Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2)

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 649-660

  Ichihara, Yoshinori ^a   Fujimura, Ryohei ^a   Tsuneki, Hiroshi ^a   Wada, Tsutomu ^a   Okamoto, Kentaro ^a   Gouda, Hiroaki ^b   Hirono, Shuichi ^b   Sugimoto, Kenji ^a   Matsuya, Yuji ^a   Sasaoka, Toshiyasu ^a   Toyooka, Naoki ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

Ligand based drug design (LBDD); N 4 (4 Chlorobenzyloxy)Pyridin 2 yl 2 (2,6 difluorophenyl) acetamide (CPDA); SH2 containing 5 inositol phosphatase 2 (SHIP2)

Indexed keywords

2 (2,6 DIFLUOROPHENYL) N [4 (4 FLUOROBENZYLOXY)PYRIDIN 2 YL]ACETAMIDE; 2 (2,6 DIFLUOROPHENYL) N [4 (4 FLUOROBENZYLOXYMETHYL)PYRIDIN 2 YL]ACETAMIDE; ACETAMIDE DERIVATIVE; AMIDE; AS 1949490; HYDROLASE INHIBITOR; INSULIN; N (4 BENZYLOXYMETHYLPYRIDIN 2 YL) 3 PHENYLPROPIONAMIDE; N (4 BENZYLOXYPYRIDIN 2 YL) 2 (2,6 DIFLUOROPHENYL)ACETAMIDE; N (4 BENZYLOXYPYRIDIN 2 YL) 2 (4 FLUOROPHENYL)ACETAMIDE; N (4 BENZYLOXYPYRIDIN 2 YL) 2 PHENYLACETAMIDE; N (4 BENZYLOXYPYRIDIN 2 YL) 3 PHENYLPROPIONAMIDE; N [4 (4 CHLOROBENZYLOXY)PYRIDIN 2 YL] 2 (2 TRIFLUOROMETHYLPHENYL)ACETAMIDE; N [4 (4 CHLOROBENZYLOXY)PYRIDIN 2 YL] 2 (2,6 DIFLUOROPHENYL)ACETAMIDE; N [4 (4 CHLOROBENZYLOXY)PYRIDIN 2 YL] 2 (3 TRIFLUOROMETHYLPHENYL)ACETAMIDE; N [4 (4 CHLOROBENZYLOXY)PYRIDIN 2 YL] 2 (4 FLUOROPHENYL); N [4 (4 CHLOROBENZYLOXY)PYRIDIN 2 YL] 2 CYCLOHEXYLACETAMIDE; N [4 (4 CHLOROBENZYLOXY)PYRIDIN 2 YL] 2 M TOLYLACETAMIDE; N [4 (4 CHLOROBENZYLOXY)PYRIDIN 2 YL] 2 O TOLYLACETAMIDE; N [4 (4 CHLOROBENZYLOXY)PYRIDIN 2 YL] 2 PHENYLACETAMIDE; N [4 (4 CHLOROBENZYLOXY)PYRIDIN 2 YL] 3 PHENYLPROPIONAMIDE; N [4 (4 CHLOROBENZYLOXYMETHYL)PYRIDIN 2 YL] 2 PHENYLACETAMIDE; N [4 (4 CHLOROBENZYLOXYMETHYL)PYRIDIN 2 YL] 3 PHENYLPROPIONAMIDE; N [4 (4 FLUOROBENZYLOXY)PYRIDIN 2 YL] 2 (4 FLUOROPHENYL)ACETAMIDE; N [4 (4 FLUOROBENZYLOXY)PYRIDIN 2 YL] 2 PHENYLACETAMIDE; N [4 (4 FLUOROBENZYLOXY)PYRIDIN 2 YL] 3 PHENYLPROPIONAMIDE; PHOSPHATASE; PROTEIN KINASE B; SH2 DOMAIN CONTAINING INOSITOL 5' PHOSPHATASE 2; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

3T3-L1 CELLS; ANIMALS; BENZENEACETAMIDES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MOLECULAR STRUCTURE; PHOSPHORIC MONOESTER HYDROLASES; PYRIDINES; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874136774     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.014     Document Type: Article

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