Treadmill and wheel exercise alleviate lipopolysaccharide-induced short-term memory impairment by enhancing neuronal maturation in rats

Molecular Medicine Reports

Volumn 7, Issue 1, 2013, Pages 31-36

  Kim, Sung Eun ^a   Ko, Il Gyu ^a,b   Park, Chang Youl ^a   Shin, Mal Soon ^a   Kim, Chang Ju ^a   Jee, Yong Seok ^b  

^a Kyung Hee University Hospital   (South Korea)

^b Hanseo University   (South Korea)

Author keywords

Brain inflammation; Doublecortin; Hippocampus; Lipopolysaccharide; Neuronal nuclear antigen; Short term memory

Indexed keywords

BROXURIDINE; CELL NUCLEUS ANTIGEN; DOUBLECORTIN; LIPOPOLYSACCHARIDE; NEURONAL NUCLEAR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DENTATE GYRUS; ENCEPHALITIS; FORCED TREADMILL EXERCISE; IMMUNOHISTOCHEMISTRY; MEMORY DISORDER; NONHUMAN; PROTEIN EXPRESSION; RAT; SHORT TERM MEMORY; TREADMILL EXERCISE; VOLUNTARY WHEEL EXERCISE; WESTERN BLOTTING;

ANIMALS; ANTIGENS, NUCLEAR; CELL DIFFERENTIATION; CELL PROLIFERATION; DENTATE GYRUS; HIPPOCAMPUS; LIPOPOLYSACCHARIDES; MALE; MEMORY, SHORT-TERM; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; NEURONS; NEUROPEPTIDES; PHYSICAL CONDITIONING, ANIMAL; RATS;

EID: 84873826591     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1160     Document Type: Article

References (31)

1. Ekdahl CT, Claasen JH, Bonde S, Kokaia Z and Lindvall O: Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci USA 100: 13632-13637, 2003.
2. Cacci E, Claasen JH and Kokaia Z: Microglia-derived tumor necrosis factor-alpha exaggerates death of newborn hippocampal progenitor cells invitro. J Neurosci Res 80: 789-797, 2005.
3. Cacci E, Ajmone-Cat MA, Anelli T, Biagioni S and Minghetti L: Invitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia. Glia 56: 412-425, 2008.
4. Guo J, Li F, Wu Q, Gong Q, Lu Y and Shi J: Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats. Phytomedicine 17: 950-955, 2010.
5. Belarbi K, Jopson T, Tweedie D, Arellano C, Luo W, Greig NH and Rosi S: TNF-β protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. JNeuroinflammation 9: 23, 2012.
6. Kim DH, Ko IG, Kim BK, etal: Treadmill exercise inhibits traumatic brain injury-induced hippocampal apoptosis. Physiol Behav 101: 660-665, 2010.
7. Kim SE, Ko IG, Kim BK, etal: Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus. Exp Gerontol 45: 357-365, 2010.
8. Sim YJ, Kim SS, Kim JY, Shin MS and Kim CJ: Treadmill exercise improves short-term memory by suppressing ischemia-induced apoptosis of neuronal cells in gerbils. Neurosci Lett 372: 256-261, 2004.
9. Cao L, Jiao X, Zuzga DS, Liu Y, Fong DM, Young D and During MJ: VEGF links hippocampal activity with neurogenesis, learning and memory. Nat Genet 36: 827-835, 2004.
10. van Praag H, Christie BR, Sejnowski TJ and Gage FH: Running enhances neurogenesis, learning and long-term potentiation in mice. Proc Natl Acad Sci USA 96: 13427-13431, 1999.
11. Eriksson PS, Perfilieva E, Bjök-Eriksson T, Alborn AM, Nordborg C, Peterson DA and Gage FH. Neurogenesis in the adult human hippocampus. Nat Med 4: 1313-1317, 1998.
12. Kempermann G, Kuhn HG and Gage FH: More hippocampal neurons in adult mice living in an enriched environment. Nature386: 493-495, 1997.
13. Kempermann G, Jessberger S, Steiner B and Kronenberg G: Milestones of neuronal development in the adult hippocampus. Trends Neurosci 27: 447-452, 2004.
14. Ming GL and Song H: Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci 28: 223-250, 2005.
15. von Bohlen and Halbach O: Immunohistological markers for proliferative events, gliogenesis and neurogenesis within the adult hippocampus. Cell Tissue Res 345: 1-19, 2011.
16. Francis F, Koulakoff A, Boucher D, etal: Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons. Neuron 23: 247-256, 1999.
17. Friocourt G, Koulakoff A, Chafey P, Boucher D, Fauchereau F, Chelly J and Francis F: Doublecortin functions at the extremities of growing neuronal processes. Cereb Cortex 13: 620-626, 2003.
18. Wolf HK, Buslei R, Schmidt-Kastner R, Schmidt-Kastner PK, Pietsch T, Wiestler OD and Blümcke I: Neu N: a useful neuronal marker for diagnostic histopathology. J Histochem Cytochem 44: 1167-1171, 1996.
19. Sarnat HB, Nochlin D and Born DE: Neuronal nuclear antigen (Neu N): a marker of neuronal maturation in early human fetal nervous system. Brain Dev 20: 88-94, 1998.
20. Tyagi E, Agrawal R, Nath C and Shukla R: Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain. J Neuroimmunol 205: 51-56, 2008.
21. van Praag H, Kempermann G and Gage FH: Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2: 266-270, 1999.
22. O'Callaghan RM, Ohle R and Kelly AM: The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial-and non-spatial learning. Behav Brain Res 176: 362-366, 2007.
23. Shors TJ, Townsend DA, Zhao M, Kozorovitskiy Y and Gould E: Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus 12: 578-584, 2002.
24. Liu J, Solway K, Messing RO and Sharp FR: Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci 18: 7768-7778, 1998.
25. Ekdahl CT, Kokaia Z and Lindvall O: Brain inflammation and adult neurogenesis: the dual role of microglia. Neuroscience 158: 1021-1029, 2009.
26. Aharoni R, Arnon R and Eilam R: Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis. J Neurosci 25: 8217-8228, 2005.
27. Ziv Y, Ron N, Butovsky O, etal: Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci 9: 268-275, 2006.
28. Huehnchen P, Prozorovski T, Klaissle P, etal: Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation. Glia 59: 132-142, 2011.
29. Deng W, Aimone JB and Gage FH: New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11: 339-350, 2010.
30. Kempermann G, Gast D and Gage FH: Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol 52: 135-143, 2002.
31. Wong-Goodrich SJ, Pfau ML, Flores CT, Fraser JA, Williams CL and Jones LW: Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation. Cancer Res 70: 9329-9338, 2010.