Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis

Regulatory Peptides

Volumn 182, Issue 1, 2013, Pages 35-40

  Banke, E ^a   Riva, M ^b   Shcherbina, L ^b   Wierup, N ^b   Degerman, E ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Adipocytes; Cellular signaling; Cocaine and amphetamine regulated transcript; Glucose metabolism; Lipid metabolism

Indexed keywords

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; GLUCOSE TRANSPORTER 4; ISOPRENALINE; MESSENGER RNA; PHOSPHODIESTERASE III; PROTEIN KINASE B; TRIACYLGLYCEROL LIPASE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE SEQUENCE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRAABDOMINAL FAT; LIPID METABOLISM; LIPOGENESIS; LIPOLYSIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT; WESTERN BLOTTING;

ADIPOCYTES; ANIMALS; BASE SEQUENCE; DNA PRIMERS; GLUCOSE; HOMEOSTASIS; ISOPROTERENOL; LIPID METABOLISM; MALE; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84873958610     PISSN: 01670115     EISSN: 18731686     Source Type: Journal    
DOI: 10.1016/j.regpep.2012.12.011     Document Type: Article

References (39)

1. Guilherme A., Virbasius J.V., Puri V., Czech M.P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 2008, 9:367-377.
2. Gutierrez D.A., Puglisi M.J., Hasty A.H. Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia. Curr Diab Rep 2009, 9:26-32.
3. Rogge G., Jones D., Hubert G.W., Lin Y., Kuhar M.J. CART peptides: regulators of body weight, reward and other functions. Nat Rev Neurosci 2008, 9:747-758.
4. Kristensen P., Judge M.E., Thim L., Ribel U., Christjansen K.N., Wulff B.S., Clausen J.T., Jensen P.B., Madsen O.D., Vrang N., Larsen P.J., Hastrup S. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 1998, 393:72-76.
5. Douglass J., McKinzie A.A., Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci 1995, 15:2471-2481.
6. Lambert P.D., Couceyro P.R., McGirr K.M., Dall Vechia S.E., Smith Y., Kuhar M.J. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse 1998, 29:293-298.
7. Dun N.J., Dun S.L., Kwok E.H., Yang J., Chang J. Cocaine- and amphetamine-regulated transcript-immunoreactivity in the rat sympatho-adrenal axis. Neurosci Lett 2000, 283:97-100.
8. Couceyro P.R., Koylu E.O., Kuhar M.J. Further studies on the anatomical distribution of CART by in situ hybridization. J Chem Neuroanat 1997, 12:229-241.
9. Dun S.L., Chianca D.A., Dun N.J., Yang J., Chang J.K. Differential expression of cocaine- and amphetamine-regulated transcript-immunoreactivity in the rat spinal preganglionic nuclei. Neurosci Lett 2000, 294:143-146.
10. Wierup N., Gunnarsdottir A., Ekblad E., Sundler F. Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands. BMC Neurosci 2007, 8:51.
11. Couceyro P., Paquet M., Koylu E., Kuhar M.J., Smith Y. Cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactivity in myenteric plexus neurons of the rat ileum and co-localization with choline acetyltransferase. Synapse 1998, 30:1-8.
12. Wierup N., Richards W.G., Bannon A.W., Kuhar M.J., Ahren B., Sundler F. CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight. Regul Pept 2005, 129:203-211.
13. Wierup N., Kuhar M., Nilsson B.O., Mulder H., Ekblad E., Sundler F. Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development. J Histochem Cytochem 2004, 52:169-177.
14. Jensen P.B., Kristensen P., Clausen J.T., Judge M.E., Hastrup S., Thim L., Wulff B.S., Foged C., Jensen J., Holst J.J., Madsen O.D. The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans. FEBS Lett 1999, 447:139-143.
15. Landerholm K., Falkmer S., Järhult J., Sundler F., Wierup N. Cocaine- and amphetamine-regulated transcript (CART) in neuroendocrine tumors. Neuroendocrinology 2011, 94:228-236.
16. Wierup N., Sundler F. CART is a novel islet regulatory peptide. Peptides 2006, 27:2031-2036.
17. Landerholm K., Shcherbina L., Falkmer S.E., Jarhult J., Wierup N. Expression of cocaine- and amphetamine-regulated transcript is associated with worse survival in small bowel carcinoid tumors. Clin Cancer Res 2012, 18:3668-3676.
18. Koylu E.O., Couceyro P.R., Lambert P.D., Ling N.C., DeSouza E.B., Kuhar M.J. Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J Neuroendocrinol 1997, 9:823-833.
19. Bech P., Winstanley V., Murphy K.G., Sam A.H., Meeran K., Ghatei M.A., Bloom S.R. Elevated cocaine- and amphetamine-regulated transcript immunoreactivity in the circulation of patients with neuroendocrine malignancy. J Clin Endocrinol Metab 2008, 93:1246-1253.
20. Asnicar M.A., Smith D.P., Yang D.D., Heiman M.L., Fox N., Chen Y.F., Hsiung H.M., Koster A. Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet. Endocrinology 2001, 142:4394-4400.
21. Wierup N., Bjorkqvist M., Kuhar M.J., Mulder H., Sundler F. CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats. Diabetes 2006, 55:305-311.
22. del Giudice E.M., Santoro N., Cirillo G., D'Urso L., Di Toro R., Perrone L. Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. Diabetes 2001, 50:2157-2160.
23. Guerardel A., Barat-Houari M., Vasseur F., Dina C., Vatin V., Clement K., Eberle D., Vasseur-Delannoy V., Bell C.G., Galan P., Hercberg S., Helbecque N., Potoczna N., Horber F.F., Boutin P., Froguel P. Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population. BMC Genet 2005, 6:19.
24. Rigoli L., Munafo C., Di Bella C., Salpietro A., Procopio V., Salpietro C. Molecular analysis of the CART gene in overweight and obese Italian children using family-based association methods. Acta Paediatr 2010, 99:722-726.
25. Honnor R.C., Dhillon G.S., Londos C. cAMP-dependent protein kinase and lipolysis in rat adipocytes. I. Cell preparation, manipulation, and predictability in behavior. J Biol Chem 1985, 260:15122-15129.
26. Dole V.P., Meinertz H. Microdetermination of long-chain fatty acids in plasma and tissues. J Biol Chem 1960, 235:2595-2599.
27. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
28. Murad F., Manganiello V., Vaughan M. A simple, sensitive protein-binding assay for guanosine 3':5'-monophosphate. Proc Natl Acad Sci U S A 1971, 68:736-739.
29. Ramlal T., Sarabia V., Bilan P.J., Klip A. Insulin-mediated translocation of glucose transporters from intracellular membranes to plasma membranes: sole mechanism of stimulation of glucose transport in L6 muscle cells. Biochem Biophys Res Commun 1988, 157:1329-1335.
30. Moody A.J., Stan M.A., Stan M., Gliemann J. A simple free fat cell bioassay for insulin. Horm Metab Res 1974, 6:12-16.
31. Carmen G.Y., Victor S.M. Signalling mechanisms regulating lipolysis. Cell Signal 2006, 18:401-408.
32. Degerman E., Ahmad F., Chung Y.W., Guirguis E., Omar B., Stenson L., Manganiello V. From PDE3B to the regulation of energy homeostasis. Curr Opin Pharmacol 2013, 11:676-682.
33. Khan A.H., Pessin J.E. Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 2002, 45:1475-1483.
34. Berggreen C., Gormand A., Omar B., Degerman E., Goransson O. Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes. Am J Physiol Endocrinol Metab 2009, 296:E635-E646.
35. Murashita K., Kurokawa T., Ebbesson L.O., Stefansson S.O., Ronnestad I. Characterization, tissue distribution, and regulation of agouti-related protein (AgRP), cocaine- and amphetamine-regulated transcript (CART) and neuropeptide Y (NPY) in Atlantic salmon (Salmo salar). Gen Comp Endocrinol 2009, 162:160-171.
36. Lindh R., Ahmad F., Resjo S., James P., Yang J.S., Fales H.M., Manganiello V., Degerman E. Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B. Biochim Biophys Acta 2007, 1773:584-592.
37. Perwitz N., Sievert H., Meier B., Drenckhan M., Fasshauer M., Klein J. Cocaine- and amphetamine-related transcript (CART) directly stimulated UCP-1 expression and enhances insulin-induced glucose uptake. Adipocytes 2005, 1:145-150.
38. Akesson L., Ahren B., Manganiello V.C., Holst L.S., Edgren G., Degerman E. Dual effects of pituitary adenylate cyclase-activating polypeptide and isoproterenol on lipid metabolism and signaling in primary rat adipocytes. Endocrinology 2003, 144:5293-5299.
39. McIntosh C.H., Widenmaier S., Kim S.J. Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP). Vitam Horm 2009, 80:409-471.