Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning

European Archives of Psychiatry and Clinical Neuroscience

Volumn 262, Issue 8, 2012, Pages 667-676

  Zilles, David ^a   Meyer, Jobst ^b   Schneider Axmann, Thomas ^a   Ekawardhani, Savira ^b   Gruber, Eva ^c   Falkai, Peter ^a   Gruber, Oliver ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b UNIVERSITY OF TRIER   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

Bipolar disorder; Endophenotype; Genetics; Neuroimaging; Schizophrenia; Working memory

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; CATECHOL METHYLTRANSFERASE; DOPAMINE TRANSPORTER; PROTEIN SLC6A3; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; BIPOLAR I DISORDER; CONTROLLED STUDY; DNA POLYMORPHISM; DOPAMINERGIC ACTIVITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; NEUROPSYCHOLOGICAL TEST; OBSESSIVE COMPULSIVE DISORDER; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA; SEROTONINERGIC SYSTEM; SPATIAL MEMORY; TANDEM REPEAT; VERBAL MEMORY; VISUAL MEMORY;

ADOLESCENT; ADULT; AGED; BIPOLAR DISORDER; CATECHOL O-METHYLTRANSFERASE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; GENOTYPE; HUMANS; LEARNING DISORDERS; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEUROPSYCHOLOGICAL TESTS; OBSESSIVE-COMPULSIVE DISORDER; POLYMORPHISM, GENETIC; SCHIZOPHRENIA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; VERBAL LEARNING; YOUNG ADULT;

EID: 84874112441     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-012-0312-0     Document Type: Article

References (73)

1. Alloway TP (2009) Working memory, but not IQ, predicts subsequent learning in children with learning difficulties. Eur J Psychol Assess 25:92-98
2. Alloway TP, Alloway RG (2010) Investigating the predictive roles of working memory and IQ in academic attainment. J Exp Child Psychol 106:20-29
3. Awh E, Jonides J, Reuter-Lorenz PA (1998) Rehearsal in spatial working memory. J Exp Psychol Human Percept Perform 24:780-790
4. Baddeley AD (1986) Working memory. Oxford University Press, Oxford, UK
5. Baddeley A (2003) Working memory: looking back and looking forward. Nat Rev Neurosci 4:829-839
6. Barch DM (2004) Pharmacological manipulation of human working memory. Psychopharmacology 174:126-135
7. Barnett JH, Scoriels L, Munafo MR (2008) Meta-analysis of the cognitive effects of the catechol-o-methyltransferase gene val158/108met polymorphism. Biol Psychiatry 64:137-144
8. Barnett JH, Xu K, Heron J, Goldman D, Jones PB (2011) Cognitive effects of genetic variation in monoamine neurotransmitter systems: a population-based study of COMT, MAOA, and 5HTTLPR. Am J Medical Genet B Neuropsychiatr Genet 156B:158-167
9. Baron RM, Kenny DA (1986) The moderator mediator variable distinction in social psychological-research-conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51:1173-1182
10. Berman RA, Colby CL, Genovese CR, Voyvodic JT, Luna B, Thulborn KR, Sweeney JA (1999) Cortical networks subserving pursuit and saccadic eye movements in humans: an fMRI study. Hum Brain Mapp 8:209-225
11. Bertolino A, Fazio L, Di Giorgio A, Blasi G, Romano R, Taurisano P, Caforio G, Sinibaldi L, Ursini G, Popolizio T, Tirotta E, Papp A, Dallapiccola B, Borrelli E, Sadee W (2009) Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans. J Neurosci 29:1224-1234
12. Blanchard MM, Chamberlain SR, Roiser J, Robbins TW, Muller U (2011) Effects of two dopamine-modulating genes (DAT1 9/10 and COMT val/met) on n-back working memory performance in healthy volunteers. Psychol Med 41:611-618
13. Borg J, Henningsson S, Saijo T, Inoue M, Bah J, Westberg L, Lundberg J, Jovanovic H, Andree B, Nordstrom AL, Halldin C, Eriksson E, Farde L (2009) Serotonin transporter genotype is associated with cognitive performance but not regional 5-HT1A receptor binding in humans. Int J Neuropsychopharmacol 12:783-792
14. Bosia M, Anselmetti S, Pirovano A, Ermoli E, Marino E, Bramanti P, Smeraldi E, Cavallaro R (2010) HTTLPR functional polymorphism in schizophrenia: Executive functions vs. Sustained attention dissociation. Prog Neuropsychopharmacol Biol Psychiatry 34:81-85
15. Brockmann H, Zobel A, Schuhmacher A, Daamen M, Joe A, Biermann K, Schwab SG, Biersack HJ, Maier W, Boecker H (2011) Influence of 5-HTTLPR polymorphism on resting state perfusion in patients with major depression. J Psychiatr Res 45:442-451
16. Bruder GE, Keilp JG, Xu HY, Shikhman M, Schori E, Gorman JM, Gilliam TC (2005) Catechol-o-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Biol Psychiatry 58:901-907
17. Caldu X, Vendrell P, Bartres-Faz D, Clemente I, Bargallo N, Jurado MA, Serra-Grabulosa JM, Junque C (2007) Impact of the COMT val(108/158) met and DAT genotypes on prefrontal function in healthy subjects. Neuroimage 37:1437-1444
18. Castner SA, Goldman-Rakic PS, Williams GV (2004) Animal models of working memory: Insights for targeting cognitive dysfunction in schizophrenia. Psychopharmacology 174:111-125
19. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR (2001) Effect of COMT val(108/158) met genotype on frontal lobe function and risk for schizophrenia. Proc Nat Acad Sci USA 98:6917-6922
20. Ellis KA, Nathan PJ (2001) The pharmacology of human working memory. Int J Neuropsychopharmacol 4:299-313
21. Forbes NF, Carrick LA, McIntosh AM, Lawrie SM (2009) Working memory in schizophrenia: a meta-analysis. Psychol Med 39:889-905
22. Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T, Kolachana BS, Goldman D, Weinberger DR (2003) Executive subprocesses in working memory-relationship to catechol-omethyltransferase val158met genotype and schizophrenia. Arch Gen Psychiatry 60:889-896
23. Goldman-Rakic PS (1995) Cellular basis of working-memory. Neuron 14:477-485
24. Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636-645
25. Greenberg BD, Tolliver TJ, Huang SJ, Li Q, Bengel D, Murphy DL (1999) Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 88:83-87
26. Gruber O (2001) Effects of domain-specific interference on brain activation associated with verbal working memory task performance. Cereb Cortex 11:1047-1055
27. Gruber O, Goschke T (2004) Executive control emerging from dynamic interactions between brain systems mediating language, working memory and attentional processes. Acta Psychol 115:105-121
28. Gruber O, Gruber E, Falkai P (2006) Articulatory rehearsal in verbal working memory: a possible neurocognitive endophenotype that differentiates between schizophrenia and schizoaffective disorder. Neurosci Lett 405:24-28
29. Gruber O, Gruber E, Falkai R (2005) Neural correlates of working memory deficits in schizophrenic patients. Ways to establish neurocognitive endophenotypes of psychiatric disorders. Radiologe 45:153-160
30. Gruber O, Muller T, Falkai P (2007) Dynamic interactions between neural systems underlying different components of verbal working memory. J Neural Trans 114:1047-1050
31. Gruber O, Tost H, Henseler I, Schmael C, Scherk H, Ende G, Ruf M, Falkai P, Rietschel M (2010) Pathological amygdala activation during working memory performance: evidence for a pathophysiological trait marker in bipolar affective disorder. Hum Brain Mapp 31:115-125
32. Gruber O, von Cramon DY (2001) Domain-specific distribution of working memory processes along human prefrontal and parietal cortices: a functional magnetic resonance imaging study. Neurosci Lett 297:29-32
33. Gruber O, von Cramon DY (2003) The functional neuroanatomy of human working memory revisited-evidence from 3-T fMRI studies using classical domain-specific interference tasks. Neuroimage 19:797-809
34. Gruber O, Zilles D, Kennel J, Gruber E, Falkai P (2011) A systematic experimental neuropsychological investigation of the functional integrity of working memory circuits in major depression. Eur Arch Psychiatry Clin Neurosci 261:179-184
35. Harrison BJ, Olver JS, Norman TR, Burrows GD, Wesnes KA, Nathan PJ (2004) Selective effects of acute serotonin and catecholamine depletion on memory in healthy women. J Psychopharmacol 18:32-40
36. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624
37. Henseler I, Falkai P, Gruber O (2009) A systematic fMRI investigation of the brain systems subserving different working memory components in schizophrenia. Eur J Neurosci 30:693-702
38. Henseler I, Falkai P, Gruber O (2010) Disturbed functional connectivity within brain networks subserving domain-specific subcomponents of working memory in schizophrenia: Relation to performance and clinical symptoms. J Psychiatr Res 44:364-372
39. Henseler I, Gruber O, Kraft S, Krick C, Reith W, Falkai P (2008) Compensatory hyperactivations as markers of latent working memory dysfunctions in patients with obsessive-compulsive disorder: an fMRI study. J Psychiatry Neurosci 33:209-215
40. Herrera-Guzman I, Gudayol-Ferre E, Herrera-Guzman D, Guardia-Olmos J, Hinojosa-Calvo E, Herrera-Abarca JE (2009) Effects of selective serotonin reuptake and dual serotonergicnoradrenergic reuptake treatments on memory and mental processing speed in patients with major depressive disorder. J Psychiatr Res 43:855-863
41. Hill SK, Harris MSH, Herbener ES, Pavuluri M, Sweeney JA (2008) Neurocognitive allied phenotypes for schizophrenia and bipolar disorder. Schizophr Bull 34:743-759
42. Hu XZ, Lipsky RH, Zhu GS, Akhtar LA, Taubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL, Murphy DL, Goldman D (2006) Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78:815-826
43. Kimberg DY, Aguirre GK, Lease J, D'Esposito M (2001) Cortical effects of bromocriptine, a D2 dopamine receptor agonist, in human subjects, revealed by fmri. Hum Brain Mapp 12:246-257
44. Koelsch S, Schulze K, Sammler D, Fritz T, Muller K, Gruber O (2009) Functional architecture of verbal and tonal working memory: an fMRI study. Hum Brain Mapp 30:859-873
45. Konneker TI, Crowley JJ, Quackenbush CR, Keefe RSE, Perkins DO, Stroup TS, Lieberman JA, van den Oord E, Sullivan PF (2010) No association of the serotonin transporter polymorphisms 5-HTTLPR and rs25531 with schizophrenia or neurocognition. Am J Med Genet B Neuropsychiatr Genet 153B:1115-1117
46. Lachman HM, Morrow B, Shprintzen R, Veit S, Parsia SS, Faedda G, Goldberg R, Kucherlapati R, Papolos DF (1996) Association of codon 108/158 catechol-o-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardiofacial syndrome. Am J Med Genet 67:468-472
47. Lewis DA, Melchitzky DS, Sesack SR, Whitehead RE, Auh S, Sampson A (2001) Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization. J Comp Neurol 432:119-136
48. Li BJ, Arime Y, Hall FS, Uhl GR, Sora I (2010) Impaired spatial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice. Eur J Pharmacol 628:104-107
49. Luciana M, Burgund ED, Berman M, Hanson KL (2001) Effects of tryptophan loading on verbal, spatial and affective working memory functions in healthy adults. J Psychopharmacol 15:219-230
50. McCann UD, Szabo Z, Vranesic M, Palermo M, Mathews WB, Ravert HT, Dannals RF, Ricaurte GA (2008) Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent ()3,4-methylenedioxymethamphetamine (''Ecstasy'') users: relationship to cognitive performance. Psychopharmacology 200:439-450
51. McGurk SR, Carter C, Goldman R, Green MF, Marder SR, Xie HY, Schooler NR, Kane JM (2005) The effects of clozapine and risperidone on spatial working memory in schizophrenia. Am J Psychiatry 162:1013-1016
52. McGurk SR, Green MF, Wirshing WC, Wirshing DA, Marder SR, Mintz J, Kern R (2004) Antipsychotic and anticholinergic effects on two types of spatial memory in schizophrenia. Schizophr Res 68:225-233
53. Naudon L, Hotte M, Jay TM (2007) Effects of acute and chronic antidepressant treatments on memory performance: a comparison between paroxetine and imipramine. Psychopharmacology 191:353-364
54. Palmason H, Moser D, Sigmund J, Vogler C, Hanig S, Schneider A, Seitz C, Marcus A, Meyer J, Freitag CM (2010) Attentiondeficit/ hyperactivity disorder phenotype is influenced by a functional catechol-o-methyltransferase variant. J Neural Trans 117:259-267
55. Prata DP, Mechelli A, Fu CHY, Picchioni M, Toulopoulou T, Bramon E, Walshe M, Murray RM, Colliera DA, McGuire P (2009) Epistasis between the DAT 30 UTR VNTR and the COMT val158met SNP on cortical function in healthy subjects and patients with schizophrenia. Proc Nat Acad Sci USA 106: 13600-13605
56. Reilly JL, Harris MSH, Keshavan MS, Sweeney JA (2006) Adverse effects of risperidone on spatial working memory in first-episode schizophrenia. Arch Gen Psychiatry 63:1189-1197
57. Rose EJ, Simonotto E, Spencer EP, Ebmeier KP (2006) The effects of escitalopram on working memory and brain activity in healthy adults during performance of the n-back task. Psychopharmacology 185:339-347
58. Scherk H, Backens M, Schneider-Axmann T, Kraft S, Kemmer C, Usher J, Reith W, Falkai P, Meyer J, Gruber O (2009) Dopamine transporter genotype influences n-acetyl-aspartate in the left putamen. World J Biol Psychiatry 10:524-530
59. Scherk H, Gruber O, Menzel P, Schneider-Axmann T, Kemmer C, Usher J, Reith W, Meyer J, Falkai P (2009) 5-HTTLPR genotype influences amygdala volume. Eur Arch Psychiatry Clin Neurosci 259:212-217
60. Seamans JK, Yang CR (2004) The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Prog Neurobiol 74:1-57
61. Sesack SR, Hawrylak VA, Matus C, Guido MA, Levey AI (1998) Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. J Neurosci 18:2697-2708
62. Sternberg S (1966) High-speed scanning in human memory. Science 153:652-654
63. Stollstorff M, Foss-Feig J, Cook EH, Stein MA, Gaillard WD, Vaidya CJ (2010) Neural response to working memory load varies by dopamine transporter genotype in children. Neuroimage 53:970-977
64. Szekeres G, Keri S, Juhasz A, Rimanoczy A, Szendi I, Czimmer C, Janka Z (2004) Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. Am J Med Genet B Neuropsychiatr Genet 124B:1-5
65. Tomasi D, Volkow ND, Wang R, Telang F, Wang G-J et al (2009) Dopamine transporters in striatum correlate with deactivation in the default mode network during visuospatial attention. PLoS ONE 4(6):e6102. doi:10.1371/journal.pone. 0006102
66. Walsh ND, Williams SCR, Brammer MJ, Bullmore ET, Kim J, Suckling J, Mitterschiffthaler MT, Cleare AJ, Pich EM, Mehta MA, Fu CHY (2007) A longitudinal functional magnetic resonance imaging study of verbal working memory in depression after antidepressant therapy. Biol Psychiatry 62:1236-1243
67. Wayment HK, Schenk JO, Sorg BA (2001) Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition. J Neurosci 21:35-44
68. Willeit M, Praschak-Rieder N (2010) Imaging the effects of genetic polymorphisms on radioligand binding in the living human brain: a review on genetic neuroreceptor imaging of monoaminergic systems in psychiatry. Neuroimage 53:878-892
69. Wonodi I, Hong LE, Stine OC, Mitchell BD, Elliott A, Roberts RC, Conley RR, McMahon RP, Thaker GK (2009) Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 150B:282-289
70. Zhang HP, Smith GN, Liu XD, Holden JJA (2010) Association of MAOA, 5-HTT, and NET promoter polymorphisms with gene expression and protein activity in human placentas. Physiol Genomics 42:85-92
71. Zilles D, Burke S, Schneider-Axmann T, Falkai P, Gruber O (2009) Diagnosis-specific effect of familial loading on verbal working memory in schizophrenia. Eur Arch Psychiatry Clin Neurosci 259:309-315
72. Zilles D, Gruber E, Falkai P, Gruber O (2010) Patients with schizophrenia show deficits of working memory maintenance components in circuit-specific tasks. Eur Arch Psychiatry Clin Neurosci 260:519-525
73. Zilles D, Jung R, Gruber E, Falkai P, Gruber O (2011) Differential working memory performance as support for the Kraepelinian dichotomy between schizophrenia and bipolar disorder? An experimental neuropsychological study using circuit-specific working memory tasks. World J Biol Psychiatry. doi:10.3109/ 15622975.2011.591825