Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment

Clinical and Experimental Allergy

Volumn 43, Issue 3, 2013, Pages 312-321

  Bratke, K ^a   Prieschenk, C ^a   Garbe, K ^a   Kuepper, M ^a   Lommatzsch, M ^a   Virchow, J C ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Asthma, chemokine receptor, inhaled corticosteroids; Plasmacytoid dendritic cells, toll like receptor

Indexed keywords

ALLERGEN; ALPHA INTERFERON; CD40 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR9; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR5; CHEMOKINE RECEPTOR CXCR6; CORTICOSTEROID; FC EPSILON RECEPTOR IALPHA; FC RECEPTOR; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 6; L SELECTIN; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ALLERGIC ASTHMA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CYTOKINE RELEASE; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HUMAN; MALE; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH2 CELL;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ADULT; ANTIGENS, CD40; ANTIGENS, SURFACE; ASTHMA; CELL ADHESION MOLECULES; DENDRITIC CELLS; FEMALE; HUMANS; MALE; RECEPTORS, CHEMOKINE; RECEPTORS, FC; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9; YOUNG ADULT;

EID: 84873972634     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12064     Document Type: Article

References (41)

1. Matsuda H, Suda T, Hashizume H et al. Alteration of balance between myeloid dendritic cells and plasmacytoid dendritic cells in peripheral blood of patients with asthma. Am J Respir Crit Care Med 2002; 166:1050-54.
2. Cella M, Facchetti F, Lanzavecchia A, Colonna M. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization. Nat Immunol 2000; 1:305-10.
3. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune response. Nat Immunol 2004; 5:987-95.
4. Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A. Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 2003; 198:513-20.
5. Lund JM, Alexopoulou L, Sato A et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. PNAS 2004; 101:5598-603.
6. Bratke K, Lommatzsch M, Julius P et al. Dendritic cell subsets in human bronchoalveolar lavage fluid after segmental allergen challenge. Thorax 2007; 62:168-75.
7. Jahnsen FL, Lund-Johansen F, Dunne JF et al. Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy. J Immunol 2000; 165:4062-68.
8. Wollenberg A, Wagner M, Günther S et al. Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases. J Invest Dermatol 2002; 119:1096-102.
9. De Heer H, Hammad H, Soullie T et al. Essential role of lung plsmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 2004; 200:89-98.
10. Kool M, van Nimwegen M, Willart MA et al. An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation. J Immunol 2009; 183:1074-82.
11. Ito T, Amakawa R, Inaba M et al. Plasmacytoid dendritic cells regulate Th cell responses through OX40 Ligand and type I IFNs. J Immunol 2004; 172:4253-59.
12. Farkas L, Kvale EO, Johansen FE, Jahnsen FL, Lund-Johansen F. Plasmacytoid dendritic cells activate allergen-specific TH2 memory cells: modulation by CpG oligodeoxynucleotides. J Allergy Clin Immunol 2004; 114:436-43.
13. Bratke K, Klein C, Kuepper M, Lommatzsch M, Virchow JC. Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus. Allergy 2011; 66:386-95.
14. Uchida Y, Kurasawa K, Nakajima H et al. Increase of dendritic cells of type 2 (DC2) by altered response to IL-4 in atopic patients. J Allergy Clin Immunol 2001; 108:1005-11.
15. Spears M, McSharry C, Donnelly I et al. Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma. Clin Exp Allergy 2011; 41:665-72.
16. Bratke K, Kuepper M, Julius P, Lommatzsch M, Virchow JC. Thrombomodulin: a novel player in allergic asthma. J Allergy Clin Immunol 2009; 123:1192.
17. Bratke K, Nielsen J, Manig F et al. Functional expression of granzyme B in human plasmacytoid dendritic cells: a role in allergic inflammation. Clin Exp Allergy 2010; 40:1015-24.
18. Campbell JJ, Haraldsen G, Pan J et al. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 1999; 400:776-80.
19. Sisirak V, Vey N, Vanbervliet B et al. CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues. Blood 2011; 118:5130-40.
20. Wendland M, Czeloth N, Mach N et al. CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine. Proc Natl Acad Sci USA 2007; 104:6347-52.
21. Alam R, York J, Boyars M et al. Increased MCP-1, RANTES, and MIP-1alpha in bronchoalveolar lavage fluid of allergic asthmatic patients. Am J Respir Crit Care Med 1996; 153:1398-404.
22. Qiu Y, Zhu J, Bandi V, Guntupalli KK, Jeffery PK. Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma. Thorax 2007; 62:475-82.
23. Baay-Guzman GJ, Huerta-Yepez S, Vega MI et al. Role of CXCL13 in allergic airway inflammation: novel therapeutic target. Chest 2012;141:886-94.
24. Morgan AJ, Guillen C, Symon FA et al. Expression of CXCR6 and ist ligand CXCL16 in the lung in health and disease. Clin Exp Allergy 2005; 35:1572-80.
25. Cella M, Jarrossay D, Facchetti F et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 1999; 5:919-23.
26. Vijayanand P, Durkin K, Hartmann G et al. Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients. J Immunol 2010; 184:4568-74.
27. Hadeiba H, Sato T, Habtezion A, Oderup C, Pan J, Butcher EC. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol 2008; 9:1253-60.
28. Tversky JR, Le TV, Bieneman AP, Chichester KL, Hamilton RG, Schroeder JT. Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-a via toll-like receptor 9. Clin Exp Allergy 2008; 38:781-8.
29. Gill MA, Bajwa G, George TA et al. Counterregulation between the FceRI pathway and antiviral responses in human plasmacytoid dendritic cells. J Immunol 2010; 184:5999-6006.
30. Ogawa A, Yoshizaki A, Yanaba K et al. The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity. J Invest Dermatol 2010; 130:1558-70.
31. Bendriss-Vermare N, Burg S, Kanzler H et al. Virus overrides the prpensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-gamma and Th1 chemokine production. J Leukoc Biol 2005; 78:954-66.
32. Roponen M, Yerkovich ST, Hollams E, Sly PD, Holt PG, Upham JW. Toll-like receptor 7 function is reduced in adolescents with asthma. Eur Respir J 2010; 35:64-71.
33. Dreschler K, Bratke K, Petermann S et al. Impact of immunotherapy on blood dendritic cells in patients with hymenoptera venom allergy. J Allergy Clin Immunol 2011; 127:487-94.
34. Lommatzsch M, Bratke K, Bier A et al. Airway dendritic cell phenotypes in inflammatory diseases of the human lung. Eur Respir J 2007; 30:878-86.
35. Boor PPC, Metselaar HJ, Mancham S, Tilanus HW, Kusters JG, Kwekkeboom J. Prednisolone suppresses the function and promotes apoptosis of plasmacytoid dendritic cells. Am J Transplant 2006; 6:2332-41.
36. Shodell M, Siegal FP. Corticosteroids depress IFN-a-producing plasmacytoid dendritic cells in human blood. J Allergy Clin Immunol 2001; 108:446-8.
37. Pan J, Ju D, Zhang M et al. Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway. Immunol Lett 2001; 76:153-61.
38. Sabatini F, Silvestri M, Sale R et al. Concentration-dependent effects of mometasone furoate and dexamethasone on foetal lung fibroblas functions involved in airway inflammation and remodeling. Pulm Pharmacol Ther 2003; 16:287-97.
39. Paolieri F, Battifora M, Riccio AM et al. Inhibition of adhesion molecules by budesonide on a human epithelial cell line (lung carcinoma). Allergy 1997; 52:935-43.
40. Moseman EA, Liang X, Dawson AJ et al. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4 + CD25 + regulatory T cells. J Immunol 2004; 173:4433-42.
41. Kawamura K, Kadowaki N, Kitawaki T, Uchiyama T. Virus-stimulated plasmacytoid dendritic cells induce CD4 + cytotoxic regulatory T cells. Blood 2006; 107:1031-8.