Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population

Journal of Molecular Neuroscience

Volumn 43, Issue 3, 2011, Pages 406-411

  Zhang, Chen ^a   Li, Zezhi ^a   Shao, Yang ^a   Xie, Bin ^a   Du, Yasong ^a   Fang, Yiru ^a   Yu, Shunying ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Association; Polymorphism; Schizophrenia; TPH2

Indexed keywords

TRYPTOPHAN HYDROXYLASE 2;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CHINESE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POSITIVE AND NEGATIVE SYNDROME SCALE; POSITIVE SYNDROME; SCHIZOPHRENIA;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; ETHNIC GROUPS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ISOENZYMES; MALE; POLYMORPHISM, GENETIC; SCHIZOPHRENIA; TRYPTOPHAN HYDROXYLASE; YOUNG ADULT;

EID: 79955794649     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-010-9458-2     Document Type: Article

References (36)

1. Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L (2008) Systematic metaanalyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 40:827-834 (Pubitemid 351913655)
2. Bailer U, Leisch F, Meszaros K, Lenzinger E, Willinger U, Strobl R, Gebhardt C, Gerhard E, Fuchs K, Sieghart W, Kasper S, Hornik K, Aschauer HN (2000) Genome scan for susceptibility loci for schizophrenia. Neuropsychobiology 42:175-182
3. Brown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE, Hariri AR (2005) A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol Psychiatry 10:884-888 (Pubitemid 43080123)
4. Canli T, Congdon E, Gutknecht L, Constable RT, Lesch KP (2005) Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J Neural Transm 112:1479-1485 (Pubitemid 41504264)
5. Carlsson A (1988) The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1:179-186
6. Chen GL, Vallender EJ, Miller GM (2008) Functional characterization of the human TPH2 5′ regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Hum Genet 122:645-657
7. Cherlyn SY, Woon PS, Liu JJ, Ong WY, Tsai GC, Sim K (2010) Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: a decade of advance. Neurosci Biobehav Rev 34:958-977
8. Davis JM, Chen N, Glick ID (2003) A meta-analysis of the efficacy of second-generation antipsychotics. Arch Gen Psychiatry 60:553-564 (Pubitemid 36682312)
9. De Luca V, Voineskos D, Wong GW, Shinkai T, Rothe C, Strauss J, Kennedy JL (2005) Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality. Psychiatry Res 134:195-198 (Pubitemid 40544287)
10. DeRosse P, Lencz T, Burdick KE, Siris SG, Kane JM, Malhotra AK (2008) The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. Schizophr Bull 34:1047-1053
11. Goghari VM, Sponheim SR, MacDonald AW 3rd (2010) The functional neuroanatomy of symptom dimensions in schizophrenia: a qualitative and quantitative review of a persistent question. Neurosci Biobehav Rev 34:468-486
12. Grayson DR, Chen Y, Costa E, Dong E, Guidotti A, Kundakovic M, Sharma RP (2006) The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia. Pharmacol Ther 111:272-286 (Pubitemid 43765535)
13. Harvey M, Gagné B, Labbé M, Barden N (2007) Polymorphisms in the neuronal isoform of tryptophan hydroxylase 2 are associated with bipolar disorder in French Canadian pedigrees. Psychiatr Genet 17:17-22 (Pubitemid 44953342)
14. Higashi S, Ohnuma T, Shibata N, Higashi M, Matsubara Y, Arai H (2007) No genetic association between tryptophan hydroxylase 2 gene polymorphisms and Japanese schizophrenia. Psychiatr Genet 17:123 (Pubitemid 46586686)
15. Hong C, Tsai S, Wang Y (2001) Association between tryptophan hydroxylase gene polymorphism (A218C) and schizophrenia disorders. Schizophr Res 49:59-63 (Pubitemid 32434312)
16. Kapur S, Remington G, Jones C, Wilson A, DaSilva J, Houle S, Zipursky R (1996) High levels of dopamine D2 receptor occupancy with low-dose haloperidol treatment: a PET study. Am J Psychiatry 153:948-950 (Pubitemid 26225470)
17. Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261-276 (Pubitemid 18039085)
18. Kim YK, Lee HJ, Yang JC, Hwang JA, Yoon HK (2009) A tryptophan hydroxylase 2 gene polymorphism is associated with panic disorder. Behav Genet 39:170-175
19. Kuperberg G, Heckers S (2000) Schizophrenia and cognitive function. Curr Opin Neurobiol 10:205-210 (Pubitemid 30201113)
20. Lim JE, Pinsonneault J, Sadee W, Saffen D (2007) Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons. Mol Psychiatry 12:491-501 (Pubitemid 46652452)
21. Manschreck TC, Boshes RA (2007) The CATIE schizophrenia trial: results, impact, controversy. Harv Rev Psychiatry 15:245-258 (Pubitemid 47557208)
22. Miyamoto S, Duncan GE, Marx CE, Lieberman JA (2005) Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry 10:79-104 (Pubitemid 40139590)
23. Mössner R, Walitza S, Geller F, Scherag A, Gutknecht L, Jacob C, Bogusch L, Remschmidt H, Simons M, Herpertz-Dahlmann B, Fleischhaker C, Schulz E, Warnke A, Hinney A, Wewetzer C, Lesch KP (2006) Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharmacol 9:437-442 (Pubitemid 43979703)
24. Roche S, McKeon P (2009) Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder. Psychiatr Genet 19:142-146
25. Scheuch K, LautenschlagerM, GrohmannM, Stahlberg S, Kirchheiner J, Zill P, Heinz A, Walther DJ, Priller J (2007) Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biol Psychiatry 62:1288-1294 (Pubitemid 350060888)
26. Sekizawa T, Iwata Y, Nakamura K, Matsumoto H, Suzuki A, Suzuki K, Sekine Y, Takei N, Minabe Y, Mori N (2004) Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism. Am J Med Genet B Neuropsychiatr Genet 128B:24-26 (Pubitemid 38849912)
27. Selvin S (2004) Statistical analysis of epidemiologic data. Oxford University Press, New York
28. Shi YY, He L (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15:97-98 (Pubitemid 41653949)
29. Shiroiwa K, Hishimoto A, Mouri K, Fukutake M, Supriyanto I, Nishiguchi N, Shirakawa O (2010) Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population. Neurosci Lett 472:194-198
30. Sodhi MS, Sanders-Bush E (2004) Serotonin and brain development. Int Rev Neurobiol 59:111-174 (Pubitemid 39752414)
31. Wadenberg ML (2010) Conditioned avoidance response in the development of new antipsychotics. Curr Pharm Des 16:358-370
32. Walitza S, Renner TJ, Dempfle A, Konrad K, Wewetzer Ch, Halbach A, Herpertz-Dahlmann B, Remschmidt H, Smidt J, Linder M, Flierl L, Knölker U, Friedel S, Schäfer H, Gross C, Hebebrand J, Warnke A, Lesch KP (2005) Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Mol Psychiatry 10:1126-1132 (Pubitemid 43251103)
33. Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M (2003) Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299:76 (Pubitemid 36042402)
34. Zaboli G, Jönsson EG, Gizatullin R, Asberg M, Leopardi R (2006) Tryptophan hydroxylase-1 gene variants associated with schizophrenia. Biol Psychiatry 60:563-569 (Pubitemid 44402374)
35. Zhang X, Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG (2004) Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305:217 (Pubitemid 38886729)
36. Zhang C, Fang YR, Xie B, Cheng WH, Du YS, Wang DX, Yu SY (2009) DNA methyltransferase 3B gene increases risk of early onset schizophrenia. Neurosci Lett 462:308-311