Stromal cell induction of regulatory dendritic cells

Frontiers in Immunology

Volumn 3, Issue AUG, 2012, Pages

  Owens, Benjamin M J ^a,b   Kaye, Paul M ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Dendritic cells; IL 10; Immune regulation; Infection; Inflammation; Stromal cells

Indexed keywords

EID: 84874100001     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00262     Document Type: Article

References (41)

1. Bogdan, C., Donhauser, N., Döring, R., Röllinghoff, M., Diefenbach, A., and Rittig, M. G. (2000). Fibroblasts as host cells in latent leishmaniasis. J. Exp. Med. 191, 2121-2130.
2. Despars, G., Periasamy, P., Tan, J., Abbey, J., O'Neill, T. J., and O'Neill, H. C. (2008). Gene signature of stro-mal cells which support dendritic cell development. Stem Cells Dev. 17, 917-927.
3. Drutman, S.B., Kendall, J.C.,andTrom-betta, E. S. (2012). Inflammatory spleen monocytes can upregulate CD11c expression without converting into dendritic cells. J. Immunol. 188, 3603-3610.
4. Engels, B., Rowley, D. A., and Schreiber, H. (2012). Targeting stroma to treat cancers. Semin. Cancer Biol. 22, 41-49.
5. Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., and Ley, K. (2010). Development of monocytes, macrophages, and dendritic cells. Science 327, 656-661.
6. Hawiger, D., Inaba, K., Dorsett, Y., Guo, M., Mahnke, K., Rivera, M., Ravetch, J. V., Steinman, R. M., and Nussen-zweig, M. C. (2001). Dendritic cells induce peripheral T cell unrespon-siveness under steady state conditions in vivo. J. Exp. Med. 194, 769-779.
7. Huang, Y., Johnston, P., Zhang, B., Zakari, A., Chowdhry, T., Smith, R. R., Marbán, E., Rabb, H., and Womer, K. L. (2009). Kidney-derived stromal cells modulate dendritic and Tcell responses. J. Am. Soc. Nephrol. 20, 831-841.
8. Ilarregui, J. M., Croci, D. O., Bianco, G. A., Toscano, M. A., Salatino, M., Vermeulen, M. E., Geffner, J. R., and Rabinovich, G. A. (2009). Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat. Immunol. 10, 981-991.
9. Jung, E. J., Moon, H.G., Cho, B.I., Jeong, C. Y., Joo, Y. T., Lee, Y. J., Hong, S. C., Choi, S. K., Ha, W. S., Kim, J. W., Lee, C. W., Lee, J. S., and Park, S. T. (2007). Galectin-1 expression in cancer-associated stromal cells correlates tumor invasiveness and tumor progression in breast cancer. Int. J. Cancer 120, 2331-2338.
10. Kalantari, T., Kamali-Sarvestani, E., Ciric, B., Karimi, M. H., Kalantari, M., Faridar, A., Xu, H., and Rostami, A. (2011). Generation of immuno-genic and tolerogenic clinical-grade dendritic cells. Immunol. Res. 51, 153-160.
11. Kantoff, P. W., Higano, C. S., Small, E. J., Whitmore, J. B., Frohlich, M. W., and Schellhammer, P. F. (2010). Sipuleucel-T immunother-apy for castration-resistant prostate cancer. N. Engl. J. Med. 363, 411-422.
12. Kaye, P. M., Svensson, M., Ato, M., Maroof, A., Polley, R., Stager, S., Zubairi, S., and Engwerda, C. R. (2004). The immunopathology of experimental visceral leish-maniasis. Immunol. Rev. 201, 239-253.
13. Khan, O., Headley, M., Gerard, A., Wei, W., Liu, L., Krummel, M. F. (2011). Regulation of T cell priming by lym-phoid stroma. PLoS ONE 6, e26138. doi:10.1371/journal.pone.0026138
14. Kleindienst, P., Wiethe, C., Lutz, M. B., and Brocker, T. (2005). Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells. J. Immunol. 174, 3941-3947.
15. Kraman, M., Bambrough, P. J., Arnold, J. N., Roberts, E. W., Magiera, L., Jones, J. O., Gopinathan, A., Tuveson, D. A., and Fearon, D. T. (2010). Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science 330, 827-830.
16. Li, Q., Guo, Z., Xu, X., Xia, S., and Cao, X. (2008). Pulmonary stromal cells induce the generation of regulatory DC attenuating T-cell-mediated lung inflammation. Eur. J. Immunol. 38, 2751-2761.
17. Li, Z., Liu, G., Chen, Y., Liu, Y., Liu, B., and Su, Z. (2011). The phe-notype and function of naturally existing regulatory dendritic cells in nematode-infected mice. Int. J. Par-asitol. 41, 1129-1137.
18. Liu, Q., Zhang, C., Sun, A., Zheng, Y., Wang, L., and Cao, X. (2009). Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I. J. Immunol. 182, 6207-6216.
19. Lukacs-Kornek, V., Malhotra, D., Fletcher, A. L., Acton, S. E., Elpek, K. G., Tayalia, P., Collier, A. R., and Turley, S. J. (2011). Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes. Nat. Immunol. 12, 1096-1104.
20. Lutz, M. B. (2012). Therapeutic potential of semi-mature dendritic cells for tolerance induction. Front. Immunol. 3:123. doi:10.3389/fimmu.2012.00123
21. Malhotra, D., Fletcher, A. L., Astarita, J., Lukacs-Kornek, V., Tayalia, P., Gonzalez, S. F., Elpek, K. G., Chang, S. K., Knoblich, K., Hemler, M. E., Brenner, M. B., Carroll, M. C., Mooney, D. J., Turley, S. J., and Immunolog-ical Genome Project Consortium. (2012). Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunolog-ical hallmarks. Nat. Immunol. 13, 499-510.
22. Maroof, A., and Kaye, P. M. (2008). Temporal regulation of interleukin-12p70 (IL-12p70) and IL-12-related cytokines in splenic dendritic cell subsets during Leishmania dono-vani infection. Infect. Immun. 76, 239-249.
23. Meredith, M. M., Liu, K., Darrasse-Jeze, G., Kamphorst, A. O., Schreiber, H. A., Guermonprez, P., Idoyaga, J., Cheong, C., Yao, K. H., Niec, R. E., and Nussenzweig, M. C. (2012). Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J. Exp. Med. 209, 1153-1165.
24. Nguyen Hoang, A. T., Liu, H., Juaréz, J., Aziz, N., Kaye, P. M., and Svensson, M. (2010). Stromal cell-derived CXCL12 and CCL8 cooperate to support increased development of regulatory dendritic cells following Leish-mania infection. J. Immunol. 185, 2360-2371.
25. Owens, B. M. J., Beattie, L., Moore, J. W. J., Brown, N., Mann, J. L., Dal-ton, J. E., Maroof, A., and Kaye, P. M. (2012). IL-10 producing Th1 cells and disease progression are regulated by distinct CD11c+ cell populations during visceral leish-maniasis. PLoS Pathog. 8, e1002827. doi:10.1371/journal.ppat.1002827
26. Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., and Hingorani, S. R. (2012). Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21, 418-429.
27. Qian, C., An, H., Yu, Y., Liu, S., and Cao, X. (2007). TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation. Blood 109, 3308-3315.
28. Qian, C., Jiang, X., An, H., Yu, Y., Guo, Z., Liu, S., Xu, H., and Cao, X. (2006). TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation. Blood 108, 2307-2315.
29. Saraiva, M.,and O'Garra, A.(2010). The regulation of IL-10 production by immunecells.Nat. Rev. Immunol.10, 170-181.
30. Satpathy, A. T., Kc, W., Albring, J. C., Edelson, B. T., Kretzer, N. M., Bhat-tacharya, D., Murphy, T.L.,andMurphy, K. M. (2012). Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J. Exp. Med. 209, 1135-1152.
31. Siegert, S., Huang, H. Y., Yang, C. Y., Scarpellino, L., Carrie, L., Essex, S., Nelson, P. J., Heikenwalder, M., Acha-Orbea, H., Buckley, C. D., Marsland, B. J., Zehn, D., and Luther, S. A. (2011). Fibroblastic reticu-lar cells from lymph nodes attenuate T cell expansion by producing nitric oxide. PLoS ONE 6, e27618. doi:10.1371/journal.pone. 0027618
32. Smith, K. A., Hochweller, K., Häm-merling, G. J., Boon, L., MacDon-ald, A. S., and Maizels, R. M. (2011). Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103-dendritic cells. J. Immunol. 186, 7098-7109.
33. Steinman, R. M., Hawiger, D., and Nussenzweig, M. C. (2003). Tolero-genic dendritic cells. Annu. Rev. Immunol. 21, 685-711.
34. Svensson, M., and Kaye, P. M. (2006). Stromalcell regulation of dendritic-cell differentiation and function. Trends Immunol. 27, 580-587.
35. Svensson, M., Maroof, A., Ato, M., and Kaye, P. M. (2004). Stromal cells direct local differentiation of regulatory dendritic cells. Immunity 21, 805-816.
36. Tang, H., Guo, Z., Zhang, M., Wang, J., Chen, G., and Cao, X. (2006). Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10. Blood 108, 1189-1197.
37. Wakkach, A., Fournier, N., Brun, V., Breittmayer, J. P., Cottrez, F., and Groux, H. (2003). Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18, 605-617.
38. Xia, S., Guo, Z., Xu, X., Yi, H., Wang, Q., Cao, X. (2008). Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance. Blood 112, 3175-3185.
39. Xu, X., Yi, H., Guo, Z., Qian, C., Xia, S., Yao, Y., and Cao, X. (2012). Splenic stroma-educated regulatory dendritic cells induce apop-tosis of activated CD4 T cells via Fas ligand-enhanced IFN-gamma and nitric oxide. J. Immunol. 188, 1168-1177.
40. Yasunaga, M., Manabe, S., Tarin, D., and Matsumura, Y. (2011). Cancer-stroma targeting therapy by cyto-toxic immunoconjugate bound to the collagen 4 network in the tumor tissue. Bioconjug. Chem. 22, 1776-1783.
41. Zhang, M., Tang, H., Guo, Z., An, H., Zhu, X., Song, W., Guo, J., Huang, X., Chen, T., Wang, J., and Cao, X. (2004). Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat. Immunol. 5, 1124-1133