Osteocalcin, glucose metabolism, lipid profile and chronic low-grade inflammation in middle-aged and elderly Chinese

Diabetic Medicine

Volumn 30, Issue 3, 2013, Pages 309-317

  Chen, L ^a   Li, Q ^a   Yang, Z ^b   Ye, Z ^a   Huang, Y ^a   He, M ^a   Wen, J ^a   Wang, X ^a   Lu, B ^a   Hu, J ^c   Liu, C ^d   Ling, C ^e   Qu, S ^b   Hu, R ^a  

^a FUDAN UNIVERSITY   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SOOCHOW UNIVERSITY   (China)

^d NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^e LUND UNIVERSITY DIABETES CENTRE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; CHOLESTEROL; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GLUCOSE; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OSTEOCALCIN; TRIACYLGLYCEROL;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CELL FUNCTION; CHINESE; CHOLESTEROL BLOOD LEVEL; CHRONIC INFLAMMATION; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; POSTMENOPAUSE; RADIOIMMUNOASSAY; SEX DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST HIP RATIO;

ADIPONECTIN; ADIPOSITY; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; C-REACTIVE PROTEIN; CHEMOKINE CXCL5; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INFLAMMATION; LIPID METABOLISM; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OSTEOCALCIN; POSTMENOPAUSE; SEX CHARACTERISTICS;

EID: 84874185722     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2012.03769.x     Document Type: Article

References (32)

1. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT et al.Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000; 100: 197-207.
2. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X et al.Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 2005; 434: 514-520.
3. Hauschka PV, Lian JB, Cole DE, Gundberg CM. Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol Rev 1989; 69: 990-1047.
4. Epstein S. Serum and urinary markers of bone remodeling: assessment of bone turnover. Endocr Rev 1988; 9: 437-449.
5. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C et al.Endocrine regulation of energy metabolism by the skeleton. Cell 2007; 130: 456-469.
6. Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta-cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A 2008; 105: 5266-5270.
7. Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S et al.Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type2 diabetes mellitus. J Clin Endocrinol Metab 2009; 94: 45-49.
8. Pittas AG, Harris SS, Eliades M, Stark P, Dawson-Hughes B. Association between serum osteocalcin and markers of metabolic phenotype. J Clin Endocrinol Metab 2009; 94: 827-832.
9. Im JA, Yu BP, Jeon JY, Kim SH. Relationship between osteocalcin and glucose metabolism in postmenopausal women. Clin Chim Acta 2008; 396: 66-69.
10. Kindblom JM, Ohlsson C, Ljunggren O, Karlsson MK, Tivesten A, Smith U et al.Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res 2009; 24: 785-791.
11. Zhou M, Ma X, Li H, Pan X, Tang J, Gao Y et al.Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals. Eur J Endocrinol 2009; 161: 723-729.
12. Yeap BB, Chubb SA, Flicker L, McCaul KA, Ebeling PR, Beilby JP et al.Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels. Eur J Endocrinol 2010; 163: 265-272.
13. Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, Kurioka S, Yano S et al.Adiponectin is associated with changes in bone markers during glycemic control in type2 diabetes mellitus. J Clin Endocrinol Metab 2009; 94: 3031-3037.
14. Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE et al.International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003; 35: 1381-1395.
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
16. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539-553.
17. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2005; 28: S37-S42.
18. Gu D, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF et al.Prevalence of the metabolic syndrome and overweight among adults in China. Lancet 2005; 365: 1398-1405.
19. Fernandez-Real JM, Izquierdo M, Ortega F, Gorostiaga E, Gomez-Ambrosi J, Moreno-Navarrete JM et al.The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J Clin Endocrinol Metab 2009; 94: 237-245.
20. Kanazawa I, Yamaguchi T, Tada Y, Yamauchi M, Yano S, Sugimoto T. Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes. Bone 2011; 48: 720-725.
21. Bao Y, Zhou M, Lu Z, Li H, Wang Y, Sun L et al.Serum levels of osteocalcin are inversely associated with the metabolic syndrome and the severity of coronary artery disease in Chinese men. Clin Endocrinol (Oxf) 2011; 75: 196-201.
22. Bullo M, Moreno-Navarrete JM, Fernandez-Real JM, Salas-Salvado J. Total and undercarboxylated osteocalcin predict changes in insulin sensitivity and beta-cell function in elderly men at high cardiovascular risk. Am J Clin Nutr 2012; 95: 249-255.
23. Hwang YC, Jeong IK, Ahn KJ, Chung HY. The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects. Diabetes Metab Res Rev 2009; 25: 768-772.
24. Hwang YC, Jeong IK, Ahn KJ, Chung HY. Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level. Osteoporos Int 2012; 23: 1337-1342.
25. Winhofer Y, Handisurya A, Tura A, Bittighofer C, Klein K, Schneider B et al.Osteocalcin is related to enhanced insulin secretion in gestational diabetes mellitus. Diabetes Care 2010; 33: 139-143.
26. Yeap BB, Chubb SA, Flicker L, McCaul KA, Ebeling PR, Hankey GJ et al.Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health in Men Study. Osteoporos Int 2011; 23: 599-606.
27. Fernandez-Real JM, Ortega F, Gomez-Ambrosi J, Salvador J, Fruhbeck G, Ricart W. Circulating osteocalcin concentrations are associated with parameters of liver fat infiltration and increase in parallel to decreased liver enzymes after weight loss. Osteoporos Int 2010; 21: 2101-2107.
28. Saleem U, Mosley TJ, Kullo IJ. Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arterioscler Thromb Vasc Biol 2010; 30: 1474-1478.
29. Tan A, Gao Y, Yang X, Zhang H, Qin X, Mo L et al.Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey. Metabolism 2011; 60: 1186-1192.
30. Albareda M, Rodriguez-Espinosa J, Murugo M, de Leiva A, Corcoy R. Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetologia 2000; 43: 1507-1511.
31. Booth SL, Lichtenstein AH, O'Brien-Morse M, McKeown NM, Wood RJ, Saltzman E et al.Effects of a hydrogenated form of vitaminK on bone formation and resorption. Am J Clin Nutr 2001; 74: 783-790.
32. Shea MK, Gundberg CM, Meigs JB, Dallal GE, Saltzman E, Yoshida M et al.Gamma-carboxylation of osteocalcin and insulin resistance in older men and women. Am J Clin Nutr 2009; 90: 1230-1235.