Experimental characterization and numerical modeling of tissue electrical conductivity during pulsed electric fields for irreversible electroporation treatment planning

IEEE Transactions on Biomedical Engineering

Volumn 59, Issue 4, 2012, Pages 1076-1085

  Neal II, Robert E ^a   Garcia, Paulo A ^a   Robertson, John L ^a   Davalos, Rafael V ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Bioimpedance; cancer therapy; electrochemotherapy; nonthermal focal tumor ablation

Indexed keywords

BIO-IMPEDANCE; CANCER THERAPY; DEGREE OF CHANGE; ELECTRIC FIELD DISTRIBUTIONS; ELECTRIC PULSE; ELECTRICAL CONDUCTIVITY; ELECTROCHEMOTHERAPY; ELECTROPORATION; EQUIVALENT CIRCUIT MODEL; EX-VIVO; EXPERIMENTAL CHARACTERIZATION; HUMAN KIDNEY; NONTHERMAL; NONTHERMAL MECHANISM; NUMERICAL MODELING; POTENTIAL METHODS; PULSE LENGTH; PULSE PROTOCOL; PULSED ELECTRIC FIELD; SINGLE PULSE; THERAPY PLANNING; TISSUE PROPERTIES; TREATMENT EFFECTS; TREATMENT PLANNING; VOLUMETRIC MESH;

CELL MEMBRANES; CYTOLOGY; ELECTRIC CONDUCTIVITY; NUMERICAL MODELS; TUMORS;

ELECTRIC FIELDS;

ABLATION THERAPY; ANIMAL TISSUE; ARTICLE; CANCER THERAPY; CELL MEMBRANE; COMPUTER ASSISTED TOMOGRAPHY; ELECTRIC CONDUCTIVITY; ELECTRIC FIELD; ELECTROCHEMOTHERAPY; ELECTROPORATION; FINITE ELEMENT ANALYSIS; HUMAN; IMAGE RECONSTRUCTION; IMPEDANCE; KIDNEY; MATHEMATICAL MODEL; NONHUMAN; NONTHERMAL FOCAL TUMOR ABLATION; PREDICTION; SWINE; TEMPERATURE; THERMAL ANALYSIS; THERMAL CONDUCTIVITY; THREE DIMENSIONAL IMAGING; TISSUES; TREATMENT PLANNING;

ANIMALS; CELL MEMBRANE PERMEABILITY; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC CONDUCTIVITY; ELECTROMAGNETIC FIELDS; ELECTROPORATION; KIDNEY; MODELS, BIOLOGICAL; RADIATION DOSAGE; SWINE;

EID: 84858980576     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2012.2182994     Document Type: Article

References (50)

1. R. Davalos, L. Mir, and B. Rubinsky, "Tissue ablation with irreversible electroporation," Ann. Biomed. Eng., vol. 33, pp. 223-231, 2005.
2. B. Al-Sakere, F. André, C. Bernat, E. Connault, P. Opolon, R. V. Davalos, B. Rubinsky, and L. M. Mir, "Tumor ablation with irreversible electroporation,"PLoS ONE, vol. 2, p. e1135, 2007.
3. J. F. Edd, L. Horowitz, R. V. Davalos, L. M. Mir, and B. Rubinsky, "In vivo results of a new focal tissue ablation technique: Irreversible electroporation," IEEE Trans. Biomed. Eng., vol. 53, no. 7, pp. 1409-1415, Jul. 2006. (Pubitemid 44172315)
4. J. C. Weaver, "Electroporation: A general phenomenon for manipulating cells and tissue," J. Cell. Biochem., vol. 51, pp. 426-435, 1993.
5. G. Onik, P. Mikus, and B. Rubinsky, "Irreversible Electroporation: Implications for Prostate Ablation," Technol. Cancer Res. Treat, vol. 6, pp. 295-300, 2007. (Pubitemid 47340121)
6. D. Miklavcic, D. Semrov, H. Mekid, and L. M. Mir, "A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy," Biochimica et Biophysica Acta, vol. 1523, pp. 73-83, 2000.
7. R. E. Neal II, J. H. Rossmeisl Jr, P. A. Garcia, O. I. Lanz, N. Henao- Guerrero, and R. V. Davalos, "Successful treatment of a large soft tissue sarcoma with irreversible electroporation," J. Clin. Oncol., vol. 14, p. 14, 2011.
8. B. Rubinsky, G. Onik, and P. Mikus, "Irreversible electroporation: A new ablation modality-clinical implications," Technol. Cancer Res. Treat, vol. 6, pp. 37-48, 2007. (Pubitemid 46389347)
9. E. W. Lee, C. T. Loh, and S. T. Kee, "Imaging guided percutaneous irreversible electroporation: Ultrasound and immunohistological correlation,"Tech. Cancer Res. Treat, vol. 6, pp. 287-293, 2007.
10. L. M. Mir and S. Orlowski, "Mechanisms of electrochemotherapy," Adv. Drug. Deliv. Rev., vol. 35, pp. 107-118, 1999.
11. R. E. Neal, II, R. Singh, H. C. Hatcher, N. D. Kock, S. V. Torti, and R. V. Davalos, "Treatment of breast cancer through the application of irreversible electroporation using a novelminimally invasive single needle electrode," Breast Cancer Res. Treat, vol. 123, pp. 295-301, Aug. 2010.
12. P. A. Garcia, T. Pancotto, J. H. Rossmeisl Jr, N. Henao-Guerrero, N. R. Gustafson, G. B. Daniel, J. L. Robertson, T. L. Ellis, and R. V. Davalos, "Non-thermal irreversible electroporation (N-TIRE) and adjuvant fractionated radiotherapeutic multimodal therapy for intracranial malignant glioma in a canine patient," Technol. Cancer Res. Treat., vol. 10, pp. 73-83, 2011.
13. K. R. Thomson, W. Cheung, S. J. Ellis, D. Federman, H. Kavnoudias, D. Loader-Oliver, S. Roberts, P. Evans, C. Ball, andA.Haydon, "Investigation of the safety of irreversible electroporation in humans," J. Vascular Interv. Radiol., vol. 22, pp. 611-621, 2011.
14. B. Kos, A. Zupanic, T. Kotnik, M. Snoj, G. Sersa, and D. Miklavcic, "Robustness of treatment planning for electrochemotherapy of deep-seated tumors," J. Membrane Biol., vol. 236, pp. 147-153, 2010.
15. R. E. Neal, 2nd, and R. V. Davalos, "The feasibility of irreversible electroporation for the treatment of breast cancer and other heterogeneous systems," Ann. Biomed. Eng., vol. 37, pp. 2615-2625, 2009.
16. J. F. Edd and R. V. Davalos, "Mathematical modeling of irreversible electroporation for treatment planning," Technol. Cancer Res. Treat, vol. 6, pp. 275-286, 2007.
17. C. Daniels and B. Rubinsky, "Electrical field and temperature model of nonthermal irreversible electroporation in heterogeneous tissues," J. Biomech. Eng., vol. 131, p. 071006, 2009.
18. F. A. Duck, Physical Properties of Tissue: A Comprehensive Reference Book. New York: Academic, 1990.
19. R. C. Lee, D. Zhang, and J. Hannig, "Biophysical injury mechanisms in electrical shock trauma," Annu. Rev. Biomed. Eng., vol. 2, pp. 477-509, 2000.
20. L. F. Cima and L. M. Mir, "Macroscopic characterization of cell electroporation in biological tissue based on electrical measurements," Appl. Phys. Lett., vol. 85, pp. 4520-4522, Nov. 2004.
21. R. V. Davalos, B. Rubinsky, and D. M. Otten, "A feasibility study for electrical impedance tomography as a means to monitor tissue electroporation for molecular medicine," IEEE Trans. Biomed. Eng., vol. 49, no. 4, pp. 400-403, Apr. 2002. (Pubitemid 34241399)
22. M. Kranjc, F. Bajd, I. Sersa, and D. Miklavcic, "Magnetic resonance electrical impedance tomography for monitoring electric field distribution during tissue electroporation," IEEE Trans. Med. Imag., vol. 30, no. 10, pp. 1771-1778, Oct. 2011.
23. D. Sel, D. Cukjati, D. Batiuskaite, T. Slivnik, L. M. Mir, and D. Miklavcic, "Sequential finite elementmodel of tissue electropermeabilization," IEEE Trans. Biomed. Eng., vol. 52, no. 5, pp. 816-827, May 2005. (Pubitemid 40675481)
24. N. Pavselj, Z. Bregar, D. Cukjati, D. Batiuskaite, L. M. Mir, and D. Miklavcic, "The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals," IEEE Trans. Biomed. Eng., vol. 52, no. 8, pp. 1373-1381, Aug. 2005. (Pubitemid 41169530)
25. A. Ivorra and B. Rubinsky, "In vivo electrical impedance measurements during and after electroporation of rat liver," Bioelectrochemistry, vol. 70, pp. 287-295, May 2007. (Pubitemid 46507979)
26. A. Ivorra, B. Al-Sakere, B. Rubinsky, and L. M. Mir, "In vivo electrical conductivity measurements during and after tumor electroporation: Conductivity changes reflect the treatment outcome," Phys. Med. Biol., vol. 54, pp. 5949-5963, Sep. 17, 2009.
27. R. V. Davalos and B. Rubinsky, "Temperature considerations during irreversible electroporation," Int. J. Heat Mass Transfer, vol. 51, pp. 5617-5622, 2008.
28. P. A. Garcia, J. H. Rossmeisl, Jr., R. E. Neal, II, T. L. Ellis, and R. V. Davalos, "A parametric study delineating irreversible electroporation from thermal damage based on a minimally invasive intracranial procedure,"Biomed. Eng. Online, vol. 10, p. 34, 2011.
29. R. E. Neal II, PauloA. Garcia, L. Robertson John, and R. V. Davalos, "Experimental characterization of intrapulse tissue conductivity changes for electroporation," in presented at the Engineering in Medicine and Biology Society Annual Int. Conf. of the IEEE, Boston, MA, 2011.
30. A. Ivorra, "Tissue electroporation as a bioelectric phenomenon: Basic concepts," in Irreversible Electroporation, B. Rubinsky, Ed. Berlin, Geramny: Springer, 2010, pp. 23-61.
31. S. Grimnes and O. G. Martinsen, "Clinical applications," in Bioimpedance and Bioelectricity Basics, 2nd ed. New York, NY: Elsevier, 2008.
32. A. Ivorra, J. Villemejane, and L. M. Mir, "Electrical modeling of the influence of medium conductivity on electroporation," Phys. Chem. Chem. Phys., vol. 12, pp. 10055-10064, Jun. 28, 2010.
33. H. Fricke, "A mathematical treatment of the electric conductivity and capacity of disperse systems: I. The electric conductivity of a suspension of homogeneous spheroids," Phys. Rev., vol. 24, p. 575, 1924.
34. Axel T. Esser, Kyle C. Smith, Thiravallur R. Gowrishankar, and J. C. Weaver, "Towards solid tumor treatment by irreversible electroporation: Intrinsic redistribution of fields and currents in tissue," Technol. Cancer Res. Treatment, vol. 6, pp. 261-273, 2007.
35. J. Kyber, H. Hansgen, and F. Pliquett, "Dielectric properties of biological tissue at low temperatures demonstrated on fatty tissue," Phys.Med. Biol., vol. 37, pp. 1675-1688, 1992.
36. M. A. Stuchly, T. W. Athey, G. M. Samaras, and G. E. Taylor, "Measurement of radio frequency permittivity of biological tissues with an open-ended coaxial line: Part II-Experimental results," IEEE Trans. Microw. Theory Tech., vol. 30, no. 1, pp. 87-92, Jan. 1982.
37. A. V. Mudaliar, B. E. Ellis, P. L. Ricketts, O. I. Lanz, C. Y. Lee, T. E. Diller, and E. P. Scott, "Noninvasive blood perfusion measurements of an isolated rat liver and an anesthetized rat kidney," J. Biomech. Eng., vol. 130, p. 061013, 2008.
38. J. Werner and M. Buse, "Temperature profiles with respect to inhomogeneity and geometry of the human body," J. Appl. Physiol, vol. 65, pp. 1110-1118, 1988.
39. K. Osswald, "Messung der leitfahigkeit und dielektrizitatkonstante biologischer gewebe und flussigkeiten beikurzen wellen hochfrequenz tech,"Elektroakustik, vol. 49, pp. 40-49, 1937.
40. H. R. Middlekauff, E. U. Nitzsche, A. H. Nguyen, C. K. Hoh, and G. G. Gibbs, "Modulation of renal cortical blood flow during static exercise in humans," Circ. Res., vol. 80, pp. 62-68, Jan. 1, 1997.
41. K. R. Foster and H. P. Schwan, "Dielectric properties of tissues and biological materials: A critical review," Crit. Rev. Biomed. Eng., vol. 17, pp. 25-104, 1989.
42. S. A. Sapareto, "Thermal dose determination in cancer therapy," Radiation Oncol., vol. 10, pp. 787-795, 1984.
43. P. Garcia, J. H. Rossmeisl Jr, R. E. Neal II, T. L. Ellis, J. D. Olson, N. Henao-Guerrero, J. Robertson, and R. V. Davalos, "Intracranial nonthermal irreversible electroporation: In vivo analysis," J. Membr. Biol., vol. 236, pp. 127-136, 2010.
44. G. Sersa, T. Jarm, T. Kotnik, A. Coer, M. Podkrajsek, M. Sentjurc, D. Miklavcic, M. Kadivec, S. Kranjc, A. Secerov, and M. Cemazar, "Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcoma," Br. J. Cancer, vol. 98, pp. 388-398, 2008. (Pubitemid 351161255)
45. A. Surowiec, S. S. Stuchly, and A. Swarup, "Radiofrequency dielectric properties of animal tissues as a function of time following death," Phys. Med. Biol., vol. 30, pp. 1131-1141, 1985. (Pubitemid 15244089)
46. A. Surowiec, S. S. Stuchly, M. Keaney, and A. Swarup, "In vivo and in vitro dielectric properties of feline tissues at low radiofrequencies," Phys. Med. Biol., vol. 31, pp. 901-909, 1986. (Pubitemid 16012116)
47. T. W. Athey, M. A. Stuchly, and S. S. Stuchly, "Measurement of radio frequency permittivity of biological tissues with an open-ended coaxial line: Part I," IEEE Trans. Microw. Theory Tech., vol. 30, no. 1, pp. 82-86, Jan. 1982.
48. R. D. Stoy, K. R. Foster, and H. P. Schwan, "Dielectric properties of mammalian tissues from 0.1 to 100 MHz: A summary of recent data,"Phys. Med. Biol., vol. 27, pp. 501-513, 1982.
49. U. Pliquett, R. P. Joshi,V. Sridhara, and K. H. Schoenbach, "High electrical field effects on cell membranes," Bioelectrochemistry, vol. 70, pp. 275-282, Oct. 18, 2007.
50. A. Ivorra, L. M. Mir, and B. Rubinsky, "Electric field redistribution due to conductivity changes during tissue electroporation: Experiments with a simple vegetal model," in IFMBE Proceedings-World Congress on Medical Physics and Biomedical Engineering, vol. 25. Heidelberg: Springer, 2009, pp. 59-62.