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Volumn 40, Issue 3, 2013, Pages 426-438

In vivo imaging of induction of heat-shock protein-70 gene expression with fluorescence reflectance imaging and intravital confocal microscopy following brain ischaemia in reporter mice

Author keywords

Hsp 70; In vivo imaging; Molecular imaging; Reporter mice; Stroke

Indexed keywords

FLUORESCENT DYE; GENOMIC DNA; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HSPA1B PROTEIN; MPLUM; UNCLASSIFIED DRUG;

EID: 84873995868     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-012-2277-7     Document Type: Article
Times cited : (13)

References (44)
  • 1
    • 4644278673 scopus 로고    scopus 로고
    • Hsp70 and Hsp90 - A relay team for protein folding
    • 14740253 10.1007/s10254-003-0021-1 1:CAS:528:DC%2BD2cXotFWqtrg%3D
    • Wegele H, Muller L, Buchner J. Hsp70 and Hsp90 - a relay team for protein folding. Rev Physiol Biochem Pharmacol. 2004;151:1-44.
    • (2004) Rev Physiol Biochem Pharmacol , vol.151 , pp. 1-44
    • Wegele, H.1    Muller, L.2    Buchner, J.3
  • 2
    • 0027522356 scopus 로고
    • Cells in stress: Transcriptional activation of heat shock genes
    • 8451637 10.1126/science.8451637 1:CAS:528:DyaK3sXhvVCnt7Y%3D
    • Morimoto RI. Cells in stress: transcriptional activation of heat shock genes. Science. 1993;259:1409-10.
    • (1993) Science , vol.259 , pp. 1409-1410
    • Morimoto, R.I.1
  • 3
    • 84858955425 scopus 로고    scopus 로고
    • Regulation of survival gene hsp70
    • 21874533 10.1007/s12192-011-0290-6 1:CAS:528:DC%2BC3MXhsFOgt7nM
    • Silver JT, Noble EG. Regulation of survival gene hsp70. Cell Stress Chaperones. 2012;17:1-9.
    • (2012) Cell Stress Chaperones , vol.17 , pp. 1-9
    • Silver, J.T.1    Noble, E.G.2
  • 4
    • 0027492357 scopus 로고
    • Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat
    • 8416999 10.1038/jcbfm.1993.13 1:CAS:528:DyaK3sXkt1Grtr4%3D
    • Kinouchi H, Sharp FR, Hill M, Koistinaho J, Sagar SM, Chan PK. Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab. 1993;13:105-15.
    • (1993) J Cereb Blood Flow Metab , vol.13 , pp. 105-115
    • Kinouchi, H.1    Sharp, F.R.2    Hill, M.3    Koistinaho, J.4    Sagar, S.M.5    Chan, P.K.6
  • 5
    • 0031007324 scopus 로고    scopus 로고
    • The heat shock stress response after brain lesions: Induction of 72 kDa heat shock protein (cell types involved, axonal transport, transcriptional regulation) and protein synthesis inhibition
    • 9175159 10.1016/S0301-0082(97)00004-X 1:CAS:528:DyaK2sXjvFehs7g%3D
    • Planas AM, Soriano MA, Estrada A, Sanz O, Martin F, Ferrer I. The heat shock stress response after brain lesions: induction of 72 kDa heat shock protein (cell types involved, axonal transport, transcriptional regulation) and protein synthesis inhibition. Prog Neurobiol. 1997;51:607-36.
    • (1997) Prog Neurobiol , vol.51 , pp. 607-636
    • Planas, A.M.1    Soriano, M.A.2    Estrada, A.3    Sanz, O.4    Martin, F.5    Ferrer, I.6
  • 6
    • 62849087045 scopus 로고    scopus 로고
    • Identification of ischemic regions in a rat model of stroke
    • 19274095 10.1371/journal.pone.0004764
    • Popp A, Jaenisch N, Witte OW, Frahm C. Identification of ischemic regions in a rat model of stroke. PLoS One. 2009;4:e4764.
    • (2009) PLoS One , vol.4 , pp. 4764
    • Popp, A.1    Jaenisch, N.2    Witte, O.W.3    Frahm, C.4
  • 7
    • 0027315657 scopus 로고
    • Stress protein and proto-oncogene expression as indicators of neuronal pathophysiology after ischemia
    • 8332741 10.1016/S0079-6123(08)63267-7 1:CAS:528:DyaK3sXlsFOisrk%3D
    • Nowak Jr TS, Osborne OC, Suga S. Stress protein and proto-oncogene expression as indicators of neuronal pathophysiology after ischemia. Prog Brain Res. 1993;96:195-208.
    • (1993) Prog Brain Res , vol.96 , pp. 195-208
    • Nowak, Jr.T.S.1    Osborne, O.C.2    Suga, S.3
  • 8
    • 0027320667 scopus 로고
    • Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra' following focal cerebral ischemia in the rat
    • 8374789 10.1016/0006-8993(93)91630-B 1:CAS:528:DyaK3sXlslylur0%3D
    • Kinouchi H, Sharp FR, Koistinaho J, Hicks K, Kamii H, Chan PH. Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra' following focal cerebral ischemia in the rat. Brain Res. 1993;619:334-8.
    • (1993) Brain Res , vol.619 , pp. 334-338
    • Kinouchi, H.1    Sharp, F.R.2    Koistinaho, J.3    Hicks, K.4    Kamii, H.5    Chan, P.H.6
  • 9
    • 0028231413 scopus 로고
    • The heat shock/stress response in focal cerebral ischemia
    • 8025704 10.1111/j.1750-3639.1994.tb00812.x
    • Nowak Jr TS, Jacewicz M. The heat shock/stress response in focal cerebral ischemia. Brain Pathol. 1994;4:67-76.
    • (1994) Brain Pathol , vol.4 , pp. 67-76
    • Nowak, Jr.T.S.1    Jacewicz, M.2
  • 10
    • 0030748881 scopus 로고    scopus 로고
    • Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid
    • 9252233 10.1016/S0306-4522(97)00089-4 1:CAS:528:DyaK2sXltFeru7o%3D
    • Sanz O, Estrada A, Ferrer I, Planas AM. Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid. Neuroscience. 1997;80:221-32.
    • (1997) Neuroscience , vol.80 , pp. 221-232
    • Sanz, O.1    Estrada, A.2    Ferrer, I.3    Planas, A.M.4
  • 11
    • 0033964104 scopus 로고    scopus 로고
    • Dynamics of regional brain metabolism and gene expression after middle cerebral artery occlusion in mice
    • 10698068 10.1097/00004647-200002000-00012 1:CAS:528:DC%2BD3cXhs1alur0%3D
    • Hata R, Maeda K, Hermann D, Mies G, Hossmann KA. Dynamics of regional brain metabolism and gene expression after middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab. 2000;20:306-15.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 306-315
    • Hata, R.1    Maeda, K.2    Hermann, D.3    Mies, G.4    Hossmann, K.A.5
  • 12
    • 0034119985 scopus 로고    scopus 로고
    • Evolution of brain infarction after transient focal cerebral ischemia in mice
    • 10894177 10.1097/00004647-200006000-00006 1:STN:280: DC%2BD3czltVKktw%3D%3D
    • Hata R, Maeda K, Hermann D, Mies G, Hossmann KA. Evolution of brain infarction after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2000;20:937-46.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 937-946
    • Hata, R.1    Maeda, K.2    Hermann, D.3    Mies, G.4    Hossmann, K.A.5
  • 13
    • 0028138636 scopus 로고
    • Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats
    • 7929654 10.1038/jcbfm.1994.120 1:STN:280:DyaK2M%2FhsVyisw%3D%3D
    • Heiss WD, Graf R, Wienhard K, Löttgen J, Saito R, Fujita T, et al. Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats. J Cereb Blood Flow Metab. 1994;14:892-902.
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 892-902
    • Heiss, W.D.1    Graf, R.2    Wienhard, K.3    Löttgen, J.4    Saito, R.5    Fujita, T.6
  • 14
    • 0035105629 scopus 로고    scopus 로고
    • Perfusion thresholds in human cerebral ischemia: Historical perspective and therapeutic implications
    • Baron JC. Perfusion thresholds in human cerebral ischemia: historical perspective and therapeutic implications. Cerebrovasc Dis. 2011;11 Suppl 1:2-8.
    • (2011) Cerebrovasc Dis , vol.11 , Issue.SUPPL. 1 , pp. 2-8
    • Baron, J.C.1
  • 15
    • 0242694042 scopus 로고    scopus 로고
    • Beyond mismatch: Evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging
    • 14576370 10.1161/01.STR.0000097608.38779.CC
    • Kidwell CS, Alger JR, Saver JL. Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging. Stroke. 2003;34:2729-35.
    • (2003) Stroke , vol.34 , pp. 2729-2735
    • Kidwell, C.S.1    Alger, J.R.2    Saver, J.L.3
  • 16
    • 79961010354 scopus 로고    scopus 로고
    • Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion
    • 21559030 10.1038/jcbfm.2011.67
    • Robertson CA, McCabe C, Gallagher L, Lopez-Gonzalez Mdel R, Holmes WM, Condon B, et al. Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion. J Cereb Blood Flow Metab. 2011;31:1788-98.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 1788-1798
    • Robertson, C.A.1    McCabe, C.2    Gallagher, L.3    Lopez-Gonzalez Mdel, R.4    Holmes, W.M.5    Condon, B.6
  • 17
    • 0028796917 scopus 로고
    • Expression of the HSP 70.1 gene, a landmark of early zygotic activity in the mouse embryo, is restricted to the first burst of transcription
    • 7867493 1:CAS:528:DyaK2MXjtlentLc%3D
    • Christians E, Campion E, Thompson EM, Renard JP. Expression of the HSP 70.1 gene, a landmark of early zygotic activity in the mouse embryo, is restricted to the first burst of transcription. Development. 1995;121:113-22.
    • (1995) Development , vol.121 , pp. 113-122
    • Christians, E.1    Campion, E.2    Thompson, E.M.3    Renard, J.P.4
  • 18
    • 0036902430 scopus 로고    scopus 로고
    • Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of hydrogen peroxide-induced cell death
    • 12472888 10.1046/j.1471-4159.2002.01230.x 1:CAS:528:DC%2BD3sXjsFKk
    • Fauconneau B, Petegnief V, Sanfeliu C, Piriou A, Planas AM. Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of hydrogen peroxide-induced cell death. J Neurochem. 2002;83:1338-48.
    • (2002) J Neurochem , vol.83 , pp. 1338-1348
    • Fauconneau, B.1    Petegnief, V.2    Sanfeliu, C.3    Piriou, A.4    Planas, A.M.5
  • 19
    • 77949417477 scopus 로고    scopus 로고
    • Genetically-defined deficiency of mannose-binding lectin protects the brain from experimental and clinical stroke
    • 10.1371/journal.pone.0008433
    • Cervera A, Planas AM, Justicia C, Urra X, Jensenius JC, Torres F, et al. Genetically-defined deficiency of mannose-binding lectin protects the brain from experimental and clinical stroke. PloS One. 2009;5(2):e8433.
    • (2009) PloS One , vol.5 , Issue.2 , pp. 8433
    • Cervera, A.1    Planas, A.M.2    Justicia, C.3    Urra, X.4    Jensenius, J.C.5    Torres, F.6
  • 20
    • 84863929636 scopus 로고    scopus 로고
    • Arrhenius analysis of the relationship between hyperthermia and Hsp70 promoter activation: A comparison between ex vivo and in vivo data
    • 22690694 10.3109/02656736.2012.674620 1:CAS:528:DC%2BC38XhtVOjsbbM
    • Deckers R, Debeissat C, Fortin PY, Moonen CT, Couillaud F. Arrhenius analysis of the relationship between hyperthermia and Hsp70 promoter activation: a comparison between ex vivo and in vivo data. Int J Hyperthermia. 2012;28:441-50.
    • (2012) Int J Hyperthermia , vol.28 , pp. 441-450
    • Deckers, R.1    Debeissat, C.2    Fortin, P.Y.3    Moonen, C.T.4    Couillaud, F.5
  • 21
    • 80355129782 scopus 로고    scopus 로고
    • A craniotomy surgery procedure for chronic brain imaging
    • doi: 10.3791/680
    • Mostany R, Portera-Cailliau C. A craniotomy surgery procedure for chronic brain imaging. J Vis Exp. 2008;12. doi: 10.3791/680.
    • (2008) J Vis Exp. , vol.12
    • Mostany, R.1    Portera-Cailliau, C.2
  • 22
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • 11846609 10.1006/meth.2001.1262 1:CAS:528:DC%2BD38XhtFelt7s%3D
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402-8.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 23
    • 44849098941 scopus 로고    scopus 로고
    • The influence of hypoxia on bioluminescence in luciferase-transfected gliosarcoma tumor cells in vitro
    • 18528551 10.1039/b719231b 1:CAS:528:DC%2BD1cXms1CjtLk%3D
    • Moriyama EH, Niedre MJ, Jarvi MT, Mocanu JD, Moriyama Y, Subarsky P, et al. The influence of hypoxia on bioluminescence in luciferase-transfected gliosarcoma tumor cells in vitro. Photochem Photobiol Sci. 2008;7:675-80.
    • (2008) Photochem Photobiol Sci , vol.7 , pp. 675-680
    • Moriyama, E.H.1    Niedre, M.J.2    Jarvi, M.T.3    Mocanu, J.D.4    Moriyama, Y.5    Subarsky, P.6
  • 24
    • 0036846795 scopus 로고    scopus 로고
    • Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain
    • 12390979 10.1093/brain/awf257
    • Schoch HJ, Fischer S, Marti HH. Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain. Brain. 2002;125:2549-57.
    • (2002) Brain , vol.125 , pp. 2549-2557
    • Schoch, H.J.1    Fischer, S.2    Marti, H.H.3
  • 25
    • 15644377983 scopus 로고    scopus 로고
    • Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy
    • 9778256 10.1002/ana.410440403 1:CAS:528:DyaK1cXmvFWgtb0%3D
    • Yenari MA, Fink SL, Sun GH, Chang LK, Patel MK, Kunis DM, et al. Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy. Ann Neurol. 1998;44:584-91.
    • (1998) Ann Neurol , vol.44 , pp. 584-591
    • Yenari, M.A.1    Fink, S.L.2    Sun, G.H.3    Chang, L.K.4    Patel, M.K.5    Kunis, D.M.6
  • 26
    • 0034089551 scopus 로고    scopus 로고
    • Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction
    • 10852544 10.1002/1531-8249(200006)47:6<782: AID-ANA11>3.0.CO;2-3 1:CAS:528:DC%2BD3cXksFSmtLk%3D
    • Rajdev S, Hara K, Kokubo Y, Mestril R, Dillmann W, Weinstein PR, et al. Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann Neurol. 2000;47:782-91.
    • (2000) Ann Neurol , vol.47 , pp. 782-791
    • Rajdev, S.1    Hara, K.2    Kokubo, Y.3    Mestril, R.4    Dillmann, W.5    Weinstein, P.R.6
  • 27
    • 0035200188 scopus 로고    scopus 로고
    • Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage
    • 11702045 10.1097/00004647-200111000-00006 1:CAS:528:DC%2BD3MXpt1Wkurw%3D
    • Hoehn B, Ringer TM, Xu L, Giffard RG, Sapolsky RM, Steinberg GK, et al. Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage. J Cereb Blood Flow Metab. 2001;21:1303-9.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 1303-1309
    • Hoehn, B.1    Ringer, T.M.2    Xu, L.3    Giffard, R.G.4    Sapolsky, R.M.5    Steinberg, G.K.6
  • 28
    • 10744224462 scopus 로고    scopus 로고
    • Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures
    • 14580286 10.1227/01.NEU.0000090341.38659.CF
    • Tsuchiya D, Hong S, Matsumori Y, Kayama T, Swanson RA, Dillman WH, et al. Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures. Neurosurgery. 2003;53:1179-87.
    • (2003) Neurosurgery , vol.53 , pp. 1179-1187
    • Tsuchiya, D.1    Hong, S.2    Matsumori, Y.3    Kayama, T.4    Swanson, R.A.5    Dillman, W.H.6
  • 29
    • 2342597809 scopus 로고    scopus 로고
    • Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury
    • 15299042 10.1242/jeb.01034 1:CAS:528:DC%2BD2cXovF2ku7w%3D
    • Giffard RG, Xu L, Zhao H, Carrico W, Ouyang Y, Qiao Y, et al. Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury. J Exp Biol. 2004;207:3213-20.
    • (2004) J Exp Biol , vol.207 , pp. 3213-3220
    • Giffard, R.G.1    Xu, L.2    Zhao, H.3    Carrico, W.4    Ouyang, Y.5    Qiao, Y.6
  • 30
    • 23644431518 scopus 로고    scopus 로고
    • Neuroprotective effects of HSP70 overexpression after cerebral ischaemia - An MRI study
    • 15936758 10.1016/j.expneurol.2005.05.002
    • van der Weerd L, Lythgoe MF, Badin RA, Valentim LM, Akbar MT, de Belleroche JS, et al. Neuroprotective effects of HSP70 overexpression after cerebral ischaemia - an MRI study. Exp Neurol. 2005;195:257-66.
    • (2005) Exp Neurol , vol.195 , pp. 257-266
    • Van Der Weerd, L.1    Lythgoe, M.F.2    Badin, R.A.3    Valentim, L.M.4    Akbar, M.T.5    De Belleroche, J.S.6
  • 31
    • 59149091608 scopus 로고    scopus 로고
    • Overexpression of mitochondrial Hsp70/Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia
    • 18985056 10.1038/jcbfm.2008.125 1:CAS:528:DC%2BD1MXhtFOrtbc%3D
    • Xu L, Voloboueva LA, Ouyang Y, Emery JF, Giffard RG. Overexpression of mitochondrial Hsp70/Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia. J Cereb Blood Flow Metab. 2009;29:365-74.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 365-374
    • Xu, L.1    Voloboueva, L.A.2    Ouyang, Y.3    Emery, J.F.4    Giffard, R.G.5
  • 33
    • 79952442166 scopus 로고    scopus 로고
    • Delayed intervention in experimental stroke with TRC051384 - A small molecule HSP70 inducer
    • 21167846 10.1016/j.neuropharm.2010.12.003 1:CAS:528:DC%2BC3MXjsFahu7w%3D
    • Mohanan A, Deshpande S, Jamadarkhana PG, Kumar P, Gupta RC, Chauthaiwale V, et al. Delayed intervention in experimental stroke with TRC051384 - a small molecule HSP70 inducer. Neuropharmacology. 2011;60:991-9.
    • (2011) Neuropharmacology , vol.60 , pp. 991-999
    • Mohanan, A.1    Deshpande, S.2    Jamadarkhana, P.G.3    Kumar, P.4    Gupta, R.C.5    Chauthaiwale, V.6
  • 34
    • 77954392450 scopus 로고    scopus 로고
    • Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia
    • 20235222 10.1002/glia.20985
    • Xu L, Emery JF, Ouyang YB, Voloboueva LA, Giffard RG. Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia. 2010;58:1042-9.
    • (2010) Glia , vol.58 , pp. 1042-1049
    • Xu, L.1    Emery, J.F.2    Ouyang, Y.B.3    Voloboueva, L.A.4    Giffard, R.G.5
  • 35
    • 67349287017 scopus 로고    scopus 로고
    • TAT-Hsp70-mediated neuroprotection and increased survival of neuronal precursor cells after focal cerebral ischemia in mice
    • 19384335 10.1038/jcbfm.2009.44 1:CAS:528:DC%2BD1MXntVykurc%3D
    • Doeppner TR, Nagel F, Dietz GP, Weise J, Tönges L, Schwarting S, et al. TAT-Hsp70-mediated neuroprotection and increased survival of neuronal precursor cells after focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2009;29:1187-96.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1187-1196
    • Doeppner, T.R.1    Nagel, F.2    Dietz, G.P.3    Weise, J.4    Tönges, L.5    Schwarting, S.6
  • 36
    • 77649118928 scopus 로고    scopus 로고
    • Recombinant Fv-Hsp70 protein mediates neuroprotection after focal cerebral ischemia in rats
    • 20075343 10.1161/STROKEAHA.109.572537 1:CAS:528:DC%2BC3cXitlejtb8%3D
    • Zhan X, Ander BP, Liao IH, Hansen JE, Kim C, Clements D, et al. Recombinant Fv-Hsp70 protein mediates neuroprotection after focal cerebral ischemia in rats. Stroke. 2010;41:538-43.
    • (2010) Stroke , vol.41 , pp. 538-543
    • Zhan, X.1    Ander, B.P.2    Liao, I.H.3    Hansen, J.E.4    Kim, C.5    Clements, D.6
  • 37
    • 1442335450 scopus 로고    scopus 로고
    • Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia
    • 14579003 10.1007/s00221-003-1683-2 1:CAS:528:DC%2BD2cXnsFGmtQ%3D%3D
    • Olsson T, Hansson O, Nylandsted J, Jäättelä M, Smith ML, Wieloch T. Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia. Exp Brain Res. 2004;154:442-9.
    • (2004) Exp Brain Res , vol.154 , pp. 442-449
    • Olsson, T.1    Hansson, O.2    Nylandsted, J.3    Jäättelä, M.4    Smith, M.L.5    Wieloch, T.6
  • 39
    • 0031148241 scopus 로고    scopus 로고
    • Induction of heat shock protein 72 kDa expression is associated with attenuation of ischaemia-reperfusion induced microvascular injury
    • 9224420 10.1006/jsre.1997.5059 1:CAS:528:DyaK2sXkvFylur0%3D
    • Chen G, Kelly C, Stokes K, Wang JH, Leahy A, Bouchier-Hayes D. Induction of heat shock protein 72 kDa expression is associated with attenuation of ischaemia-reperfusion induced microvascular injury. J Surg Res. 1997;69:435-9.
    • (1997) J Surg Res , vol.69 , pp. 435-439
    • Chen, G.1    Kelly, C.2    Stokes, K.3    Wang, J.H.4    Leahy, A.5    Bouchier-Hayes, D.6
  • 40
    • 0032528185 scopus 로고    scopus 로고
    • Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs
    • 9664071 10.1172/JCI2465 1:CAS:528:DyaK1cXkslOkt7w%3D
    • Schett G, Redlich K, Xu Q, Bizan P, Gröger M, Tohidast-Akrad M, et al. Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. J Clin Invest. 1998;102:302-11.
    • (1998) J Clin Invest , vol.102 , pp. 302-311
    • Schett, G.1    Redlich, K.2    Xu, Q.3    Bizan, P.4    Gröger, M.5    Tohidast-Akrad, M.6
  • 41
    • 0036319568 scopus 로고    scopus 로고
    • Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia
    • 12064483 10.1046/j.1471-4159.2002.00835.x 1:CAS:528:DC%2BD38Xjt1Cjt7w%3D
    • Lu A, Ran R, Parmentier-Batteur S, Nee A, Sharp FR. Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia. J Neurochem. 2002;81:355-64.
    • (2002) J Neurochem , vol.81 , pp. 355-364
    • Lu, A.1    Ran, R.2    Parmentier-Batteur, S.3    Nee, A.4    Sharp, F.R.5
  • 42
    • 51649109912 scopus 로고    scopus 로고
    • Geldanamycin protects rat brain through overexpression of HSP70 and reducing brain edema after cerebral focal ischemia
    • 18534054 10.1179/174313208X289615 1:CAS:528:DC%2BD1cXhtlKhsLfO
    • Kwon HM, Kim Y, Yang SI, Kim YJ, Lee SH, Yoon BW. Geldanamycin protects rat brain through overexpression of HSP70 and reducing brain edema after cerebral focal ischemia. Neurol Res. 2008;30:740-5.
    • (2008) Neurol Res , vol.30 , pp. 740-745
    • Kwon, H.M.1    Kim, Y.2    Yang, S.I.3    Kim, Y.J.4    Lee, S.H.5    Yoon, B.W.6
  • 43
    • 71549124950 scopus 로고    scopus 로고
    • Oligonucleotide-gold nanoparticle networks for detection of Cryptosporidium parvum heat shock protein 70 mRNA
    • 19828740 10.1128/JCM.00807-09 1:CAS:528:DC%2BC3cXlsFGrsw%3D%3D
    • Javier DJ, Castellanos-Gonzalez A, Weigum SE, White Jr AC, Richards-Kortum R. Oligonucleotide-gold nanoparticle networks for detection of Cryptosporidium parvum heat shock protein 70 mRNA. J Clin Microbiol. 2009;47:4060-6.
    • (2009) J Clin Microbiol , vol.47 , pp. 4060-4066
    • Javier, D.J.1    Castellanos-Gonzalez, A.2    Weigum, S.E.3    White, Jr.A.C.4    Richards-Kortum, R.5
  • 44
    • 84857315582 scopus 로고    scopus 로고
    • Monitoring the induction of heat shock factor 1/heat shock protein 70 expression following 17-allylamino-demethoxygeldanamycin treatment by positron emission tomography and optical reporter gene imaging
    • 22418029 1:CAS:528:DC%2BC38XmtVGrtLk%3D
    • Doubrovin M, Che JT, Serganova I, Moroz E, Solit DB, Ageyeva L, et al. Monitoring the induction of heat shock factor 1/heat shock protein 70 expression following 17-allylamino-demethoxygeldanamycin treatment by positron emission tomography and optical reporter gene imaging. Mol Imaging. 2012;11:67-76.
    • (2012) Mol Imaging , vol.11 , pp. 67-76
    • Doubrovin, M.1    Che, J.T.2    Serganova, I.3    Moroz, E.4    Solit, D.B.5    Ageyeva, L.6


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