Effects of metformin on the regulation of free fatty acids in insulin resistance: A double-blind, placebo-controlled study

Journal of Nutrition and Metabolism

Volumn 2012, Issue , 2012, Pages

  Castro Cabezas, Manuel ^a   Van Wijk, Jeroen P H ^b   Elte, Jan Willem F ^a   Klop, Boudewijn ^a  

^a SINT FRANCISCUS GASTHUIS   (Netherlands)

^b GELDERSE VALLEI HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84873813897     PISSN: 20900724     EISSN: 20900732     Source Type: Journal    
DOI: 10.1155/2012/394623     Document Type: Article

References (34)

1. Zechner R., Kienesberger P. C., Haemmerle G., Zimmermann R., Lass A., Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. Journal of Lipid Research 2009 50 1 3 21 2-s2.0-63449127032 10.1194/jlr.R800031-JLR200
2. Funada J. I., Sekiya M., Hamada M., Hiwada K., Postprandial elevation of remnant lipoprotein leads to endothelial dysfunction. Circulation Journal 2002 66 2 127 132 2-s2.0-0036236264 10.1253/circj.66.127 (Pubitemid 34464718)
3. Jaworski K., Sarkadi-Nagy E., Duncan R. E., Ahmadian M., Sul H. S., Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue. American Journal of Physiology 2007 293 1 G1 G4 2-s2.0-34547125141 10.1152/ajpgi.00554.2006 (Pubitemid 47105157)
4. Jensen M. D., Haymond M. W., Rizza R. A., Cryer P. E., Miles J. M., Influence of body fat distribution on free fatty acid metabolism in obesity. Journal of Clinical Investigation 1989 83 4 1168 1173 2-s2.0-0024602053 (Pubitemid 19113028)
5. Miles J. M., Nelson R. H., Contribution of triglyceride-rich lipoproteins to plasma free fatty acids. Hormone and Metabolic Research 2007 39 10 726 729 2-s2.0-36048992887 10.1055/s-2007-990273 (Pubitemid 350099820)
6. Reardon M. F., Goldrick R. B., Fidge N. H., Dependence of rates of lipolysis, esterification, and free fatty acid release in isolated fat cells on age, cell size, and nutritional state. Journal of Lipid Research 1973 14 3 319 326 2-s2.0-0015807328
7. Zimmermann R., Strauss J. G., Haemmerle G., Schoiswohl G., Birner-Gruenberger R., Riederer M., Lass A., Neuberger G., Eisenhaber F., Hermetter A., Zechner R., Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 2004 306 5700 1383 1386 2-s2.0-8844226709 10.1126/science.1100747 (Pubitemid 39532517)
8. Coppack S. W., Jensen M. D., Miles J. M., In vivo regulation of lipolysis in humans. Journal of Lipid Research 1994 35 2 177 193 2-s2.0-0028044526 (Pubitemid 24050431)
9. Kolditz C. I., Langin D., Adipose tissue lipolysis. Current Opinion in Clinical Nutrition and Metabolic Care 2010 13 4 377 381 2-s2.0-77954348827 10.1097/MCO.0b013e32833bed6a
10. Ruge T., Hodson L., Cheeseman J., Dennis A. L., Fielding B. A., Humphreys S. M., Frayn K. N., Karpe F., Fasted to fed trafficking of fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage. Journal of Clinical Endocrinology and Metabolism 2009 94 5 1781 1788 2-s2.0-66149116077 10.1210/jc.2008-2090
11. Thompson D., Karpe F., Lafontan M., Frayn K., Physical activity and exercise in the regulation of human adipose tissue physiology. Physiological Reviews 2012 92 1 157 191
12. Carmen G. Y., Víctor S. M., Signalling mechanisms regulating lipolysis. Cellular Signalling 2006 18 4 401 408 2-s2.0-29044440372 10.1016/j.cellsig.2005.08.009 (Pubitemid 41790362)
13. Meijssen S., Castro Cabezas M., Ballieux C. G. M., Derksen R. J., Bilecen S., Erkelens D. W., Insulin mediated inhibition of hormone sensitive lipase activity in vivo in relation to endogenous catecholamines in healthy subjects. Journal of Clinical Endocrinology and Metabolism 2001 86 9 4193 4197 2-s2.0-0034841110 10.1210/jc.86.9.4193 (Pubitemid 32848535)
14. Meijssen S., Derksen R. J., Bilecen S., Erkelens D. W., Castro Cabezas M., In vivo modulation of plasma free fatty acids in patients with familial combined hyperlipidemia using lipid-lowering medication. Journal of Clinical Endocrinology and Metabolism 2002 87 4 1576 1580 2-s2.0-0036281385 10.1210/jc.87.4.1576 (Pubitemid 34615242)
15. Bickerton A. S. T., Roberts R., Fielding B. A., Tornqvist H., Blaak E. E., Wagenmakers A. J. M., Gilbert M., Humphreys S. M., Karpe F., Frayn K. N., Adipose tissue fatty acid metabolism in insulin-resistant men. Diabetologia 2008 51 8 1466 1474 2-s2.0-48149097201 10.1007/s00125-008-1040-x
16. Mook S., Halkes C. J. M., Bilecen S., Castro Cabezas M., In vivo regulation of plasma free fatty acids in insulin resistance. Metabolism 2004 53 9 1197 1201 2-s2.0-4344712936 10.1016/j.metabol.2004.02.023 (Pubitemid 39140757)
17. Zhang T., He J., Xu C., Zu L., Jiang H., Pu S., Guo X., Xu G., Mechanisms of metformin inhibiting lipolytic response to isoproterenol in primary rat adipocytes. Journal of Molecular Endocrinology 2009 42 1 57 66 2-s2.0-58849137050 10.1677/JME-08-0130
18. Flechtner-Mors M., Ditschuneit H. H., Jenkinson C. P., Alt A., Adler G., Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study. Diabetic Medicine 1999 16 12 1000 1006 2-s2.0-0033390614 10.1046/j.1464-5491.1999.00189.x (Pubitemid 30051426)
19. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Journal of the American Medical Association 2001 285 19 2486 2497 2-s2.0-0035897696 10.1001/jama.285.19.2486
20. Krebs M., Stingl H., Nowotny P., Weghuber D., Bischof M., Waldhäusl W., Roden M., Prevention of in vitro lipolysis by tetrahydrolipstatin. Clinical Chemistry 2000 46 7 950 954 2-s2.0-0033939992 (Pubitemid 30461265)
21. Matthews D. R., Hosker J. P., Rudenski A. S., Naylor B. A., Treacher D. F., Turner R. C., Homeostasis model assessment: insulin resistance and β -cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 7 412 419 2-s2.0-0021813187 (Pubitemid 15018832)
22. Boden G., Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997 46 1 3 10 2-s2.0-0031014830 (Pubitemid 27009941)
23. Paolisso G., Howard B. V., Role of non-esterified fatty acids in the pathogenesis of type 2 diabetes mellitus. Diabetes Medicine 1998 15 5 360 366 (Pubitemid 28197102)
24. Wilding J. P. H., The importance of free fatty acids in the development of Type 2 diabetes. Diabetic Medicine 2007 24 9 934 945 2-s2.0-34548186474 10.1111/j.1464-5491.2007.02186.x (Pubitemid 47304378)
25. Samuel V. T., Petersen K. F., Shulman G. I., Lipid-induced insulin resistance: unravelling the mechanism. The Lancet 2010 375 9733 2267 2277 2-s2.0-77953868236 10.1016/S0140-6736(10)60408-4
26. Abbasi F., Carantoni M., Chen Y. D. I., Reaven G. M., Further evidence for a central role of adipose tissue in the antihyperglycemic effect of metformin. Diabetes Care 1998 21 8 1301 1305 2-s2.0-0031881129 10.2337/diacare.21.8.1301 (Pubitemid 28365687)
27. Abbasi F., Chu J. W., McLaughlin T., Lamendola C., Leary E. T., Reaven G. M., Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus. Metabolism 2004 53 2 159 164 2-s2.0-0842306338 10.1016/j.metabol.2003.07.020 (Pubitemid 38168886)
28. Del Prato S., Marchetto S., Pipitone A., Zanon M., De Kreutzenberg S. V., Tiengo A., Metformin and free fatty acid metabolism. Diabetes/Metabolism Reviews 1995 11 1, Supplement 1 S33 S41 2-s2.0-0029101513
29. Magalhães F. O., Gouveia L. M. B., Torquato M. T. C. G., Paccola G. M. G. F., Piccinato C. E., Foss M. C., Metformin increases blood flow and forearm glucose uptake in a group of non-obese type 2 diabetes patients. Hormone and Metabolic Research 2006 38 8 513 517 2-s2.0-33748585929 10.1055/s-2006-949522 (Pubitemid 44378793)
30. Stumvoll M., Nurjhan N., Perriello G., Dailey G., Gerich J. E., Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England Journal of Medicine 1995 333 9 550 554 2-s2.0-0029133235 10.1056/NEJM199508313330903
31. Wu M. S., Johnston P., Sheu W. H. H., Hollenbeck C. B., Jeng C. Y., Goldfine I. D., Chen Y. D. I., Reaven G. M., Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients. Diabetes Care 1990 13 1 1 8 2-s2.0-0025057564 (Pubitemid 20024723)
32. Foretz M., Hébrard S., Leclerc J., Zarrinpashneh E., Soty M., Mithieux G., Sakamoto K., Andreelli F., Viollet B., Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. Journal of Clinical Investigation 2010 120 7 2355 2369 2-s2.0-77954933558 10.1172/JCI40671
33. Iannello S., Camuto M., Cavaleri A., Milazzo P., Pisano M. G., Bellomia D., Belfiore F., Effects of short-term metformin treatment on insulin sensitivity of blood glucose and free fatty acids. Diabetes, Obesity and Metabolism 2004 6 1 8 15 2-s2.0-0742271972 10.1111/j.1463-1326.2004.00306.x (Pubitemid 38159723)
34. Randle P. J., Garland P. B., Hales C. N., Newsholme E. A., The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. The Lancet 1963 281 7285 785 789 2-s2.0-50549202600