메뉴 건너뛰기




Volumn 66, Issue 4-5, 2013, Pages 719-742

Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): From systems biology to systems pharmacology

Author keywords

Receptors; Signal transduction; Singular perturbation; Systems biology; Systems pharmacology; Tyrosine Kinase

Indexed keywords


EID: 84874209469     PISSN: 03036812     EISSN: 14321416     Source Type: Journal    
DOI: 10.1007/s00285-012-0620-z     Document Type: Article
Times cited : (9)

References (20)
  • 1
    • 79956201217 scopus 로고    scopus 로고
    • Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting in vivo potency
    • Aston PJ, Derks G, Raji A, Agoram BM, van der Graaf PH (2011) Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting in vivo potency. J Theor Biol 281: 113-121.
    • (2011) J Theor Biol , vol.281 , pp. 113-121
    • Aston, P.J.1    Derks, G.2    Raji, A.3    Agoram, B.M.4    van der Graaf, P.H.5
  • 2
    • 84855980577 scopus 로고    scopus 로고
    • Reducing systems biology to practice in pharmaceutical company research; selected case studies
    • Benson N, Cucurull-Sanchez L, Demin O, Smirnov S, van der Graaf PH (2012) Reducing systems biology to practice in pharmaceutical company research; selected case studies. Adv Syst Biol 736: 607-615.
    • (2012) Adv Syst Biol , vol.736 , pp. 607-615
    • Benson, N.1    Cucurull-Sanchez, L.2    Demin, O.3    Smirnov, S.4    van der Graaf, P.H.5
  • 4
    • 57749111624 scopus 로고    scopus 로고
    • Approximations of the target-mediated drug disposition model and identifiability of model parameters
    • Gibiansky L, Gibiansky E, Kakkar T, Ma P (2008) Approximations of the target-mediated drug disposition model and identifiability of model parameters. J Pharmacokinet Pharmacodyn 35: 573-591.
    • (2008) J Pharmacokinet Pharmacodyn , vol.35 , pp. 573-591
    • Gibiansky, L.1    Gibiansky, E.2    Kakkar, T.3    Ma, P.4
  • 7
    • 0032556454 scopus 로고    scopus 로고
    • Analysis of receptor internalisation as a mechanism of modulating signal transduction
    • Haugh J, Lauffenburger DA (1998) Analysis of receptor internalisation as a mechanism of modulating signal transduction. J Theor Biol 195: 187-217.
    • (1998) J Theor Biol , vol.195 , pp. 187-217
    • Haugh, J.1    Lauffenburger, D.A.2
  • 9
    • 33646901012 scopus 로고    scopus 로고
    • Target-mediated drug disposition and dynamics
    • Mager D (2006) Target-mediated drug disposition and dynamics. Biochem Pharmacol 72: 1-10.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1-10
    • Mager, D.1
  • 10
    • 0035730322 scopus 로고    scopus 로고
    • General pharmacokinetic model for drugs exhibiting target-mediated drug disposition
    • Mager D, Jusko WJ (2001) General pharmacokinetic model for drugs exhibiting target-mediated drug disposition. J Pharmacokinet Phamacodyn 28: 507-532.
    • (2001) J Pharmacokinet Phamacodyn , vol.28 , pp. 507-532
    • Mager, D.1    Jusko, W.J.2
  • 12
    • 84870468930 scopus 로고    scopus 로고
    • Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification
    • Peletier LA, Gabrielsson J (2012) Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification. J Pharmacokinet Phamacodyn 39: 429-451.
    • (2012) J Pharmacokinet Phamacodyn , vol.39 , pp. 429-451
    • Peletier, L.A.1    Gabrielsson, J.2
  • 13
    • 0034693799 scopus 로고    scopus 로고
    • The protein tyrosine kinase family of the human genome
    • Robinson DR, Wu YM, Lin SF (2000) The protein tyrosine kinase family of the human genome. Oncogene 19: 5548-5557.
    • (2000) Oncogene , vol.19 , pp. 5548-5557
    • Robinson, D.R.1    Wu, Y.M.2    Lin, S.F.3
  • 14
    • 84862619047 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology
    • Rostami-Hodjegan A (2012) Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology. Clin Pharmacol Ther 92: 50-61.
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 50-61
    • Rostami-Hodjegan, A.1
  • 15
    • 17344362384 scopus 로고    scopus 로고
    • Prediction and validation of the distinct dynamics of transient and sustained ERK activation
    • Sasagawa S, Ozaki Y-I, Fujita K, Kuroda S (2005) Prediction and validation of the distinct dynamics of transient and sustained ERK activation. Nat Cell Biol 7: 365-373.
    • (2005) Nat Cell Biol , vol.7 , pp. 365-373
    • Sasagawa, S.1    Ozaki, Y.-I.2    Fujita, K.3    Kuroda, S.4
  • 16
    • 0024731820 scopus 로고
    • The quasi-steady-state assumption: a case study in perturbation
    • Segel LA, Slemrod M (1989) The quasi-steady-state assumption: a case study in perturbation. SIAM Rev 31: 446-477.
    • (1989) SIAM Rev , vol.31 , pp. 446-477
    • Segel, L.A.1    Slemrod, M.2
  • 17
    • 34347355576 scopus 로고    scopus 로고
    • Cell surface receptors for signal transduction and ligand transport: a design principles study
    • Shankaran H, Resat H, Wiley HS (2007) Cell surface receptors for signal transduction and ligand transport: a design principles study. PLoS Comput Biol 3: 986-999.
    • (2007) PLoS Comput Biol , vol.3 , pp. 986-999
    • Shankaran, H.1    Resat, H.2    Wiley, H.S.3
  • 18
    • 84881200963 scopus 로고    scopus 로고
    • CPT: pharmacometrics and systems pharmacology
    • doi:10.1038/psp.2012.8
    • van der Graaf PH (2012) CPT: pharmacometrics and systems pharmacology. CPT: Pharmacomet Syst Pharmacol 1: e1. doi: 10. 1038/psp. 2012. 8.
    • (2012) CPT: Pharmacomet Syst Pharmacol , vol.1
    • van der Graaf, P.H.1
  • 19
    • 79959900575 scopus 로고    scopus 로고
    • Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development
    • van der Graaf PH, Benson N (2011) Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development. Pharm Res 28: 1460-1464.
    • (2011) Pharm Res , vol.28 , pp. 1460-1464
    • van der Graaf, P.H.1    Benson, N.2
  • 20
    • 23044515099 scopus 로고    scopus 로고
    • Functions and mechanisms of retrograde neurotrophin signalling
    • Zweifel LS, Kuruvilla R, Ginty DD (2005) Functions and mechanisms of retrograde neurotrophin signalling. Nat Rev Neurosci 6: 615-625.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 615-625
    • Zweifel, L.S.1    Kuruvilla, R.2    Ginty, D.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.