Five most common Prognostically important fusion oncogenes are detected in the majority of Pakistani pediatric Acute lymphoblastic leukemia patients and are strongly associated with disease biology and treatment outcome

Asian Pacific Journal of Cancer Prevention

Volumn 13, Issue 11, 2012, Pages 5469-5475

  Awan, Tashfeen ^a   Iqbal, Zafar ^a,b,h   Aleem, Aamer ^a,c   Sabir, Noreen ^a   Absar, Muhammad ^a,d   Rasool, Mahmood ^e   Tahir, Ammara H ^a,d,f   Basit, Sulman ^g   Khalid, Ahmad Mukhtar ^h   Sabar, Muhammad Farooq ⁱ   Asad, Sultan ⁱ   Ali, Agha Shabbir ^j   Mahmood, Amer ^k   Akram, Muhammad ^l   Saeed, Tariq ^l   Saleem, Arsalan ^m   Mohsin, Danish ^m   Shah, Ijaz Hussain ⁿ   Khalid, Muhammad ⁿ   Asif, Muhammad ^o   Haq, Riazul ^p   Iqbal, Mudassar ^a,q   Akhtar, Tanveer ^a   more..

^a UNIVERSITY OF THE PUNJAB   (Pakistan)

^b KING ABDULLAH INTERNATIONAL MEDICAL RESEARCH CENTER   (Saudi Arabia)

^c Department of Medicine   (Saudi Arabia)

^d Mircobiology Section   (Saudi Arabia)

^e KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^f MONTEFIORE MEDICAL CENTER   (United States)

^g Biochemistry Research Section   (Pakistan)

^h UNIVERSITY OF SARGODHA   (Pakistan)

ⁱ National Centre of Excellence in Molecular Biology   (Pakistan)

^j Institute of Public Health (IPH)   (Pakistan)

^k KING KHALID UNIVERSITY HOSPITAL   (Saudi Arabia)

^l ALLAMA IQBAL MEDICAL COLLEGE   (Pakistan)

^m UNIVERSITY OF HEALTH SCIENCES   (Pakistan)

ⁿ PUNJAB MEDICAL COLLEGE   (Pakistan)

^o BALOCHISTAN UNIVERSITY OF INFORMATION TECHNOLOGY   (Pakistan)

^p UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^q National Surgical Centre Bishkek   (Kyrgyzstan)

more..

Author keywords

Acute lymphoblastic leukemia; Fusion oncogenes; Pakistan; Pediatric ALL

Indexed keywords

EID: 84874026117     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.11.5469     Document Type: Article

References (40)

1. Andersen MK, Autio K, Barbany G, et al (2011). Paediatric B-cell precursor acute lymphoblastic leukaemia with t(1;19) (q23;p13): clinical and cytogenetic characteristics of 47 cases from the Nordic countries treated according to NOPHO protocols. Br J Haematol, 155, 235-43.
2. Ariffin H, Chen SP, Kwok CS, et al (2007). Ethnic differences in the frequency of subtypes of childhood acute lymphoblastic leukemia: results of the Malaysia-Singapore Leukemia Study Group. J Pediatr Hematol Oncol, 29, 27-31.
3. Ashraf MS (2012) Pediatric Oncology in Pakistan. J Pediatr Hematol Oncol, 34, 23-5.
4. Bhojwani D, Pei D, Sandlund JT, et al (2012). ETV6-RUNX1- positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy. Leukemia, 26, 265-70.
5. Bowman WP, Larsen EL, Devidas M, et al (2011). Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia: results of Children's Oncology Group trial P9906. Pediatr Blood Cancer, 57, 569-77.
6. Burmeister T, Nicola G, Stefan S, et al (2010). Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia. Haematologic, 5, 241-6.
7. Cheok MH, Evans WE (2006). Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer Therapy. Nat Rev Cancer, 6, 117-29.
8. DeBraekeleer E, Basinko A, Douet-Guilbert N, et al (2010). Cytogenetics in pre-B and B-cell acute lymphoblastic leukemia: a study of 208 patients diagnosed between 1981 and 2008. Cancer Genetics and Cytogenetics, 200, 8-15.
9. El-Sissy A, El-Mashari M, Bassuni W, et al (2006). A molecular detection of BCR/ABL fusion gene in Saudi acute lymphoblastic leukemia patients. J Egypt Natl Canc Inst, 18, 109-16.
10. Faiz M, Qureshi AM, Qazi JI (2011). Molecular characterization of different fusion oncogenes associated with childhood Acute Lymphoblastic leukaemia from Pakistan. IJAVMS, 5, 497-507.
11. Gaynon PS, Crotty ML, Sather HN, et al (1997). Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: a Children's Cancer Group initiative. Leuk Lymphoma, 26, 57-65.
12. Hunger SP, Lu X, Devidas M, et al (2012). Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group. J Clin Oncol, 30, 1663-9.
13. Iacobucci I, Papayannidis C, Lonetti A, et al (2012). Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments. Curr Hematol Malig Rep, 7, 133-43.
14. Iqbal Z, Tanveer A (2006). Incidence of different fusion oncogenes in acute Lymphoblastic Leukemia (ALL) patients from Pakistan: possible implications in differential diagnosis, prognosis, treatment and management of ALL. Haematologica, 91, 64.
15. Iqbal Z, Iqbal M, Akhter T (2007). Frequency of BCR-ABL fusion oncogene in Pakistani childhood acute lymphoid leukemia (ALL) patients reflects ethnic differences in molecular genetics of ALL. J Pediatr Hematol Oncol, 29, 585.
16. Iqbal Z, Awan T, Iqbal M, et al (2012). High frequency of BCRABL oncogene in pediatric acute lymphoblastic leukemia (ALL) patients as revealed by RT-PCR and interphase FISH: association with disease biology and treatment outcome. J Clin Oncol, 30, 444.
17. Jiménez-Morales S, Miranda-Peralta E, Saldaña-Alvarez Y, et al (2008). BCR-ABL, ETV6-RUNX1 and E2A-PBX1: prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients. Leuk Res, 32, 1518-22.
18. Kuiper RP, Schoenmakers EF, van Reijmersdal SV, et al (2007). High resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia, 21, 1258-66.
19. Lazic J, Tosic N, Dokmanovic L, et al (2010). Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia. Med Oncol, 27, 449-53.
20. Leung W, Campana D, Yang J, et al (2011). High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia. Blood, 118, 223-30.
21. McGregor S, McNeer J, Gurbuxani S (2012). Beyond the 2008 World Health Organization classification: the role of the hematopathology laboratory in the diagnosis and management of acute lymphoblastic leukemia. Semin Diagn Pathol, 29, 2-11.
22. Mesquita DR, Córdoba JC, Magalhães IQ, et al (2009). Molecular and chromosomal mutations among children with B-lineage lymphoblastic leukemia in Brazil's federal district. Genet Mol Res, 8, 345-53.
23. Pui CH, Carroll WL, Meshinchi S, et al (2011). Biology, risk stratification, and therapy of pediatric acute leukemias: an update. J Clin Oncol, 29, 551-65.
24. Pui CH, Robison LL, Look AT (2008). Acute Lymphoblastic Leukaemia. Lancet, 371, 1030-43.
25. Pui CH, Sandlund JT, Pei D, et al (2004). Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital. Blood, 104, 2690-6.
26. Pui CH, Sandlund JT, Pei D, et al (2003). Results of therapy for acute lymphoblastic leukemia in black and white children. JAMA, 290, 2001-7.
27. Pulsipher MA, Peters C, Pui CH (2011). High-risk pediatric acute lymphoblastic leukemia: to transplant or not to transplant? Biol Blood Marrow Transplant, 17, 137-48.
28. Raimondi SC, Pui CH, Hancock ML, et al (1996). Heterogeneity of hyperdiploid (51-67) childhood acute lymphoblastic leukemia. Leukemia, 10, 213-24.
29. Reichard KK, Kang H, Robinett S (2011). Pediatric B-lymphoblastic leukemia with RUNX1 amplification: clinicopathologic study of eight cases. Mod Pathol, 24, 1606-11.
30. Rives S, Estella J, Gómez P, et al (2011). Intermediate dose of imatinib in combination with chemotherapy followed by allogeneic stem cell transplantation improves early outcome in paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL): results of the Spanish Cooperative Group SHOP studies ALL-94, ALL-99 and ALL-2005. Br J Haematol, 154, 600-11.
31. Romana SP, Poirel H, Leconiat M, et al (1995). High frequency of t(12; 21) in childhood B-lineage acute lymphoblastic leukemia. Blood, 86, 4263-9.
32. Sabir N, Iqbal Z, Aleem A, et al (2012). Prognostically Significant Fusion Oncogenes in Pakistani Patients with Adult Acute Lymphoblastic Leukemia and their Association with Disease Biology and Outcome. Asian Pac J Cancer Prev, 13, 3349-55.
33. Schmiegelow K, Lausten TU, Baruchel A, et al (2012). High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia. Leukemia, 26, 675-81.
34. Schultz KR, Bowman WP, Aledo A, et al (2009). Improved early EFS with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study. J Clin Oncol, 27, 5175-81.
35. Siddiqui R, Nancy N, Naing WP, et al (2010). Distribution of common genetic subgroups in childhood acute lymphoblasticleukemia in four developing countries. Cancer Genet Cytogenet, 200, 149-53.
36. Siraj AK, Ozbek U, Sazawal S, et al (2002). Preclinical validation of a monochrome real-time multiplex assay for translocations in childhood acute lymphoblastic leukemia. Clin Cancer Res, 8, 3832-40.
37. Treviño LR, Yang W, French D, et al (2009). Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet, 41, 1001-5.
38. van Dongen JJ, Macintyre EA, Gabert JA, et al (1999). Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia, 13, 1901-28.
39. Xu H, Cheng C, Devidas M, et al (2012). ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia. J Clin Oncol, 30, 751-7.
40. Zhang J, Mullighan CG, Harvey RC, et al (2011). Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood, 118, 3080-7.