Syndecan-2 is a key regulator of transforming growth factor beta 2/smad2-mediated adhesion in fibrosarcoma cells

IUBMB Life

Volumn 65, Issue 2, 2013, Pages 134-143

  Mytilinaiou, Maria ^a   Bano, Artan ^a   Nikitovic, Dragana ^a   Berdiaki, Aikaterini ^a   Voudouri, Kallirroi ^a   Kalogeraki, Alexandra ^a   Karamanos, Nikos K ^b   Tzanakakis, George N ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

cell adhesion; fibrosarcoma; Smad2; syndecan 2; transforming growth factor 2 signaling

Indexed keywords

BETA1 INTEGRIN; CELL ADHESION MOLECULE; FOCAL ADHESION KINASE; MESSENGER RNA; SMAD2 PROTEIN; SMALL INTERFERING RNA; SYNDECAN 2; TRANSFORMING GROWTH FACTOR BETA2;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; DOWN REGULATION; FIBROSARCOMA; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SARCOMA CELL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ACTINS; ANTIGENS, CD29; CELL ADHESION; CELL LINE, TUMOR; FIBRONECTINS; FIBROSARCOMA; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, SMALL INTERFERING; SMAD2 PROTEIN; SYNDECAN-2; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84873851547     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1112     Document Type: Article

References (35)

1. Massague, J., Blain, S. W., and, Lo, R. S., (2000) TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103, 295-309.
2. Whitman, M., (1998) Smads and early developmental signaling by the TGFbeta superfamily. Genes Dev. 12, 2445-2462.
3. Inman, G. J., (2011) Switching TGF beta from a tumor suppressor to a tumor promoter. Curr. Opin. Genet. Dev. 21, 93-99.
4. Massague, J., (1998) TGF-beta signal transduction. Annu. Rev. Biochem. 67, 753-791.
5. Bilandzic, M., and, Stenvers, K. L., (2011) Betaglycan: a multifunctional accessory. Mol. Cell. Endocrinol. 339, 180-189.
6. Lopez-Casillas, F., Wrana, J. L., and, Massague, J., (1993) Betaglycan presents ligand to the TGF beta signaling receptor. Cell 73, 1435-1444.
7. Del Re, E., Babitt, J. L., Pirani, A., Schneyer, A. L., and, Lin, H. Y., (2004) In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2. J. Biol. Chem. 279, 22765-22772.
8. Chen, L., Klass, C., and, Woods, A., (2004) Syndecan-2 regulates transforming growth factor-beta signalling. J. Biol. Chem. 279, 15715-15718.
9. Willems, S. M., Wiweger, M., van Roggen, J. F., and, Hogendoorn, P. C., (2010) Running GAGs: myxoid matrix in tumor pathology revisited: what's in it for the pathologist? Virchows Arch. 456, 181-192.
10. Berdiaki, A., Nikitovic, D., Tsatsakis, A., Katonis, P., Karamanos, N. K., et al. (2009) bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells. Biochim. Biophys. Acta 1790, 1258-1265.
11. Fthenou, E., Zong, F., Zafiropoulos, A., Dobra, K., Hjerpe, A., et al. (2009) Chondroitin sulfate A regulates fibrosarcoma cell adhesion, motility and migration through JNK and tyrosine kinase signaling pathways. In Vivo 23, 69-76.
12. Spearman, M., Taylor, W. R., Greenberg, A. H., and, Wright, J. A., (1994) Antisense oligodeoxyribonucleotide inhibition of TGF-beta 1 gene expression and alterations in the growth and malignant properties of mouse fibrosarcoma cells. Gene 149, 25-29.
13. Suzuki, H., Kato, Y., Kaneko, M. K., Okita, Y., Narimatsu, H., et al. (2008) Induction of podoplanin by transforming growth factor-beta in human fibrosarcoma. FEBS Lett. 582, 341-345.
14. Berdiaki, A., Zafiropoulos, A., Fthenou, E., Katonis, P., Tsatsakis, A., et al. (2008) Regulation of hyaluronan and versican deposition by growth factors in fibrosarcoma cell lines. Biochim. Biophys. Acta 1780, 194-202.
15. Kwak, H. J., Park, M. J., Cho, H., Park, C. M., Moon, S. I., et al. (2006) Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells. Mol. Cancer Res. 4, 209-220.
16. Sokol, J. P., and, Schiemann, W. P., (2004) Cystatin C antagonizes transforming growth factor beta signaling in normal and cancer cells. Mol. Cancer Res. 2, 183-195.
17. Rasheed, S., Nelson-Rees, W. A., Toth, E. M., Arnstein, P., and, Gardner, M. B., (1974) Characterization of a newly derived human sarcoma cell line (HT-1080). Cancer 33, 1027-1033.
18. Orosco, A., Fromigue, O., Bazille, C., Entz-Werle, N., Levillain, P., et al. (2007) Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma. Cancer Res. 67, 3708-3715.
19. Kouvidi, K., Berdiaki, A., Nikitovic, D., Katonis, P., Afratis, N., et al. (2011) Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion J. Biol. Chem. 286, 38509-38520.
20. Chalkiadaki, G., Nikitovic, D., Berdiaki, A., Katonis, P., Karamanos, N. K., et al. (2011) Heparin plays a key regulatory role via a p53/FAK-dependent signaling in melanoma cell adhesion and migration. IUBMB Life 63, 109-119.
21. Park, H., Han, I., Kwon, H. J., and, Oh, E. S., (2005) Focal adhesion kinase regulates syndecan-2-mediated tumorigenic activity of HT1080 fibrosarcoma cells. Cancer Res. 65, 9899-9905.
22. Whiteford, J. R., Behrends, V., Kirby, H., Kusche-Gullberg, M., Muramatsu, T., et al. (2007) Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways. Exp. Cell. Res. 313, 3902-3913.
23. Whiteford, J. R., Xian, X., Chaussade, C., Vanhaesebroeck, B., Nourshargh, S., et al. (2011) Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148. Mol. Biol. Cell. 22, 3609-3624.
24. Oh, E. S., and, Couchman, J. R., (2004) Syndecans-2 and -4; close cousins, but not identical twins. Mol. Cells 17, 181-187.
25. Kähäri, V. M., Peltonen, J., Chen, Y. Q., and, Uitto, J., (1991) Differential modulation of basement membrane gene expression in human fibrosarcoma HT-1080 cells by transforming growth factor-beta 1. Enhanced type IV collagen and fibronectin gene expression correlates with altered culture phenotype of the cells. Lab. Invest. 64, 807-818.
26. Walsh, M. F., Ampasala, D. R., Rishi, A. K., and, Basson, M. D., (2009) TGF-beta1 modulates focal adhesion kinase expression in rat intestinal epithelial IEC-6 cells via stimulatory and inhibitory Smad binding elements. Biochim. Biophys. Acta 1789, 88-98.
27. Hauck, C. R., Hsia, D. A., and, Schlaepfer, D. D., (2002) The focal adhesion kinase-a regulator of cell migration and invasion. IUBMB Life 53, 115-119.
28. Guan, J. L., (2010) Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. IUBMB Life 62, 268-276.
29. Hu, M., Pollock, R. E., and, Nicolson, G. L., (1997) Purification and characterization of human lung fibroblast motility-stimulating factor for human soft tissue sarcoma cells: identification as an NH2-terminal fragment of human fibronectin. Cancer Res. 57, 3577-3584.
30. Cevikbas, F., Schaefer, L., Uhlig, P., Robenek, H., Theilmeier, G., et al. (2008) Unilateral nephrectomy leads to up-regulation of syndecan-2- and TGF-beta-mediated glomerulosclerosis in syndecan-4 deficient male mice. Matrix Biol. 27, 42-52.
31. Blobe, G. C., Liu, X., Fang, S. J., How, T., and, Lodish, H. F., (2001) A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. J. Biol. Chem. 276, 39608-39617.
32. Kusano, Y., Oguri, K., Nagayasu, Y., Munesue, S., Ishihara, M., et al. (2000) Participation of syndecan 2 in the induction of stress fiber formation in cooperation with integrin alpha5beta1: structural characteristics of heparan sulfate chains with avidity to COOH-terminal heparin-binding domain of fibronectin. Exp. Cell. Res. 256, 434-444.
33. Lõpez-Casillas, F., Payne, H. M., Andres, J. L., and, Massagué, J., (1994) Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. J. Cell. Biol. 124, 557-568.
34. Tsutsumi, K., Kasaoka, T., Park, H. M., Nishiyama, H., Nakajima, M., et al. (2008) Tumor growth inhibition by synthetic and expressed siRNA targeting focal adhesion kinase. Int. J. Oncol. 33, 215-224.
35. Galante, L. L., and, Schwarzbauer, J. E., (2007) Requirements for sulfate transport and the diastrophic dysplasia sulfate transporter in fibronectin matrix assembly. J. Cell. Biol. 179, 999-1009.