Functionalised silica nanoparticles stable in serum-containing medium efficiently deliver siRNA targeting HIV-1 co-receptor CXCR4 in mammalian cells

International Journal of Nano and Biomaterials

Volumn 4, Issue 3-4, 2012, Pages 223-242

  Kell, Arnold J ^a   Barnes, Michael L ^a   Slater, Kathryn ^b   Lavigne, Carole ^b  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

Cellular uptake; CXCR4; Dye doped silica nanoparticles; Gene silencing; HIV 1 co receptor; Nanomaterials; Serum containing medium; SiRNA delivery; TZM bl cells

Indexed keywords

CELLS; CYTOLOGY; DRUG THERAPY; MAMMALS; NANOPARTICLES; NANOSTRUCTURED MATERIALS; SILICA;

CELLULAR UPTAKE; CORECEPTORS; CXCR4; DYE-DOPED SILICA NANOPARTICLES; GENE SILENCING; SERUM-CONTAINING MEDIUM; SIRNA DELIVERY;

SILICA NANOPARTICLES;

CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA; NANOPARTICLE; NUCLEASE; POLYETHYLENEIMINE; SILICON DIOXIDE; SMALL INTERFERING RNA; TETRAMETHYLRHODAMINE; TETRAMETHYLRHODAMINE DOPED SILICA NANOPARTICLE; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CELLULAR DISTRIBUTION; CHEMICAL BINDING; ENDOSOME; ENZYME DEGRADATION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LYSOSOME; MAMMAL CELL; NONVIRAL GENE DELIVERY SYSTEM; PROTEIN EXPRESSION; RNA BINDING; RNA DEGRADATION; SURFACE PROPERTY; SYNTHESIS; TARGET CELL;

EID: 84873820859     PISSN: 17528933     EISSN: 17528941     Source Type: Journal    
DOI: 10.1504/IJNBM.2012.051704     Document Type: Article

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