Role of an Iron-Dependent Transcriptional Regulator in the Pathogenesis and Host Response to Infection with Streptococcus pneumoniae

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Gupta, Radha ^a   Bhatty, Minny ^b   Swiatlo, Edwin ^a   Nanduri, Bindu ^b  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IRON DEPENDENT TRANSCRIPTIONAL REGULATOR; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE COURSE; DISEASE EXACERBATION; DOWN REGULATION; GENE DELETION; GENE EXPRESSION REGULATION; GROWTH RATE; HOST PATHOGEN INTERACTION; IDTR GENE; IMMUNE RESPONSE; IN VITRO STUDY; INFECTIOUS PNEUMONIA; INFLAMMATION; MOUSE; NONHUMAN; PATHOGENESIS; PNEUMOCOCCAL INFECTION; PROGNOSIS; RHINOPHARYNGITIS; SEPSIS; SURVIVAL;

ANIMALS; BACTERIAL PROTEINS; COLONY COUNT, MICROBIAL; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, BACTERIAL; HOST-PATHOGEN INTERACTIONS; IRON; MICE; MICE, INBRED C57BL; MICROBIAL VIABILITY; PNEUMOCOCCAL INFECTIONS; SEPSIS; STREPTOCOCCUS PNEUMONIAE; TRANS-ACTIVATORS; VIRULENCE;

EID: 84874258606     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055157     Document Type: Article

References (45)

1. AlonsoDeVelasco E, Verheul AF, Verhoef J, Snippe H, (1995) Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccines. Microbiol Rev 59: 591-603.
2. Brown JS, Gilliland SM, Ruiz-Albert J, Holden DW, (2002) Characterization of pit, a Streptococcus pneumoniae iron uptake ABC transporter. Infect Immun 70: 4389-4398.
3. Brown JS, Gilliland SM, Holden DW, (2001) A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence. Mol Microbiol 40: 572-585.
4. Brown JS, Ogunniyi AD, Woodrow MC, Holden DW, Paton JC, (2001) Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection. Infect Immun 69: 6702-6706.
5. Tai SS, Lee CJ, Winter RE, (1993) Hemin utilization is related to virulence of Streptococcus pneumoniae. Infect Immun 61: 5401-5405.
6. Gupta R, Shah P, Swiatlo E, (2009) Differential gene expression in Streptococcus pneumoniae in response to various iron sources. Microbial Pathogenesis 47: 101-109.
7. Escolar L, Pérez-Martín J, de Lorenzo V, (1998) Binding of the Fur (ferric uptake regulator) repressor of Escherichia coli to arrays of the GATAAT sequence. J Mol Biol 283: 537-547.
8. Staggs TM, Perry RD, (1992) Fur regulation in Yersinia species. Mol Microbiol 6: 2507-2516.
9. Goldberg MB, Boyko SA, Calderwood SB, (1990) Transcriptional regulation by iron of a Vibrio cholerae virulence gene and homology of the gene to the Escherichia coli fur system. J Bacteriol 172: 6863-6870.
10. Litwin CM, Calderwood SB, (1993) Cloning and genetic analysis of the Vibrio vulnificus fur gene and construction of a fur mutant by in vivo marker exchange. J Bacteriol 175: 706-715.
11. Prince RW, Cox CD, Vasil ML, (1993) Coordinate regulation of siderophore and exotoxin A production: molecular cloning and sequencing of the Pseudomonas aeruginosa fur gene. J Bacteriol 175: 2589-2598.
12. Thomas CE, Sparling PF, (1994) Identification and cloning of a fur homologue from Neisseria meningitidis. Mol Microbiol 11: 725-737.
13. Gunter-Seeboth K, Schupp T, (1995) Cloning and sequence analysis of the Corynebacterium diphtheriae DtxR homologue from Streptomyces lividans and S. pilosus encoding a putative iron repressor protein Gene. 166: 117-119.
14. Hill PJ, Cockayne A, Landers P, Morrissey JA, Sims CM, et al. (1998) SirR, a novel iron-dependent repressor in Staphylococcus epidermidis. Infect Immun 66: 4123-4129.
15. Fiss EH, Yu S, Jacobs WR, (1994) Identification of genes involved in the sequestration of iron in mycobacteria: the ferric exochelin biosynthetic and uptake pathways. Mol Microbiol 14: 557-569.
16. Brett PJ, Burtnick MN, Fenno JC, Gherardini FC, (2008) Treponema denticola TroR is a manganese- and iron-dependent transcriptional repressor. Mol Microbiol 70: 396-409.
17. Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, et al. (2001) Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science 293: 498-506.
18. Quin LR, Moore QC 3rd, Thornton JA, McDaniel LS (2008) Peritoneal challenge modulates expression of pneumococcal surface protein C during bacteremia in mice. Infect Immun 76: 1122-1127.
19. Knapp S, Hareng L, Rijneveld AW, Bresser P, van der Zee JS, et al. (2004) Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumonia. J Infect Dis 189: 1506-1515.
20. Khan AQ, Shen Y, Wu ZQ, Wynn TA, Snapper CM, (2002) Endogenous pro- and anti-inflammatory cytokines differentially regulate an in vivo humoral response to Streptococcus pneumoniae. Infect Immun 70: 749-761.
21. Jones MR, Simms BT, Lupa MM, Kogan MS, Mizgerd JP, (2005) Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. J Immunol 175: 7530-7535.
22. Ferreira DM, Darrieux M, Silva DA, Leite LC, Ferreira JM Jr, et al. (2009) Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface protein PspA and PspC nasal vaccines against a respiratory pneumococcal challenge in mice. Clin Vaccine Immunol 16: 636-645.
23. Draing C, Pfitzenmaier M, Zummo S, Mancuso G, Geyer A, et al. (2006) Comparison of lipoteichoic acid from different serotypes of Streptococcus pneumoniae. J Biol Chem 281: 33849-33859.
24. Bernatoniene J, Zhang Q, Dogan S, Mitchell TJ, Paton JC, et al. (2008) Induction of CC and CXC chemokines in human antigen-presenting dendritic cells by the pneumococcal proteins pneumolysin and CbpA, and the role played by toll-like receptor 4, NF-kappaB, and mitogen-activated protein kinases. J Infect Dis 198: 1823-1833.
25. Lau GW, Haataja S, Lonetto M, Kensit SE, Marra A, et al. (2001) A functional genomic analysis of type 3 Streptococcus pneumoniae virulence. Mol Microbiol 40: 555-571.
26. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, et al. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Crit Care Med. Chest 101: 1644-1655.
27. de Jong HK, van der Poll T, Wiersinga WJ, (2010) The systemic pro-inflammatory response in sepsis. J Innate Immun 2: 422-430.
28. Biffl WL, Moore EE, Moore FA, Barnett CC Jr, (1996) Interleukin-6 delays neutrophil apoptosis via a mechanism involving platelet-activating factor. J Trauma 40: 575-578.
29. Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW, (1994) Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood 83: 113-118.
30. Tamayo E, Fernandez A, Almansa R, Carrasco E, Heredia M, et al. (2011) Pro- and anti-inflammatory responses are regulated simultaneously from the first moments of septic shock. Eur Cytokine Netw 22: 82-87.
31. Osuchowski MF, Welch K, Siddiqui J, Remick DG, (2006) Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol 177: 1967-1974.
32. van der Poll T, de Waal Malefyt R, Coyle SM, Lowry SF, (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis 175: 118-122.
33. Wu HP, Shih CC, Lin CY, Hua CC, Chuang DY, (2011) Serial increase of interleukin-12 response and HLA-DR expression in severe sepsis survivors. Crit Care 15: R224.
34. Zhu S, Ashok M, Li J, Li W, Yang H, et al. (2009) Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers. Mol Med 15: 275-282.
35. Ness TL, Carpenter KJ, Ewing JL, Gerard CJ, Hogaboam CM, et al. (2004) CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis. J Immunol 173: 6938-6948.
36. Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, et al. (2007) Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 167: 1655-1663.
37. Richardson AR, Dunman PM, Fang FC, (2006) The nitrosative stress response of Staphylococcus aureus is required for resistance to innate immunity. Mol Microbiol 61: 927-939.
38. Rodriguez GM, Voskuil MI, Gold B, (2002) Schoolnik GK, Smith I (2002) ideR, an essential gene in Mycobacterium tuberculosis: role of ideR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect Immun 70: 3371-3381.
39. van de Rijn I, Kessler RE, (1980) Growth characteristics of group A streptococci in a new chemically defined medium. Infect Immun 27: 444-448.
40. Pozzi G, Masala L, Iannelli F, Manganelli R, Havarstein L, et al. (1996) Competence for genetic transformation in encapsulated strains of Streptococcus pneumoniae: two allelic variants of the peptide pheromone. J Bacteriol 178: 6087-6090.
41. Adrian PV, Thomson CJ, Klugman KP, Amyes SGB, (2000) New gene cassettes for trimethoprim resistance, dfr13, and streptomycin-spectinomycin resistance, aadA4, inserted on a class 1 integron. Antimicrob Agents Chemother 44: 355-361.
42. Lau PCY, Sung CK, Lee JH, Morrison DA, Cvitkovitch DG, (2002) PCR ligation mutagenesis in transformable streptococci: application and efficiency. J Microbiol Methods 49: 193-205.
43. Wu HY, Virolainen A, Mathews B, King J, Russell MW, et al. (1997) Establishment of a Streptococcus pneumoniae nasopharyngeal colonization model in adult mice. Microb Pathog 23: 127-137.
44. Ogunniyi AD, Giammarinaro P, Paton JC, (2002) The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology 148: 2045-2053.
45. Pfaffl MW, Horgan GW, Dempfle L (2002) Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucl Acids Res 30: e36-.