Mitochondrial accumulation of a lipophilic cation conjugated to an ionisable group depends on membrane potential, pH gradient and pK a: Implications for the design of mitochondrial probes and therapies

Journal of Bioenergetics and Biomembranes

Volumn 45, Issue 1-2, 2013, Pages 165-173

  Finichiu, Peter G ^a   James, Andrew M ^a   Larsen, Lesley ^b   Smith, Robin A J ^b   Murphy, Michael P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Lipophilic cation; Mitochondria; Mitochondria targeting; Mitochondrial pH gradient; Triphenylphosphonium cation

Indexed keywords

AMINE; CARBOXYLIC ACID; CATION;

ARTICLE; CHEMICAL STRUCTURE; HYDROPHOBICITY; ION SELECTIVE ELECTRODE; LIPOPHILICITY; LIVER MITOCHONDRION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR PROBE; PARTITION COEFFICIENT; PH; PKA; PROTON MOTIVE FORCE; PROTON TRANSPORT; SYNTHESIS;

ANIMALS; DRUG DESIGN; FEMALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; MOLECULAR PROBES; ORGANOSELENIUM COMPOUNDS; PROTON-MOTIVE FORCE; RATS; RATS, WISTAR;

EID: 84874117161     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-012-9493-5     Document Type: Article

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