Novel quinazolinone derivatives: Synthesis and antimicrobial activity

Medicinal Chemistry Research

Volumn 22, Issue 2, 2013, Pages 507-519

  Habib, Osman M O ^a   Hassan, Hussein M ^a   El Mekabaty, Ahmed ^a  

^a Mansoura University   (Egypt)

Author keywords

Antimicrobial activity; Benzoxazinone; Quinazolinone; Tetrazole; Thiazolidinone

Indexed keywords

4 (3 (2 METHYL 4 OXOQUINAZOLIN 3(4H) YL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PHENYL 4 METHYLBENZENESULFONATE; 4 (3 (4 (3 (4 METHOXYPHENYL)ACRYLOYL)PHENYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL) PHENYL 4 METHYLBENZENESULFONATE; 4 (3 (4 (5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL)PHENYL) 4 OXO 3,4 DIHYDRO QUINAZOLIN 2 YL)PHENYL 4 METHYLBENZENESULFONATE; 4 (3 (4 ACETYLPHENYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PHENYL 4 METHYLBENZENESULFONATE; 4 (3 (4 AMINO PHENYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PHENYL 4 METHYLBENZENESULFONATE; 4 (3 (4 CHLOROPHENYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PHENYL 4 METHYLBENZENESULFONATE; 4 (3 (4 CINNAMOYLPHENYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PHENYL 4 METHYLBENZENESULFONATE; 4 (3 (4 METHOXYPHENYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PHENYL 4 METHYLBENZENESULFONATE; 4 (3 (BENZO[D] THIAZOL 2 YL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL) PHENYL 4 METHYLBENZENESULFONATE; 4 (3 PHENYL 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PHENL 4 METHYLBENZENESULFONATE; 4 (4 BENZO[4,5]IMIDAZOL[1,2 C]QUINAZOLINE 6 YL)PHENYL 4 METHYLBENZENESULFONATE; 4 (4 OXO 2 (4 (TOSYLOXY)PHENYL) QUINAZOLIN 3(4H) YL) BENZOIC ACID; 4 (4 OXO 3 (4 (3 (4 TOLYL)ACRYLOYL)PHENYL) 3,4 DIHYDROQUINAZOLIN 2 YL)PHENYL 4 METHYLBENZENESULFONATE; 4 (4 OXO 3 (4 (5 (4 TOLYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL)PHENYL) 3,4 DIHYDROQUINAZOLIN 2 YL)PHENYL 4 METHYLBENZENESULFONATE; 4 (4 OXO 3 (4 (5 PHENYL 4,5 DIHYDRO 1H PYRAZOL 3 YL)PHENYL) 3,4 DIHYDROQUINAZOLIN 2 YL) PHENYL 4 METHYLBENZENESULFONATE; 4 [(2 (1H BENZO[D]IMIDAZOL 2 YL)PHENYL)CARBAMOYL]PHENYL 4 METHYLBENZENESULFONATE; 4 [4 OXO 3 (5 OXO 4 PHENYLAZO 4,5 DIHYDRO 1H PYRAZOL 3 YL) 3,4 DIHYDROQUINAZOLIN 2 YL] PHENYL 4 METHYLBENZENESULFONATE; ANTHRANILIC ACID; ANTIINFECTIVE AGENT; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

AGAR DIFFUSION; ANTIMICROBIAL ACTIVITY; ASPERGILLUS FUMIGATUS; CONFERENCE PAPER; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGAL STRAIN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; STRUCTURE ACTIVITY RELATION;

EID: 84873998248     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0079-x     Document Type: Conference Paper

References (17)

1. Bain DI, Smalley RKJ (1968) Chem Soc 13C:1593
2. Bansal E, Ram T, Sharma S, Tyagi M, Archana, Rani P, Bajai K, Tyagi R, Goel B, Srivastava VK, Gurtu JN, Kumar A (2002) Indian J Chem 40B:307
3. Farghaly AM, Chaaban I, Khalil MA, Bekhit AA, Alexandria J (1990) Pharm Sci 4:52
4. Gilmore JL, Hays SJ, Caprathe BW, Lee C, Emmerling MR, Michael W, Jaen JC (1996) Bioorg Med Chem Lett 6:679
5. Gutschow M, Neumann U (1997) Bioorg Med Chem 5:1935
6. Habib OMO, Moawad EB, Badawy DS, Mansour FA (1990) J Prakt Chem 332:791
7. Hays SJ, Caprathe BW, Gilmore JL, Amin N, Emmerling MR, Michael W, Nadimpalli R, Nath R, Raser KJ, Stafford D, Watson D, Wang K, Jaen JCJ (1998) Med Chem 41:1060
8. Kassem TM, Habib OMO, Eissa AI (1982) Bull Natl Res Cent Egypt 7:1
9. Krantz A, Spencer RW, Tam TF, Liak TJ, Copp LJ, Thomas EM, Rafferty SBJ (1990) Med Chem 33:464
10. Pandey VK, Misra D, Shukla A (1994) Indian Drugs 31:532
11. Parkanyi C, Yuan HL, Stroemberg Bo HE, Evenzahav A (1992) J Heterocycl Chem 29(4):749
12. Saxena S, Verma M, Saxena AK, Gupta GP, Shanker K (1991) Indian J Chem 30B:453
13. Shah BR, Bhatt JJ, Patel HH, Undavia NK, Trivedi PB, Desai NC (1995) Indian J Chem 34B:201
14. Shamroukh AH, Zaki MEA, Morsy EMH, Abdel-Motti FM, Abdel-Megeid FME (2007) Arch Pharm Chem Life Sci 340:345-351
15. Shirodkar PY, Vartak Meghana M (2000) Indian J Heterocycl Chem 9:239
16. Wesley JD, Henry EHJ (1956) Am Chem Soc 78:2543
17. Zhou D, Harrison BL, Shah U, Andree TH, Hornby GA, Scerni R, Schechter LE, Smith DL, Sullivan KM, Mewshaw RE (2006) Bioorg Med Chem Lett 16:1338