Modeling of electric field distribution in tissues during electroporation

BioMedical Engineering Online

Volumn 12, Issue 1, 2013, Pages

  Corovic, Selma ^a   Lackovic, Igor ^b   Sustaric, Primoz ^a   Sustar, Tomaz ^a   Rodic, Tomaz ^a   Miklavcic, Damijan ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

Electric field distribution; Electroporation; Inverse analysis; Liver electroporation; Numerical modeling; Tissue conductivity; Tumor electroporation

Indexed keywords

ELECTRIC FIELD DISTRIBUTIONS; ELECTRICAL CONDUCTIVITY; ELECTROPORATION; INVERSE ANALYSIS; LOCAL ELECTRIC FIELD DISTRIBUTIONS; SUBCUTANEOUS TUMOR MODELS; TISSUE CONDUCTIVITY; TRANSDERMAL DRUG DELIVERY;

COMPUTER SIMULATION; ELECTRIC CONDUCTIVITY; ELECTRIC CONDUCTIVITY MEASUREMENT; FINITE ELEMENT METHOD; GENE THERAPY; HISTOLOGY; NUMERICAL MODELS; PATIENT TREATMENT; TUMORS;

ELECTRIC FIELDS;

DNA VACCINE;

ARTICLE; COMPARATIVE STUDY; COMPUTER SIMULATION; DRUG DELIVERY SYSTEM; ELECTRIC CONDUCTIVITY; ELECTRICITY; ELECTROCHEMOTHERAPY; ELECTROPORATION; GENE THERAPY; HUMAN; METHODOLOGY; NEOPLASM; NONLINEAR SYSTEM; THEORETICAL MODEL; TISSUE DISTRIBUTION;

COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; ELECTRIC CONDUCTIVITY; ELECTRICITY; ELECTROCHEMOTHERAPY; ELECTROPORATION; GENETIC THERAPY; HUMANS; MODELS, THEORETICAL; NEOPLASMS; NONLINEAR DYNAMICS; TISSUE DISTRIBUTION; VACCINES, DNA;

MLCS; MLOWN;

EID: 84874013075     PISSN: None     EISSN: 1475925X     Source Type: Journal    
DOI: 10.1186/1475-925X-12-16     Document Type: Article

References (70)

1. Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH. Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J 1982, 1:841-845. 553119, 6329708.
2. Pavlin M, Kanduser M, Rebersek M, Pucihar G, Hart FX, Magjarevic R, Miklavcic D. Effect of cell electroporation on the conductivity of a cell suspension. Biophys J 2005, 88:4378-4390. 10.1529/biophysj.104.048975, 1305665, 15792975.
3. Kotnik T, Pucihar G, Miklavcic D. Induced transmembrane voltage and its correlation with electroporation-mediated molecular transport. J Membrane Biol 2010, 236:3-13.
4. Pucihar G, Krmelj J, Rebersek M, Napotnik TB, Miklavcic D. Equivalent Pulse Parameters for Electroporation. IEEE T Biomed Eng 2011, 58:3279-3288.
5. Teissié J, Rols MP. An experimental evaluation of the critical potential difference inducing cell membrane electropermeabilization. Biophys J 1993, 65(1):409-413. 10.1016/S0006-3495(93)81052-X, 1225735, 8369446.
6. Cemazar M, Jarm T, Miklavcic D, Macek Lebar A, Ihan A, Kopitar NA, Sersa G. Effect of electric-field intensity on electropermeabilization and electrosensitivity of various tumor-cell lines in vitro. Electro Magnetobiol 1998, 17:263-272.
7. Valic B, Golzio M, Pavlin M, Schatz A, Faurie C, Gabriel B, Teissie J, Rols MP, Miklavcic D. Effect of electric field induced transmembrane potential on spheroidal cells: theory and experiments. Eur Biophys J 2003, 32:519-528. 10.1007/s00249-003-0296-9, 12712266.
8. Pucihar G, Kotnik T, Valic B, Miklavcic D. Numerical determination of transmembrane voltage induced on irregularly shaped cells. Annals Biomed Eng 2006, 34:642-652.
9. Corovic S, Zupanic A, Kranjc S, Al Sakere B, Leroy-Willig A, Mir LM, Miklavcic D. The influence of skeletal muscle anisotropy on electroporation: in vivo study and numerical modeling. Med Biol Eng Comput 2010, 48:637-648. 10.1007/s11517-010-0614-1, 2886894, 20424926.
10. Prud'homme GJ, Glinka Y, Khan AS, Draghia-Akli R. Electroporation enhanced nonviral gene transfer for the prevention or treatment of immunological, endocrine and neoplastic diseases. Curr Gene Ther 2006, 6:243-273. 10.2174/156652306776359504, 16611045.
11. Miklavcic D, Beravs K, Semrov D, Cemazar M, Demsar F, Sersa G. The importance of electric field distribution for effective in vivo electroporation of tissues. Biophys J 1998, 74:2152-2158. 10.1016/S0006-3495(98)77924-X, 1299558, 9591642.
12. Kotnik T, Bobanovic F, Miklavcic D. Sensitivity of transmembrane voltage induced by applied electric fields - a theoretical analysis. Bioelectrochem Bioenerg 1997, 43:285-291.
13. Miklavcic D, Corovic S, Pucihar G, Pavselj N. Importance of tumour coverage by sufficiently high local electric field for effective electrochemotherapy. Eur J Cancer 2006, 4(Suppl):45-51.
14. Rols MP, Teissié J. Electropermeabilization of mammalian cells, Quantitative analysis of the phenomenon. Biophys J 1990, 58(5):1089-1098. 10.1016/S0006-3495(90)82451-6, 1281055, 2291935.
15. Miklavcic D, Semrov D, Mekid H, Mir LM. A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy. Biochim Biophys Acta 2000, 1523:73-83. 10.1016/S0304-4165(00)00101-X, 11099860.
16. Corovic S, Mir LM, Miklavcic D. In vivo muscle electroporation threshold determination: realistic numerical models and in vivo experiments. J Membrane Biol 2012, 245:509-520.
17. Davalos RV, Mir LM, Rubinsky B. Tissue ablation with irreversible electroporation. Ann Biomed Eng 2005, 33:223. 10.1007/s10439-005-8981-8, 15771276.
18. Rubinsky J, Onik G, Mikus P, Rubinsky B. Optimal parameters for the destruction of prostate cancer using irreversible electroporation. J Urol 2008, 180:2668-2674. 10.1016/j.juro.2008.08.003, 18951581.
19. Al-Sakere B, Andre F, Bernat C, Connault E, Opolon P, Davalos RV, Rubinsky B, Mir LM. Tumor ablation with irreversible electroporation. PlosOne 2007, 2:1135.
20. Vorobiev E, Lebovka N. Electrotechnologies for Extraction from Food Plants and Biomaterials 2008, New York: Springer Science.
21. Sack M, Sigler J, Frenzel S, Chr E, Arnold J, Michelberger T, Frey W, Attmann F, Stukenbrock L, Mueller G. Research on Industrial-Scale Electroporation Devices Fostering the Extraction of Substances from Biological Tissue. Food Eng Rev 2010, 2:147-156.
22. Cemazar M, Tamzali Y, Sersa G, Tozon N, Mir LM, Miklavcic D, Lowe R, Teissie J. Electrochemotherapy in veterinary oncology. J Vet Intern Med 2008, 22(4):826-831. 10.1111/j.1939-1676.2008.0117.x, 18537879.
23. Testori A, Tosti G, Martinoli C, Spadola G, Cataldo F, Verrecchia F, Baldini F, Mosconi M, Soteldo J, Tedeschi I, Passoni C, Pari C, Di Pietro A, Ferrucci PF. Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach. Dermatol Ther 2010, 23(6):651-661. 10.1111/j.1529-8019.2010.01370.x, 21054709.
24. Cemazar M, Jarm T, Sersa G. Cancer electrogene therapy with interleukin-12. Curr Gene Ther 2010, 10(4):300-311. 10.2174/156652310791823425, 20560875.
25. Heller LC, Heller R. Electroporation gene therapy preclinical and clinical trials for melanoma. Curr Gene Ther 2010, 10(4):312-317. 10.2174/156652310791823489, 20557286.
26. Neal RE, Rossmeisl JH, Garcia PA, Lantz O, Henao-Guerrero N, Davalos RV. Successful treatment of a large soft-tissue sarcoma with irreversible electroporation. J Clin Oncol 2011, 29(13):372-377.
27. Sersa G, Cufer T, Paulin Kosir S, Cemazar M, Snoj M. Electrochemotherapy of chest wall breast cancer recurrence. Cancer Treat Rev 2012, 38(5):379-386. 10.1016/j.ctrv.2011.07.006, 21856080.
28. Morales-de La Peña M, Elez-Martínez P, Martín-Belloso O. Food preservation by pulsed electric fields: an engineering perspective. Food Eng Rev 2011, 3:94-107.
29. Rieder A, Schwartz T, Schön-Hölz K, Marten SM, Süß J, Gusbeth C, Kohnen W, Swoboda W, Obst U, Frey W. Molecular monitoring of inactivation efficiencies of bacteria during pulsed electric field (PEF) treatment of clinical wastewater. J Appl Microbiol 2008, 105:2035-2045. 10.1111/j.1365-2672.2008.03972.x, 19120649.
30. Campana LG, Valpione S, Mocellin S, Sundararajan R, Granziera E, Sartore L, Chiarion-Sileni V, Rossi CR. Electrochemotherapy for disseminated superficial metastases from malignant melanoma. BJS 2012, 99:821-830.
31. Pech M, Janitzky A, Wendler JJ, Strang C, Blaschke S, Dudeck O, Ricke J, Liehr UB. Irreversible electroporation of renal cell carcinoma: a first-in-man phase I clinical study. Cardiovasc Intervent Radiol 2011, 34(1):132-138. 10.1007/s00270-010-9964-1, 20711837.
32. Onik G, Rubinsky B. Irreversible electroporation: First patient experience-Focal therapy of prostate cancer. Irreversible Electroporation 2010, 235-247. Heidelberg, Germany: Springer Berlin, Rubinsky B.
33. Daud AI, DeConti RC, Andrews S, Urbas P, Riker AI, Sondak VK, Munster PN, Sullivan DM, Ugen KE, Messina JL, Heller R. Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma. J Clin Oncol 2008, 26:896-903.
34. Ahmad S, Casey G, Sweeney P, Tangney M, O'Sullivan GC. Optimized electroporation mediated DNA vaccination for treatment of prostate cancer. Genet Vaccines Ther 2010, 8:1. 10.1186/1479-0556-8-1, 2829554, 20181099.
35. Mir LM. Bases and rationale of the electrochemotherapy. EJC 2006, 4(Suppl):38-44.
36. Campana LG, Mocellin S, Basso M, Puccetti O, De Salvo GL, Chiarion-Sileni V, Vecchiato A, Corti L, Rossi CR, Nitti D. Bleomycin-based electrochemotherapy: clinical outcome from a single institution's experience with 52 patients. Ann Surg Oncol 2009, 16(1):191-199. 10.1245/s10434-008-0204-8, 18987914.
37. Matthiessen LW, Chalmers RL, Sainsbury DC, Veeramani S, Kessell G, Humphreys AC, Bond JE, Muir T, Gehl J. Management of cutaneous metastases using electrochemotherapy. Acta Oncol 2011, 50(5):621-629. 10.3109/0284186X.2011.573626, 3130997, 21574833.
38. Gargiulo M, Papa A, Capasso P, Moio M, Cubicciotti E, Parascandolo S. Electrochemotherapy for non-melanoma head and neck cancers: clinical outcomes in 25 patients. Ann Surg 2012, 255(6):1158-1164. 10.1097/SLA.0b013e31824f68b2, 22549747.
39. Miklavcic D, Snoj M, Zupanic A, Kos B, Cemazar M, Kropivnik M, Bracko M, Pecnik T, Gadzijev E, Sersa G. Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy. Biomed Eng Online 2010, 9:10. 10.1186/1475-925X-9-10, 2843684, 20178589.
40. Edhemovic I, Gadzijev EM, Brecelj E, Miklavcic D, Kos B, Zupanic A, Mali B, Jarm T, Pavliha D, Marcan M, Gasljevic G, Gorjup V, Music M, Pecnik Vavpotic T, Cemazar M, Snoj M, Sersa G. Electrochemotherapy: A new technological approach in treatment of metastases in the liver. Technol Cancer Res Treat 2011, 10:475-485.
41. Corovic S, Al-Sakere B, Haddad V, Miklavcic D, Mir LM. Importance of contact surface between electrodes and treated tissue in electrochemotherapy. Technol Cancer Res Treat 2008, 7:393-400.
42. Ivorra A, Al-Sakere B, Rubinsky B, Mir LM. Use of conductive gels for electric field homogenization increases the antitumor efficacy of electroporation therapies. Phys Med Biol 2008, 53:6605-6618. 10.1088/0031-9155/53/22/020, 18978447.
43. Kos B, Zupanic A, Kotnik T, Snoj M, Sersa G, Miklavcic D. Robustness of treatment planning for electrochemotherapy of deep-seated tumors. J Membrane Biol 2010, 236:147-153.
44. Pavliha D, Kos B, Zupanic A, Marcan M, Sersa G, Miklavcic D. Patient-specific treatment planning of electrochemotherapy: Procedure design and possible pitfalls. Bioelectrochemistry 2012, 87:265-273.
45. Fini M, Tschon M, Alberghini M, Bianchi G, Mercuri M, Campanacci L, Cavani F, Ronchetti M, De Terlizzi F, Cadossi R. Cell electroporation in bone tissue. Clinical aspects of electroporation 2011, 115-127. New York: Springer, Kee ST, Gehl J, Lee EW.
46. Agerholm-Larsen B, Iversen HK, Ibsen P, Moller JM, Mahmood F, Jensen KS, Gehl J. Preclinical validation of electrochemotherapy as an effective treatment for brain tumors. Cancer Res 2011, 71(11):3753-3762. 10.1158/0008-5472.CAN-11-0451, 21507935.
47. Garcia PA, Pancotto T, Rossmeisl JH, Henao-Guerrero N, Gustafson NR, Daniel GB, Robertson JL, Ellis TL, Davalos RV. Non-Thermal Irreversible Electroporation (N-TIRE) and Adjuvant Fractionated Radiotherapeutic Multimodal Therapy for Intracranial Malignant Glioma in a Canine Patient. Technol Cancer Res Treat 2011, 10:73-83.
48. Corovic S, Zupanic A, Miklavcic D. Numerical modeling and optimization of electric field distribution in subcutaneous tumor treated with electrochemotherapy using needle electrodes. IEEE T Plasma Sci 2008, 36:1665-1672.
49. Zupanic A, Corovic S, Miklavcic D. Optimization of electrode position and electric pulse amplitude in electrochemotherapy. Radiol Oncol 2008, 42:93-101.
50. Zupanic A, Corovic S, Miklavcic D, Pavlin M. Numerical optimization of gene electrotransfer into muscle tissue. Biomed Eng Online 2010, 9:66. 10.1186/1475-925X-9-66, 2990758, 21050435.
51. Zupanic A, Miklavcic D. Optimization and numerical modeling in irreversible electroporation treatment planning. Irreversible Electroporation 2010, 203-222. Heidelberg: Springer, Rubinsky B.
52. Neal RE, Garcia PA, Robertson JL, Davalos RV. Experimental characterization and numerical modeling of tissue electrical conductivity during pulsed electric fields for irreversible electroporation treatment planning. IEEE T Biomed Eng 2012, 59(4):1077-1085.
53. Garcia PA, Rossmeisl JH, Neal RE, Ellis TL, Olson JD, Henao-Guerrero N, Robertson J, Davalos RV. Intracranial Nonthermal Irreversible Electroporation: In Vivo Analysis. J Membr Biol 2010, 236:127-136. 10.1007/s00232-010-9284-z, 20668843.
54. Mahmood F, Gehl J. Optimizing clinical performance and geometrical robustness of a new electrode device for intracranial tumor electroporation. Bioelectrochemistry 2011, 81:10-16. 10.1016/j.bioelechem.2010.12.002, 21256816.
55. Zupanic A, Kos B, Miklavcic D. Treatment planning of electroporation-based medical interventions: electrochemotherapy, gene electrotransfer and irreversible electroporation. Phys Med Biol 2012, 57:5425-5440. 10.1088/0031-9155/57/17/5425, 22864181.
56. Cukjati D, Batiuskaite D, André F, Miklavčič D, Mir LM. Real time electroporation control for accurate and safe in vivo non-viral gene therapy. Bioelectrochemistry 2007, 70:501-507. 10.1016/j.bioelechem.2006.11.001, 17258942.
57. Essone Mezeme M, Pucihar G, Pavlin M, Brosseau C, Miklavcic D. A numerical analysis of multicellular environment for modeling tissue electroporation. Appl Phys Lett 2012, 100:143701.
58. Sel D, Cukjati D, Batiuskaite D, Slivnik T, Mir LM, Miklavcic D. Sequential finite element model of tissue electropermeabilization. IEEE Trans Biomed Eng 2005, 52:816-27. 10.1109/TBME.2005.845212, 15887531.
59. Pavselj N, Bregar Z, Cukjati D, Batiuskaite D, Mir LM, Miklavcic D. The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals. IEEE Trans Biomed Eng 2005, 52:1373. 10.1109/TBME.2005.851524, 16119232.
60. Gresovnik I. A General Purpose Computational Shell for Solving Inverse and Optimisation Problems - Applications to Metal Forming Processes 2000, PhD Thesis: University of Wales Swansea, UK.
61. Center for Computational Continuum Mechanics (Ljubljana, Slovenia) [http://www.c3m.si].
62. Lackovic I, Magjarevic R, Miklavcic D. Incorporating Electroporation-related conductivity changes into models for the calculation of the electric field distribution in tissue. Proceedings of IFMBE (XII Mediterranean Conference on Medical and Biological Engineering and Computing) 2010, 695-698. Berlin Heidelberg: Springer, Magjarevic R, Bamidis Panagiotis D, Pallikarakis N.
63. Giavazzi S, Ganatea MF, Trkov M, Sustarsic P, Rodic T. Inverse determination of viscoelastic properties of human fingertip skin. Materials and Geoenvironment 2010, 57:1-16.
64. Korelc J. AceGEN (Multi-language, Multi-environment Numerical Code Generation) - Users manual 2009, [http://www.fgg.uni-lj.si/symech/].
65. Korelc J. AceFEM ((The Mathematica Finite Element Environment) - Users manual 2009, [http://www.fgg.uni-lj.si/symech/].
66. Korelc J. Automation of primal and sensitivity analysis of transient coupled problems. Comput Mech 2009, 44:631-649.
67. Haemmerich D, Staelin ST, Stai JZ, Tungjitkusolmun S, Mahvi DM, Webster JG. In vivo electrical conductivity of hepatic tumours. Physiol Meas 2003, 24:251-260. 10.1088/0967-3334/24/2/302, 12812412.
68. Gabriel C, Peyman A, Grant EH. Electrical conductivity of tissue at frequencies below 1 MHz. Phys Med Biol 2009, 54:4863-4878. 10.1088/0031-9155/54/16/002, 19636081.
69. Pavselj N, Miklavcic D. A numerical model of permeabilized skin with local transport regions. IEEE T Biomed Eng 2008, 55:1927-1930.
70. Corovic S, Pavlin M, Miklavcic D. Analytical and numerical quantification and comparison of the local electric field in the tissue for different electrode configurations. Biomed Eng Online 2007, 6:37. 10.1186/1475-925X-6-37, 2100058, 17937793.