T102C polymorphism of serotonin 2A type receptor gene confers susceptibility to (early onset) schizophrenia in Han Chinese: An association study and meta-analysis

Asia-Pacific Psychiatry

Volumn 5, Issue 1, 2013, Pages 24-30

  Ni, Jianliang ^a   Lu, Weihong ^b   Wu, Zhiguo ^b   Chen, Jun ^b   Yi, Zhenghui ^b   Zhang, Chen ^b  

^a Tongde Hospital of Zhejiang Province   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Association; Meta analysis; Schizophrenia; Serotonin 2A receptor; T102C polymorphism

Indexed keywords

GENOMIC DNA; SEROTONIN 2A RECEPTOR;

ADULT; ARTICLE; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; POPULATION GENETICS; PRIORITY JOURNAL; SCHIZOPHRENIA;

ASSOCIATION; META-ANALYSIS; SCHIZOPHRENIA; SEROTONIN 2A RECEPTOR; T102C POLYMORPHISM;

ADOLESCENT; ADULT; AGE OF ONSET; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHINA; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HETEROZYGOTE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, GENETIC; RECEPTOR, SEROTONIN, 5-HT2A; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84874303932     PISSN: 17585864     EISSN: 17585872     Source Type: Journal    
DOI: 10.1111/appy.12027     Document Type: Article

References (39)

1. Abdolmaleky H.M., Faraone S.V., Glatt S.J., Tsuang M.T. (2004) Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Schizophr Res. 67, 53-62.
2. Abdolmaleky H.M., Yaqubi S., Papageorgis P., etal. (2011) Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr Res. 129, 183-190.
3. Allen N.C., Bagade S., McQueen M.B., etal. (2008) Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet. 40, 827-834.
4. Bird A. (2002) DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6-21.
5. Chen C.H., Lee Y.R., Wei F.C., Koong F.J., Hwu H.G., Hsiao K.J. (1997) Lack of allelic association between 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia in Chinese. Psychiatr Genet. 7, 35-38.
6. Chen R.Y., Sham P., Chen E.Y., etal. (2001) No association between T102C polymorphism of serotonin-2A receptor gene and clinical phenotypes of Chinese schizophrenic patients. Psychiatry Res. 105, 175-185.
7. DerSimonian R. (1990) Combining evidence from clinical trials. Anesth Analg. 70, 475-476.
8. Ghadirivasfi M., Nohesara S., Ahmadkhaniha H.R., etal. (2011) Hypomethylation of the serotonin receptor type-2A Gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 156B, 536-545.
9. Golimbet V.E., Lavrushina O.M., Kaleda V.G., Abramova L.I., Lezheiko T.V. (2007) Supportive evidence for the association between the T102C 5-HTR2A gene polymorphism and schizophrenia: a large-scale case-control and family-based study. Eur Psychiatry. 22, 167-170.
10. Hashimoto R., Ohi K., Yasuda Y., etal. (2011) No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. Schizophr Res. 129, 80-84.
11. He L., Li T., Melville C., etal. (1999) 102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations. Am J Med Genet. 88, 95-98.
12. Hurlemann R., Boy C., Meyer P.T., etal. (2005) Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia. Anat Embryol (Berl). 210, 519-523.
13. Hurlemann R., Matusch A., Kuhn K.U., etal. (2008) 5-HT2A receptor density is decreased in the at-risk mental state. Psychopharmacology (Berl). 195, 579-590.
14. Inayama Y., Yoneda H., Sakai T., etal. (1996) Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia. Am J Med Genet. 67, 103-105.
15. Iwata Y., Matsumoto H., Minabe Y., etal. (2003) Early-onset schizophrenia and dopamine-related gene polymorphism. Am J Med Genet B Neuropsychiatr Genet. 116B, 23-26.
16. Joober R., Benkelfat C., Brisebois K., etal. (1999) T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variability. J Psychiatry Neurosci. 24, 141-146.
17. Kim Y.K., Yoon H.K. (2011) Effect of serotonin-related gene polymorphisms on pathogenesis and treatment response in Korean schizophrenic patients. Behav Genet. 41, 709-715.
18. Klar A.J. (2004) A genetic mechanism implicates chromosome 11 in schizophrenia and bipolar diseases. Genetics. 167, 1833-1840.
19. Kumra S., Charles Schulz S. (2008) Editorial: research progress in early-onset schizophrenia. Schizophr Bull. 34, 15-17.
20. Li D., Duan Y., He L. (2006) Association study of serotonin 2A receptor (5-HT2A) gene with schizophrenia and suicidal behavior using systematic meta-analysis. Biochem Biophys Res Commun. 340, 1006-1015.
21. Lin C.H., Tsai S.J., Yu Y.W., etal. (1999) No evidence for association of serotonin-2A receptor variant (102T/C) with schizophrenia or clozapine response in a Chinese population. Neuroreport. 10, 57-60.
22. Manschreck T.C., Boshes R.A. (2007) The CATIE schizophrenia trial: results, impact, controversy. Harv Rev Psychiatry. 15, 245-258.
23. Miyamoto S., Duncan G.E., Marx C.E., Lieberman J.A. (2005) Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry. 10, 79-104.
24. Nocjar C., Roth B.L., Pehek E.A. (2002) Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. 111, 163-176.
25. Parsons M.J., D'Souza U.M., Arranz M.J., Kerwin R.W., Makoff A.J. (2004) The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity. Biol Psychiatry. 56, 406-410.
26. Polesskaya O.O., Sokolov B.P. (2002) Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. J Neurosci Res. 67, 812-822.
27. Shi Y.Y., He L. (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 15, 97-98.
28. Sodhi M.S., Sanders-Bush E. (2004) Serotonin and brain development. Int Rev Neurobiol. 59, 111-174.
29. Steward L.J., Kennedy M.D., Morris B.J., Pratt J.A. (2004) The atypical antipsychotic drug clozapine enhances chronic PCP-induced regulation of prefrontal cortex 5-HT2A receptors. Neuropharmacology. 47, 527-537.
30. Waterwort D.M., Bassett A.S., Brzustowicz L.M. (2002) Recent advances in the genetics of schizophrenia. Cell Mol Life Sci. 59, 331-348.
31. Williams J., Spurlock G., McGuffin P., etal. (1996) Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group. Lancet. 347, 1294-1296.
32. Woolf B. (1995) On estimating the relation between blood group and disease. Ann Hum Genet. 19, 251-253.
33. Yi Z., Zhang C., Wu Z., etal. (2011) Lack of effect of brain derived neurotrophic factor (BDNF) Val66Met polymorphism on early onset schizophrenia in Chinese Han population. Brain Res. 1417, 146-150.
34. Yi Z., Zhang C., Lu W., etal. (2012) Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia. J Mol Neurosci. 47, 465-469.
35. Zhang C., Fang Y., Xie B., etal. (2009a) DNA methyltransferase 3B gene increases risk of early onset schizophrenia. Neurosci Lett. 462, 308-311.
36. Zhang C., Fang Y., Xie B., etal. (2010) No genetic association between dopamine D1 receptor gene and [early onset] schizophrenia. Psychiatry Res. 177, 350-353.
37. Zhang C., Li Z., Shao Y., etal. (2011) Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population. J Mol Neurosci. 43, 406-411.
38. Zhang X.N., Jiang S.D., He X.H., Zhang L.N. (2004) 102T/C SNP in the 5-hydroxytryptamine receptor 2A (HTR2A) gene and schizophrenia in two southern Han Chinese populations: lack of association. Am J Med Genet B Neuropsychiatr Genet. 126B, 16-18.
39. Zhang Z., Lindpaintner K., Che R., etal. (2009b) The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis. J Neural Transm. 116, 1193-1200.