Cobalt Protoporphyrin Accelerates TFEB Activation and Lysosome Reformation during LPS-Induced Septic Insults in the Rat Heart

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Unuma, Kana ^a   Aki, Toshihiko ^a   Funakoshi, Takeshi ^a   Yoshida, Ken Ichi ^b   Uemura, Koichi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; HEME OXYGENASE 1; LIPOPOLYSACCHARIDE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; PROTOPORPHYRIN COBALT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BIOGENESIS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HEART PERFORMANCE; HEART PROTECTION; LYSOSOME; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEGRADATION; RAT; TRANSCRIPTION INITIATION;

ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL NUCLEUS; CHLOROQUINE; ENZYME INDUCTION; HEART; HEART INJURIES; HEME OXYGENASE-1; LIPOPOLYSACCHARIDES; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOMES; MALE; MITOCHONDRIA; PROTOPORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; TIME FACTORS; VACUOLES;

EID: 84874046703     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056526     Document Type: Article

References (43)

1. Lin WJ, Yeh WC, (2005) Implication of Toll-like receptor and tumor necrosis factor alpha signaling in septic shock. Shock 24: 206-209.
2. Boyd JH, Mathur S, Wang Y, Bateman RM, Walley KR, (2006) Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response. Cardiovasc Res 72: 384-393.
3. Avlas O, Fallach R, Shainberg A, Porat E, Hochhauser E, (2011) Toll-like receptor 4 stimulation initiates an inflammatory response that decreases cardiomyocyte contractility. Antioxid Redox Signal 15: 1895-1909.
4. Andrades M, Ritter C, de Oliveira MR, Streck EL, Fonseca Moreira JC, et al. (2011) Antioxidant treatment reverses organ failure in rat model of sepsis: role of antioxidant enzymes imbalance, neutrophil infiltration, and oxidative stress. J Surg Res 167: e307-313.
5. Dare AJ, Phillips AR, Hickey AJ, Mittal A, Loveday B, et al. (2009) A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome. Free Radic Biol Med 47: 1517-1525.
6. Gottlieb RA, Carreira RS, (2010) Autophagy in health and disease. 5. Mitophagy as a way of life. Am J Physiol Cell Physiol 299: C203-210.
7. Suliman HB, Carraway MS, Tatro LG, Piantadosi CA, (2007) A new activating role for CO in cardiac mitochondrial biogenesis. J Cell Sci 120: 299-308.
8. Piantadosi CA, Carraway MS, Babiker A, Suliman HB, (2008) Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res 103: 1232-1240.
9. Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, et al. (2009) LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. Am J Physiol Heart Circ Physiol 296: H470-479.
10. Hickson-Bick DL, Jones C, Buja LM, (2008) Stimulation of mitochondrial biogenesis and autophagy by lipopolysaccharide in the neonatal rat cardiomyocyte protects against programmed cell death. J Mol Cell Cardiol 44: 411-418.
11. Suliman HB, Sweeney TE, Withers CM, Piantadosi CA, (2010) Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis. J Cell Sci 123: 2565-2575.
12. Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, et al. (2010) Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 465: 942-946.
13. Dehay B, Bove J, Rodriguez-Muela N, Perier C, Recasens A, et al. (2010) Pathogenic lysosomal depletion in Parkinson's disease. J Neurosci 30: 12535-12544.
14. Fortunato F, Burgers H, Bergmann F, Rieger P, Buchler MW, et al. (2009) Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis. Gastroenterology 137: 350-360, 360 e351-355.
15. Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, et al. (2009) A gene network regulating lysosomal biogenesis and function. Science 325: 473-477.
16. Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, et al. (2011) TFEB links autophagy to lysosomal biogenesis. Science 332: 1429-1433.
17. Ma X, Godar RJ, Liu H, Diwan A, (2012) Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death. Autophagy 8.
18. Ryter SW, Alam J, Choi AM, (2006) Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86: 583-650.
19. Shan Y, Pepe J, Lu TH, Elbirt KK, Lambrecht RW, et al. (2000) Induction of the heme oxygenase-1 gene by metalloporphyrins. Arch Biochem Biophys 380: 219-227.
20. Unuma K, Aki T, Matsuda S, Funakoshi T, Yoshida KI, et al. (2012) Inducer of heme oxygenase-1 cobalt protoporphyrin accelerates autophagy and suppresses oxidative damages during lipopolysaccharide treatment in rat liver. Hepatol Res.
21. Carchman EH, Rao J, Loughran PA, Rosengart MR, Zuckerbraun BS, (2011) Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice. Hepatology 53: 2053-2062.
22. Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, et al. (2000) Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 406: 902-906.
23. Srigley JR, Delahunt B, (2009) Uncommon and recently described renal carcinomas. Mod Pathol 22 Suppl 2: S2-S23.
24. Pena-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, Wolff NC, Tran TA, et al. (2011) Regulation of TFEB and V-ATPases by mTORC1. EMBO J 30: 3242-3258.
25. Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, et al. (2012) A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J 31: 1095-1108.
26. Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, et al. (2011) Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum Mol Genet 20: 3852-3866.
27. Cuervo AM, Dice JF, (1996) A receptor for the selective uptake and degradation of proteins by lysosomes. Science 273: 501-503.
28. Ruivo R, Anne C, Sagne C, Gasnier B, (2009) Molecular and cellular basis of lysosomal transmembrane protein dysfunction. Biochim Biophys Acta 1793: 636-649.
29. Nishino I, Fu J, Tanji K, Yamada T, Shimojo S, et al. (2000) Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature 406: 906-910.
30. Hsieh CH, Pai PY, Hsueh HW, Yuan SS, Hsieh YC, (2011) Complete induction of autophagy is essential for cardioprotection in sepsis. Ann Surg 253: 1190-1200.
31. Ma X, Liu H, Foyil SR, Godar RJ, Weinheimer CJ, et al. (2012) Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia-Reperfusion Injury. Circulation.
32. Zuckerbraun BS, Chin BY, Bilban M, d'Avila JC, Rao J, et al. (2007) Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species. FASEB J 21: 1099-1106.
33. Chen B, Guo L, Fan C, Bolisetty S, Joseph R, et al. (2009) Carbon monoxide rescues heme oxygenase-1-deficient mice from arterial thrombosis in allogeneic aortic transplantation. Am J Pathol 175: 422-429.
34. Lee SJ, Ryter SW, Xu JF, Nakahira K, Kim HP, et al. (2011) Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation. Am J Respir Cell Mol Biol 45: 867-873.
35. Lancel S, Hassoun SM, Favory R, Decoster B, Motterlini R, et al. (2009) Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis. J Pharmacol Exp Ther 329: 641-648.
36. Shan Y, Lambrecht RW, Donohue SE, Bonkovsky HL, (2006) Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin. FASEB J 20: 2651-2653.
37. O'Brien PJ, (2008) Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. Toxicology 245: 206-218.
38. Galbraith RA, Kappas A, (1989) Regulation of food intake and body weight by cobalt porphyrins in animals. Proc Natl Acad Sci U S A 86: 7653-7657.
39. Smith TJ, Drummond GS, Kappas A, (1987) Cobalt-protoporphyrin suppresses thyroid and testicular hormone concentrations in rat serum: a novel action of this synthetic heme analogue. Pharmacology 34: 9-16.
40. Schmidt R, Tritschler E, Hoetzel A, Loop T, Humar M, et al. (2007) Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury. Ann Surg 245: 931-942.
41. Schmidt R, Hoetzel A, Baechle T, Loop T, Humar M, et al. (2004) Isoflurane pretreatment lowers portal venous resistance by increasing hepatic heme oxygenase activity in the rat liver in vivo. J Hepatol 41: 706-713.
42. Minutoli L, Altavilla D, Bitto A, Polito F, Bellocco E, et al. (2008) Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock. Eur J Pharmacol 589: 272-280.
43. Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC, (2007) Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 282: 5641-5652.