Towards the validation of a lung tumorigenesis model with mainstream cigarette smoke inhalation using the A/J mouse

Toxicology

Volumn 305, Issue , 2013, Pages 49-64

  Stinn, Walter ^a   Berges, An ^b   Meurrens, Kris ^b   Buettner, Ansgar ^c   Gebel, Stephan ^a   Lichtner, Rosemarie B ^a   Janssens, Kris ^a   Veljkovic, Emilija ^d   Xiang, Yang ^d   Roemer, Ewald ^d   Haussmann, Hans Juergen ^e  

^a Philip Morris Research Laboratories GmbH   (Germany)

^b Philip Morris Research Laboratories Bvba   (Belgium)

^c Histovia GmbH   (Germany)

^d PHILIP MORRIS PRODUCTS S A   (Switzerland)

^e NONE

Author keywords

Cigarette mainstream smoke; Discriminatory power; Gene expression signature; Lung tumorigenesis; Validation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RISK; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; LARYNX PAPILLOMATOSIS; LUNG CARCINOGENESIS; LUNG TUMOR; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SHAM PROCEDURE; SMOKING; TOBACCO; VALIDATION STUDY;

ANIMALS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDPOINT DETERMINATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; INHALATION EXPOSURE; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED A; NEOPLASMS; ORGAN SIZE; REPRODUCIBILITY OF RESULTS; RESPIRATORY SYSTEM; RNA, NEOPLASM; SEX CHARACTERISTICS; SMOKING; TISSUE FIXATION;

EID: 84873965504     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.01.005     Document Type: Article

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