Treadmill exercise during pregnancy ameliorates post traumatic stress disorder induced anxiety like responses in maternal rats

Molecular Medicine Reports

Volumn 7, Issue 2, 2013, Pages 389-395

  Seo, Jin Hee ^a   Kim, Tae Woon ^b   Kim, Chang Ju ^b   Sung, Yun Hee ^c   Lee, Sam Jun ^d  

^a Baekseok University   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

^c Kyungnam University   (South Korea)

^d Tongmyong University   (South Korea)

Author keywords

Anxiety; Post traumatic stress disorder; Pregnancy; Rats; Treadmill exercise

Indexed keywords

NEURONAL NITRIC OXIDE SYNTHASE; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DOG; DORSAL RAPHE NUCLEUS; FEMALE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LOCUS CERULEUS; NONHUMAN; ONCOGENE C FOS; POSTTRAUMATIC STRESS DISORDER; PREDATOR STRESS; PREGNANCY; PROTEIN EXPRESSION; RAT; TREADMILL EXERCISE;

ANIMALS; ANXIETY; EXERCISE THERAPY; FEMALE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LOCUS COERULEUS; NITRIC OXIDE SYNTHASE TYPE I; PHYSICAL CONDITIONING, ANIMAL; PREGNANCY; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PHYSIOLOGICAL; TRYPTOPHAN HYDROXYLASE;

EID: 84873824446     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1197     Document Type: Article

References (48)

1. Cryan JF and Holmes A: The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discov 4: 775-790, 2005.
2. Myers KM and Davis M: Mechanisms of fear extinction. Mol Psychiatry 12: 120-150, 2007.
3. Yehuda R: Post-traumatic stress disorder. N Engl J Med 346: 108-114, 2002.
4. Baker DG, Nievergelt CM and Risbrough VB: Post-traumatic stress disorder: emerging concepts of pharmacotherapy. Expert Opin Emerg Drugs 14: 251-272, 2009.
5. Davis LL, Frazier EC, Williford RB and Newell JM: Long-term pharmacotherapy for post-traumatic stress disorder. CNS Drugs 20: 465-476, 2006.
6. Bannai M, Fish EW, Faccidomo S and Miczek KA: Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of mice. Psychopharmacology (Berl) 193: 295-304, 2007.
7. Barnes NM and Sharp T: A review of central 5-HT receptors and their function. Neuropharmacology 38: 1083-1152, 1999.
8. 1A autoreceptors in the dorsal raphe nucleus reduces the behavioral consequences of social defeat. Psychoneuroendocrinology 33: 1236-1247, 2008.
9. Graeff FG and Zangrossi H Jr: The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders. Cent Nerv Syst Agents Med Chem 10: 207-217, 2010.
10. Boldrini M, Underwood MD, Mann JJ and Arango V: More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides. Brain Res 1041: 19-28, 2005.
11. Underwood MD, Khaibulina AA, Ellis SP, Moran A, Rice PM, Mann JJ and Arango V: Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victims. Biol Psychiatry 46: 473-483, 1999.
12. Chamas FM, Underwood MD, Arango V, Serova L, Kassir SA, Mann JJ and Sabban EL: Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nuclei. Biol Psychiatry 55: 278-283, 2004.
13. Kim SU, Ko IG, Kim BK, et al: Transplantation of human adipose-derived stem cells into the urethra ameliorates stress urinary incontinence and blunts the induction of c-Fos immunoreactivities in brain areas related to micturition in female rats. Anim Cells Syst 14: 237-244, 2010.
14. Martinez M, Phillips PJ and Herbert J: Adaptation in patterns of c fos expression in the brain associated with exposure to either single or repeated social stress in male rats. Eur J Neurosci 10: 20-33, 1998.
15. Weinberg MS, Girotti M and Spencer RL: Restraint-induced fra-2 and c-fos expression in the rat forebrain: relationship to stress duration. Neuroscience 150: 478-486, 2007.
16. Amat J, Aleksejev RM, Paul E, Watkins LR and Maier SF: Behavioral control over shock blocks behavioral and neurochemical effects of later social defeat. Neuroscience 165: 1031-1038, 2010.
17. Forestiero D, Manfrim CM, Guimarães FS and de Oliveira RM: Anxiolytic-like effects induced by nitric oxide synthase inhibitors microinjected into the medial amygdala of rats. Psychopharmacology (Berl) 184: 166-172, 2006.
18. Pokk P and Väli M: The effects of the nitric oxide synthase inhibitors on the behaviour of small-platform-stressed mice in the plus-maze test. Prog Neuropsychopharmacol Biol Psychiatry 26: 241-247, 2002.
19. Bredt DS, Glatt CE, Hwang PM, Fotuhi M, Dawson TM and Snyder SH: Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron 7: 615-624, 1991.
20. Dawson TM, Bredt DS, Fotuhi M, Hwang PM and Snyder SH: Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci USA 88: 7797-7801, 1991.
21. Jesse CR, Bortolatto CF, Savegnago L, Rocha JB and Nogueira CW: Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of tramadol in the rat forced swimming test. Prog Neuropsychopharmacol Biol Psychiatry 32: 1838-1843, 2008.
22. Colcombe S and Kramer AF: Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci 14: 125-130, 2003.
23. Galper DI, Trivedi MH, Barlow CE, Dunn AL and Kampert JB: Inverse association between physical inactivity and mental health in men and women. Med Sci Sports Exerc 38: 173-178, 2006.
24. Rovio S, Kåreholt I, Helkala EL, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A and Kivipelto M: Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol 4: 705-711, 2005.
25. Blumenthal JA, Babyak MA, Doraiswamy PM, et al: Exercise and pharmacotherapy in the treatment of major depressive disorder. Psychosom Med 69: 587-596, 2007.
26. Newman CL and Motta RW: The effects of aerobic exercise on childhood PTSD, anxiety and depression. Int J Emerg Ment Health 9: 133-158, 2007.
27. Perraton LG, Kumar S and Machotka Z: Exercise parameters in the treatment of clinical depression: a systematic review of randomized controlled trials. J Eval Clin Pract 16: 597-604, 2010.
28. Sung YH, Shin MS, Cho S, Baik HH, Jin BK, Chang HK, Lee EK and Kim CJ: Depression-like state in maternal rats induced by repeated separation of pups is accompanied by a decrease of cell proliferation and an increase of apoptosis in the hippocampus. Neurosci Lett 470: 86-90, 2010.
29. Adamec R, Walling S and Burton P: Long-lasting, selective, anxiogenic effects of feline predator stress in mice. Physiol Behav 83: 401-410, 2004.
30. Kung JC, Chen TC, Shyu BC, Hsiao S and Huang AC: Anxiety- and depressive-like responses and c-fos activity in preproenkephalin knockout mice: oversensitivity hypothesis of enkephalin deficit induced posttraumatic stress disorder. J Biomed Sci 17: 29-43, 2010.
31. Sterley TL, Howells FM and Russell VA: Effects of early life trauma are dependent on genetic predisposition: a rat study. Behav Brain Funct 7: 11-25, 2011.
32. Kim EK, Lee MH, Kim H, et al: Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring. Brain Dev 27: 472-476, 2005.
33. Greenwood BN, Strong PV, Dorey AA and Fleshner M: Therapeutic effects of exercise: wheel running reverses stress-induced interference with shuttle box escape. Behav Neurosci 121: 992-1000, 2007.
34. Fulk LJ, Stock HS, Lynn A, Marshall J, Wilson MA and Hand GA: Chronic physical exercise reduces anxiety-like behavior in rats. Int J Sports Med 25: 78-82, 2004.
35. Sandford JJ, Argyropoulos SV and Nutt DJ: The psychobiology of anxiolytic drugs. Part 1: Basic neurobiology. Pharmacol Ther 88: 197-212, 2000.
36. 1A mRNA in the hamster dorsal raphe nucleus. Neuroscience 161: 680-690, 2009.
37. 1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder. Mol Med Rep 4: 843-847, 2011.
38. 1A receptor is involved in neuronal apoptosis of the amygdala in a rat model of post-traumatic stress disorder. Mol Med Rep 4: 291-295, 2011.
39. Greenwood BN, Foley TE, Burhans D, Maier SF and Fleshner M: The consequences of uncontrollable stress are sensitive to duration of prior wheel running. Brain Res 1033: 164-178, 2005.
40. Herman JP, Ostrander MM, Mueller NK and Figueiredo H: Limbic system mechanisms of stress regulation: hypothalamopituitary-adrenocortical axis. Prog Neuropsychopharmacol Biol Psychiatry 29: 1201-1213, 2005.
41. Jankord R and Herman JP: Limbic regulation of hypothalamo-pituitary- adrenocortical function during acute and chronic stress. Ann NY Acad Sci 1148: 64-73, 2008.
42. O'Mahony CM, Sweeney FF, Daly E, Dinan TG and Cryan JF: Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour. Behav Brain Res 213: 148-154, 2010.
43. Burow A, Day HE and Campeau S: A detailed characterization of loud noise stress: intensity analysis of hypothalamo-pituitary-adrenocortical axis and brain activation. Brain Res 1062: 63-73, 2005.
44. Kwon MS, Seo YJ, Shim EJ, Choi SS, Lee JY and Suh HW: The effect of single or repeated restraint stress on several signal molecules in paraventricular nucleus, arcuate nucleus and locus coeruleus. Neuroscience 142: 1281-1292, 2006.
45. Goebel M, Stengel A, Wang L and Taché Y: Restraint stress activates nesfatin-1-immunoreactive brain nuclei in rats. Brain Res 1300: 114-124, 2009.
46. Miguel TT and Nunes-de-Souza RL: Anxiogenic-like effects induced by NMDA receptor activation are prevented by inhibition of neuronal nitric oxide synthase in the periaqueductal gray in mice. Brain Res 1240: 39-46, 2008.
47. Workman JL, Trainor BC, Finy MS and Nelson RJ: Inhibition of neuronal nitric oxide reduces anxiety-like responses to pair housing. Behav Brain Res 187: 109-115, 2008.
48. Zhou QG, Hu Y, Hua Y, Hu M, Luo CX, Han X, Zhu XJ, Wang B, Xu JS and Zhu DY: Neuronal nitric oxide synthase contributes to chronic stress induced depression by suppressing hippocampal neurogenesis. J Neurochem 103: 1843-1854, 2007.