Long-chain 3-hydroxy fatty acids accumulating in long-chain 3-hydroxyacyl-CoA dehydrogenase and mitochondrial trifunctional protein deficiencies uncouple oxidative phosphorylation in heart mitochondria

Journal of Bioenergetics and Biomembranes

Volumn 45, Issue 1-2, 2013, Pages 47-57

  Tonin, Anelise M ^a   Amaral, Alexandre U ^a   Busanello, Estela N B ^a   Grings, Mateus ^a   Castilho, Roger F ^b   Wajner, Moacir ^a,c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Heart bioenergetics; Long chain 3 hydroxy fatty acids; Mitochondria; Oxidative phosphorylation; Permeability transition

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; 3 HYDROXYDECANOIC ACID; 3 HYDROXYDODECANOIC ACID; 3 HYDROXYMYRISTIC ACID; 3 HYDROXYPALMITIC ACID; ADENINE NUCLEOTIDE TRANSLOCASE; CYCLOSPORIN A; GLUTAMIC ACID; HYDROGEN PEROXIDE; LONG CHAIN FATTY ACID; MALIC ACID; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; SUCCINIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOENERGY; CONTROLLED STUDY; HEART MITOCHONDRION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXIMETRY; PROTEIN DEFICIENCY; RAT; RESPIRATION CONTROL;

3-HYDROXYACYL COA DEHYDROGENASES; ANIMALS; CARDIOMYOPATHIES; FATTY ACIDS; HYDROGEN PEROXIDE; LIPID METABOLISM, INBORN ERRORS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; MITOCHONDRIAL PROTEINS; MUSCLE PROTEINS; MYOCARDIUM; OXIDATION-REDUCTION; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, WISTAR; RETINITIS PIGMENTOSA;

RATTUS;

EID: 84874109990     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-012-9481-9     Document Type: Article

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