-
1
-
-
65349189958
-
American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
-
C.J. Allegra, J.M. Jessup, M.R. Somerfield et al., American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J Clin Oncol 27 (2009), 2091-2096.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2091-2096
-
-
Allegra, C.J.1
Jessup, J.M.2
Somerfield, M.R.3
-
2
-
-
77949435827
-
Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
-
A. Bardelli and S. Siena, Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. Clin Oncol 28 (2010), 1254-1261.
-
(2010)
Clin Oncol
, vol.28
, pp. 1254-1261
-
-
Bardelli, A.1
Siena, S.2
-
3
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
H. Davies, G.R. Bignell, C. Cox et al.,Mutations of the BRAF gene in human cancer. Nature 417 (2002), 949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
4
-
-
77952883863
-
Molecular prognostic markers in papillary and follicular thyroid cancer: Current status and future directions
-
D. Handkiewicz-Junak, A. Czarniecka and B. Jarza̧b, Molecular prognostic markers in papillary and follicular thyroid cancer: Current status and future directions. Mol Cell Endocrinol 322 (2010), 8-28.
-
(2010)
Mol Cell Endocrinol
, vol.322
, pp. 8-28
-
-
Handkiewicz-Junak, D.1
Czarniecka, A.2
Jarza̧b, B.3
-
5
-
-
53149097362
-
BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?
-
S. Velho, C. Moutinho, L. Cirnes et al., BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis? BMC Cancer 8 (2008), 255.
-
(2008)
BMC Cancer
, vol.8
, pp. 255
-
-
Velho, S.1
Moutinho, C.2
Cirnes, L.3
-
6
-
-
0042743826
-
BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma
-
J. Dong, R.G. Phelps, R. Qiao et al., BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma. Cancer Res 63 (2003), 3883-3885.
-
(2003)
Cancer Res
, vol.63
, pp. 3883-3885
-
-
Dong, J.1
Phelps, R.G.2
Qiao, R.3
-
7
-
-
33846201272
-
New insight into BRAF mutations in cancer
-
N. Dhomen and R. Marais, New insight into BRAF mutations in cancer. Curr Opin Genet Dev 17 (2007), 31-39.
-
(2007)
Curr Opin Genet Dev
, vol.17
, pp. 31-39
-
-
Dhomen, N.1
Marais, R.2
-
8
-
-
9144271690
-
Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation
-
E. Domingo, E. Esṕn, M. Armengol et al., Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation. Genes Chromosomes Cancer 39 (2004), 138-142.
-
(2004)
Genes Chromosomes Cancer
, vol.39
, pp. 138-142
-
-
Domingo, E.1
Esṕn, E.2
Armengol, M.3
-
9
-
-
33745541234
-
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
-
D.J. Weisenberger, K.D. Siegmund, M. Campan et al., CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 38 (2006), 787-793.
-
(2006)
Nat Genet
, vol.38
, pp. 787-793
-
-
Weisenberger, D.J.1
Siegmund, K.D.2
Campan, M.3
-
10
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
F. Di Nicolantonio, M. Martini, F. Molinari et al., Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 26 (2008), 5705-5712.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
-
11
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
H. Rajagopalan, A. Bardelli, C. Lengauer et al., Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 418 (2002), 934.
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
-
12
-
-
77954218212
-
BRAF as therapeutic target in melanoma
-
C.Wellbrock and A. Hurlstone, BRAF as therapeutic target in melanoma. Biochem Pharmacol 80 (2010), 561-567.
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 561-567
-
-
Wellbrock, C.1
Hurlstone, A.2
-
13
-
-
70350445909
-
Sensitive detection of KRAS mutations in archived formalinfixed paraffin-embedded tissue using mutant-enriched PCR and reverse-hybridization
-
C. Ausch, V. Buxhofer-Ausch, C. Oberkanins et al., Sensitive detection of KRAS mutations in archived formalinfixed paraffin-embedded tissue using mutant-enriched PCR and reverse-hybridization. J Mol Diagn 11 (2009), 508-513.
-
(2009)
J Mol Diagn
, vol.11
, pp. 508-513
-
-
Ausch, C.1
Buxhofer-Ausch, V.2
Oberkanins, C.3
-
14
-
-
79951949395
-
KRAS mutation analysis in genomic DNA isolated from formalin-fixed paraffin-embedded ovarian tissue: Evaluation of a strip-based reverse-hybridization assay
-
G. Kriegsḧauser, V. Auner, E. Schuster et al., KRAS mutation analysis in genomic DNA isolated from formalin-fixed paraffin-embedded ovarian tissue: evaluation of a strip-based reverse-hybridization assay. J Clin Pathol 64 (2011), 252-256.
-
(2011)
J Clin Pathol
, vol.64
, pp. 252-256
-
-
Kriegsḧauser, G.1
Auner, V.2
Schuster, E.3
-
15
-
-
79952257109
-
SNaPshot and StripAssay as valuable alternatives to direct sequencing for KRAS mutation detection in colon cancer routine diagnostics
-
A. Fariña Sarasqueta, E.Moerland, H. de Bruyne et al., SNaPshot and StripAssay as valuable alternatives to direct sequencing for KRAS mutation detection in colon cancer routine diagnostics. J Mol Diagn 13 (2011), 199-205.
-
(2011)
J Mol Diagn
, vol.13
, pp. 199-205
-
-
Fariña Sarasqueta, A.1
Moerland, E.2
De Bruyne, H.3
-
16
-
-
64249106774
-
Evaluation of highresolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors
-
M. Pichler, M. Balic, E Stadelmeyer et al., Evaluation of highresolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors. J Mol Diagn 11 (2009),140-147.
-
(2009)
J Mol Diagn
, vol.11
, pp. 140-147
-
-
Pichler, M.1
Balic, M.2
Stadelmeyer, E.3
-
17
-
-
0036177726
-
Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool
-
L. Prix, P. Uciechowski, B. B̈ockmann et al., Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool. Clin Chem 48 (2002), 428-435.
-
(2002)
Clin Chem
, vol.48
, pp. 428-435
-
-
Prix, L.1
Uciechowski, P.2
B̈ockmann, B.3
-
18
-
-
78651241644
-
Colorectal cancer molecular biologymoves into clinical practice
-
C.C. Pritchard and W.M. Grady, Colorectal Cancer Molecular BiologyMoves Into Clinical Practice. Gut 60 (2011), 116-129.
-
(2011)
Gut
, vol.60
, pp. 116-129
-
-
Pritchard, C.C.1
Grady, W.M.2
-
20
-
-
33749316418
-
The epidermal growth factor receptor pathway: A model for targeted therapy
-
M. Scaltriti and J. Baselga, The epidermal growth factor receptor pathway: a model for targeted therapy. Clin Cancer Res 12 (2006), 5268-5272.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5268-5272
-
-
Scaltriti, M.1
Baselga, J.2
-
21
-
-
70349939382
-
A biomarkers predictingclinicaloutcome of epidermalgrowth factor-targeted therapyin metastatic colorectal cancer
-
S. Siena, A. Sartore-Bianci, F. Di Nicolantonio et al., A Biomarkers PredictingClinicalOutcome of EpidermalGrowth Factor-Targeted Therapyin Metastatic Colorectal Cancer. J Natl Cancer Inst 101 (2009), 1308-1324.
-
(2009)
J Natl Cancer Inst
, vol.101
, pp. 1308-1324
-
-
Siena, S.1
Sartore-Bianci, A.2
Di Nicolantonio, F.3
-
22
-
-
57449092484
-
KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer
-
N. Nakayama, K. Nakayama, S. Yeasmin et al., KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. Br J Cancer 99 (2008), 2020-2028.
-
(2008)
Br J Cancer
, vol.99
, pp. 2020-2028
-
-
Nakayama, N.1
Nakayama, K.2
Yeasmin, S.3
-
23
-
-
0037454224
-
Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma
-
G. Singer, R. Oldt 3rd, Y. Cohen et al., Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 95 (2003), 484-486.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 484-486
-
-
Singer, G.1
Oldt Iii., R.2
Cohen, Y.3
-
24
-
-
84855341896
-
Current status of immunotherapy for the treatment of lung cancer
-
S. Murala, V. Alli, D. Kreisel et al., Current status of immunotherapy for the treatment of lung cancer. J Thorac Dis 2 (2010), 237-244.
-
(2010)
J Thorac Dis
, vol.2
, pp. 237-244
-
-
Murala, S.1
Alli, V.2
Kreisel, D.3
-
25
-
-
77952236279
-
B-RAF inhibitors: An evolving role in the therapy of malignant melanoma
-
Shepherd C, Puzanov I, Sosman JA. B-RAF inhibitors: an evolving role in the therapy of malignant melanoma. Curr Oncol Rep 12 (2010), 146-152.
-
(2010)
Curr Oncol Rep
, vol.12
, pp. 146-152
-
-
Shepherd, C.1
Puzanov, I.2
Sosman, J.A.3
-
26
-
-
75149133181
-
Selectively targeting mutant BRAF in thyroid cancer
-
D.W. Ball, Selectively targeting mutant BRAF in thyroid cancer. J Clin Endocrinol Metab 95 (2010), 60-61.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 60-61
-
-
Ball, D.W.1
-
27
-
-
0026775621
-
K-ras genemutations in adenomas and carcinomas of the colon
-
I.S. Boughdady, A.R. Kinsella, N.Y. Haboubi et al., K-ras genemutations in adenomas and carcinomas of the colon. Surg Oncol 1 (1992), 275-282.
-
(1992)
Surg Oncol
, vol.1
, pp. 275-282
-
-
Boughdady, I.S.1
Kinsella, A.R.2
Haboubi, N.Y.3
-
28
-
-
30644473641
-
Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies
-
A. Russo, V. Bazan, V. Agnese et al., Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies. Ann Oncol 16 (2005), Suppl 4: iv44-49.
-
(2005)
Ann Oncol
, vol.16
, Issue.SUPPL. 4
-
-
Russo, A.1
Bazan, V.2
Agnese, V.3
-
29
-
-
33845608798
-
Classification of colorectal cancer based on correlation of clinical, morphological and molecular features
-
J.R. Jass, Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 50 (2007), 113-130.
-
(2007)
Histopathology
, vol.50
, pp. 113-130
-
-
Jass, J.R.1
-
30
-
-
70149110218
-
Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors: An important role for mutations in minor clones
-
A. Marchetti, M. Milella, L. Felicioni et al., Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors: an important role for mutations in minor clones. Neoplasia 11 (2009), 1084-1092.
-
(2009)
Neoplasia
, vol.11
, pp. 1084-1092
-
-
Marchetti, A.1
Milella, M.2
Felicioni, L.3
-
31
-
-
0027239995
-
Immunobead-PCR: A technique for the detection of circulating tumor cells using immunomagnetic beads and the polymerase chain reaction
-
J.E. Hardingham, D. Kotasek, B. Farmer et al., Immunobead-PCR: a technique for the detection of circulating tumor cells using immunomagnetic beads and the polymerase chain reaction. Cancer Res 53 (1993), 3455-3458.
-
(1993)
Cancer Res
, vol.53
, pp. 3455-3458
-
-
Hardingham, J.E.1
Kotasek, D.2
Farmer, B.3
-
32
-
-
0033963547
-
Facilitated detection of oncogene mutations from exfoliated tissue material by a PNA-mediated 'enriched PCR' protocol
-
M. Behn, C. Thiede, A. Neuberger et al., Facilitated detection of oncogene mutations from exfoliated tissue material by a PNA-mediated 'enriched PCR' protocol. J Pathol 190 (2000), 69-75.
-
(2000)
J Pathol
, vol.190
, pp. 69-75
-
-
Behn, M.1
Thiede, C.2
Neuberger, A.3
-
33
-
-
3242697688
-
High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations inAPC,TP53,K-RAS, andBRAF geneswith a novel DHPLC fluorescence detection platform
-
S.L. Lilleberg, J. Durocher, C. Sanders et al., High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations inAPC,TP53,K-RAS, andBRAF geneswith a novel DHPLC fluorescence detection platform. Ann N Y Acad Sci 1022 (2004), 250-256.
-
(2004)
Ann N y Acad Sci
, vol.1022
, pp. 250-256
-
-
Lilleberg, S.L.1
Durocher, J.2
Sanders, C.3
-
34
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
R.G. Amado, M. Wolf, M. Peeters et al., Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 26 (2008), 1626-1634.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
35
-
-
78650838966
-
Sensitive multiplex detection of KRAS codons 12 and 13 mutations in paraffinembedded tissue specimens
-
W. Laosinchai-Wolf, F. Ye, V. Tran et al., Sensitive multiplex detection of KRAS codons 12 and 13 mutations in paraffinembedded tissue specimens. J Clin Pathol 64 (2011), 30-36.
-
(2011)
J Clin Pathol
, vol.64
, pp. 30-36
-
-
Laosinchai-Wolf, W.1
Ye, F.2
Tran, V.3
-
36
-
-
77957129235
-
High sensitivity of both sequencing and real-time PCR analysis of KRAS mutations in colorectal cancer tissue
-
J. Tol, J.R. Dijkstra, M.E. Vink-Borger et al., High sensitivity of both sequencing and real-time PCR analysis of KRAS mutations in colorectal cancer tissue. J Cell Mol Med 14 (2010), 2122-2131.
-
(2010)
J Cell Mol Med
, vol.14
, pp. 2122-2131
-
-
Tol, J.1
Dijkstra, J.R.2
Vink-Borger, M.E.3
-
37
-
-
33846641709
-
High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer
-
M. Krypuy, G.M. Newnham, D.M. Thomas et al., High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer. BMC Cancer 6 (2006), 295.
-
(2006)
BMC Cancer
, vol.6
, pp. 295
-
-
Krypuy, M.1
Newnham, G.M.2
Thomas, D.M.3
-
38
-
-
70349653814
-
Detection ofKRASmutations in colorectal cancer by high-resolution melting analysis
-
E.S. Ma, C.L.Wong, F.B. Lawet al.,Detection ofKRASmutations in colorectal cancer by high-resolution melting analysis. J Clin Pathol 62 (2009), 886-891.
-
(2009)
J Clin Pathol
, vol.62
, pp. 886-891
-
-
A, E.S.M.1
Wong, C.L.2
Law, F.B.3
-
39
-
-
34250658870
-
High-resolution DNA melting analysis for simple and efficient molecular diagnostics
-
G.H. Reed, J.O. Kent and C.T.Wittwer, High-resolution DNA melting analysis for simple and efficient molecular diagnostics. Pharmacogenomics 8 (2007), 597-608.
-
(2007)
Pharmacogenomics
, vol.8
, pp. 597-608
-
-
Reed, G.H.1
Kent, J.O.2
Wittwer, C.T.3
|