Mutations for decreasing the immunogenicity and maintaining the function of core streptavidin

Protein Science

Volumn 22, Issue 2, 2013, Pages 213-221

  Yumura, Kyohei ^a   Ui, Mihoko ^a   Doi, Hirofumi ^b   Hamakubo, Takao ^b   Kodama, Tatsuhiko ^b   Tsumoto, Kouhei ^a   Sugiyama, Akira ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Differential scanning calorimetry; therapeutic protein; Isothermal titration calorimetry; Low immunogenicity; Protein engineering; Streptavidin; Thermodynamic analysis

Indexed keywords

BIOTIN; CORE STREPTAVIDIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; STREPTAVIDIN; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; DIFFERENTIAL SCANNING CALORIMETRY; IMMUNOGENICITY; IMMUNOREACTIVITY; ISOTHERMAL TITRATION CALORIMETRY; MUTATION; NONHUMAN; PHYSICAL CHEMISTRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; STOICHIOMETRY; THERMOSTABILITY;

CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MODELS, MOLECULAR; MUTATION; SODIUM DODECYL SULFATE; STATIC ELECTRICITY; STREPTAVIDIN;

EID: 84874036934     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2203     Document Type: Article

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