LC-MS/MS determination of budesonide in dog plasma

Yaoxue Xuebao

Volumn 43, Issue 1, 2008, Pages 76-80

  Deng, Pan ^a,b   Duan, Xiao Tao ^a,b   Chen, Xiao Yan ^a   Li, San Ming ^b   Zhong, Da Fang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Budesonide; Controlled release formulation; LC MS MS; Pharmacokinetics

Indexed keywords

ANTIINFLAMMATORY AGENT; BUDESONIDE;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BLOOD; DELAYED RELEASE FORMULATION; DOG; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MALE; METHODOLOGY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AREA UNDER CURVE; BUDESONIDE; CHROMATOGRAPHY, LIQUID; DELAYED-ACTION PREPARATIONS; DOGS; MALE; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 38849133636     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Seibold F, Wagner AC , Coke B, et al. Drug treatment of chronic inflammatory bowel diseases: current status and prospects [J]. Schweiz Med Wochenschr, 2000,130: 222-223.
2. Edsbacker S, Andersson P, Lindberg C, et al. Liver metabolism of budesonide in rat, mouse, and man. Comparative aspects [J]. Drug Metab Dispos, 1987,15: 403-411.
3. Greenberg GR. Budesonide for the treatment of inflammatory bowel disease [J]. Can J Gastroenterol, 1994,8:369-372.
4. Krishnamachari Y, Madan P, Lin SS. Development of pH- and time-dependent oral microparticles to optimize budesonide delivery to ileum and colon [J]. Int J Pharm, 2007,338:238-247.
5. Liu Y, Zhang JS, Hu LS. Study on the preparation and drug release of controlled-release micropellets for budesonide colon specific deliver [J]. J Chin Pharm Univ, 2003,34:419-422.
6. Cui JH, Yan YD, Guo JP, et al. Studies on the preparation and release in vitro of budesonide pulsatile controlled-release tablet for colon-specific deliver [J]. Pharm J Chin PLA, 2004,20: 418-419.
7. Ryrfeldt A, Tonnesson M, Nilsson E, et al. Pharmacokinetic studies of a potent glucocorticoid (budesonide) in dogs by high-performance liquid chromatography [J]. J Steroid Biochem, 1979,10:317-324.
8. Hochhaus G, Fröehlich P, Hochhaus R, et al. A selective HPLC/RIA for the determination of budesonide [J]. J Pharm Biomed Anal, 1998,17:1235-1242.
9. Qu J, Qu Y, Straubinger RM. Ultra-sensitive quantification of corticosteroids in plasma samples using selective solid-phase extraction and reversed-phase capillary high-performance liquid chromatography/tandem mass spectrometry [J]. Anal Chem, 2007,79:3786-3793.
10. Kronkvist K, Gustavsson M, Wendel AK, et al. Automated sample preparation for the determination of budesonide in plasma samples by liquid chromatography and tandem mass spectrometry [J]. J Chromatogr A, 1998,823:401-409.
11. Wang YN, Tang YF, Moellmann H, et al. Simultaneous quantification of budesonide and its two metabolites, 6β-hydrobudesonide and 16α-hydroxyprednisolone in human plasma by liquid chromatography negative electrospray ionization tandem mass spectrometry? [J]. Biomed Chromatogr, 2003,17:158-164.
12. Deventer K, Mikulcíková P, Van Hoecke H, et al. Detection of budesonide in human urine after inhalation by liquid chromatography-mass spectrometry [J]. J Pharm Biomed Anal, 2006,42:474-479.