Role of epidermal growth factor-triggered PI3K/Akt signaling in the migration of medulloblastoma-derived cells

Cellular and Molecular Bioengineering

Volumn 5, Issue 4, 2012, Pages 402-413

  Dudu, Veronica ^a   Able, Richard A ^a,b   Rotari, Veronica ^a   Kong, Qingjun ^a   Vazquez, Maribel ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Chemotaxis; Daoy; EGF; Microfluidics; PI3K Akt

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ARTICLE; CANCER CELL CULTURE; CASE REPORT; CELL ASSAY; CELL COUNT; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; CHILD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MALE; MEDULLOBLASTOMA; MICROFLUIDIC ANALYSIS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

EID: 84874111956     PISSN: 18655025     EISSN: 18655033     Source Type: Journal    
DOI: 10.1007/s12195-012-0253-8     Document Type: Article

References (43)

1. Able, R. A., C. Ngnabeuye, C. Beck, E. C. Holland, and M. Vazquez. Low concentration microenvironments enhance the migration of neonatal cells of glial lineage. Cell. Mol. Bioeng. 5(2):128-142, 2012.
2. Abouantoun, T. J., and T. J. Macdonald. Imatinib blocks migration and invasion of medulloblastoma cells by concurrently inhibiting activation of platelet-derived growth factor receptor and transactivation of epidermal growth factor receptor. Mol. Cancer Ther. 8(5):1137-1147, 2009.
3. Brockmann, M. A., U. Ulbricht, K. Gruner, R. Fillbrandt, M. Westphal, and K. Lamszus. Glioblastoma and cerebral microvascular endothelial cell migration in response to tumor-associated growth factors. Neurosurgery 52(6): 1391-1399, 2003.
4. Cadena, D. L., C. L. Chan, and G. N. Gill. The intracellular tyrosine kinase domain of the epidermal growth factor receptor undergoes a conformational change upon autophosphorylation. J. Biol. Chem. 269(1):260-265, 1994.
5. Calabrese, C., A. Frank, K. Maclean, and R. Gilbertson. Medulloblastoma sensitivity to 17-allylamino-17-demethoxygeldanamycin requires MEK/ERKM. J. Biol. Chem. 278:24951-24959, 2003.
6. Condeelis, J., and J. E. Segall. Intravital imaging of cell movement in tumours. Nat. Rev. Cancer 3(12):921-930, 2003.
7. Dudu, V., M. Ramcharan, M. L. Gilchrist, E. C. Holland, and M. Vazquez. Liposome delivery of quantum dots to the cytosol of live cells. J. Nanosci. Nanotechnol. 8(5):2293-2300, 2008.
8. Dudu, V., V. Rotari, and M. Vazquez. Sendai virus-based liposomes enable targeted cytosolic delivery of nanoparticles in brain tumor-derived cells. J. Nanobiotechnol. 10(1):9, 2012.
9. Duffner, P. K., M. E. Horowitz, J. P. Krischer, P. C. Burger, M. E. Cohen, R. A. Sanford, H. S. Friedman, and L. E. Kun. The treatment of malignant brain tumors in infants and very young children: an update of the Pediatric Oncology Group experience. Neuro. Oncol. 1(2):152-161, 1999.
10. Ekani-Nkodo, A., and D. K. Fygenson. Size exclusion and diffusion of fluoresceinated probes within collagen fibrils. Phys. Rev. E 67(2 Pt 1):021909, 2003.
11. Fukazawa, T., S. Miyake, V. Band, and H. Band. Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. J. Biol. Chem. 271(24):14554-14559, 1996.
12. Girish, M., S. Nair, T. Muthurethinam, K. Krishnakumar, and R. N. Bhattacharya. Medulloblastoma in children: prognostic factors and predictors of outcome. J. Pediatr. Neurosci. 1(1):16-20, 2006.
13. Guessous, F., Y. Zhang, C. diPierro, L. Marcinkiewicz, J. Sarkaria, D. Schiff, S. Buchanan, and R. Abounader. An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth. Anticancer Agents Med. Chem. 10(1):28-35, 2010.
14. Herbst, R. S. Erlotinib. Clin. Adv. Hematol. Oncol. 3(2):124-141, 2005.
15. Hernan, R., R. Fasheh, C. Calabrese, A. J. Frank, K. H. Maclean, D. Allard, R. Barraclough, and R. J. Gilbertson. ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma. Cancer Res. 63(1):140-148, 2003.
16. Hirata, A., S. Ogawa, T. Kometani, T. Kuwano, S. Naito, M. Kuwano, and M. Ono. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res. 62(9):2554-2560, 2002.
17. Huse, J. T., and E. C. Holland. Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nat. Rev. Cancer 10(5):319-331, 2010.
18. Kim, M. J., and K. S. Breuer. Enhanced diffusion due to motile bacteria. Phys. Fluids 16(9):L78-L81, 2004.
19. Kim, H., and W. J. Muller. The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis. Exp. Cell Res. 253(1):78-87, 1999.
20. Kong, Q., R. Able, V. Dudu, and M. Vazquez. A microfluidic device to establish concentration gradients using reagent density differences. J. Biomech. Eng. 132(12): 121012, 2010.
21. Kong, Q., R. J. Majeska, and M. Vazquez. Migration of connective tissue-derived cells is mediated by ultra-low concentration gradient fields of EGF. Exp. Cell Res. 317:1491-1502, 2011.
22. Kruger, J. S., and K. B. Reddy. Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells. Mol. Cancer Res. 1(11):801-809, 2003.
23. Lang, I., M. Scholz, and R. Peters. Molecular mobility and nucleocytoplasmic flux in hepatoma cells. J. Cell Biol. 102(4):1183-1190, 1986.
24. Lauffenburger, D. A., and A. F. Horwitz. Cell migration: a physically integrated molecular process. Cell 84(3):359-369, 1996.
25. Le Roy, C., and J. L. Wrana. Clathrin-and non-clathrinmediated endocytic regulation of cell signalling. Nat. Rev. Mol. Cell Biol. 6(2):112-126, 2005.
26. Meco, D., T. Servidei, A. Riccardi, C. Ferlini, G. Cusano, G. F. Zannoni, F. Giangaspero, and R. Riccardi. Antitumor effect in medulloblastoma cells by gefitinib: ectopic HER2 overexpression enhances gefitinib effects in vivo. Neuro. Oncol. 11:250-259, 2009.
27. Mosadegh, B., W. Saadi, S. J. Wang, and N. L. Jeon. Epidermal growth factor promotes breast cancer cell chemotaxis in CXCL12 gradients. Biotechnol. Bioeng. 100(6):1205-1213, 2008.
28. Nicholson, C., and L. Tao. Hindered diffusion of high molecular weight compounds in brain extracellular microenvironment measured with integrative optical imaging. Biophys. J. 65(6):2277-2290, 1993.
29. Ono, M., and M. Kuwano. Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs. Clin. Cancer Res. 12(24):7242-7251, 2006.
30. Payet, L., A. Ponton, L. Lger, H. Hervet, J. L. Grossiord, and F. Agnely. Self-diffusion in chitosan networks: from a gel-gel method to fluorescence recovery after photobleaching by fringe pattern. Macromolecules 41(23):9376-9381, 2008.
31. Reddy, A. T. Advances in biology and treatment of childhood brain tumors. Curr. Neurol. Neurosci. Rep. 1(2):137-143, 2001.
32. Saadi, W., S. J. Wang, F. Lin, and N. L. Jeon. A parallelgradient microfluidic chamber for quantitative analysis of breast cancer cell chemotaxis. Biomed. Microdevices 8(2):109-118, 2006.
33. Sahai, E. Mechanisms of cancer cell invasion. Curr. Opin. Genet. Dev. 15(1):87-96, 2005.
34. Salomon, D. S., R. Brandt, F. Ciardiello, and N. Normanno. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19(3):183-232, 1995.
35. Seroogy, K. B., C. M. Gall, D. C. Lee, and H. I. Kornblum. Proliferative zones of postnatal rat brain express epidermal growth factor receptor mRNA. Brain Res. 670(1):157-164, 1995.
36. Shen, J. Y., M. B. Chan-Park, B. He, A. P. Zhu, X. Zhu, R. W. Beuerman, E. B. Yang, W. Chen, and V. Chan. Threedimensional microchannels in biodegradable polymeric films for control orientation and phenotype of vascular smooth muscle cells. Tissue Eng. 12(8):2229-2240, 2006.
37. Wechsler-Reya, R., and M. P. Scott. The developmental biology of brain tumors. Annu. Rev. Neurosci. 24:385-428, 2001.
38. Xia, P., P. M. Bungay, C. C. Gibson, O. N. Kovbasnjuk, and K. R. Spring. Diffusion coefficients in the lateral intercellular spaces of Madin-Darby canine kidney cell epithelium determined with caged compounds. Biophys. J. 74(6):3302-3312, 1998.
39. Yamada, K. M., and E. Cukierman. Modeling tissue morphogenesis and cancer in 3D. Cell 130(4):601-610, 2007.
40. Yarden, Y. The EGFR family and its ligands in human cancer signalling mechanisms and therapeutic opportunities. Eur. J. Cancer 37(Suppl 4):S3-S8, 2001.
41. Yuan, L., M. Santi, E. J. Rushing, R. Cornelison, and T. J. MacDonald. ERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migration. Clin. Exp. Metastasis 27(7):481-491, 2010.
42. Yuan, K., R. Singh, G. Rezonzew, and G. P. Siegal. In vitro matrices for studying tumor cell invasion. In: Cell Motility in Cancer Invasion and Metastasis, Vol. 8, edited by A. Wells. New York: Springer, 2006, pp. 25-54.
43. Zohrabian, V. M., B. Forzani, Z. Chau, R. Murali, and M. Jhanwar-Uniyal. Rho/ROCK and MAPK signaling pathways are involved in glioblastoma cell migration and proliferation. Anticancer Res. 29(1):119-123, 2009.