Prognostically Significant Fusion Oncogenes in Pakistani Patients with Adult Acute Lymphoblastic Leukemia and their Association with Disease Biology and Outcome

Asian Pacific Journal of Cancer Prevention

Volumn 13, Issue 7, 2012, Pages 3349-3355

  Sabir, Noreen ^a   Iqbal, Zafar ^a,b,c,d   Aleem, Aamer ^a,b   Awan, Tashfeen ^a   Naeem, Tahir ^a,b   Asad, Sultan ^c   Tahir, Ammara H ^a,c,o   Absar, Muhammad ^a,b   Hasanato, Rana MW ^b   Basit, Sulman ^b   Chishti, Muhammad Azhar ^b   Ul Haque, Muhammad Faiyaz ^b   Khalid, Ahmad Muktar ^d   Sabar, Muhammad Farooq ^c   Rasool, Mahmood ^e   Karim, Sajjad ^e   Khan, Mahwish ^a,c   Samreen, Baila ^a,f   Akram, Afia M ^a   Siddiqi, Muhammad Hassan ^a   Shahzadi, Saba ^a   Shahbaz, Sana ^a   Ali, Agha Shabbir ^g   Mahmood, Amer ^h   Akram, Muhammad ⁱ   Saeed, Tariq ⁱ   Saleem, Arsalan ^j   Mohsin, Danish ^j   Shah, Ijaz Hussain ^k   Khalid, Muhammad ^k   Asif, Muhammad ^l   Iqbal, Mudassar ^a,m,n   Akhtar, Tanveer ^a   more..

^a UNIVERSITY OF THE PUNJAB   (Pakistan)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF LAHORE   (Pakistan)

^d UNIVERSITY OF SARGODHA   (Pakistan)

^e KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^f Sind Institute of Urology and Transplantation   (Pakistan)

^g Institute of Public Health (IPH)   (Pakistan)

^h KING KHALID UNIVERSITY HOSPITAL   (Saudi Arabia)

ⁱ JINNAH HOSPITAL   (Pakistan)

^j UNIVERSITY OF HEALTH SCIENCES   (Pakistan)

^k PUNJAB MEDICAL COLLEGE   (Pakistan)

^l BALOCHISTAN UNIVERSITY OF INFORMATION TECHNOLOGY   (Pakistan)

^m Asian Medical Institute   (Kyrgyzstan)

ⁿ National Surgical Centre   (Kyrgyzstan)

^o MONTEFIORE MEDICAL CENTER   (United States)

more..

Author keywords

Acute lymphoblastic leukemia; Adult; All; Fusion oncogenes; Pakistan

Indexed keywords

EID: 84873583054     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.7.3349     Document Type: Article

References (23)

1. Andreasson P, Schwaller J, Anastasiadou E, et al (2001). The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo. Cancer Genet Cytogenet, 130,93-104.
2. Bassan R (2005). Evolving strategies for the management of high-risk adult acute lymphoblastic leukemia. Haematologica, 90, 1299.
3. Burmeister T, Gokbuget N, Schwartz S, et al (2010). Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia. Haematologica, 95, 241-6.
4. Devaraj PE, Foroni L, Janossy G, et al (1995). Expression of the E2A-PBX1 fusion transcripts in t (1; 19) (q23; p13) and der (19) t (1; 19) at diagnosis and in remission of acute lymphoblastic leukemia with different B lineage immunophenotypes. Leukemia, 9, 821-5.
5. Faderl S, Kantarjian HM, Talpaz M, Estrov Z (1998). Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia. Blood, 91, 3995-4019.
6. Faiz M, Iqbal QJ, Qureshi A (2011). High prevalence of BCR-ABL fusion transcripts with poor prognostic impact among adult ALL patients: report from Pakistan. Asia Pac J Clin Oncol, 7, 47-55.
7. Fielding AK (2010). How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood, 116,3409-17.
8. Foa R, Vitale A, Mancini M, et al (2003). E2A-PBX1 fusion in adult acute lymphoblastic leukaemia: biological and clinical features. Br J Haematol, 120, 484-7.
9. Harrison CJ, Foroni L (2002). Cytogenetics and molecular genetics of acute lymphoblastic leukemia. Rev Clin Exp Hematol, 6, 91-113.
10. Iacobucci I, Papayannidis C, Lonetti A, et al (2012). Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments. Curr Hematol Malig Rep, 7, 133-43.
11. Iqbal Z (2006). Frequency of chromosomal abnormalities and corresponding fusion oncogenes in acute lymphoblastic leukemia (ALL) patients of Pakistan and its implication in differential diagnosis and prognosis of leukemia. Haematologica, 91, 65.
12. Iqbal Z, Tanveer A (2006) Incidence of different fusion oncogenes in acute lymphoblastic leukemia (ALL) patients from Pakistan: possible implication in differential diagnosis, prognosis, treatment and management of ALL. Haematologica, 91, 64.
13. Iqbal Z, Akhtar T, Iqbal M, et al (2009). First comprehensive report of strong interplay of genetic and environmental factors as well as high degree of ethnic and geographical variations in biology of leukemia as manifested by frequencies of common fusion oncogenes of prognostic significance associated with different Leukemic subtypes in Pakistani population. In: Online proceedings American Association for Cancer Research 100TH Annual Meeting, April 18-22, Colorado, Denver.
14. Mancini M, Scappaticci D, Cimino G, et al (2005). A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): analysis of the GIMEMA 0496 protocol. Blood, 105, 3434-41.
15. Moorman AV, Harrison CJ, Buck GA, et al (2007). Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the medical research council (MRC) UKALLXII/ eastern cooperative oncology group (ECOG) 2993 trial. Blood, 109,3189-97.
16. Pui CH, Evans WE (2006). Treatment of acute lymphoblastic leukemia. N EnglJ Med, 354, 166-78.
17. Pui CH, Robison LL, Look AT (2008). Acute lymphoblastic leukaemia. Lancet, 371, 1030-43.
18. Pui CH, Sandlund JT, Pei D, et al (2004). Improved outcome for children with acute lymphoblastic leukemia: results of total therapy study XIIIB at St jude children's research hospital. Blood, 104, 2690-6.
19. Soverini S, Colarossi S, Gnani A, et al (2007). Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain. Haematologica, 92, 401-4.
20. The groupe franGais de cytoghetique hematologique (1996). Cytogenetic abnormalities in adult acute lymphoblastic leukemia: correlations with hematologic findings and outcome. Blood, 87, 3135-42.
21. Thomas X, Boiron JM, Huguet F, et al (2004). Outcome of treatment in adults with acute lymphoblastic leukemia: analysis of the LALA-94 trial. J Clin Oncol, 22, 4075-86.
22. Van Dongen JJ, Macintyre EA, Gabert JA, et al (1999). Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia, 13, 1901-28.
23. Xing H, Yang X, Liu T, et al (2012). The study of resistant mechanisms and reversal in an imatinib resistant Ph+ acute lymphoblastic leukemia cell line. LeukRes, 36, 509-13.