SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal

Epigenetics

Volumn 8, Issue 2, 2013, Pages 177-183

  Binda, Olivier ^a   Sevilla, Ana ^b   LeRoy, Gary ^c   Lemischka, Ihor R ^b   Garcia, Benjamin A ^c   Richard, Stéphane ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c PRINCETON UNIVERSITY   (United States)

Author keywords

Embryonic stem cells; H2AZ; Histone variant; Lysine methylation; Lysine methyltransferase; SETD6

Indexed keywords

FIBROBLAST GROWTH FACTOR 5; HISTONE H2AZ; HISTONE LYSINE METHYLTRANSFERASE; KI 67 ANTIGEN; LYSINE;

ARTICLE; CELL DIFFERENTIATION; CELL RENEWAL; CONTROLLED STUDY; EMBRYONIC STEM CELL; FLUORESCENCE ACTIVATED CELL SORTING; HISTONE METHYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MASS SPECTROMETRY; PROTEIN EXPRESSION;

EID: 84874355579     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.23416     Document Type: Article

References (18)

1. Schneider R, Bannister AJ, Kouzarides T. Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem Sci 2002; 27:396-402; PMID:12151224; http://dx.doi.org/10.1016/S0968-0004(02)02141-2.
2. Albert M, Helin K. Histone methyltransferases in cancer. Semin Cell Dev Biol 2010; 21:209-20; PMID:19892027; http://dx.doi.org/10.1016/j. semcdb.2009.10.007.
3. Rahman N. Mechanisms predisposing to childhood overgrowth and cancer. Curr Opin Genet Dev 2005; 15:227-33; PMID:15917196; http://dx.doi. org/10.1016/j.gde.2005.04.007.
4. Nimura K, Ura K, Shiratori H, Ikawa M, Okabe M, Schwartz RJ, et al. A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature 2009; 460:287-91; PMID:19483677; http://dx.doi.org/10.1038/nature08086.
5. Ryu H, Lee J, Hagerty SW, Soh BY, McAlpin SE, Cormier KA, et al. ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Proc Natl Acad Sci U S A 2006; 103:19176-81; PMID:17142323; http://dx.doi.org/10.1073/ pnas.0606373103.
6. Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, et al. High-resolution profiling of histone methylations in the human genome. Cell 2007; 129:823-37; PMID:17512414; http://dx.doi. org/10.1016/j.cell.2007.05.009.
7. Valdés-Mora F, Song JZ, Statham AL, Strbenac D, Robinson MD, Nair SS, et al. Acetylation of H2A. Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer. Genome Res 2012; 22:307-21; PMID:21788347; http://dx.doi.org/10.1101/gr.118919.110.
8. Creyghton MP, Markoulaki S, Levine SS, Hanna J, Lodato MA, Sha K, et al. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell 2008; 135:649-61; PMID:18992931; http://dx.doi.org/10.1016/j. cell.2008.09.056.
9. Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 2006; 441:349-53; PMID:16625203; http:// dx.doi.org/10.1038/nature04733.
10. Illingworth RS, Botting CH, Grimes GR, Bickmore WA, Eskeland R. PRC1 and PRC2 are not required for targeting of H2A. Z to developmental genes in embryonic stem cells. PLoS One 2012; 7:e34848; PMID:22496869; http://dx.doi.org/10.1371/journal. pone.0034848.
11. Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, et al. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol 2011; 12:29-36; PMID:21131967; http://dx.doi.org/10.1038/ni.1968.
12. Ivanova N, Dobrin R, Lu R, Kotenko I, Levorse J, DeCoste C, et al. Dissecting self-renewal in stem cells with RNA interference. Nature 2006; 442:533-8; PMID:16767105; http://dx.doi.org/10.1038/ nature04915.
13. Bruce K, Myers FA, Mantouvalou E, Lefevre P, Greaves I, Bonifer C, et al. The replacement histone H2A. Z in a hyperacetylated form is a feature of active genes in the chicken. Nucleic Acids Res 2005; 33:5633-9; PMID:16204459; http://dx.doi.org/10.1093/nar/ gki874.
14. Lee DF, Su J, Sevilla A, Gingold J, Schaniel C, Lemischka IR. Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Nat Protoc 2012; 7:729-48; PMID:22441292; http:// dx.doi.org/10.1038/nprot.2012.018.
15. Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, et al. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell 2012; 11:179-94; PMID:22862944; http://dx.doi.org/10.1016/j.stem.2012.05.020.
16. Bilodeau S, Kagey MH, Frampton GM, Rahl PB, Young RA. SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state. Genes Dev 2009; 23:2484-9; PMID:19884255; http://dx.doi.org/10.1101/ gad.1837309.
17. Draker R, Sarcinella E, Cheung P. USP10 deubiquitylates the histone variant H2A. Z and both are required for androgen receptor-mediated gene activation. Nucleic Acids Res 2011; 39:3529-42; PMID:21245042; http://dx.doi.org/10.1093/nar/ gkq1352.
18. Sarcinella E, Zuzarte PC, Lau PNI, Draker R, Cheung P. Monoubiquitylation of H2A. Z distinguishes its association with euchromatin or facultative heterochromatin. Mol Cell Biol 2007; 27:6457-68; PMID:17636032; http://dx.doi.org/10.1128/MCB.00241-07.