Pentadecapeptide BPC 157 and the esophagocutaneous fistula healing therapy

European Journal of Pharmacology

Volumn 701, Issue 1-3, 2013, Pages 203-212

  Cesarec, Vedran ^a   Becejac, Tomislav ^a   Misic, Marija ^a   Djakovic, Zeljko ^a   Olujic, Danijela ^a   Drmic, Domagoj ^a   Brcic, Luka ^a   Rokotov, Dinko Stancic ^a   Seiwerth, Sven ^a   Sikiric, Predrag ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

BPC 157; eNOS; Esophagus; Fistula; NO system; Rats

Indexed keywords

ARGININE; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCYLGLUTAMYLPROLYLPROLYLPROLYLGLYCYLLYSYLPROLYLALANYLASPARTYLASPARTYLALANYLGLYCYLLEUCYLVALINE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ESOPHAGITIS; ESOPHAGOCUTANEOUS FISTULA; ESOPHAGUS DISEASE; ESOPHAGUS FISTULA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN DEFECT; SKIN FISTULA; UPREGULATION; WOUND HEALING;

ANIMALS; ARGININE; CUTANEOUS FISTULA; DRUG INTERACTIONS; ESOPHAGEAL DISEASES; MALE; NG-NITROARGININE METHYL ESTER; PEPTIDE FRAGMENTS; PROTEINS; RATS; RATS, WISTAR; WOUND HEALING;

EID: 84874017074     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.11.055     Document Type: Article

References (44)

1. D. Balenovic, M.L. Bencic, M. Udovicic, K. Simonji, J.S. Hanzevacki, I. Barisic, S. Kranjcevic, I. Prkacin, V. Coric, L. Brcic, M. Coric, I. Brcic, S. Borovic, B. Radic, D. Drmic, H. Vrcic, S. Seiwerth, and P. Sikiric Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157, a relation with NO-system Regul. Pept. 156 2009 83 89
2. 2 laser healing in mice Burns 31 2005 310 315
3. A. Boban-Blagaic, V. Blagaic, Z. Romic, N. Jelovac, G. Dodig, R. Rucman, M. Petek, B. Turkovic, S. Seiwerth, and P. Sikiric The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of N(G)-nitro-l-arginine methyl ester and l-arginine Med. Sci. Monit. 12 2006 BR36 45
4. L. Brcic, I. Brcic, M. Staresinic, T. Novinscak, P. Sikiric, and S. Seiwerth Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing J. Physiol. Pharmacol. 60 2009 191 196
5. I. Dobric, P. Drvis, I. Petrovic, D. Shejbal, L. Brcic, A.B. Blagaic, L. Batelja, M. Sever, N. Kokic, A. Tonkic, I. Zoricic, S. Mise, M. Staresinic, B. Radic, A. Jakir, J. Babel, S. Ilic, T. Vuksic, I. Jelic, T. Anic, S. Seiwerth, and P. Sikiric Prolonged esophagitis after primary dysfunction of the pyloric sphincter in the rat and therapeutic potential of the gastric pentadecapeptide BPC 157 J. Pharmacol. Sci. 104 2007 7 18
6. C.E. Foster 3rd, and A.T. Lefor General management of gastrointestinal fistulas. Recognition, stabilization, and correction of fluid and electrolyte imbalances Surg. Clin. North Am. 76 1996 1019 1033
7. S. Frank, M. Madlener, J. Pfeilschifter, and S. Werner Induction of inducible nitric oxide synthase and its corresponding tetrahydrobiopterin cofactor-synthesizing enzyme GTP-cyclohydrolase I during cutaneous wound repair J. Invest. Dermatol. 111 1998 1058 1064
8. M.A. Gaballa, T.E. Raya, C.A. Hoover, and S. Goldman Effects of endothelial and inducible nitric oxide synthases inhibition on circulatory function in rats after myocardial infarction Cardiovasc. Res. 42 1999 627 635
9. Z. Grabarevic, M. Tisljar, B. Artukovic, M. Bratulic, P. Dzaja, S. Seiwerth, P. Sikiric, J. Peric, D. Geres, and J. Kos The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks J. Physiol. (Paris) 91 1997 139 149
10. M. Hrelec, R. Klicek, L. Brcic, I. Brcic, I. Cvjetko, S. Seiwerth, and P. Sikiric Abdominal aorta anastomosis in rats and stable gastric pentadecapeptide BPC 157, prophylaxis and therapy J. Physiol. Pharmacol. 60 7 2009 161 165
11. M. Inamori, T. Shimamura, H. Nagase, Y. Abe, T. Umezawa, A. Nakajima, T. Saito, N. Ueno, K. Tanaka, H. Sekihara, J. Togawa, H. Kaifu, H. Tsuboi, H. Kayama, and S. Tominaga mRNA expression of inducible nitric oxide synthase, endothelial nitric oxide synthase and vascular endothelial growth factor in esophageal mucosa biopsy specimens from patients with reflux esophagitis Hepatogastroenterology 53 2006 361 365
12. S. Kato, F. Ohkawa, Y. Ito, K. Amagase, and K. Takeuchi Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats J. Physiol. Pharmacol. 60 2009 147 155
13. R. Klicek, M. Sever, B. Radic, D. Drmic, I. Kocman, I. Zoricic, T. Vuksic, M. Ivica, I. Barisic, S. Ilic, L. Berkopic, H. Vrcic, L. Brcic, A.B. Blagaic, M. Coric, I. Brcic, D.S. Rokotov, T. Anic, S. Seiwerth, and P. Sikiric Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL 14736, Pliva), is effective in the healing of colocutaneous fistulas in rats, the role of NO-system J. Pharmacol. Sci. 108 2008 7 17
14. J. Lopez-Belmonte, B.J.R. Whittle, and S. Moncada The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa Br. J. Pharmacol. 108 1993 73 78
15. M. Lovric-Bencic, P. Sikiric, J.S. Hanzevacki, S. Seiwerth, D. Rogic, V. Kusec, G. Aralica, P. Konjevoda, L. Batelja, and A.B. Blagaic Doxorubicine congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse J. Pharmacol. Sci. 95 2004 119 126
16. D. Mikus, P. Sikiric, S. Seiwerth, A. Petricevic, G. Aralica, N. Druzijancic, R. Rucman, M. Petek, B. Pigac, D. Perovic, M. Kolombo, N. Kokic, S. Mikus, B. Duplancic, I. Fattorini, B. Turkovic, I. Rotkvic, S. Mise, I. Prkacin, P. Konjevoda, N. Stambuk, and T. Anic Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice Burns 27 2001 817 827
17. S. Moncada, R.M.J. Palmer, and E.A. Higgs Nitric oxide: physiology, pathophysiology and pharmacology Pharmacol. Rev. 43 1991 109 142
18. M. Morita, K. Ikeda, M. Sugiyama, H. Saeki, A. Egashira, K. Yoshinaga, E. Oki, N. Sadanaga, Y. Kakeji, J. Fukushima, and Y. Maehara Repair using the pectoralis major muscle flap for anastomotic leakage after esophageal reconstruction via the subcutaneous route Surgery 147 2010 212 218
19. I. Petrovic, I. Dobric, P. Drvis, D. Shejbal, L. Brcic, A.B. Blagaic, L. Batelja, N. Kokic, A. Tonkic, S. Mise, T. Baotic, M. Staresinic, B. Radic, A. Jakir, T. Vuksic, T. Anic, S. Seiwerth, and P. Sikiric An experimental model of prolonged esophagitis with sphincter failure in the rat and the therapeutic potential of gastric pentadecapeptide BPC 157 J. Pharmacol. Sci. 102 2006 269 277
20. Petrovic I., Dobric I., Drmic D., Sever M., Klicek R., Radic B., Brcic L., Kolenc D., Zlatar M., Kunjko K., Jurcic D., Martinac M., Rasic Z., Boban Blagaic A., Romic Z., Seiwerth S., Sikiric P., 2011.BPC 157 therapy to detriment sphincters failure-esophagitis-pancreatitis in rat and acute pancreatitis patients low sphincters pressure. J. Physiol. Pharmacol. 62(5), 527-534.
21. D.H. Present Crohn's fistula: current concepts in management Gastroenterology 124 2003 1629 1635
22. A. Patruno, P. Amerio, M. Pesce, G. Vianale, S. Di Luzio, A. Tulli, S. Franceschelli, A. Grilli, R. Muraro, and M. Reale Extremely low frequency electromagnetic fields modulate expression of inducible nitric oxide synthase, endothelial nitric oxide synthase and cyclooxygenase-2 in the human keratinocyte cell line HaCat, potential therapeutic effects in wound healing Br. J. Dermatol. 162 2010 258 266
23. L.R. Rábago, N. Ventosa, J.L. Castro, J. Marco, N. Herrera, and F. Gea Endoscopic treatment of postoperative fistulas resistant to conservative management using biological fibrin glue Endoscopy 34 2002 632 638
24. D. Seveljevic-Jaran, S. Cuzic, M. Dominis-Kramaric, I. Glojnaric, V. Ivetic, S. Radosevic, and M.J. Parnham Accelerated healing of excisional skin wound by PL 14736 in alloxan-hyperglycemic rats Skin Pharmacol. Physiol. 19 2006 266 274
25. M. Sever, R. Klicek, B. Radic, L. Brcic, I. Zoricic, D. Drmic, M. Ivica, I. Barisic, S. Ilic, L. Berkopic, A.B. Blagaic, M. Coric, D. Kolenc, H. Vrcic, T. Anic, S. Seiwerth, and P. Sikiric Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats Dig. Dis. Sci. 54 2009 2070 2083
26. A.S. Sidhu, and G. Triadafilopoulos Neuro-regulation of lower esophageal sphincter function as treatment for gastroesophageal reflux disease World J. Gastroenterol. 14 2008 985 990
27. 2 receptor antagonists, dopamine promoters and gut peptides Life Sci. 54 1994 PL63 PL68
28. P. Sikiric, S. Seiwerth, Z. Grabarevic, R. Rucman, M. Petek, V. Jagic, B. Turkovic, I. Rotkvic, S. Mise, I. Zoricic, P. Konjevoda, D. Perovic, L. Jurina, J. Separovic, M. Hanzevacki, B. Artukovic, M. Bratulic, M. Tisljar, M. Gjurasin, P. Miklic, D. Stancic-Rokotov, Z. Slobodnjak, N. Jelovac, and A. Marovic The influence of a novel pentadecapeptide BPC 157 on NG-nitro-l-arginine methylester and l-arginine effect on stomach mucosal integrity and blood pressure Eur. J. Pharmacol. 332 1997 23 33
29. P. Sikiric, S. Jadrijevic, S. Seiwerth, T. Sosa, S. Deskovic, D. Perovic, G. Aralica, Z. Grabarevic, R. Rucman, M. Petek, V. Jagic, B. Turkovic, T. Ziger, I. Rotkvic, S. Mise, I. Zoricic, B. Sebecic, L. Patrlj, B. Kocman, M. Sarlija, D. Mikus, J. Separovic, M. Hanzevacki, M. Gjurasin, and P. Miklic Long-lasting cytoprotection after pentadecapeptide BPC 157, ranitidine, sucralfate or cholestyramine application in reflux oesophagitis in rats J. Physiol. (Paris) 93 1999 467 477
30. 2-blockers, omeprazole and sucralfate on new vessels and new granulation tissue formation J. Physiol. (Paris) 93 1999 479 485
31. P. Sikiric, S. Seiwerth, S. Mise, M. Staresinic, V. Bedekovic, N. Zarkovic, S. Borovic, M. Gjurasin, A. Boban-Blagaic, L. Batelja, R. Rucman, and T. Anic Corticosteroid-impairment of healing and gastric pentadecapeptide BPC-157 creams in burned mice Burns 29 2003 323 334
32. P. Sikiric, S. Seiwerth, L. Brcic, A.B. Blagaic, I. Zoricic, M. Sever, R. Klicek, B. Radic, N. Keller, K. Sipos, A. Jakir, M. Udovicic, A. Tonkic, N. Kokic, B. Turkovic, S. Mise, and T. Anic Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, Pliva, Croatia). Full and distended stomach and vascular response Inflammopharmacology 14 2006 214 221
33. P. Sikiric, S. Seiwerth, L. Brcic, M. Sever, R. Klicek, B. Radic, D. Drmic, S. Ilic, and D. Kolenc Revised Robert's cytoprotection and adaptive cytoprotection and stable gastric pentadecapeptide BPC 157. Possible significance and implications for novel mediator Curr. Pharm. Des. 16 2010 1224 1234
34. P. Sikiric, S. Seiwerth, R. Rucman, B. Turkovic, D.S. Rokotov, L. Brcic, M. Sever, R. Klicek, B. Radic, D. Drmic, S. Ilic, D. Kolenc, H. Vrcic, and B. Sebecic Stable gastric pentadecapeptide BPC 157, novel therapy in gastrointestinal tract Curr. Pharm. Des. 17 16 2011 1612 1632
35. P. Sikiric, S. Seiwerth, R. Rucman, B. Turkovic, D.S. Rokotov, L. Brcic, M. Sever, R. Klicek, B. Radic, D. Drmic, S. Ilic, D. Kolenc, V. Stambolija, Z. Zoricic, H. Vrcic, and B. Sebecic Focus on ulcerative colitis, stable gastric pentadecapeptide BPC 157 Curr. Med. Chem. 19 1 2012 126 132
36. S. Skorjanec, Z. Dolovski, I. Kocman, L. Brcic, A. Blagaic Boban, L. Batelja, M. Coric, M. Sever, R. Klicek, L. Berkopic, B. Radic, D. Drmic, D. Kolenc, S. Ilic, V. Cesarec, A. Tonkic, I. Zoricic, S. Mise, M. Staresinic, M. Ivica, M. Lovric Bencic, T. Anic, S. Seiwerth, and P. Sikiric Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers, stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole Dig. Dis. Sci. 54 2009 46 56
37. P. Singh, N. Singh, and G. Palit Analysing the role of COX-2 in acute oesophagitis and in melatonin-exerted protection against experimental reflux oesophagitis in rats J. Pharm. Pharmacol. 63 2011 1572 1580
38. M. Stupnisek, S. Franjic, D. Drmic, M. Hrelec, D. Kolenc, B. Radic, D. Bojic, A. Vcev, S. Seiwerth, and P. Sikiric Pentadecapeptide BPC 157 reduces bleeding time and thrombocytopenia after amputation in rats treated with heparin, warfarin or aspirin Thromb. Res. 129 2012 652 659
39. V.I. Tkalcevic, S. Cuzic, K. Brajsa, B. Mildner, A. Bokulic, K. Situm, D. Perovic, I. Glojnaric, and M.J. Parnham Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression Eur. J. Pharmacol. 570 2007 212 221
40. G.R. Tobin, D.T. Netscher, R.A. Williams, J.D. Richardson, L.M. Flint Jr, J.B. Sharp Jr, and H.C. Polk Jr. Epithelial lining methods in esophageal repair, a comparative study using pedicle flaps in cats Surgery 98 1985 158 165
41. T. Vuksic, I. Zoricic, L. Brcic, M. Sever, R. Klicek, B. Radic, V. Cesarec, L. Berkopic, N. Keller, A.B. Blagaic, N. Kokic, I. Jelic, J. Geber, T. Anic, S. Seiwerth, and P. Sikiric Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat Surg. Today 37 2007 768 777
42. B.J.R. Whittle, N.K. Boughton-Smith, and S. Moncada Biosynthesis and role of the endothelium-derived vasodilator, nitric oxide in gastric mucosa Ann. N.Y. Acad. Sci. 664 1992 126 139
43. S. Wolfrum, M. Grimm, M. Heidbreder, A. Dendorfer, H.A. Katus, J.K. Liao, and G. Richardt Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase J. Cardiovasc. Pharmacol. 41 2003 474 480
44. M. Yurtçu, H. Arbag, O. Caǧlayan, A. Abasiyanik, and M. Oz The effect of cyanoacrylate in esophagocutaneous leakages occurring after esophageal anastomosis Int. J. Pediatr. Otorhinolaryngol. 73 2009 1053 1055