Levels of Aqueous Humor Trace Elements in Patients with Non-Exsudative Age-related Macular Degeneration: A Case-control Study

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Jünemann, Anselm G M ^a   Stopa, Piotr ^b   Michalke, Bernhard ^c   Chaudhri, Anwar ^d   Reulbach, Udo ^e   Huchzermeyer, Cord ^a   Schlötzer Schrehardt, Ursula ^a   Kruse, Friedrich E ^a   Zrenner, Eberhart ^f   Rejdak, Robert ^b,g  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e TRINITY COLLEGE DUBLIN   (Ireland)

^f Centre for Ophthalmology   (Germany)

^g MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; ANTIANDROGEN; ANTIARRHYTHMIC AGENT; ANTIDEPRESSANT AGENT; ANTIDIABETIC AGENT; ANTIDIURETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTITHROMBOCYTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CADMIUM; COBALT; COPPER; COUMARIN DERIVATIVE; ESTROGEN; HERBACEOUS AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IRON; MANGANESE; METHYLXANTHINE; NITRATE; NONSTEROID ANTIINFLAMMATORY AGENT; PROTON PUMP INHIBITOR; SELENIUM; STEROID; THYROXINE; TRACE ELEMENT; TRAMADOL; ZINC;

AGE; AGED; AQUEOUS HUMOR; ARTICLE; CASE CONTROL STUDY; CATARACT EXTRACTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW INJECTION ANALYSIS; GENDER; HUMAN; MALE; MASS SPECTROMETRY; PILOT STUDY; PROSPECTIVE STUDY; QUALITY CONTROL; RETINA MACULA AGE RELATED DEGENERATION;

AGED; AQUEOUS HUMOR; CASE-CONTROL STUDIES; FEMALE; HUMANS; MACULAR DEGENERATION; MALE; TRACE ELEMENTS;

EID: 84874023749     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056734     Document Type: Article

References (25)

1. Montezuma SR, Sobrin L, Seddon JM, (2007) Review of genetics in age related macular degeneration. Semin Ophthalmol 22: 229-240 doi:10.1080/08820530701745140.
2. Terman A, Gustafsson B, Brunk UT, (2006) The lysosomal-mitochondrial axis theory of postmitotic aging and cell death. Chem Biol Interact 163: 29-37 doi:10.1016/j.cbi.2006.04.013.
3. Hahn P, Milam AH, Dunaief JL, (2003) Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane. Arch Ophthalmol 121: 1099-1105 doi:10.1001/archopht.121.8.1099.
4. Klein R, Knudtson MD, Lee KE, Gangnon RE, Klein BEK, (2008) Age-Period-Cohort Effect on the Incidence of Age-Related Macular Degeneration. Ophthalmology 115: 1460-1467 doi:10.1016/j.ophtha.2008.01.026.
5. Erie JC, Butz JA, Good JA, Erie EA, Burritt MF, et al. (2005) Heavy Metal Concentrations in Human Eyes. American Journal of Ophthalmology 139: 888-893 doi:10.1016/j.ajo.2004.12.007.
6. Erie JC, Good JA, Butz JA, Hodge DO, Pulido JS, (2007) Urinary Cadmium and Age-related Macular Degeneration. American Journal of Ophthalmology 144: 414-418 doi:10.1016/j.ajo.2007.05.020.
7. Wills NK, Ramanujam VMS, Chang J, Kalariya N, Lewis JR, et al. (2008) Cadmium accumulation in the human retina: Effects of age, gender, and cellular toxicity. Experimental Eye Research 86: 41-51 doi:10.1016/j.exer.2007.09.005.
8. Hollyfield JG, Bonilha VL, Rayborn ME, Yang X, Shadrach KG, et al. (2008) Oxidative damage-induced inflammation initiates age-related macular degeneration. Nature Medicine 14: 194-198 doi:10.1038/nm1709.
9. Ugarte M, Osborne NN, (2001) Zinc in the retina. Progress in Neurobiology 64: 219-249 doi:10.1016/S0301-0082(00)00057-5.
10. Zou W, Yan M, Xu W, Huo H, Sun L, et al. (2001) Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. J Neurosci Res 64: 646-653.
11. Kowalski M, Bielecka-Kowalska A, Oszajca K, Makandjou-Ola E, Jaworski P, et al. (2010) Manganese superoxide dismutase (MnSOD) gene (Ala-9Val, Ile58Thr) polymorphism in patients with age-related macular degeneration (AMD). Med Sci Monit 16: CR190-196.
12. Moulis J-M, (2010) Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals. BioMetals 23: 877-896 doi:10.1007/s10534-010-9336-y.
13. Nicolas MG, Fujiki K, Murayama K, Suzuki MT, Shindo N, et al. (1996) Studies on the Mechanism of Early Onset Macular Degeneration in Cynomolgus Monkeys. II. Suppression of Metallothionein Synthesis in the Retina in Oxidative Stress. Experimental Eye Research 62: 399-408 doi:10.1006/exer.1996.0045.
14. Sabolić I, Breljak D, Škarica M, Herak-Kramberger CM, (2010) Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs. BioMetals 23: 897-926 doi:10.1007/s10534-010-9351-z.
15. Wills NK, Sadagopa Ramanujam VM, Kalariya N, Lewis JR, van Kuijk FJGM, (2008) Copper and zinc distribution in the human retina: Relationship to cadmium accumulation, age, and gender. Experimental Eye Research 87: 80-88 doi:10.1016/j.exer.2008.04.013.
16. Rousselet E, Martelli A, Chevallet M, Diemer H, Van Dorsselaer A, et al. (2008) Zinc adaptation and resistance to cadmium toxicity in mammalian cells: Molecular insight by proteomic analysis. PROTEOMICS 8: 2244-2255 doi:10.1002/pmic.200701067.
17. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8 (2001). Arch Ophthalmol 119: 1417-1436.
18. Erie JC, Good JA, Butz JA, Pulido JS, (2009) Reduced Zinc and Copper in the Retinal Pigment Epithelium and Choroid in Age-related Macular Degeneration. American Journal of Ophthalmology 147: 276-282.e1 doi:10.1016/j.ajo.2008.08.014.
19. Lengyel I, Flinn JM, Peto{double acute} T, Linkous DH, Cano K, et al. (2007) High concentration of zinc in sub-retinal pigment epithelial deposits. Experimental Eye Research 84: 772-780 doi:10.1016/j.exer.2006.12.015.
20. Zou W, Zeng J, Zhuo M, Xu W, Sun L, et al. (2002) Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells. Journal of Neuroscience Research 67: 837-843 doi:10.1002/jnr.10168.
21. Ortega R, Bresson C, Fraysse A, Sandre C, Devès G, et al. (2009) Cobalt distribution in keratinocyte cells indicates nuclear and perinuclear accumulation and interaction with magnesium and zinc homeostasis. Toxicology Letters 188: 26-32 doi:10.1016/j.toxlet.2009.02.024.
22. Karovic O, Tonazzini I, Rebola N, Edström E, Lövdahl C, et al. (2007) Toxic effects of cobalt in primary cultures of mouse astrocytes. Biochemical Pharmacology 73: 694-708 doi:10.1016/j.bcp.2006.11.008.
23. Yuan Y, (2003) Cobalt Inhibits the Interaction between Hypoxia-inducible Factor-alpha and von Hippel-Lindau Protein by Direct Binding to Hypoxia-inducible Factor-alpha. Journal of Biological Chemistry 278: 15911-15916 doi:10.1074/jbc.M300463200.
24. Wenger RH, (2002) Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. The FASEB Journal 16: 1151-1162 doi:10.1096/fj.01-0944rev.
25. Olbryt M, Jarzab M, Jazowiecka-Rakus J, Simek K, Szala S, et al. (2006) Gene expression profile of B 16(F10) murine melanoma cells exposed to hypoxic conditions in vitro. Gene Expr 13: 191-203.