Corticosteroids depress IFN-α-producing plasmacytoid dendritic cells in human blood

Journal of Allergy and Clinical Immunology

Volumn 108, Issue 3, 2001, Pages 446-448

  Shodell, Michael ^a,b   Siegal, Frederick P ^a  

^a ST VINCENT S HOSPITAL   (United States)

^b LONG ISLAND UNIVERSITY   (United States)

Author keywords

Corticosteroids; Dendritic cells; Flow cytometry; IFN producing cells; Immunosuppression; pDC; Plasmacytoid; Steroid effects

Indexed keywords

CORTICOSTEROID; GAMMA INTERFERON;

ARTICLE; BLOOD; CONTROLLED STUDY; DENDRITIC CELL; DRUG EFFECT; FLOW CYTOMETRY; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE TREATMENT; INTERFERON PRODUCTION; PLASMA CELL; PRIORITY JOURNAL;

EID: 0034820289     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2001.117928     Document Type: Article

References (10)

1. Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity
2. Interferon-α generation and immune reconstitution during antiretroviral therapy for human immunodeficiency virus infection
3. Identity of the principal type-I IFN-producing cells in human blood
4. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
5. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent Th1 polarization
6. Differential effects of corticosteroids during different stages of dendritic cell maturation
7. Glucocorticoids affect human dendritic cell differentiation and maturation
8. Molecular mechanisms of immunosuppression and anti-inflammatory activities by glucocorticoids
9. Inhibition of Th1 immune response by glucocorticoids: Dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes
10. Increased cortisol levels in human umbilical cord blood inhibit interferon alpha production of neonate