Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 5, 2006, Pages 1338-1341

  Zhou, Dahui ^a   Harrison, Boyd L ^a   Shah, Uresh ^a   Andree, Terrance H ^a   Hornby, Geoffrey A ^a   Scerni, Rosemary ^a   Schechter, Lee E ^a   Smith, Deborah L ^a   Sullivan, Kelly M ^a   Mewshaw, Richard E ^a  

^a PFIZER INC   (United States)

Author keywords

5 HT1A receptor; Antidepressants; Serotonin transporter

Indexed keywords

3 INDOLETETRAHYDROPIRIDINE; 3,4 DIHYDRO 2H BENZO[1,4]OXAZINE DERIVATIVE; ANTIDEPRESSANT AGENT; BENZOXAZINE 3 INDOLEALKYLAMINE DERIVATIVE; BENZOXAZINE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BENZOXAZINES; HUMANS; MOLECULAR STRUCTURE; RATS; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 31344468111     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.054     Document Type: Article

References (22)

1. P. Blier, and R. Bergerpm J. Clin. Psychiat. 1998 16
2. D.S. Kreiss, and I. Lucki J. Pharmacol. Exp. Ther. 274 1995 219
3. S. Hjorth, and S.B. Auerbach Behav. Brain Res. 73 1996 281
4. L. Romero, N. Bel, J.M. Casanovas, and F. Artigas Int. Clin. Psychopharmacol. 11 1996 1
5. S. Hjorth, D. Westlin, and H.J. Bengtsson Neuropharmacology 36 1997 461
6. L.A. Dawson, D.L. Nguyen, and L.E. Schechter J. Psychopharacol. 16 2002 145
7. F. Artigas, V. Perez, and E. Alvarez Arch. Gen. Psychiat. 51 1994 248
8. P. Blier, and R. Bergeron J. Clin. Psychopharmacol. 15 1995 217
9. J. Martinez-Esparza, A.M. Oficialdegui, S. Perez-Silanes, B. Heras, L. Orus, J.A. Palop, B. Lasheras, J. Roca, M. Mourelle, A. Bosch, J.C. Del Castillo, R. Tordera, J. Del Rio, and A. Monge J. Med. Chem. 44 2001 418
10. K. Takeuchi, T.J. kohn, N.A. Honigschmidt, V.P. Rocco, P.G. Spinazze, D.J. Koch, S.T. Atkinsion, L.W. Hertel, D.L. Nelson, D.B. Wainscott, L.J. Ahmad, J. Shaw, P.G. Threlkeld, and D.T. Wong Bioorg. Med. Chem. Lett. 13 2003 2393
11. V.P. Rocco, P.G. Spinazze, T.J. Kohn, N.A. Honigschmidt, D.L. Nelson, D.B. Wainscott, L.J. Ahmad, J. Shaw, P.G. Threlkeld, D.T. Wong, and K. Takeuchi Bioorg. Med. Chem. 14 2004 2653
12. R.E. Mewshaw, K.L. Meagher, P. Zhou, D. Zhou, X. Shi, R. Scerni, D.L. Smith, L.E. Schechter, and T.H. Andree Bioorg. Med. Chem. Lett. 12 2002 307
13. R.E. Mewshaw, D. Zhou, P. Zhou, X. Shi, G. Hornby, T. Spangler, R. Scerni, D. Smith, L.E. Schechter, and T.H. Andree J. Med. Chem. 47 2004 3823
14. Kang, Y.; Stack, G. P. U.S. Patent 5,750,724, 1998.
15. Husbands, G. M.; Stack, G, P.; Mewshaw, R. E. U.S. Patent 6,559,169, 2003.
16. S.C. Cheetham, J.A. Viggers, N.A. Slater, D.J. Heal, and W.R. Buckett Neuropharmacology 32 1993 737
17. J. Dunlop, Y. Zhang, D.L. Smith, and L.E. Schechter J. Pharmacol. Toxicol. Methods 40 1998 47
18. S. Larenzo, and N.J. Birdsall Br. J. Pharmacol. 109 1993 1120
19. A. Morrow, and I. Creese Mol. Pharmacol. 29 1986 321
20. For experimental procedures, see US patents: Mewshaw, R. E.; Zhou, D. U.S. Patent 6,221,863, 2001.
21. Mewshaw, R. E.; Shaw, U. U.S. Patent 6,313,114, 2001.
22. S.J. Peroutka, D.C. U'Prichard, D.A. Greenberg, and S.H. Snyder Neuropharmacology 16 1977 549