Amino acid substitutions in naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4 result in regio- and stereo-specific hydroxylation of flavanone and isoflavanone

Applied Microbiology and Biotechnology

Volumn 97, Issue 2, 2013, Pages 693-704

  Seo, Jiyoung ^a   Ryu, Ji Young ^b   Han, Jaehong ^c   Ahn, Joong Hoon ^d   Sadowsky, Michael J ^e   Hur, Hor Gil ^a   Chong, Youhoon ^d  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Korea Research Institute of Ships and Ocean Engineering   (South Korea)

^c Chung Ang University   (South Korea)

^d Konkuk University   (South Korea)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Biotransformation; Flavanone; Flavone; Naphthalene dioxygenase; Site directed mutagenesis

Indexed keywords

BIOTRANSFORMATION; FLAVANONE; FLAVONE; NAPHTHALENE DIOXYGENASE; SITE DIRECTED MUTAGENESIS;

AMINO ACIDS; BACTERIA; HYDROXYLATION; NAPHTHALENE; STEREOCHEMISTRY; SUBSTRATES;

FLAVONOIDS;

AMINO ACID; BACTERIAL ENZYME; FLAVANONE; FLAVANONE DERIVATIVE; ISOFLAVANONE; NAPHTHALENE DIOXYGENASE; UNCLASSIFIED DRUG;

AMINO ACID; BIOTRANSFORMATION; ENZYME ACTIVITY; HYDROPHOBICITY; MUTAGENICITY; NAPHTHALENE; PROTEIN; REACTION KINETICS; SUBSTRATE;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL STRAIN; BINDING SITE; BIOTRANSFORMATION; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; COVALENT BOND; ENZYME STRUCTURE; HYDROXYLATION; MUTAGENESIS; NONHUMAN; PROTEIN PROTEIN INTERACTION; PSEUDOMONAS; WILD TYPE;

AMINO ACID SUBSTITUTION; DIOXYGENASES; FLAVANONES; HYDROXYLATION; ISOFLAVONES; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PSEUDOMONAS;

PSEUDOMONAS SP.;

EID: 84873991194     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-3962-y     Document Type: Article

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