A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence

Molecular Microbiology

Volumn 40, Issue 3, 2001, Pages 572-585

  Brown, Jeremy S ^a   Gilliland, Sarah M ^a   Holden, David W ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; RUFOCROMOMYCIN;

ARTICLE; BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERIAL VIRULENCE; EVOLUTION; GENE LOCUS; IRON TRANSPORT; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; OPTICAL DENSITY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; DISEASE MODELS, ANIMAL; FERRIC COMPOUNDS; GENES, BACTERIAL; HUMANS; IRON; MICE; PNEUMOCOCCAL INFECTIONS; SEQUENCE ANALYSIS, DNA; STREPTOCOCCUS PNEUMONIAE; STREPTONIGRIN; VIRULENCE;

EID: 0035006337     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02414.x     Document Type: Article

References (49)

1. Bearden, S.W., and Perry, R.D. (1999) The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague. Mol Microbiol 32: 403-414.
2. Beuzón, C.R., and Casadesús, J. (1997) Conserved structure of IS200 elements in Salmonella typhimurium. Nucleic Acids Res 25: 1355-1361.
3. Beuzón, C.R., Méresse, S., Unsworth, K.E., Ruiz-Albert, J., Garvis, S., Waterman, S.R., et al. (2000) Salmonella typhimurium maintains the integrity of its intracellular vacuole through the action of SifA. EMBO J 19: 3235-3249.
4. Bracken, C.S., Baer, M.T., Abdur-Rashid, A., Helms, W., and Stojiljkovic, I. (1999) Use of heme-protein complexes by the Yersinia enterocolitica HemR receptor: histidine residues are essential for receptor function. J Bacteriol 181: 6063-6072.
5. Braun, V., Gross, R., Koster, W., and Zimmermann, L. (1983) Plasmid and chromosomal mutants in the iron (III)-aerobactin transport system of Escherichia coli. Use of streptonigrin for selection. Mol Gen Genet 192: 131-139.
6. Buchrieser, C., Brosch, R., Bach, S., Guiyoule, A., and Carniel, E. (1998) The high-pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genes. Mol Microbiol 30: 965-978.
7. Chakraboty, T., Hain, T., and Domann, E. (2000) Genome organisation and the evolution of the virulence gene locus in Listeria species. Int J Med Microbiol 290: 167-174.
8. Claverys, J.P., Dintilhac, A., Pestova, E.V., Martin, B., and Morrison, D.A. (1995) Construction and evaluation of new drug-resistance cassettes for gene disruption mutagenesis in Streptococcus pneumoniae, using an ami test platform. Gene 164: 123-128.
9. Claverys, J.P., Prudhomme, M., Mortier-Barrière, I., and Martin, B. (2000) Adaptation to the environment: Streptococcus pneumoniae, a paradigm for recombination-mediated genetic plasticity. Mol Microbiol 35: 251-259.
10. Cockayne, A., Hill, P.J., Powell, N.B., Bishop, K., Sims, C., and Williams, P. (1998) Molecular cloning of a 32-kilodalton lipoprotein component of a novet iron regulated Staphylococcus epidermis ABC transporter. Infect Immun 66: 3767-3774.
11. Cornelissen, C.N., and Sparling, P.F. (1994) Iron piracy: acquisition of transferrin-bound iron by bacterial pathogens. Mol Microbiol 14: 843-850.
12. Drazek, E.S., Hammack, A., Sr, and Schmitt, M.P. (2000) Corynebacterium diphtheriae genes required for acquisition of iron from haemin and haemoglobin are homologous to ABC haemin transporters. Mol Microbiol 36: 68-84.
13. Fetherston, J.D., Bertolino, V.J., and Perry, R.D. (1999) YbtP and YbtQ: two ABC transporters required for iron uptake in Yersinia pestis. Mol Microbiol 32: 289-299.
14. Genco, C.A., and Dixon, D.W. (2001) Emerging strategies in microbial haem capture. Mol Microbiol 39: 1-11.
15. Hacker, J., and Kaper, J.B. (2000) Pathogenicity islands and the evolution of microbes. Annu Rev Microbiol 54: 641-679.
16. Hacker, J., Blum-Oehler, G., Mühldorfer, I., and Tschäpe, H. (1997) Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution. Mol Microbiol 23: 1089-1097.
17. Hammerschmidt, S., Bethe, G.H., Remane, P., and Chhatwal, G.S. (1999) Identification of pneumococcal surface protein A as a lactoferrin-binding protein of Streptococcus pneumoniae. Infect Immun 67: 1683-1687.
18. Hardie, J.M. (1986) Genus Streptococcus. In Bergey's Manual of Systematic Bacteriology. Krieg, N.R., and Holt, J.G. (eds). Baltimore: Williams & Wilkins, pp. 1043-1071.
19. Håvarstein, L.S., Coomaraswami, G., and Morrison, D.A. (1995) An unmodified heptadecapeptide pheromone induces competence for genetic transformation of Streptococcus pneumoniae. Proc Natl Acad Sci USA 92: 11140-11144.
20. Holden, D.W., Kronstad, J.W., and Leong, S.A. (1989) Mutation in a heat-regulated hsp70 of Ustilago maydis. EMBO J 8: 1927-1934.
21. Ito, I., Katayama, Y., and Hiramatsu, K. (1999) Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315. Antimicrob Agents Chemother 43: 1449-1458.
22. Janakiraman, A., and Slauch, J.M. (2000) The putative iron transport system SitABCD encoded on SPI1 is required for full virulence of Salmonella typhimurium. Mol Microbiol 35: 1146-1155.
23. Kawamura, Y., Hou, X.G., Sultana, F., Miura, H., and Ezakl, T. (1995) Determination of 16S rRNA sequences of Streptococcus mitis and Streptococcus gordonii and phylogenetic relationships among members of the genus Streptococcus. Int J Syst Bacteriol 45: 406-408.
24. LaForce, F.M., Boose, D.S., and Ellison, R.T. (1986) Effect of aerosolised Escherichia coli and Staphylococcus aureus on iron and iron-binding proteins in lung lavage. J Infect Dis 154: 959-965.
25. Lau, G.W., Haataja, S., Lonetto, M., Kensit, S.E., Marra, A., Bryant, A.P., et al. (2001) A functional genomic analysis of type 3 Streptococcus pneumoniae virulence. Mol Microbiol 40: 555-571.
26. Lee, J.H., Wang, T., Ault, K., Liu, J., Schmitt, M.P., and Holmes, R.K. (1997) Identification and characterisation of three new promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin repressor (DtxR) and iron. Infect Immun 65: 4273-4280.
27. Lindsay, J.A., Ruzin, A., Ross, H.R., Kurepina, N., and Novik, R. (1998) The gene for toxic shock is carried by a family of mobile pathogenicity islands in Staphylococcus aureus. Mol Microbiol 29: 527-543.
28. Linton, K.J., and Higgins, C.F. (1998) The Escherichia coli ATP-binding cassette (ABC) proteins. Mol Microbiol 28: 5-13.
29. Mahillon, J., and Chandler, M. (1998) Insertion sequences. Microbiol Mol Biol Rev 62: 725-774.
30. Martin, B., Humbert, O., Camara, M., Guenzi, E., Walker, J., Mitchells, T., et al. (1992) A highly conserved repeated DNA element located in the chromosome of Streptococcus pneumoniae. Nucleic Acids Res 20: 3479-3483.
31. Ochman, H., Lawrence, J.G., and Groisman, E.A. (2000) Lateral gene transfer and the nature of bacterial innovation. Nature 405: 299-304.
32. Oggioni, M.R., and Claverys, J.P. (1999) Repeated extragenic sequences in prokaryotic genomes: a proposal for the origin and dynamics of the RUP element in Streptococcus pneumoniae. Microbiology 145: 2647-2653.
33. Pope, C.D., O'Connell, W., and Cianciotto, N.P. (1996) Legionella pneumophila mutants that are defective for iron acquisition and intracellular infection. Infect Immun 64: 629-636.
34. Richardson, P.T., and Park, S.F. (1995) Enterochelin acquisition in Campylobacter coli: characterisation of components of a binding-protein-dependent transport system. Microbiology 141: 3181-3191.
35. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
36. Schryvers, A.B., and Stojiljkovic, I. (1999) Iron acquisition systems in the pathogenic Neisseria. Mol Microbiol 32: 1117-1123.
37. Shea, J.E., Hensel, M., Gleeson, C., and Holden, D.W. (1996) Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium. Proc Natl Acad Sci USA 93: 2593-2597.
38. Sicard, A.M. (1964) A new synthetic medium for Diplococcus pneumoniae, and its use for the study of reciprocal transformations at the amiA locus. Genetics 50: 31-44.
39. Sutcliffe, I., and Russell, R.R.B. (1995) Lipoproteins of Gram-positive bacteria. J Bacteriol 177: 1123-1128.
40. Tai, S.S., Lee, C., and Winter, R.E. (1993) Hemin utilization is related to virulence of Streptococcus pneumoniae. Infect Immun 61: 5401-5405.
41. Tai, S.S., Wang, T.R., and Lee, C. (1997) Characterisation of hemin binding activity of Streptococcus pneumoniae. Infect Immun 65: 1083-1087.
42. Takase, H., Nitanai, H., Hoshino, K., and Otani, T. (2000) Impact of siderophore production on Pseudomonas aeruginosa infections in immunosuppressed mice. Infect Immun 68: 1834-1839.
43. Thompson, A.B., Bohling, T., Payvandi, F., and Rennard, S.I. (1990) Lower respiratory tract lactoferrin and lysozyme arise primarily in the airways and are elevated in association with chronic bronchitis. J Lab Clin Med 115: 148-158.
44. Velayudhan, J., Hughes, N.J., McColm, A.A., Bagshaw, J., Clayton, C.L., Andrews, S.C., and Kelly, D.J. (2000) Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high affinity ferrous iron transporter. Mol Microbiol 37: 274-286.
45. Viswanathan, V.K., Edelstein, P.H., Pope, C.D., and Cianciotto, N.P. (2000) The Legionella pneumophila iraAB locus is required for iron assimilation, intracellular infection, and virulence. Infect Immun 68: 1069-1079.
46. Vokes, S.A., Reeves, S.A., Torres, A.G., and Payne, S.M. (1999) The aerobactin iron transport system genes in Shigella flexneri are present within a pathogenicity island. Mol Microbiol 33: 63-73.
47. Wandersman, C., and Stojiljkovic, I. (2000) Bacterial heme sources: the role of heme, hemoprotein receptors and hemophores. Curr Opin Microbiol 3: 215-220.
48. Wooldridge, K.G., and Williams, P.H. (1993) Iron uptake mechanisms of pathogenic bacteria. FEMS Microbiol Rev 12: 325-348.
49. Yeowell, H.N., and White, J.R. (1982) Iron requirement in the bacteriocidal mechanism of streptonigrin. Antimicrob Agents Chemother 22: 961-968.