Mannosyl-Recognizing Receptors Induce an M1-Like Phenotype in Macrophages of Susceptible Mice but an M2-Like Phenotype in Mice Resistant to a Fungal Infection

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Feriotti, Claudia ^a   Loures, Flávio V ^a   Frank de Araújo, Eliseu ^a   da Costa, Tania Alves ^a   Calich, Vera L G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ARGINASE 1; CD 11B ANTIBODY; COMPLEMENT RECEPTOR; COMPLEMENT RECEPTOR 3; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; INTERLEUKIN 6; MANNAN; MANNOSE RECEPTOR; MONOCLONAL ANTIBODY; NITRIC OXIDE; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 4 ANTIBODY; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CELL FUNCTION; CELL KILLING; CONTROLLED STUDY; CYTOKINE PRODUCTION; INFECTION RESISTANCE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PROTEIN EXPRESSION; SOUTH AMERICAN BLASTOMYCOSIS;

ANIMALS; ANTIFUNGAL AGENTS; ARGINASE; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; DISEASE SUSCEPTIBILITY; DRUG SYNERGISM; INTERFERON-GAMMA; LECTINS, C-TYPE; MACROPHAGE-1 ANTIGEN; MACROPHAGES; MANNANS; MANNOSE-BINDING LECTINS; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PARACOCCIDIOIDES; PARACOCCIDIOIDOMYCOSIS; PHAGOCYTOSIS; PHENOTYPE; RECEPTORS, CELL SURFACE; RECEPTORS, PATTERN RECOGNITION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84873819412     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054845     Document Type: Article

References (69)

1. Cambi A, Koopman M, Figdor CG, (2005) How C-type lectins detect pathogens. Cell Microbiol 7: 481-488.
2. Apostolopoulos V, McKenzie IF, (2001) Role of the mannose receptor in the immune response. Curr Mol Med 1: 469-474.
3. Brown GD, Gordon S, (2005) Immune recognition of fungal beta-glucans. Cell Microbiol 7: 471-479.
4. Ferwerda G, Meyer-Wentrup F, Kullberg BJ, Netea MG, Adema GJ, (2008) Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages. Cell Microbiol 10: 2058-2066.
5. van Kooyk Y, (2008) C-type lectins on dendritic cells: key modulators for the induction of immune responses. Biochem Soc Trans 36: 1478-1481.
6. Levitz SM, (2002) Receptor-mediated recognition of Cryptococcus neoformans. J Med Mycol 43: 133-136.
7. Stahl PD, Ezekowitz RA, (1998) The mannose receptor is a pattern recognition receptor involved in host defense. Curr Opin Immunol 10: 50-55.
8. Underhill DM, (2007) Collaboration between the innate immune receptors dectin-1, TLRs, and Nods. Immunol 219: 75-87.
9. Willment JA, Brown GD, (2008) C-type lectin receptors in antifungal immunity. Trends Microbiol 16: 27-32.
10. Mackenzie E, Taylor PR, Stillion J, Lucas AD, Harris J, et al. (2007) Mannose receptor expression and function define a new population of murine dendritic cells. J Immunol 178: 4975-4983.
11. Taylor PR, Martinez-Pomares L, Stacey M, Lin HH, Brown GD, et al. (2005) Macrophage receptors and immune recognition. Annu Rev Immunol 23: 901-944.
12. Kumagai Y, Takeuchi O, Akira S, (2008) Pathogen recognition by innate receptors. J Infect Chemother 14: 86-92.
13. Levitz SM, (2010) Innate Recognition of Fungal Cell Wall. PLoS Pathog 6: 1-3.
14. Netea MG, Ferwerda G, Van Der Graaf CA, Van Der Meer JW, Kullberg BJ, (2006) Recognition of fungal by tool-like receptors. Curr Pharm Des 12: 4195-4201.
15. Vautier S, MacCallum DM, Brown GD, (2012) C-type lectin receptors and cytokines in fungal immunity. Cytokine 58: 89-99.
16. Netea MG, Gow NA, Munro CA, Bates S, Collins C, et al. (2006) Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J Clin Invest 116: 1642-1650.
17. Levitz SM, (2004) Interactions of Toll-like receptors with fungi. Microbes Infect 6: 1351-1355.
18. Baida H, Biselli PJC, Juvenale M, Del Negro GM, Mendes-Giannini MJ, et al. (1999) Differential antibody isotype expression to the major Paracoccidioides brasiliensis antigen in juvenile and adult form paracoccidioidomycosis. Microbes Infect 1: 273-278.
19. Oliveira SJ, Mamoni RL, Musatti CC, Papaiordanou PMO, Blotta MHSL, (2002) Cytokines and lymphocyte proliferation in juvenile and adults forms of paracoccidioidomycosis: comparison with infected and non-infected controls. Microb Infect 4: 139-144.
20. Calich VLG, Singer-Vermes LM, Siqueira AM, Burger E, (1985) Susceptibility and resistance of inbred mice to Paracoccidioides brasiliensis. Br J Exp Pathol 66: 585-594.
21. Cano LE, Kashino SS, Arruda C, André D, Xidieh CF, (1998) Protective role of gamma interferon in experimental pulmonary paracoccidioidomycosis. Infect Immun 66: 800-806.
22. Cano L, Singer-Vermes LM, Vaz CA, Russo M, Calich VLG, (1995) Pulmonary paracoccidioidomycosis in resistant and susceptible mice: relationship among progression of infection, bronchoalveolar cell activation, cellular immune response, and specific isotype patterns. Infect Immun 63: 1777-1783.
23. Pina A, Bernardino S, Calich VLG, (2008) Alveolar macrophages from susceptible mice are more competent than those of resistant mice to control initial Paracoccidioides brasiliensis infection. J Leuk Biol 83: 1088-1099.
24. Nascimento FR, Calich VLG, Rodriguez D, Russo M, (2002) Dual role for nitric oxide in paracoccidioidomycosis: essential for resistance, but overproduction associated with susceptibility. J Immunol 168: 4593-4600.
25. Romani L, (2011) Immunity to fungal infections. Nat Rev Immunol 11: 275-288.
26. Calich VL, Kipnis TL, Mariano M, Neto CF, Dias da Silva WD, (1979) The activation of the complement system by Paracoccidioides brasiliensis in vitro: its opsonic effect and possible significance for an in vivo model of infection. Clin Immunol Immunopathol 12: 21-30.
27. Loures FV, Pina A, Felonato M, Calich VLG, (2009) TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection. J Immunol 183: 1279-1290.
28. Loures FV, Pina A, Felonato M, Araújo EF, Leite KR, et al. (2010) TLR4 signaling leads to a more severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells. Infec Immun 78: 1078-1088.
29. Loures FV, Pina A, Felonato M, Feriotti C, Araujo EF, et al. (2011) MyD88 signaling is required for efficient innate and adaptative immune responses to Paracoccidioides brasiliensis infection. Infect Immun79: 2470-2480.
30. Jiménez M del P, Restrepo A, Radzioch D, Cano LE, García LF, (2006) Importance of complement 3 and mannose receptors in phagocytosis of Paracoccidioides brasiliensis conidia by Nramp1 congenic macrophages lines. FEMS Immunol Med Microbiol 47: 56-66.
31. Popi AF, Lopes JD, Mariano M, (2002) Gp43 from Paracoccidioides brasiliensis inhibits macrophage functions. An evasion mechanism of the fungus. Cell Immunol 218: 87-94.
32. Bonfim CV, Mamoni RL, Souza MH, Blotta MHS, (2009) TLR-2, TLR-4 and dectin-1 expression in human monocytes and neutrophils stimulated by Paracoccidioides brasiliensis. Med Mycol 17: 1-12.
33. Nakaira-Takahagi E, Golim MA, Bannwart CF, Puccia R, Peraçoli MT, (2011) Interactions between TLR2, TLR4, and mannose receptors with gp43 from Paracoccidioides brasiliensis induce cytokine production by human monocytes. Med Mycol 49: 694-703.
34. Carbonell LM, Kanetsuna F, Gil F, (1970) Chemical morphology of glucan and chitin in the cell wall of the yeast phase of Paracoccidioides brasiliensis. J Bacteriol 101: 636-642.
35. Kanetsuna F, Carbonell LM, Moreno RE, Rodriguez J, (1969) Cell wall composition of the yeast and mycelial forms of Paracoccidioides brasiliensis. J Bacteriol 97: 1036-1041.
36. Kanetsuna F, Carbonell LM, Azuma I, Yamamura Y, (1972) Biochemical studies on the thermal dimorphism of Paracoccidioides brasiliensis. J Bacteriol 110: 208-218.
37. Puccia R, Vallejo MC, Matsuo AL, Longo LV, (2011) The Paracoccidioides cell wall: past and present layers toward understanding interaction with the host. Front Microbiol 257: 1-7.
38. Felonato M, Pina A, de Araujo EF, Loures FV, Bazan BS, et al. (2012) Anti-CD25 Treatment Depletes Treg Cells and Decreases Disease Severity in Susceptible and Resistant Mice Infected with Paracoccidioides brasiliensis. PLoS One. doi: 10.1371/journal.pone.0051071.
39. Netto CF, Vegas VS, Sciannaméa IM, Guarnieri DB, (1969) [The polysaccharidic antigen from Paracoccidioides brasiliensis. Study of the time of cultivation necessary for the preparation of the antigen]. Rev Inst Med Trop São Paulo. 11: 177-81.
40. Kashino SS, Singer-Vermes LM, Calich VLG, Burger E, (1990) Alterations in the pathogenicity of one Paracoccidioides brasiliensis isolate do not correlate with its in vitro growth. Mycopathologia 111: 173-180.
41. Cano LE, Brummer E, Stevens DA, Restrepo A, (1992) Fate of conidia from Paracoccidioides brasiliensis after ingestion by resident macrophages or cytokine-treated macrophages. Infect Immun 60: 2096-2100.
42. Cano LE, Gómez B, Brummer E, Restrepo A, Stevens DA, (1994) Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin. Infect Immun 62: 1494-1496.
43. Singer-Vermes LM, Ciavaglia MC, Kashino SS, Burger E, Calich VLG, (1992) The source of the growth-promoting factor (s) affects the plating efficiency of Paracoccidioides brasiliensis. J Med Vet Mycol 30: 261-264.
44. Pfaffl MW, (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 129(9): e45.
45. Gordon S, Martinez FO, (2010) Alternative activation of macrophages: mechanism and functions. Immunity 32: 593-604.
46. Whyte CS, Bishop ET, Rückerl D, Gaspar-Pereira S, Barker RN, (2011) Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function. J Leukoc Biol 90: 845-854.
47. Yoshimura A, Suzuki M, Sakaguchi R, Hanada T, Yasukawa H, (2012) SOCS, Inflammation, and Autoimmunity. Front Immunol 3: 1-9.
48. Kawai T, Akira S, (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34: 637-650.
49. Gazi U, Martinez-Pomares L, (2009) Influence of the mannose receptor in host immune responses. Immunobiology 214: 554-561.
50. Qin H, Holdbrooks AT, Liu Y, Reynolds SL, Yanagisawa LL, et al. (2012) SOCS3 deficiency promotes M1 macrophage polarization and inflammation. J Immunol 189: 3439-48.
51. Briken V, Mosser DM, (2011) Editorial: switching on arginase in M2 macrophages. J Leukoc Biol. 90: 839-41.
52. Toledo RG, Da Silva WD, Calich VL, Kipnis TL, (2010) Mannose-binding lectin complement pathway plays a key role in complement activation by Paracoccidioides brasiliensis. Mol Immunol 48: 26-36.
53. Lee MS, Kim YJ, (2007) Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem 76: 447-480.
54. Aderem A, Underhill DM, (1999) Mechanisms of phagocytosis in macrophages. Annu Rev Immunol 17: 593-623.
55. Kaplan G, (1977) Differences in the mode of phagocytosis with Fc and C3 receptors in macrophages. Scand J Immunol 6: 797-807.
56. Wright SD, Craigmyle LS, Silverstein SC, (1983) Fibronectin and serum amyloid P component stimulate C3b- and C3bi-mediated phagocytosis in cultured human monocytes. J Exp Med 158: 1338-43.
57. Brandhorst TT, Wüthrich M, Finkel-Jimenez B, Warner T, Klein BS, (2004) Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infection. J Immunol 173: 7444-7453.
58. Rappleye CA, Eissenberg LG, Goldman WE, (2007) Histoplasma capsulatum alpha-(1,3)-glucan blocks innate immune recognition by the beta-glucan receptor. Proc Natl Acad Sci U S A 104: 1366-1370.
59. Brown GD, Taylor PR, Reid DM, (2002) Dectin-1 is a major beta glucan receptor on macrophages. J Exp Med 296: 407-412.
60. Vautier S, Sousa Mda G, Brown GD, (2010) C-type lectins, fungi and Th17 responses. Cytokine Growth Factor Rev 21: 405-412.
61. Calich VL, da Costa TA, Felonato M, Arruda C, Bernardino S, et al. (2008) Innate immunity to Paracoccidioides brasiliensis infection. Mycopathologia 165: 223-36.
62. Mosser DM, Edwards JP, (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-69.
63. Guzik TJ, Korbut R, Adamek-Guzik T, (2003) Nitric oxide and superoxide in inflammation and immune regulation. J. Phys.Pharm. 54: 469-487.
64. Bogdan C, (2001) Nitric oxide and the regulation of gene expression. Trends Cell Biol 11: 66-75.
65. Raes G, Noël W, Beschin A, Brys L, de Baetselier P, et al. (2002) FIZZ1 and Ym as tools to discriminate between differentially activated macrophages. Dev Immunol 9: 151-159.
66. Chang NC, Hung SI, Hwa KY, Kato I, Chen JE, et al. (2001) A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin. J Biol Chem. 276: 17497-17506.
67. Goerdt S, Politz O, Schledzewski K, Birk R, Gratchev A, et al. (1999) Alternative versus classical activation of macrophages. Pathobiology 67: 222-226.
68. Martinez FO, Helming L, Gordon S, (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 27: 451-483.
69. Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M (2012) Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol. doi:10.1002/path.4133. [Epub ahead of print].