Simultaneous quantification of 22R and 22S epimers of budesonide in human plasma by ultra-high-performance liquid chromatography-tandem mass spectrometry: Application in a stereoselective pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 921-922, Issue , 2013, Pages 27-34

  Lu, Youming ^a,b   Sun, Zuoming ^b   Zhang, Yifan ^b   Chen, Xiaoyan ^b   Zhong, Dafang ^a,b  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Budesonide epimers; Stereoselective pharmacokinetics; Ultra high performance liquid chromatography tandem mass spectrometry (UHPLC MS MS)

Indexed keywords

ACQUITY; ALKALINE CONDITIONS; AMMONIUM ACETATE; BASELINE SEPARATION; CALIBRATION CURVES; CONCENTRATION RANGES; CONTROLLED RELEASE; EPIMERS; HUMAN PLASMAS; INFLAMMATORY BOWEL DISEASE; INTERNAL STANDARDS; ISOCRATIC MOBILE PHASE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; MASS SPECTROMETRIC DETECTION; MULTIPLE-REACTION MONITORING MODES; N-HEXANE; PHARMACOKINETIC STUDIES; QUANTITATIVE DETERMINATIONS; STEREO-SELECTIVE; STEREOSELECTIVE PHARMACOKINETICS; TOPICAL TREATMENTS; U-HPLC-MS;

AMMONIUM COMPOUNDS; CHROMATOGRAPHY; DISEASES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN);

STEREOSELECTIVITY;

2 PROPANOL; ACETIC ACID; ACETONITRILE; AMMONIUM ACETATE; BUDESONIDE; DICHLOROMETHANE; HEXANE;

ADULT; ALKALINITY; ARTICLE; CALIBRATION; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG ELIMINATION; DRUG PURITY; EPIMER; FEMALE; HUMAN; HUMAN EXPERIMENT; LIMIT OF QUANTITATION; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHASE TRANSITION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPEATED DRUG DOSE; SINGLE DRUG DOSE; STEREOCHEMISTRY; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ADULT; ANTI-INFLAMMATORY AGENTS; BUDESONIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLUCOCORTICOIDS; HUMANS; MALE; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

EID: 84873953943     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.01.015     Document Type: Article

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