGFbeta signal transduction
    • Moustakas A, Souchelnytskyi S, Heldin CH. Smad regulation in TGFbeta signal transduction. J Cell Sci. 2001;114(Pt 24):4359-4369.
    • (2001) J Cell Sci , vol.114 , Issue.PART 24 , pp. 4359-4369
    • Moustakas, A.1    Souchelnytskyi, S.2    Heldin, C.H.3
  • 16
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • Moustakas A, Heldin CH. Non-Smad TGF-beta signals. J Cell Sci. 2005;118(Pt 16):3573-3584.
    • (2005) J Cell Sci , vol.118 , Issue.PART 16 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 17
    • 45949086682 scopus 로고    scopus 로고
    • TGFbeta regulated gene expression by Smads and Sp1/KLF-like transcription factors in cancer
    • Ellenrieder V. TGFbeta regulated gene expression by Smads and Sp1/KLF-like transcription factors in cancer. Anticancer Res. 2008;28(3A):1531-1539.
    • (2008) Anticancer Res , vol.28 , Issue.3 A , pp. 1531-1539
    • Ellenrieder, V.1
  • 18
    • 33845296149 scopus 로고    scopus 로고
    • The tumor suppressor KLF11 mediates a novel mechanism in transforming growth factor beta-induced growth inhibition that is inactivated in pancreatic cancer
    • Buck A, Buchholz M, Wagner M, Adler G, Gress T, Ellenrieder V. The tumor suppressor KLF11 mediates a novel mechanism in transforming growth factor beta-induced growth inhibition that is inactivated in pancreatic cancer. Mol Cancer Res. 2006;4:861-872.
    • (2006) Mol Cancer Res , vol.4 , pp. 861-872
    • Buck, A.1    Buchholz, M.2    Wagner, M.3    Adler, G.4    Gress, T.5    Ellenrieder, V.6
  • 19
    • 38149054804 scopus 로고    scopus 로고
    • Axin and GSK3-control Smad3 protein stability and modulate TGF-signaling
    • Guo X, Ramirez A, Waddell DS, Li Z, Liu X, Wang XF. Axin and GSK3-control Smad3 protein stability and modulate TGF-signaling. Genes Dev. 2008;22:106-120.
    • (2008) Genes Dev , vol.22 , pp. 106-120
    • Guo, X.1    Ramirez, A.2    Waddell, D.S.3    Li, Z.4    Liu, X.5    Wang, X.F.6
  • 20
    • 65649084845 scopus 로고    scopus 로고
    • Transforming growth factor-{beta}-inducible phosphorylation of Smad3
    • Wang G, Matsuura I, He D, Liu F. Transforming growth factor-{beta}- inducible phosphorylation of Smad3. J Biol Chem. 2009;284:9663-9673.
    • (2009) J Biol Chem , vol.284 , pp. 9663-9673
    • Wang, G.1    Matsuura, I.2    He, D.3    Liu, F.4
  • 21
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • Doble BW, Woodgett JR. GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci. 2003;116(Pt 7):1175-1186.
    • (2003) J Cell Sci , vol.116 , Issue.PART 7 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 23
    • 0036890093 scopus 로고    scopus 로고
    • Effect of fenofibrate on brachial artery flow-mediated dilatation in type 2 diabetes mellitus
    • Playford DA, Watts GF, Best JD, Burke V. Effect of fenofibrate on brachial artery flow-mediated dilatation in type 2 diabetes mellitus. Am J Cardiol. 2002;90:1254-1257.
    • (2002) Am J Cardiol , vol.90 , pp. 1254-1257
    • Playford, D.A.1    Watts, G.F.2    Best, J.D.3    Burke, V.4
  • 25
    • 0033520304 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
    • Delerive P, Martin-Nizard F, Chinetti G, Trottein F, Fruchart JC, Najib J, Duriez P, Staels B. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ Res. 1999;85:394-402.
    • (1999) Circ Res , vol.85 , pp. 394-402
    • Delerive, P.1    Martin-Nizard, F.2    Chinetti, G.3    Trottein, F.4    Fruchart, J.C.5    Najib, J.6    Duriez, P.7    Staels, B.8
  • 26
    • 78149481592 scopus 로고    scopus 로고
    • Mammalian Krüppel-like factors in health and diseases
    • McConnell BB, Yang VW. Mammalian Krüppel-like factors in health and diseases. Physiol Rev. 2010;90:1337-1381.
    • (2010) Physiol Rev , vol.90 , pp. 1337-1381
    • McConnell, B.B.1    Yang, V.W.2
  • 27
    • 69449086702 scopus 로고    scopus 로고
    • Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human
    • Rakhshandehroo M, Hooiveld G, Müller M, Kersten S. Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS ONE. 2009;4:e6796.
    • (2009) PLoS ONE , vol.4
    • Rakhshandehroo, M.1    Hooiveld, G.2    Müller, M.3    Kersten, S.4
  • 28
  • 29
    • 0034603858 scopus 로고    scopus 로고
    • Roles for insulin receptor PI3-kinase and Akt in insulinsignaling pathways related to production of nitric oxide in human vascular endothelial cells
    • Zeng G, Nystrom FH, Ravichandran LV, Cong LN, Kirby M, Mostowski H, Quon MJ. Roles for insulin receptor, PI3-kinase, and Akt in insulinsignaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation. 2000;101:1539-1545.
    • (2000) Circulation , vol.101 , pp. 1539-1545
    • Zeng, G.1    Nystrom, F.H.2    Ravichandran, L.V.3    Cong, L.N.4    Kirby, M.5    Mostowski, H.6    Quon, M.J.7
  • 30
    • 34248183465 scopus 로고    scopus 로고
    • Signaling by ALK5 mediates TGF-betainduced ET-1 expression in endothelial cells: A role for migration and proliferation
    • Castañares C, Redondo-Horcajo M, Magán-Marchal N, ten Dijke P, Lamas S, Rodríguez-Pascual F. Signaling by ALK5 mediates TGF-betainduced ET-1 expression in endothelial cells: a role for migration and proliferation. J Cell Sci. 2007;120(Pt 7):1256-1266.
    • (2007) J Cell Sci , vol.120 , Issue.PART 7 , pp. 1256-1266
    • Castañares, C.1    Redondo-Horcajo, M.2    Magán-Marchal, N.3    Ten Dijke, P.4    Lamas, S.5    Rodríguez-Pascual, F.6
  • 31
    • 0032557646 scopus 로고    scopus 로고
    • Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB
    • van Weeren PC, de Bruyn KM, de Vries-Smits AM, van Lint J, Burgering BM. Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB. J Biol Chem. 1998;273:13150-13156.
    • (1998) J Biol Chem , vol.273 , pp. 13150-13156
    • Van Weeren, P.C.1    De Bruyn, K.M.2    De Vries-Smits, A.M.3    Van Lint, J.4    Burgering, B.M.5
  • 32
    • 10744227563 scopus 로고    scopus 로고
    • Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-alpha partly via blockade of c-Jun NH2-terminal kinase pathway
    • Irukayama-Tomobe Y, Miyauchi T, Sakai S, Kasuya Y, Ogata T, Takanashi M, Iemitsu M, Sudo T, Goto K, Yamaguchi I. Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-alpha partly via blockade of c-Jun NH2-terminal kinase pathway. Circulation. 2004;109:904-910.
    • (2004) Circulation , vol.109 , pp. 904-910
    • Irukayama-Tomobe, Y.1    Miyauchi, T.2    Sakai, S.3    Kasuya, Y.4    Ogata, T.5    Takanashi, M.6    Iemitsu, M.7    Sudo, T.8    Goto, K.9    Yamaguchi, I.10
  • 33
    • 1942484870 scopus 로고    scopus 로고
    • Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway
    • Ogata T, Miyauchi T, Sakai S, Takanashi M, Irukayama-Tomobe Y, Yamaguchi I. Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway. J Am Coll Cardiol. 2004;43:1481-1488.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1481-1488
    • Ogata, T.1    Miyauchi, T.2    Sakai, S.3    Takanashi, M.4    Irukayama-Tomobe, Y.5    Yamaguchi, I.6
  • 34
    • 49649117315 scopus 로고    scopus 로고
    • Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction
    • Chew GT, Watts GF, Davis TM, Stuckey BG, Beilin LJ, Thompson PL, Burke V, Currie PJ. Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction. Diabetes Care. 2008;31:1502-1509.
    • (2008) Diabetes Care , vol.31 , pp. 1502-1509
    • Chew, G.T.1    Watts, G.F.2    Davis, T.M.3    Stuckey, B.G.4    Beilin, L.J.5    Thompson, P.L.6    Burke, V.7    Currie, P.J.8
  • 35
    • 77954078831 scopus 로고    scopus 로고
    • Fenofibrate improves endothelial function in the brachial artery and forearm resistance arterioles of statin-treated Type 2 diabetic patients
    • Hamilton SJ, Chew GT, Davis TM, Watts GF. Fenofibrate improves endothelial function in the brachial artery and forearm resistance arterioles of statin-treated Type 2 diabetic patients. Clin Sci. 2010;118:607-615.
    • (2010) Clin Sci , vol.118 , pp. 607-615
    • Hamilton, S.J.1    Chew, G.T.2    Davis, T.M.3    Watts, G.F.4
  • 36
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
    • FIELD Study Investigators
    • Keech A, Simes RJ, Barter P, et al.; FIELD Study Investigators. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet. 2005;366:1849-1861.
    • (2005) Lancet , vol.366 , pp. 1849-1861
    • Keech, A.1    Simes, R.J.2    Barter, P.3
  • 37
    • 36049001784 scopus 로고    scopus 로고
    • Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): A randomised controlled trial
    • FIELD Study Investigators
    • Keech AC, Mitchell P, Summanen PA, et al.; FIELD Study Investigators. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet. 2007;370: 1687-1697.
    • (2007) Lancet , vol.370 , pp. 1687-1697
    • Keech, A.C.1    Mitchell, P.2    Summanen, P.A.3
  • 38
    • 80052048877 scopus 로고    scopus 로고
    • Non-invited review: Prevention of microvascular diabetic complications by fenofibrate: Lessons from FIELD and ACCORD
    • Hermans MP. Non-invited review: prevention of microvascular diabetic complications by fenofibrate: lessons from FIELD and ACCORD. Diab Vasc Dis Res. 2011;8:180-189.
    • (2011) Diab Vasc Dis Res , vol.8 , pp. 180-189
    • Hermans, M.P.1
  • 39
    • 65649142619 scopus 로고    scopus 로고
    • Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): A prespecified analysis of a randomised controlled trial
    • FIELD Study Investigators
    • Rajamani K, Colman PG, Li LP, Best JD, Voysey M, D'Emden MC, Laakso M, Baker JR, Keech AC; FIELD Study Investigators. Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial. Lancet. 2009;373:1780-1788.
    • (2009) Lancet , vol.373 , pp. 1780-1788
    • Rajamani, K.1    Colman, P.G.2    Li, L.P.3    Best, J.D.4    Voysey, M.5    D'Emden, M.C.6    Laakso, M.7    Baker, J.R.8    Keech, A.C.9
  • 40
    • 10144243313 scopus 로고    scopus 로고
    • Elevated plasma levels of transforming growth factor-beta 1 in NIDDM
    • Pfeiffer A, Middelberg-Bisping K, Drewes C, Schatz H. Elevated plasma levels of transforming growth factor-beta 1 in NIDDM. Diabetes Care. 1996;19:1113-1117.
    • (1996) Diabetes Care , vol.19 , pp. 1113-1117
    • Pfeiffer, A.1    Middelberg-Bisping, K.2    Drewes, C.3    Schatz, H.4
  • 41
    • 0348226831 scopus 로고    scopus 로고
    • Diabetic nephropathy and transforming growth factor-beta: Transforming our view of glomerulosclerosis and fibrosis build-up
    • Chen S, Jim B, Ziyadeh FN. Diabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up. Semin Nephrol. 2003;23:532-543.
    • (2003) Semin Nephrol , vol.23 , pp. 532-543
    • Chen, S.1    Jim, B.2    Ziyadeh, F.N.3
  • 42
    • 67650227476 scopus 로고    scopus 로고
    • The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy
    • Gerhardinger C, Dagher Z, Sebastiani P, Park YS, Lorenzi M. The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy. Diabetes. 2009;58:1659-1667.
    • (2009) Diabetes , vol.58 , pp. 1659-1667
    • Gerhardinger, C.1    Dagher, Z.2    Sebastiani, P.3    Park, Y.S.4    Lorenzi, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.