Defective immunoregulation in RSV vaccineaugmented viral lung disease restored by selective chemoattraction of regulatory T cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 8, 2013, Pages 2987-2992

  Loebbermann, Jens ^a   Durant, Lydia ^a   Thornton, Hannah ^a   Johansson, Cecilia ^a   Openshaw, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Bronchiolitis; Chemokines; Lung infection

Indexed keywords

CD9 ANTIGEN; INTERLEUKIN 2; MACROPHAGE DERIVED CHEMOKINE; RESPIRATORY SYNCYTIAL VIRUS VACCINE; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; IMMUNOREGULATION; LYMPHOCYTE DEPLETION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY SYNCYTIAL VIRUS INFECTION; VACCINATION; VIRUS IMMUNITY;

ADOPTIVE TRANSFER; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; MICE; MICE, INBRED BALB C; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; T-LYMPHOCYTES, REGULATORY; VIRAL VACCINES;

EID: 84874225887     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217580110     Document Type: Article

References (31)

1. Hall CB, et al. (2009) The burden of respiratory syncytial virus infection in young children. N Engl J Med 360 (6):588-598.
2. Nair H, et al. (2010) Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 375:1545-1555.
3. Smyth RL, Openshaw PJ (2006) Bronchiolitis. Lancet 368 (9532):312-322.
4. Moghaddam A, et al. (2006) A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines. Nat Med 12 (8):905-907.
5. Delgado MF, et al. (2009) Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease. Nat Med 15 (1):34-41.
6. Murphy BR, et al. (1986) Dissociation between serum neutralizing and glycoprotein antibody responses of infants and children who received inactivated respiratory syncytial virus vaccine. J Clin Microbiol 24 (2):197-202.
7. Bennett CL, et al. (2001) The immune dysregulation, polyendocrinopathy, enteropa-thy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 27 (1):20-21.
8. Littman DR, Rudensky AY (2010) Th17 and regulatory T cells in mediating and restraining inflammation. Cell 140 (6):845-858.
9. Kim J, et al. (2009) Cutting edge: Depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol 183 (12):7631-7634.
10. Kim JM, Rasmussen JP, Rudensky AY (2007) Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 8 (2):191-197.
11. Campbell DJ, Koch MA (2011) Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat Rev Immunol 11 (2):119-130.
12. Iellem A, et al. (2001) Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4 (+) CD25 (+) regulatory T cells. J Exp Med 194 (6):847-853.
13. Haas J, et al. (2008) Specific recruitment of regulatory T cells into the CSF in lym-phomatous and carcinomatous meningitis. Blood 111 (2):761-766.
14. Soler D, et al. (2006) CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes. J Immunol 177 (10):6940-6951.
15. Hirahara K, et al. (2006) The majority of human peripheral blood CD4+CD25high-Foxp3+ regulatory T cells bear functional skin-homing receptors. J Immunol 177 (7):4488-4494.
16. Sather BD, et al. (2007) Altering the distribution of Foxp3 (+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med 204 (6):1335-1347.
17. Montane J, et al. (2011) Prevention of murine autoimmune diabetes by CCL22-me-diated Treg recruitment to the pancreatic islets. J Clin Invest 121 (8):3024-3028.
18. Boelen A, et al. (2000) Both immunisation with a formalin-inactivated respiratory syncytial virus (RSV) vaccine and a mock antigen vaccine induce severe lung pathology and a Th2 cytokine profile in RSV-challenged mice. Vaccine 19 (7-8):982-991.
19. Webster KE, et al. (2009) In vivo expansion of T reg cells with IL-2-mAb complexes: Induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med 206 (4):751-760.
20. Loebbermann J, et al. (2012) Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol 5 (2):161-172.
21. Oldenhove G, et al. (2009) Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity 31 (5):772-786.
22. Lahl K, et al. (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 204 (1):57-63.
23. Yuan Q, et al. (2007) CCR4-dependent regulatory T cell function in inflammatory bowel disease. J Exp Med 204 (6):1327-1334.
24. Openshaw PJ, Tregoning JS (2005) Immune responses and disease enhancement during respiratory syncytial virus infection. Clin Microbiol Rev 18 (3):541-555.
25. Shin H, Iwasaki A (2012) A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature 491 (7424):463-467, 10.1038/nature11522.
26. Ruckwardt TJ, Bonaparte KL, Nason MC, Graham BS (2009) Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities. J Virol 83 (7):3019-3028.
27. Fulton RB, Meyerholz DK, Varga SM (2010) Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. J Immunol 185 (4):2382-2392.
28. Lee DC, et al. (2010) CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection. J Virol 84 (17):8790-8798.
29. Pease JE (2011) Targeting chemokine receptors in allergic disease. Biochem J 434 (1):11-24.
30. Strutt TM, McKinstry KK, Swain SL (2011) Control of innate immunity by memory CD4 T cells. Adv Exp Med Biol 780:57-68.
31. Loebbermann J, et al. (2012) IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice. PLoS ONE 7 (2):e32371.