메뉴 건너뛰기




Volumn 13, Issue 2, 2013, Pages 165-178

Chemotherapy regimens in early breast cancer: Major controversies and future outlook

Author keywords

adjuvant chemotherapy; anthracyclines; breast cancer; estrogen receptor; gene expression signatures; HER2; taxanes

Indexed keywords

ANTHRACYCLINE; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; ESTROGEN RECEPTOR; FLUOROURACIL; METHOTREXATE; PACLITAXEL; PLASMINOGEN ACTIVATOR INHIBITOR; PROGESTERONE RECEPTOR; TAMOXIFEN; TRASTUZUMAB; UROKINASE;

EID: 84873890597     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/era.12.172     Document Type: Review
Times cited : (20)

References (95)
  • 1
    • 84856636292 scopus 로고    scopus 로고
    • Comparisons between different polychem-otherapy regimens for early breast cancer: Meta-analyses of long-term outcome among 100, 000 women in 123 randomised trials
    • Peto R, Davies C, Godwin J et al. Comparisons between different polychem-otherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100, 000 women in 123 randomised trials. Lancet 379(9814), 432-444 (2012).
    • (2012) Lancet , vol.379 , Issue.9814 , pp. 432-444
    • Peto, R.1    Davies, C.2    Godwin, J.3
  • 2
    • 37849035252 scopus 로고    scopus 로고
    • Taxane-based combinations as adjuvant chemotherapy of early breast cancer: A meta-analysis of randomized trials
    • De Laurentiis M, Cancello G, D'Agostino D et al. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials. J. Clin. Oncol. 26(1), 44-53 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.1 , pp. 44-53
    • De Laurentiis, M.1    Cancello, G.2    D'Agostino, D.3
  • 3
    • 79960980007 scopus 로고    scopus 로고
    • Strategies for subtypes-dealing with the diversity of breast cancer: Highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
    • Panel members.
    • Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thürlimann B, Senn HJ; Panel members. Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann. Oncol. 22(8), 1736-1747 (2011)
    • (2011) Ann. Oncol. , vol.22 , Issue.8 , pp. 1736-1747
    • Goldhirsch, A.1    Wood, W.C.2    Coates, A.S.3    Gelber, R.D.4    Thürlimann, B.5    Senn, H.J.6
  • 5
    • 0141576783 scopus 로고    scopus 로고
    • Meeting highlights: Updated international expert consensus on the primary therapy of early breast cancer
    • Goldhirsch A, Wood WC, Gelber RD, Coates AS, Thürlimann B, Senn HJ. Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer. J. Clin. Oncol. 21(17), 3357-3365 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.17 , pp. 3357-3365
    • Goldhirsch, A.1    Wood, W.C.2    Gelber, R.D.3    Coates, A.S.4    Thürlimann, B.5    Senn, H.J.6
  • 6
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sørlie T, Perou CM, Tibshirani R et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl Acad. Sci. USA 98(19), 10869-10874 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , Issue.19 , pp. 10869-10874
    • Sørlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 7
    • 0037687355 scopus 로고    scopus 로고
    • Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: Frst report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741
    • Citron ML, Berry DA, Cirrincione C et al. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: frst report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741. J. Clin. Oncol. 21(8), 1431-1439 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.8 , pp. 1431-1439
    • Citron, M.L.1    Berry, D.A.2    Cirrincione, C.3
  • 8
    • 21144435932 scopus 로고    scopus 로고
    • Adjuvant docetaxel for node-positive breast cancer
    • Breast Cancer International Research Group 001 Investigators.
    • Martin M, Pienkowski T, Mackey J et al.; Breast Cancer International Research Group 001 Investigators. Adjuvant docetaxel for node-positive breast cancer. N. Engl. J. Med. 352(22), 2302-2313 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , Issue.22 , pp. 2302-2313
    • Martin, M.1    Pienkowski, T.2    MacKey, J.3
  • 9
    • 34247329446 scopus 로고    scopus 로고
    • Sequential adjuvant epirubicin-based and docetaxel chemotherapy for node-positive breast cancer patients: The FNCLCC PACS 01 Trial
    • Roché H, Fumoleau P, Spielmann M et al. Sequential adjuvant epirubicin-based and docetaxel chemotherapy for node-positive breast cancer patients: the FNCLCC PACS 01 Trial. J. Clin. Oncol. 24(36), 5664-5671 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.36 , pp. 5664-5671
    • Roché, H.1    Fumoleau, P.2    Spielmann, M.3
  • 10
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365(9472), 1687-1717 (2005).
    • (2005) Lancet , vol.365 , Issue.9472 , pp. 1687-1717
  • 11
    • 72149104757 scopus 로고    scopus 로고
    • Adjuvant chemotherapy and timing of tamoxifen in postmenopausal patients with endocrine-responsive, node-positive breast cancer: A Phase 3, open-label, randomised controlled trial
    • Breast Cancer Intergroup of North America
    • Albain KS, Barlow WE, Ravdin PM et al.; Breast Cancer Intergroup of North America. Adjuvant chemotherapy and timing of tamoxifen in postmenopausal patients with endocrine-responsive, node-positive breast cancer: a Phase 3, open-label, randomised controlled trial. Lancet 374(9707), 2055-2063 (2009).
    • (2009) Lancet , vol.374 , Issue.9707 , pp. 2055-2063
    • Albain, K.S.1    Barlow, W.E.2    Ravdin, P.M.3
  • 12
    • 0025063119 scopus 로고
    • Two months of doxorubicin-cyclophospha-mide with and without interval reinduction therapy compared with 6 months of cyclophosphamide, methotrexate, and fuorouracil in positive-node breast cancer patients with tamoxifen-nonresponsive tumors: Results from the National Surgical Adjuvant Breast and Bowel Project B-15
    • Fisher B, Brown AM, Dimitrov NV et al. Two months of doxorubicin- cyclophospha-mide with and without interval reinduction therapy compared with 6 months of cyclophosphamide, methotrexate, and fuorouracil in positive-node breast cancer patients with tamoxifen-nonresponsive tumors: results from the National Surgical Adjuvant Breast and Bowel Project B-15. J. Clin. Oncol. 8 (9), 1483-1496 (1990).
    • (1990) J. Clin. Oncol. , vol.8 , Issue.9 , pp. 1483-1496
    • Fisher, B.1    Brown, A.M.2    Dimitrov, N.V.3
  • 13
    • 32944465779 scopus 로고    scopus 로고
    • Randomized, controlled trial of cyclophos-phamide, methotrexate, and fuorouracil versus cyclophosphamide, doxorubicin, and fuorouracil with and without tamoxifen for high-risk, node-negative breast cancer: Treatment results of Intergroup Protocol INT-0102
    • Hutchins LF, Green SJ, Ravdin PM et al. Randomized, controlled trial of cyclophos-phamide, methotrexate, and fuorouracil versus cyclophosphamide, doxorubicin, and fuorouracil with and without tamoxifen for high-risk, node-negative breast cancer: treatment results of Intergroup Protocol INT-0102. J. Clin. Oncol. 23(33), 8313-8321 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.33 , pp. 8313-8321
    • Hutchins, L.F.1    Green, S.J.2    Ravdin, P.M.3
  • 14
    • 0027506071 scopus 로고
    • A pilot study of intensive cyclophospha-mide, epirubicin and fuorouracil in patients with axillary node positive or locally advanced breast cancer
    • Levine MN, Bramwell V, Pritchard K et al. A pilot study of intensive cyclophospha-mide, epirubicin and fuorouracil in patients with axillary node positive or locally advanced breast cancer. Eur. J. Cancer 29A(1), 37-43 (1992).
    • (1992) Eur. J. Cancer , vol.29 A , Issue.1 , pp. 37-43
    • Levine, M.N.1    Bramwell, V.2    Pritchard, K.3
  • 15
    • 0031927983 scopus 로고    scopus 로고
    • Randomized trial of intensive cyclophosphamide, epirubicin, and fuorouracil chemotherapy compared with cyclophosphamide, methotrexate, and fuorouracil in premenopausal women with node-positive breast cancer. National Cancer Institute of Canada Clinical Trials Group
    • Levine MN, Bramwell VH, Pritchard KI et al. Randomized trial of intensive cyclophosphamide, epirubicin, and fuorouracil chemotherapy compared with cyclophosphamide, methotrexate, and fuorouracil in premenopausal women with node-positive breast cancer. National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 16(8), 2651-2658 (1998).
    • (1998) J. Clin. Oncol. , vol.16 , Issue.8 , pp. 2651-2658
    • Levine, M.N.1    Bramwell, V.H.2    Pritchard, K.I.3
  • 16
    • 24644476579 scopus 로고    scopus 로고
    • Randomized trial comparing cyclophosphamide, epirubicin, and fuorouracil with cyclophosphamide, methotrexate, and fuorouracil in premenopausal women with node-positive breast cancer: Update of National Cancer Institute of Canada Clinical Trials Group Trial MA5
    • National Cancer Institute of Canada Clinical Trials Group.
    • Levine MN, Pritchard KI, Bramwell VH, Shepherd LE, Tu D, Paul N; National Cancer Institute of Canada Clinical Trials Group. Randomized trial comparing cyclophosphamide, epirubicin, and fuorouracil with cyclophosphamide, methotrexate, and fuorouracil in premenopausal women with node-positive breast cancer: update of National Cancer Institute of Canada Clinical Trials Group Trial MA5. J. Clin. Oncol. 23(22), 5166-5170 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.22 , pp. 5166-5170
    • Levine, M.N.1    Pritchard, K.I.2    Bramwell, V.H.3    Shepherd, L.E.4    Tu, D.5    Paul, N.6
  • 17
    • 0038688702 scopus 로고    scopus 로고
    • Doxorubicin in combination with fuorouracil and cyclophosphamide (i.v. FAC regimen, day 1, 21) versus methotrexate in combination with fuorouracil and cyclophosphamide (i.v. CMF regimen, day 1, 21) as adjuvant chemotherapy for operable breast cancer: A study by the GEICAM group
    • GEICAM Group (Spanish Breast Cancer Research Group), Spain
    • Martin M, Villar A, Sole-Calvo A et al.; GEICAM Group (Spanish Breast Cancer Research Group), Spain. Doxorubicin in combination with fuorouracil and cyclophosphamide (i.v. FAC regimen, day 1, 21) versus methotrexate in combination with fuorouracil and cyclophosphamide (i.v. CMF regimen, day 1, 21) as adjuvant chemotherapy for operable breast cancer: a study by the GEICAM group. Ann. Oncol. 14(6), 833-842 (2003).
    • (2003) Ann. Oncol. , vol.14 , Issue.6 , pp. 833-842
    • Martin, M.1    Villar, A.2    Sole-Calvo, A.3
  • 18
    • 21044437811 scopus 로고    scopus 로고
    • Epirubicin increases long-term survival in adjuvant chemotherapy of patients with poor-prognosis, node-positive, early breast cancer: 10-year follow-up results of the French Adjuvant Study Group 05 randomized trial
    • Bonneterre J, Roché H, Kerbrat P et al. Epirubicin increases long-term survival in adjuvant chemotherapy of patients with poor-prognosis, node-positive, early breast cancer: 10-year follow-up results of the French Adjuvant Study Group 05 randomized trial. J. Clin. Oncol. 23(12), 2686-2693 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.12 , pp. 2686-2693
    • Bonneterre, J.1    Roché, H.2    Kerbrat, P.3
  • 19
    • 27744441618 scopus 로고    scopus 로고
    • Selection of adjuvant chemotherapy for treatment of node-positive breast cancer
    • Trudeau M, Charbonneau F, Gelmon K et al. Selection of adjuvant chemotherapy for treatment of node-positive breast cancer. Lancet Oncol. 6(11), 886-898 (2005).
    • (2005) Lancet Oncol. , vol.6 , Issue.11 , pp. 886-898
    • Trudeau, M.1    Charbonneau, F.2    Gelmon, K.3
  • 20
    • 0032547342 scopus 로고    scopus 로고
    • Dose and dose intensity as determinants of outcome in the adjuvant treatment of breast cancer. The Cancer and Leukemia Group B
    • Budman DR, Berry DA, Cirrincione CT et al. Dose and dose intensity as determinants of outcome in the adjuvant treatment of breast cancer. The Cancer and Leukemia Group B. J. Natl Cancer Inst. 90(16), 1205-1211 (1998).
    • (1998) J. Natl Cancer Inst. , vol.90 , Issue.16 , pp. 1205-1211
    • Budman, D.R.1    Berry, D.A.2    Cirrincione, C.T.3
  • 21
    • 0030913595 scopus 로고    scopus 로고
    • Increased intensifcation and total dose of cyclophosphamide in a doxorubicin-cyclo-phosphamide regimen for the treatment of primary breast cancer: Fndings from National Surgical Adjuvant Breast and Bowel Project B-22
    • Fisher B, Anderson S, Wickerham DL et al. Increased intensifcation and total dose of cyclophosphamide in a doxorubicin-cyclo-phosphamide regimen for the treatment of primary breast cancer: fndings from National Surgical Adjuvant Breast and Bowel Project B-22. J. Clin. Oncol. 15 (5), 1858-1869 (1997).
    • (1997) J. Clin. Oncol. , vol.15 , Issue.5 , pp. 1858-1869
    • Fisher, B.1    Anderson, S.2    Wickerham, D.L.3
  • 22
    • 0037445132 scopus 로고    scopus 로고
    • Improved outcomes from adding sequential Paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer
    • Henderson IC, Berry DA, Demetri GD et al. Improved outcomes from adding sequential Paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer. J. Clin. Oncol. 21(6), 976-983 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.6 , pp. 976-983
    • Henderson, I.C.1    Berry, D.A.2    Demetri, G.D.3
  • 23
    • 0035875815 scopus 로고    scopus 로고
    • Phase III trial comparing two dose levels of epirubicin combined with cyclophospha-mide with cyclophosphamide, methotrex-ate, and fuorouracil in node-positive breast cancer
    • Piccart MJ, Di Leo A, Beauduin M et al. Phase III trial comparing two dose levels of epirubicin combined with cyclophospha-mide with cyclophosphamide, methotrex-ate, and fuorouracil in node-positive breast cancer. J. Clin. Oncol. 19 (12), 3103-3110 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , Issue.12 , pp. 3103-3110
    • Piccart, M.J.1    Di Leo, A.2    Beauduin, M.3
  • 24
    • 0028354305 scopus 로고
    • C-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer
    • Muss HB, Thor AD, Berry DA et al. c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer. N. Engl. J. Med. 330(18), 1260-1266 (1994).
    • (1994) N. Engl. J. Med. , vol.330 , Issue.18 , pp. 1260-1266
    • Muss, H.B.1    Thor, A.D.2    Berry, D.A.3
  • 25
    • 23044452221 scopus 로고    scopus 로고
    • HER2 expression and effcacy of dose-dense anthracycline-containing adjuvant chemotherapy in breast cancer patients
    • Del Mastro L, Bruzzi P, Nicolò G et al. HER2 expression and effcacy of dose-dense anthracycline-containing adjuvant chemotherapy in breast cancer patients. Br. J. Cancer 93(1), 7-14 (2005).
    • (2005) Br. J. Cancer , vol.93 , Issue.1 , pp. 7-14
    • Del Mastro, L.1    Bruzzi, P.2    Nicolò, G.3
  • 26
    • 35248895346 scopus 로고    scopus 로고
    • HER2 and response to paclitaxel in node-positive breast cancer
    • Cancer and Leukemia Group B (CALGB) Investigators.
    • Hayes DF, Thor AD, Dressler LG et al.; Cancer and Leukemia Group B (CALGB) Investigators. HER2 and response to paclitaxel in node-positive breast cancer. N. Engl. J. Med. 357 (15), 1496-1506 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , Issue.15 , pp. 1496-1506
    • Hayes, D.F.1    Thor, A.D.2    Dressler, L.G.3
  • 27
    • 38049103907 scopus 로고    scopus 로고
    • HER2 status and effcacy of adjuvant anthracyclines in early breast cancer: A pooled analysis of randomized trials
    • Gennari A, Sormani MP, Pronzato P et al. HER2 status and effcacy of adjuvant anthracyclines in early breast cancer: a pooled analysis of randomized trials. J. Natl Cancer Inst. 100(1), 14-20 (2008).
    • (2008) J. Natl Cancer Inst. , vol.100 , Issue.1 , pp. 14-20
    • Gennari, A.1    Sormani, M.P.2    Pronzato, P.3
  • 29
    • 33750615735 scopus 로고    scopus 로고
    • Simultaneous amplifcation of HER-2 (ERBB2) and topoisomerase IIα (TOP2A) genes-molecular basis for combination chemotherapy in cancer
    • Järvinen TA, Liu ET. Simultaneous amplifcation of HER-2 (ERBB2) and topoisomerase IIα (TOP2A) genes-molecular basis for combination chemotherapy in cancer. Curr. Cancer Drug Targets 6(7), 579-602 (2006).
    • (2006) Curr. Cancer Drug Targets , vol.6 , Issue.7 , pp. 579-602
    • Järvinen, T.A.1    Liu, E.T.2
  • 30
    • 79959705252 scopus 로고    scopus 로고
    • Topoi-somerase II α protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA.5 adjuvant trial
    • O'Malley FP, Chia S, Tu D et al. Topoi-somerase II α protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA.5 adjuvant trial. Breast Cancer Res. Treat. 128(2), 401-409 (2011).
    • (2011) Breast Cancer Res. Treat. , vol.128 , Issue.2 , pp. 401-409
    • O'Malley, F.P.1    Chia, S.2    Tu, D.3
  • 31
    • 79952323665 scopus 로고    scopus 로고
    • Alteration of topoisomerase II-α gene in human breast cancer: Association with responsiveness to anthracycline-based chemotherapy
    • Press MF, Sauter G, Buyse M et al. Alteration of topoisomerase II-α gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy. J. Clin. Oncol. 29(7), 859-867 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.7 , pp. 859-867
    • Press, M.F.1    Sauter, G.2    Buyse, M.3
  • 32
    • 1442265950 scopus 로고    scopus 로고
    • Amplifcation of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes
    • Danish Breast Cancer Co-operative Group.
    • Olsen KE, Knudsen H, Rasmussen BB et al.; Danish Breast Cancer Co-operative Group. Amplifcation of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes. Acta Oncol. 43(1), 35-42 (2004).
    • (2004) Acta Oncol. , vol.43 , Issue.1 , pp. 35-42
    • Olsen, K.E.1    Knudsen, H.2    Rasmussen, B.B.3
  • 33
    • 0043145754 scopus 로고    scopus 로고
    • Characterization of topoisomer-ase II α gene amplifcation and deletion in breast cancer
    • Järvinen TA, Tanner M, Bärlund M, Borg A, Isola J. Characterization of topoisomer-ase II α gene amplifcation and deletion in breast cancer. Genes. Chromosomes Cancer 26(2), 142-150 (1999).
    • (1999) Genes. Chromosomes Cancer , vol.26 , Issue.2 , pp. 142-150
    • Järvinen, T.A.1    Tanner, M.2    Bärlund, M.3    Borg, A.4    Isola, J.5
  • 34
    • 0036091354 scopus 로고    scopus 로고
    • HER-2 amplifcation and topoisomerase IIα gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracy-cline-based therapy or with cyclophospha-mide, methotrexate, and 5-fuorouracil
    • Di Leo A, Gancberg D, Larsimont D et al. HER-2 amplifcation and topoisomerase IIα gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracy-cline-based therapy or with cyclophospha-mide, methotrexate, and 5-fuorouracil. Clin. Cancer Res. 8 (5), 1107-1116 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , Issue.5 , pp. 1107-1116
    • Di Leo, A.1    Gancberg, D.2    Larsimont, D.3
  • 36
    • 0035865147 scopus 로고    scopus 로고
    • Tamoxifen and chemotherapy for axillary node-negative, estrogen receptor-negative breast cancer: Fndings from National Surgical Adjuvant Breast and Bowel Project B-23
    • Fisher B, Anderson S, Tan-Chiu E et al. Tamoxifen and chemotherapy for axillary node-negative, estrogen receptor-negative breast cancer: fndings from National Surgical Adjuvant Breast and Bowel Project B-23. J. Clin. Oncol. 19(4), 931-942 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , Issue.4 , pp. 931-942
    • Fisher, B.1    Anderson, S.2    Tan-Chiu, E.3
  • 37
    • 20544434991 scopus 로고    scopus 로고
    • Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemothera py for node-positive breast cancer: Results from NSABP B-28
    • Mamounas EP, Bryant J, Lembersky B et al. Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemothera py for node-positive breast cancer: results from NSABP B-28. J. Clin. Oncol. 23(16), 3686-3696 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16 , pp. 3686-3696
    • Mamounas, E.P.1    Bryant, J.2    Lembersky, B.3
  • 38
    • 66549090114 scopus 로고    scopus 로고
    • Primary breast cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up
    • ESMO Guidelines Working Group.
    • Kataja V, Castiglione M; ESMO Guidelines Working Group. Primary breast cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann. Oncol. 20(Suppl. 4), 10-14 (2009).
    • (2009) Ann. Oncol. , vol.20 , Issue.SUPPL. 4 , pp. 10-14
    • Kataja, V.1    Castiglione, M.2
  • 39
    • 0033958915 scopus 로고    scopus 로고
    • Clinical and immune responses in advanced melanoma patients immunized with an anti-idiotype antibody mimicking disialoganglioside GD2
    • Foon KA, Lutzky J, Baral RN et al. Clinical and immune responses in advanced melanoma patients immunized with an anti-idiotype antibody mimicking disialoganglioside GD2. J. Clin. Oncol. 18(2), 376-384 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , Issue.2 , pp. 376-384
    • Foon, K.A.1    Lutzky, J.2    Baral, R.N.3
  • 40
    • 44949228316 scopus 로고    scopus 로고
    • Randomized Phase 3 trial of fuorouracil, epirubicin, and cyclophosphamide alone or followed by Paclitaxel for early breast cancer
    • GEICAM 9906 Study Investigators.
    • Martín M, Rodríguez-Lescure A, Ruiz A et al.; GEICAM 9906 Study Investigators. Randomized Phase 3 trial of fuorouracil, epirubicin, and cyclophosphamide alone or followed by Paclitaxel for early breast cancer. J. Natl Cancer Inst. 100(11), 805-814 (2008).
    • (2008) J. Natl Cancer Inst. , vol.100 , Issue.11 , pp. 805-814
    • Martín, M.1    Rodríguez-Lescure, A.2    Ruiz, A.3
  • 41
    • 73949090093 scopus 로고    scopus 로고
    • Cyclophosphamide, epirubicin, and fuorouracil versus dose-dense epirubicin and cyclophosphamide followed by paclitaxel versus doxorubicin and cyclophosphamide followed by paclitaxel in node-positive or high-risk node-negative breast cancer
    • Burnell M, Levine MN, Chapman JA et al. Cyclophosphamide, epirubicin, and fuorouracil versus dose-dense epirubicin and cyclophosphamide followed by paclitaxel versus doxorubicin and cyclophosphamide followed by paclitaxel in node-positive or high-risk node-negative breast cancer. J. Clin. Oncol. 28(1), 77-82 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.1 , pp. 77-82
    • Burnell, M.1    Levine, M.N.2    Chapman, J.A.3
  • 42
    • 72449138560 scopus 로고    scopus 로고
    • FEC versus sequential docetaxel followed by epirubicin/cyclophosphamide as adjuvant chemotherapy in women with axillary node-positive early breast cancer: A randomized study of the Hellenic Oncology Research Group (HORG)
    • Polyzos A, Malamos N, Boukovinas I et al. FEC versus sequential docetaxel followed by epirubicin/cyclophosphamide as adjuvant chemotherapy in women with axillary node-positive early breast cancer: a randomized study of the Hellenic Oncology Research Group (HORG). Breast Cancer Res. Treat. 119(1), 95-104 (2010).
    • (2010) Breast Cancer Res. Treat. , vol.119 , Issue.1 , pp. 95-104
    • Polyzos, A.1    Malamos, N.2    Boukovinas, I.3
  • 43
    • 38449108413 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with sequential or concurrent anthracycline and docetaxel: Breast International Group 02-98 randomized trial
    • BIG 02-98 Collaborative Group.
    • Francis P, Crown J, Di Leo A et al.; BIG 02-98 Collaborative Group. Adjuvant chemotherapy with sequential or concurrent anthracycline and docetaxel: Breast International Group 02-98 randomized trial. J. Natl Cancer Inst. 100 (2), 121-133 (2008).
    • (2008) J. Natl Cancer Inst. , vol.100 , Issue.2 , pp. 121-133
    • Francis, P.1    Crown, J.2    Di Leo, A.3
  • 44
    • 51749093141 scopus 로고    scopus 로고
    • Concurrent doxorubicin plus docetaxel is not more effective than concurrent doxorubicin plus cyclophosphamide in operable breast cancer with 0 to 3 positive axillary nodes: North American Breast Cancer Intergroup Trial e 2197
    • Goldstein LJ, O'Neill A, Sparano JA et al. Concurrent doxorubicin plus docetaxel is not more effective than concurrent doxorubicin plus cyclophosphamide in operable breast cancer with 0 to 3 positive axillary nodes: North American Breast Cancer Intergroup Trial E 2197. J. Clin. Oncol. 26(25), 4092-4099 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.25 , pp. 4092-4099
    • Goldstein, L.J.1    O'Neill, A.2    Sparano, J.A.3
  • 45
    • 62449193617 scopus 로고    scopus 로고
    • Docetaxel with cyclophosphamide is associated with an overall survival beneft compared with doxorubicin and cyclophos-phamide: 7-year follow-up of US Oncology Research Trial 9735
    • Jones S, Holmes FA, O'Shaughnessy J et al. Docetaxel with cyclophosphamide is associated with an overall survival beneft compared with doxorubicin and cyclophos-phamide: 7-year follow-up of US Oncology Research Trial 9735. J. Clin. Oncol. 27(8), 1177-1183 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.8 , pp. 1177-1183
    • Jones, S.1    Holmes, F.A.2    O'Shaughnessy, J.3
  • 46
    • 80055114453 scopus 로고    scopus 로고
    • Adjuvant chemotherapy, with or without taxanes, in early or operable breast cancer: A meta-analysis of 19 randomized trials with 30698 patients
    • Qin Y Y, Li H, Guo XJ et al. Adjuvant chemotherapy, with or without taxanes, in early or operable breast cancer: a meta-analysis of 19 randomized trials with 30698 patients. PLoS ONE 6(11), e26946 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.11
    • Qin, Y.Y.1    Li, H.2    Guo, X.J.3
  • 47
    • 42249083269 scopus 로고    scopus 로고
    • Weekly paclitaxel in the adjuvant treatment of breast cancer
    • Sparano JA, Wang M, Martino S et al. Weekly paclitaxel in the adjuvant treatment of breast cancer. N. Engl. J. Med. 358(16), 1663-1671 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , Issue.16 , pp. 1663-1671
    • Sparano, J.A.1    Wang, M.2    Martino, S.3
  • 48
    • 78651156947 scopus 로고
    • Experimental evaluation of potential anticancer agents. XIII. on the criteria and kinetics associated with 'curability' of experimental leukemia
    • Skipper HE, Schabel FM Jr, Wilcox WS. Experimental evaluation of potential anticancer agents. XIII. On the criteria and kinetics associated with 'curability' of experimental leukemia. Cancer Chemother. Rep. 35, 1-111 (1964).
    • (1964) Cancer Chemother. Rep. , vol.35 , pp. 1-111
    • Skipper, H.E.1    Schabel Jr., F.M.2    Wilcox, W.S.3
  • 49
    • 0028829306 scopus 로고
    • Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer
    • Fisher B, Anderson S, Redmond CK, Wolmark N, Wickerham DL, Cronin WM. Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. N. Engl. J. Med. 333 (22), 1456-1461 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , Issue.22 , pp. 1456-1461
    • Fisher, B.1    Anderson, S.2    Redmond, C.K.3    Wolmark, N.4    Wickerham, D.L.5    Cronin, W.M.6
  • 50
    • 0022600727 scopus 로고
    • The Norton-Simon hypothesis revisited
    • Norton L, Simon R. The Norton-Simon hypothesis revisited. Cancer Treat. Rep. 70(1) 163-169 (1986).
    • (1986) Cancer Treat. Rep. , vol.70 , Issue.1 , pp. 163-169
    • Norton, L.1    Simon, R.2
  • 51
    • 0024214663 scopus 로고
    • A Gompertzian model of human breast cancer growth
    • Norton L. A Gompertzian model of human breast cancer growth. Cancer Res. 48(24 Pt 1) 7067-7071 (1988).
    • (1988) Cancer Res. , vol.48 , Issue.24 PART 1 , pp. 7067-7071
    • Norton, L.1
  • 52
    • 28944442051 scopus 로고    scopus 로고
    • Dose-dense adjuvant chemotherapy in early breast cancer patients: Results from a randomized trial
    • Venturini M, Del Mastro L, Aitini E et al. Dose-dense adjuvant chemotherapy in early breast cancer patients: results from a randomized trial. J. Natl Cancer Inst. 97(23), 1724-1733 (2005).
    • (2005) J. Natl Cancer Inst. , vol.97 , Issue.23 , pp. 1724-1733
    • Venturini, M.1    Del Mastro, L.2    Aitini, E.3
  • 53
    • 77956170294 scopus 로고    scopus 로고
    • Intense dose-dense sequential chemotherapy with epirubicin, paclitaxel, and cyclophosphamide compared with conventionally scheduled chemotherapy in high-risk primary breast cancer: Mature results of an AGO Phase III study
    • Moebus V, Jackisch C, Lueck HJ et al. Intense dose-dense sequential chemotherapy with epirubicin, paclitaxel, and cyclophosphamide compared with conventionally scheduled chemotherapy in high-risk primary breast cancer: mature results of an AGO Phase III study. J. Clin. Oncol. 28(17), 2874-2880 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.17 , pp. 2874-2880
    • Moebus, V.1    Jackisch, C.2    Lueck, H.J.3
  • 54
    • 0037365648 scopus 로고    scopus 로고
    • Final results of a randomized Phase III trial comparing cyclophosphamide, epirubicin, and fuorouracil with a dose-intensifed epirubicin and cyclophosphamide + flgrastim as neoadjuvant treatment in locally advanced breast cancer: An EORTC-NCIC-SAKK multicenter study
    • EORTC.
    • Therasse P, Mauriac L, Welnicka-Jaskiewicz M et al.; EORTC. Final results of a randomized Phase III trial comparing cyclophosphamide, epirubicin, and fuorouracil with a dose-intensifed epirubicin and cyclophosphamide + flgrastim as neoadjuvant treatment in locally advanced breast cancer: an EORTC-NCIC-SAKK multicenter study. J. Clin. Oncol. 21(5), 843-850 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.5 , pp. 843-850
    • Therasse, P.1    Mauriac, L.2    Welnicka-Jaskiewicz, M.3
  • 55
    • 33646495104 scopus 로고    scopus 로고
    • Randomised trial: Survival beneft and safety of adjuvant dose-dense chemotherapy for node-positive breast cancer
    • Kümmel S, Krocker J, Kohls A et al. Randomised trial: survival beneft and safety of adjuvant dose-dense chemotherapy for node-positive breast cancer. Br. J. Cancer 94(9), 1237-1244 (2006).
    • (2006) Br. J. Cancer , vol.94 , Issue.9 , pp. 1237-1244
    • Kümmel, S.1    Krocker, J.2    Kohls, A.3
  • 56
    • 84862535625 scopus 로고    scopus 로고
    • Dose-dense chemotherapy versus conventional chemotherapy for early breast cancer: A systematic review with meta-analysis
    • Lemos Duarte I, da Silveira Nogueira Lima JP, Passos Lima CS, Deeke Sasse A. Dose-dense chemotherapy versus conventional chemotherapy for early breast cancer: a systematic review with meta-analysis. Breast 21(3), 343-349 (2012).
    • (2012) Breast , vol.21 , Issue.3 , pp. 343-349
    • Lemos Duarte, I.1    Da Silveira Nogueira Lima, J.P.2    Passos Lima, C.S.3    Deeke Sasse, A.4
  • 57
    • 0242418151 scopus 로고    scopus 로고
    • Accelerated versus standard cyclophospha-mide, epirubicin and 5-fuorouracil or cyclophosphamide, methotrexate and 5-fuorouracil: A randomized Phase III trial in locally advanced breast cancer
    • Baldini E, Gardin G, Giannessi PG et al. Accelerated versus standard cyclophospha-mide, epirubicin and 5-fuorouracil or cyclophosphamide, methotrexate and 5-fuorouracil: a randomized Phase III trial in locally advanced breast cancer. Ann. Oncol. 14(2), 227-232 (2003).
    • (2003) Ann. Oncol. , vol.14 , Issue.2 , pp. 227-232
    • Baldini, E.1    Gardin, G.2    Giannessi, P.G.3
  • 58
    • 58749096903 scopus 로고    scopus 로고
    • A randomised pilot Phase II study of doxorubicin and cyclophosphamide (AC) or epirubicin and cyclophosphamide (EC) given 2 weekly with pegflgrastim (accelerated) vs 3 weekly (standard) for women with early breast cancer
    • Jones RL, Walsh G, Ashley S et al. A randomised pilot Phase II study of doxorubicin and cyclophosphamide (AC) or epirubicin and cyclophosphamide (EC) given 2 weekly with pegflgrastim (accelerated) vs 3 weekly (standard) for women with early breast cancer. Br. J. Cancer 100(2), 305-310 (2009).
    • (2009) Br. J. Cancer , vol.100 , Issue.2 , pp. 305-310
    • Jones, R.L.1    Walsh, G.2    Ashley, S.3
  • 59
    • 33847277446 scopus 로고    scopus 로고
    • The use of gene-expression profling to better understand the clinical heterogeneity of estrogen receptor positive breast cancers and tamoxifen response
    • Loi S, Piccart M, Sotiriou C. The use of gene-expression profling to better understand the clinical heterogeneity of estrogen receptor positive breast cancers and tamoxifen response. Crit. Rev. Oncol. Hematol. 61(3), 187-194 (2007).
    • (2007) Crit. Rev. Oncol. Hematol. , vol.61 , Issue.3 , pp. 187-194
    • Loi, S.1    Piccart, M.2    Sotiriou, C.3
  • 60
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sørlie T, Eisen MB et al. Molecular portraits of human breast tumours. Nature 406(6797), 747-752 (2000).
    • (2000) Nature , vol.406 , Issue.6797 , pp. 747-752
    • Perou, C.M.1    Sørlie, T.2    Eisen, M.B.3
  • 61
    • 83755174643 scopus 로고    scopus 로고
    • Molecular classifcation of estrogen receptor-positive/luminal breast cancers
    • Geyer FC, Rodrigues DN, Weigelt B, Reis-Filho JS. Molecular classifcation of estrogen receptor-positive/luminal breast cancers. Adv. Anat. Pathol. 19(1), 39-53 (2012).
    • (2012) Adv. Anat. Pathol. , vol.19 , Issue.1 , pp. 39-53
    • Geyer, F.C.1    Rodrigues, D.N.2    Weigelt, B.3    Reis-Filho, J.S.4
  • 62
    • 66849140730 scopus 로고    scopus 로고
    • Ki67 index HER2 status and prognosis of patients with luminal B breast cancer
    • Cheang MC, Chia SK, Voduc D et al. Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J. Natl Cancer Inst. 101(10), 736-750 (2009).
    • (2009) J. Natl Cancer Inst. , vol.101 , Issue.10 , pp. 736-750
    • Cheang, M.C.1    Chia, S.K.2    Voduc, D.3
  • 63
    • 69049113989 scopus 로고    scopus 로고
    • Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer
    • Mouridsen H, Giobbie-Hurder A, Goldhirsch A et al. Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer. N. Engl. J. Med. 361(8), 766-776 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.8 , pp. 766-776
    • Mouridsen, H.1    Giobbie-Hurder, A.2    Goldhirsch, A.3
  • 64
    • 11444251764 scopus 로고    scopus 로고
    • Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer
    • ATAC Trialists' Group
    • Howell A, Cuzick J, Baum M et al.; ATAC Trialists' Group. Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet 365(9453), 60-62 (2005).
    • (2005) Lancet , vol.365 , Issue.9453 , pp. 60-62
    • Howell, A.1    Cuzick, J.2    Baum, M.3
  • 65
    • 70349581483 scopus 로고    scopus 로고
    • Is adjuvant chemotherapy of beneft for postmenopausal women who receive endocrine treatment for highly endocrine-responsive, node-positive breast cancer? International Breast Cancer Study Group Trials VII and 12-93
    • International Breast Cancer Study Group.
    • Pagani O, Gelber S, Simoncini E et al.; International Breast Cancer Study Group. Is adjuvant chemotherapy of beneft for postmenopausal women who receive endocrine treatment for highly endocrine-responsive, node-positive breast cancer? International Breast Cancer Study Group Trials VII and 12-93. Breast Cancer Res. Treat. 116(3), 491-500 (2009).
    • (2009) Breast Cancer Res. Treat. , vol.116 , Issue.3 , pp. 491-500
    • Pagani, O.1    Gelber, S.2    Simoncini, E.3
  • 66
    • 46249110367 scopus 로고    scopus 로고
    • Premenopausal endocrine-responsive early breast cancer: Who receives chemotherapy?
    • SOFT/TEXT/PERCHE Steering Committee; International Breast Cancer Study Group
    • Regan MM, Pagani O, Walley B et al.; SOFT/TEXT/PERCHE Steering Committee; International Breast Cancer Study Group. Premenopausal endocrine-responsive early breast cancer: who receives chemotherapy? Ann. Oncol. 19 (7), 1231-1241 (2008).
    • (2008) Ann. Oncol. , vol.19 , Issue.7 , pp. 1231-1241
    • Regan, M.M.1    Pagani, O.2    Walley, B.3
  • 67
    • 58049196789 scopus 로고    scopus 로고
    • Is chemotherapy necessary for premeno-pausal women with lower-risk node-positive, endocrine responsive breast cancer? 10-year update of International Breast Cancer Study Group Trial 11-93
    • Thürlimann B, Price KN, Gelber RD et al. Is chemotherapy necessary for premeno-pausal women with lower-risk node-positive, endocrine responsive breast cancer? 10-year update of International Breast Cancer Study Group Trial 11-93. Breast Cancer Res. Treat. 113(1), 137-144 (2009).
    • (2009) Breast Cancer Res. Treat. , vol.113 , Issue.1 , pp. 137-144
    • Thürlimann, B.1    Price, K.N.2    Gelber, R.D.3
  • 68
    • 0022623005 scopus 로고
    • Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer: 5-year results from the National Surgical Adjuvant Breast and Bowel Project Trial
    • Fisher B, Redmond C, Brown A et al. Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer: 5-year results from the National Surgical Adjuvant Breast and Bowel Project Trial. J. Clin. Oncol. 4(4), 459-471 (1986).
    • (1986) J. Clin. Oncol. , vol.4 , Issue.4 , pp. 459-471
    • Fisher, B.1    Redmond, C.2    Brown, A.3
  • 69
    • 0025334752 scopus 로고
    • Postoperative chemotherapy and tamoxifen compared with tamoxifen alone in the treatment of positive-node breast cancer patients aged 50 years and older with tumors responsive to tamoxifen: Results from the National Surgical Adjuvant Breast and Bowel Project B-16
    • Fisher B, Redmond C, Legault-Poisson S et al. Postoperative chemotherapy and tamoxifen compared with tamoxifen alone in the treatment of positive-node breast cancer patients aged 50 years and older with tumors responsive to tamoxifen: results from the National Surgical Adjuvant Breast and Bowel Project B-16. J. Clin. Oncol. 8(6), 1005-1018 (1990).
    • (1990) J. Clin. Oncol. , vol.8 , Issue.6 , pp. 1005-1018
    • Fisher, B.1    Redmond, C.2    Legault-Poisson, S.3
  • 70
    • 0030693661 scopus 로고    scopus 로고
    • Tamoxifen and chemotherapy for lymph node-negative, estrogen receptor-positive breast cancer
    • Fisher B, Dignam J, Wolmark N et al. Tamoxifen and chemotherapy for lymph node-negative, estrogen receptor-positive breast cancer. J. Natl Cancer Inst. 89(22), 1673-1682 (1997).
    • (1997) J. Natl Cancer Inst. , vol.89 , Issue.22 , pp. 1673-1682
    • Fisher, B.1    Dignam, J.2    Wolmark, N.3
  • 71
    • 0037125429 scopus 로고    scopus 로고
    • Endocrine responsiveness and tailoring adjuvant therapy for postmeno-pausal lymph node-negative breast cancer: A randomized trial
    • International Breast Cancer Study Group (IBCSG)
    • International Breast Cancer Study Group (IBCSG). Endocrine responsiveness and tailoring adjuvant therapy for postmeno-pausal lymph node-negative breast cancer: a randomized trial. J. Natl Cancer Inst. 94(14), 1054-1065 (2002).
    • (2002) J. Natl Cancer Inst. , vol.94 , Issue.14 , pp. 1054-1065
  • 72
    • 33645729203 scopus 로고    scopus 로고
    • Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer
    • Berry DA, Cirrincione C, Henderson IC et al. Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. JAMA 295(14), 1658-1667 (2006).
    • (2006) JAMA , vol.295 , Issue.14 , pp. 1658-1667
    • Berry, D.A.1    Cirrincione, C.2    Henderson, I.C.3
  • 73
    • 33644973070 scopus 로고    scopus 로고
    • Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors
    • Guarneri V, Broglio K, Kau SW et al. Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors. J. Clin. Oncol. 24(7), 1037-1044 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.7 , pp. 1037-1044
    • Guarneri, V.1    Broglio, K.2    Kau, S.W.3
  • 74
    • 34447333123 scopus 로고    scopus 로고
    • Inclusion of taxanes, particularly weekly paclitaxel, in preoperative chemotherapy improves pathologic complete response rate in estrogen receptor-positive breast cancers
    • Mazouni C, Kau SW, Frye D et al. Inclusion of taxanes, particularly weekly paclitaxel, in preoperative chemotherapy improves pathologic complete response rate in estrogen receptor-positive breast cancers. Ann. Oncol. 18(5), 874-880 (2007).
    • (2007) Ann. Oncol. , vol.18 , Issue.5 , pp. 874-880
    • Mazouni, C.1    Kau, S.W.2    Frye, D.3
  • 75
    • 67649159045 scopus 로고    scopus 로고
    • Increasing steroid hormone receptors expression defnes breast cancer subtypes non responsive to preoperative chemotherapy
    • Colleoni M, Bagnardi V, Rotmensz N et al. Increasing steroid hormone receptors expression defnes breast cancer subtypes non responsive to preoperative chemotherapy. Breast Cancer Res. Treat. 116 (2), 359-369 (2009).
    • (2009) Breast Cancer Res. Treat. , vol.116 , Issue.2 , pp. 359-369
    • Colleoni, M.1    Bagnardi, V.2    Rotmensz, N.3
  • 76
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N. Engl. J. Med. 360(8), 790-800 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.8 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 77
    • 80052845090 scopus 로고    scopus 로고
    • HER2-negative breast cancer adds independent information to conventional clinical risk factors
    • EP Investigators. A new molecular predictor of distant recurrence in ER-positive
    • Filipits M, Rudas M, Jakesz R et al.; EP Investigators. A new molecular predictor of distant recurrence in ER-positive, HER2-negative breast cancer adds independent information to conventional clinical risk factors. Clin. Cancer Res. 17(18), 6012-6020 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.18 , pp. 6012-6020
    • Filipits, M.1    Rudas, M.2    Jakesz, R.3
  • 78
    • 34447132081 scopus 로고    scopus 로고
    • Development and clinical utility of a 21-gene recurrence score prognostic assay in patients with early breast cancer treated with tamoxifen
    • Paik S. Development and clinical utility of a 21-gene recurrence score prognostic assay in patients with early breast cancer treated with tamoxifen. Oncologist 12(6), 631-635 (2007).
    • (2007) Oncologist , vol.12 , Issue.6 , pp. 631-635
    • Paik, S.1
  • 79
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S, Shak S, Tang G et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. 351(27), 2817-2826 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , Issue.27 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 80
    • 33744808550 scopus 로고    scopus 로고
    • A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients
    • Habel LA, Shak S, Jacobs MK et al. A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients. Breast Cancer Res. 8(3), R25 (2006).
    • (2006) Breast Cancer Res. , vol.8 , Issue.3
    • Habel, L.A.1    Shak, S.2    Jacobs, M.K.3
  • 81
    • 33744814477 scopus 로고    scopus 로고
    • Gene expression and beneft of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    • Paik S, Tang G, Shak S et al. Gene expression and beneft of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J. Clin. Oncol. 24(23), 3726-3734 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.23 , pp. 3726-3734
    • Paik, S.1    Tang, G.2    Shak, S.3
  • 82
    • 58149330982 scopus 로고    scopus 로고
    • Meta-analysis of gene expression profles in breast cancer: Toward a unifed understanding of breast cancer subtyping and prognosis signatures
    • Wirapati P, Sotiriou C, Kunkel S et al. Meta-analysis of gene expression profles in breast cancer: toward a unifed understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res. 10(4), R65 (2008).
    • (2008) Breast Cancer Res. , vol.10 , Issue.4
    • Wirapati, P.1    Sotiriou, C.2    Kunkel, S.3
  • 83
    • 52949124120 scopus 로고    scopus 로고
    • A comparative study of survival models for breast cancer prognostication based on microarray data: Does a single gene beat them all?
    • Haibe-Kains B, Desmedt C, Sotiriou C, Bontempi G. A comparative study of survival models for breast cancer prognostication based on microarray data: does a single gene beat them all? Bioinformatics 24(19), 2200-2208 (2008).
    • (2008) Bioinformatics , vol.24 , Issue.19 , pp. 2200-2208
    • Haibe-Kains, B.1    Desmedt, C.2    Sotiriou, C.3    Bontempi, G.4
  • 84
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profling predicts clinical outcome of breast cancer
    • van 't Veer LJ, Dai H, van de Vijver MJ et al. Gene expression profling predicts clinical outcome of breast cancer. Nature 415(6871) 530-536 (2002).
    • (2002) Nature , vol.415 , Issue.6871 , pp. 530-536
    • Van't Veer, L.J.1    Dai, H.2    Van De Vijver, M.J.3
  • 85
    • 28044462186 scopus 로고    scopus 로고
    • Gene-expression profling and the future of adjuvant therapy
    • van de Vijver M. Gene-expression profling and the future of adjuvant therapy. Oncologist, 10(Suppl. 2), 30-34 (2005).
    • (2005) Oncologist , vol.10 , Issue.SUPPL. 2 , pp. 30-34
    • Van De Vijver, M.1
  • 86
    • 33748693297 scopus 로고    scopus 로고
    • Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer
    • TRANSBIG Consortium.
    • Buyse M, Loi S, van't Veer L et al.; TRANSBIG Consortium. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J. Natl Cancer Inst. 98 (17), 1183-1192 (2006).
    • (2006) J. Natl Cancer Inst. , vol.98 , Issue.17 , pp. 1183-1192
    • Buyse, M.1    Loi, S.2    Van'T Veer, L.3
  • 88
    • 3042685205 scopus 로고    scopus 로고
    • The urokinase plasminogen activator system: A rich source of tumour markers for the individualised management of patients with cancer
    • Duffy MJ, Duggan C. The urokinase plasminogen activator system: a rich source of tumour markers for the individualised management of patients with cancer. Clin. Biochem. 37(7), 541-548 (2004).
    • (2004) Clin. Biochem. , vol.37 , Issue.7 , pp. 541-548
    • Duffy, M.J.1    Duggan, C.2
  • 89
    • 12144261490 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator and its inhibitor type 1 predict disease outcome and therapy response in primary breast cancer
    • Harbeck N, Kates RE, Schmitt M et al. Urokinase-type plasminogen activator and its inhibitor type 1 predict disease outcome and therapy response in primary breast cancer. Clin. Breast Cancer 5(5), 348-352 (2004).
    • (2004) Clin. Breast Cancer , vol.5 , Issue.5 , pp. 348-352
    • Harbeck, N.1    Kates, R.E.2    Schmitt, M.3
  • 90
    • 7844236388 scopus 로고    scopus 로고
    • External quality assessment of trans-European multicentre antigen determinations (enzyme-linked immunosorbent assay) of urokinase-type plasminogen activator (uPA) and its type 1 inhibitor (PAI-1) in human breast cancer tissue extracts
    • Sweep CG, Geurts-Moespot J, Grebenschikov N et al. External quality assessment of trans-European multicentre antigen determinations (enzyme-linked immunosorbent assay) of urokinase-type plasminogen activator (uPA) and its type 1 inhibitor (PAI-1) in human breast cancer tissue extracts. Br. J. Cancer 78(11), 1434-1441 (1998).
    • (1998) Br. J. Cancer , vol.78 , Issue.11 , pp. 1434-1441
    • Sweep, C.G.1    Geurts-Moespot, J.2    Grebenschikov, N.3
  • 91
    • 0037116616 scopus 로고    scopus 로고
    • Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients
    • Look MP, van Putten WL, Duffy MJ et al. Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients. J. Natl Cancer Inst. 94(2), 116-128 (2002).
    • (2002) J. Natl Cancer Inst. , vol.94 , Issue.2 , pp. 116-128
    • Look, M.P.1    Van Putten, W.L.2    Duffy, M.J.3
  • 92
    • 36849069347 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer
    • American Society of Clinical Oncology.
    • Harris L, Fritsche H, Mennel R et al.; American Society of Clinical Oncology. American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J. Clin. Oncol. 25(33), 5287-5312 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.33 , pp. 5287-5312
    • Harris, L.1    Fritsche, H.2    Mennel, R.3
  • 94
    • 84863994288 scopus 로고    scopus 로고
    • Dissecting the heterogeneity of triple-negative breast cancer
    • Metzger-Filho O, Tutt A, de Azambuja E et al. Dissecting the heterogeneity of triple-negative breast cancer. J. Clin. Oncol. 30(15), 1879-1887 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.15 , pp. 1879-1887
    • Metzger-Filho, O.1    Tutt, A.2    De Azambuja, E.3
  • 95
    • 0030979449 scopus 로고    scopus 로고
    • Randomized trial of cyclophosphamide, methotrexate, and fuorouracil chemotherapy added to tamoxifen as adjuvant therapy in postmenopausal women with node-positive estrogen and/or progesterone receptor-positive breast cancer: A report of the National Cancer Institute of Canada Clinical Trials Group. Breast Cancer Site Group
    • Pritchard KI, Paterson AH, Fine S et al. Randomized trial of cyclophosphamide, methotrexate, and fuorouracil chemotherapy added to tamoxifen as adjuvant therapy in postmenopausal women with node-positive estrogen and/or progesterone receptor-positive breast cancer: a report of the National Cancer Institute of Canada Clinical Trials Group. Breast Cancer Site Group. J. Clin. Oncol. 15(6), 2302-2311 (1997).
    • (1997) J. Clin. Oncol. , vol.15 , Issue.6 , pp. 2302-2311
    • Pritchard, K.I.1    Paterson, A.H.2    Fine, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.