Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus)

Environmental Toxicology and Chemistry

Volumn 32, Issue 3, 2013, Pages 713-722

  Greaves, Alana K ^a   Letcher, Robert J ^a   Sonne, Christian ^b   Dietz, Rune ^b  

^a CARLETON UNIVERSITY   (Canada)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Brain region; East Greenland; Perfluorinated compound; Polar bear; Polyfluoroalkyl substance

Indexed keywords

BRAIN REGIONS; GREENLAND; PERFLUORINATED COMPOUNDS; POLAR BEARS; POLYFLUOROALKYL SUBSTANCES;

BLOOD; CARBOXYLATION; CHAIN LENGTH; MAMMALS; SULFUR COMPOUNDS;

BRAIN;

CARBOXYLIC ACID DERIVATIVE; PERFLUOROALKYL CARBOXYLATE; PERFLUOROOCTANE SULFONAMIDE; PERFLUOROTRIDECANOIC ACID; SULFONAMIDE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

BEAR; BIOACCUMULATION; BLOOD; BRAIN; CONCENTRATION (COMPOSITION); ECOTOXICOLOGY; ESTER; LIPID; SULFONATE; WEIGHT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BLOOD BRAIN BARRIER; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; FRONTAL CORTEX; GREENLAND; HYPOTHALAMUS; MALE; MEDULLA OBLONGATA; NONHUMAN; OCCIPITAL CORTEX; POLAR BEAR; PRIORITY JOURNAL; TEMPORAL CORTEX; THALAMUS;

ANIMALS; BRAIN; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; FLUOROCARBONS; GREENLAND; MALE; TISSUE DISTRIBUTION; URSIDAE;

ARCTIC; GREENLAND; SCORESBY SUND;

EID: 84873970329     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.2107     Document Type: Article

References (40)

1. Buck RC, Franklin J, Berger U, Conder JM, Cousins IT, de Voogt P, Astrup Jensen A, Kannan K, Mabury SA, van Leeuwen SPJ. 2011. Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins. Integr Environ Assess Manag 7:513-541.
2. Butt CM, Berger U, Bossi R, Tomy GT. 2010. Levels and trends of poly- and perfluorinated compounds in the arctic environment. Sci Total Environ 408:2936-2965.
3. Letcher RJ, Bustnes JO, Dietz R, Jenssen BM, Jorgensen EH, Sonne C, Verreault J, Vijayan MM, Gabrielsen GW. 2010. Exposure and effects assessment of persistent organohalogen contaminants in arctic wildlife and fish. Sci Total Environ 408:2995-3043.
4. Bossi R, Riget FF, Dietz R, Sonne C, Fauser P, Dam M, Vorkamp K. 2005. Preliminary screening of perfluorooctane sulfonate (PFOS) and other fluorochemicals in fish, birds, and marine mammals from Greenland and the Faroe Islands. Environ Pollut 136:323-329.
5. Kelly BC, Ikonomou MG, Blair JD, Blair S, Hoover D, Grace R, Gobas FAPC. 2009. Perfluoroalkyl contaminants in an arctic marine food web: Trophic magnification and wildlife exposure. Environ Sci Technol 43:4037-4043.
6. Letcher RJ. 2010. Temporal and spatial trends of contaminants in Canadian polar bears: Part III. In: Smith SL, Stow J, Edwards J, eds, Synopsis of Research Conducted Under the 2009/2010, Northern Contaminants Program. Ottawa: Indian and Northern Affairs Canada. Ottawa, pp 107-125.
7. Dietz R, Bossi R, Riget FF, Sonne C, Born EW. 2008. Increasing perfluoroalkyl contaminants in East Greenland polar bears (Ursus maritimus): A new toxic threat to the Arctic bears. Environ Sci Technol 42:2701-2707.
8. McKinney MA, Letcher RJ, Aars J, Born EW, Branigan M, Dietz R, Evans TJ, Gabrielsen GW, Peacock E, Sonne C. 2011. Flame retardants and legacy contaminants in polar bears from Alaska, Canada, East Greenland and Svalbard, 2005-2008. Environ Int 37:365-374.
9. Gebbink WA, Sonne C, Dietz R, Kirkegaard M, Born EW, Muir DCG, Letcher RJ. 2008. Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environ Sci Technol 42:752-759.
10. Goecke Flora CM, Reo NV. 1996. Influence of carbon chain length on the hepatic effects of perfluorinated fatty acids. A F-19- and P-31-NMR investigation. Chem Res Toxicol 9:689-695.
11. Yang CH, Glover KP, Han X. 2010. Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates. Toxicol Sci 117:294-302.
12. Houde M, Balmer BC, Brandsma S, Wells RS, Rowles TK, Solomon KR, Muir DCG. 2006. Perfluoroalkyl compounds in relation to life-history and reproductive parameters in bottlenose dolphins (Tursiops truncatus) from Sarasota Bay, Florida, USA. Environ Toxicol Chem 25:2405-2412.
13. Kannan K, Yun SH, Evans TJ. 2005. Chlorinated, brominated, and perfluorinated contaminants in livers of polar bears from Alaska. Environ Sci Technol 39:9057-9063.
14. Kannan K, Newsted J, Halbrook RS, Giesy JP. 2002. Perfluorooctanesulfonate and related fluorinated hydrocarbons in mink and river otters from the United States. Environ Sci Technol 36:2566-2571.
15. Jones PD, Hu WY, De Coen W, Newsted JL, Giesy JP. 2003. Binding of perfluorinated fatty acids to serum proteins. Environ Toxicol Chem 22:2639-2649.
16. Luebker DJ, Hansen KJ, Bass NM, Butenhoff JL, Seacat AM. 2002. Interactions of fluorochemicals with rat liver fatty acid-binding protein. Toxicology 176:175-185.
17. Ahrens L, Siebert U, Ebinghaus R. 2009. Total body burden and tissue distribution of polyfluorinated compounds in harbor seals (Tursiops truncatus) from the German Bight. Mar Pollut Bull 58:520-525.
18. Cassone CG, Vongphachan V, Chiu SZ, Williams KL, Letcher RJ, Pelletier E, Crump D, Kennedy SW. 2012. In ovo effects of perfluorohexane sulfonate and perfluorohexanoate on toxicity, development, mRNA expression and thyroid hormone levels in chicken embryos. Toxicol Sci 127:216-224.
19. Gebbink WA, Letcher RJ. 2012. Comparative tissue and body compartment accumulation and maternal transfer to eggs of perfluoroalkyl sulfonates and carboxylates in Great Lakes herring gulls. Environ Pollut 162:40-47.
20. Rubarth J, Dreyer A, Guse N, Einax JW, Ebinghaus R. 2011. Perfluorinated compounds in red-throated divers from the German Baltic Sea: New findings from their distribution in 10 different tissues. Environ Chem 8:419-428.
21. Van de Vijver KI, Hoslbeek L, Das K, Blust R, Joiris C, De Coen W. 2007. Occurrence of perfluorooctane sulfonate and other perfluorinated alkylated substances in harbor porpoises from the Black Sea. Environ Sci Technol 41:315-320.
22. Olivero-Verbel J, Tao L, Johnston-Restrepo B, Guette-Fernandez J, Baldiris-Avila R, O'Byrne-Hoyos I, Kannan K. 2006. Perfluorooctanesulfonate and related fluorochemicals in biological samples from the north coast of Colombia. Environ Pollut 142:367-372.
23. Van de Vijver KI, Hoff P, Das K, Brasseur S, Van Dongen W, Esmans E, Reijnders P, Blust R, De Coen W. 2005. Tissue distribution of perfluorinated chemicals in harbor seals (Phoca vitulina) from the Dutch Wadden Sea. Environ Sci Technol 39:6978-6984.
24. Verreault J, Houde M, Gabrielsen GW, Berger U, Haukas M, Letcher RJ, Muir DCG. 2005. Perfluorinated alkyl substances in plasma, liver, brain, and eggs of glaucous gulls (Larus hyperboreus) from the Norwegian Arctic. Environ Sci Technol 39:7439-7445.
25. Wang FQ, Liu W, Jin YH, Dai JY, Yu WG, Liu XH, Liu L. 2010. Transcriptional effects of prenatal and neonatal exposure to PFOS in developing rat brain. Environ Sci Technol 44:1847-1853.
26. Johansson N, Fredriksson A, Eriksson P. 2008. Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. Neurotoxicology 29:160-169.
27. Slotkin TA, MacKillop EA, Melnick RL, Thayer KA, Seidler FJ. 2008. Developmental neurotoxicity of perfluorinated chemicals modeled in vitro. Environ Health Perspect 116:716-722.
28. Chu SG, Covaci A, Jacobs W, Haraguchi K, Schepens P. 2003. Distribution of methyl sulfone metabolites of polychlorinated biphenyls and p, p'-DDE in human tissues. Environ Health Perspect 111:1222-1227.
29. Siegel GJ, Agranoff BW, Albers RW, Fisher SK, Uhler MD. eds. 1999. Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 6th ed. Lippincott-Raven Philadelphia, PA, USA
30. Château-Degat M-L, Pereg D, Dallaire R, Ayotte P, Dery S, Dewailly E. 2010. Effects of perfluorooctanesulfonate exposure on plasma lipid levels in the Inuit population of Nunavik (northern Quebec). Environ Res 110:710-717.
31. Benskin JP, De Silva AO, Martin LJ, Arsenault G, McCrindle R, Riddell N, Mabury SA, Martin JW. 2009. Disposition of perfluorinated acid isomers in Sprague-Dawley rats. Part 1: Single dose. Environ Toxicol Chem 28:542-554.
32. De Silva AO, Benskin JP, Martin LJ, Arsenault G, McCrindle R, Riddell N, Martin JW, Mabury SA. 2009. Disposition of perfluorinated acid isomers in Sprague-Dawley rats. Part 2: Subchronic dose. Environ Toxicol Chem 28:555-567.
33. Martin JW, Asher BJ, Beesoon S, Benskin JP, Ross MS. 2010. PFOS or PreFOS? Are perfluorooctane sulfonate precursors (PreFOS) important determinants of human and environmental perfluorooctane sulfonate (PFOS) exposure? J Environ Monit 12:1979-2004.
34. Mitchell RW, Hatch GM. 2011. Fatty acid transport into the brain: Of fatty acid fables and lipid tails. Prostaglandins Leukot Essent Fatty Acids 85:293-302.
35. Cipolla MJ. 2010. The Cerebral Circulation. Morgan & Claypool Life Sciences San Rafael, CA, USA.
36. Kamiya T, Pirlot P. 1988. The brain of the Malayan bear (Helarctos malayanus). Z Zool Syst Evolutionsforsch 26:225-235.
37. Smithwick M, Muir DCG, Mabury SA, Solomon KR, Martin JW, Sonne C, Born EW, Letcher RJ, Dietz R. 2005. Perfluoroalkyl contaminants in liver tissue from East Greenland polar bears (Ursus maritimus). Environ Toxicol Chem 24:981-986.
38. Smithwick M, Mabury SA, Solomon KR, Sonne C, Martin JW, Born EW, Dietz R, Derocher AE, Letcher RJ, Evans TJ, Gabrielsen GW, Nagy J, Stirling I, Taylor MK, Muir DCG. 2005. Circumpolar study of perfluoroalkyl contaminants in polar bears (Ursus maritimus). Environ Sci Technol 39:5517-5523.
39. Ellis DA, Martin JW, De Silva AO, Mabury SA, Hurley MD, Andersen MPS, Wallington TJ. 2004. Degradation of fluorotelomer alcohols: A likely atmospheric source of perfluorinated carboxylic acids. Environ Sci Technol 38:3316-3321.
40. Seacat AM, Thomford PJ, Hansen KJ, Olsen GW, Case MT, Butenhoff JL. 2002. Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys. Toxicol Sci 68:249-264.