Evaluation of the RBE4 cell line to explore carrier-mediated drug delivery to the CNS via the L-system amino acid transporter at the blood-brain barrier

Journal of Drug Targeting

Volumn 10, Issue 4, 2002, Pages 277-283

  Reichel, Andreas ^a   Abbott, N Joan ^a   Begley, David J ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Amino acid; Blood brain barrier; Drug delivery; In vitro; L system; RBE4; Transport kinetics

Indexed keywords

CARRIER PROTEIN; CENTRAL NERVOUS SYSTEM AGENTS; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; DRUG CARRIER; LEUCINE; PHENYLALANINE; SODIUM ION; AMINO ACID TRANSPORTER;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CELL; CELL LINE; CELL STIMULATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG TARGETING; DRUG TRANSPORT; ENDOTHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPRODUCIBILITY; ANIMAL; DRUG EFFECT; EVALUATION; METABOLISM; METHODOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

AMINO ACID TRANSPORT SYSTEM L; ANIMAL; BLOOD-BRAIN BARRIER; CELL LINE; CENTRAL NERVOUS SYSTEM; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENDOTHELIUM, VASCULAR; RATS; SUPPORT, NON-U.S. GOV'T; ANIMALS;

EID: 0035984823     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10611860290031930     Document Type: Article

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